Article(id=1317115233290797059, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.047, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954342433, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954342433, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954342433, creator=13701087609, updateTime=1791954342433, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=239, endPage=242, ext={EN=ArticleExt(id=1317115233487929348, articleId=1317115233290797059, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Study of Mahuang Lianqiao Chixiaodou Decoction（麻黄连翘赤小豆汤）in Treatment of Primary Nephrotic Syndrome with Damp-Heat Syndrome, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the clinical efficacy of Mahuang Lianqiao Chixiaodou Decoction（麻黄连翘赤小豆汤）combined with routine treatment of primary nephrotic syndrome（PNS）with damp-heat syndrome.
Methods A total of 120 patients with PNS in the hospital from March 2022 to March 2024 were included and assigned into observation and control group randomly. The control group received conventional treatment. The observation group received Mahuang Lianqiao Chixiaodou Decoction additionally. The clinical efficacy, TCMsyndrome scores, the levels of urea nitrogen（BUN）, creatinine（Scr）, albumin（ALB）, 24 h urine protein, T lymphocyte CD4+, CD8+, CD4+/CD8+, triglycerides（TG）and total cholesterol（TC）and occurrence of adverse reactions were compared between the two groups after treatment.
Results The observation group detected a higher clinical efficacy rate compared to control group（P<0.05）. After treatment, the observation group had lower scores on TCM syndromes compared to control group（P<0.05）. The levels of BUN, Scr and 24 h urinary protein decreased, ALB increased and the improvement was more obvious in the observation group（P<0.05）. The levels of CD4+ and CD4+/CD8+ in both groups were increased than those before treatment, the levels of CD8+, TG and TC decreased, and the improvement was more obvious in the observation group（P<0.05）. No statistical difference was found in adverse reaction rate between two groups（P>0.05）.
Conclusion Mahuang Lianqiao Chixiaodou Decoction has a high efficacy in treating PNS with damp-heat syndrome. It can improve the renal function, blood lipids and immune function of the patients and relieve the clinical symptoms while ensuring safety.
, authors=Jie KOU
1, Xin'ai WANG
1, Zhe LYU
1, Mingjun HOU
2, Dong BIAN
1, authorsList=Jie KOU, Xin'ai WANG, Zhe LYU, Mingjun HOU, Dong BIAN, authorCompany=null, correspAuthors=Dong BIAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115235752853511, articleId=1317115233290797059, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=麻黄连翘赤小豆汤治疗原发性肾病综合征湿热壅盛证的临床研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探索麻黄连翘赤小豆汤对原发性肾病综合征（Primary nephrotic syndrome，PNS）湿热壅盛证的治疗效果。
方法 选取2022年3月—2024年3月在医院诊治的PNS患者共120例，随机平均分为观察组（60例）和对照组（60例）。对照组采取常规治疗，观察组在此基础上联合麻黄连翘赤小豆汤。对比两组治疗后的临床疗效、中医证候积分、尿素氮（Blood urea nitrogen，BUN）、肌酐（Serum creatinine，Scr）、白蛋白（Albumin，ALB）、24 h尿蛋白、T淋巴细胞CD4+、CD8+、CD4+/CD8+、甘油三酯（Triglyceride，TG）、总胆固醇（Total cholesterol，TC）及不良反应发生率。
结果 观察组治疗有效率高于对照组（P<0.05）；治疗后观察组中医证候积分低于对照组（P<0.05）；两组BUN、Scr、24 h尿蛋白均降低，ALB升高，且观察组改善程度更明显（P<0.05）；两组CD4+、CD4+/CD8+均较前提升，CD8+、TG、TC降低，且观察组改善更明显（P<0.05）；两组不良反应发生率差异无统计学意义（P>0.05）。
结论 麻黄连翘赤小豆汤治疗PNS湿热壅盛证有较高的疗效，其能在保障安全性的基础上改善患者肾功能、血脂及免疫功能、缓解临床症状。
, authors=寇杰
1, 王新爱
1, 吕哲
1, 侯明君
2, 边东
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寇杰（1987-），女，河北石家庄人，主治医师，硕士，研究方向：肾病诊治。
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