Article(id=1317115204744368756, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.06.046, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954335628, onlineDateStr=2026-10-14, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954335628, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954335628, creator=13701087609, updateTime=1791954335628, updator=13701087609, issue=Issue{id=1317114999827452826, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954286772, creator='13701087609', updateTime=1791958677365, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133415753831385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133415753831386, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=239, endPage=242, ext={EN=ArticleExt(id=1317115204945695349, articleId=1317115204744368756, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Therapeutic Effect of Wenzhong Jianpi Decoction (温中健脾汤) on Chronic Atrophic Gastritis with Deficiency of Spleen and Stomach Syndrome and Its Impact on Levels of CGRP, EGF and ET, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the therapeutic effect of Wenzhong Jianpi Decoction (温中健脾汤) on chronic atrophic gastritis (deficiency of spleen and stomach syndrome) and its impact on the levels of calcitonin gene related peptide (CGRP), epidermal growth factor (EGF) and gastrointestinal hormone endothelin (ET).
Method Ninety patients with chronic atrophic gastritis with deficiency of spleen and stomach syndrome met the inclusion criteria for this study were randomly divided into two groups using a random number table method. The control group received symptomatic treatment with conventional Western medicine, while the observation group was additionally treated with Wenzhong Jianpi Decoction orally. After 8 weeks of continuous treatment, the pathological scores (atrophy, intestinal metaplasia, dysplasia, chronic inflammation and motility), the gastric mucosal blood flow (anterior and posterior walls of gastric antrum, greater and lesser curvature of gastric antrum) and the serum levels of gastrointestinal hormones (ET, CGRP, EGF) before and after treatment between the two groups were compared, and the total effective rate and drug safety of the two groups were also observed.
Result After treatment, the scores of atrophy, intestinal metaplasia, dysplasia, chronic inflammation and activity, the serum levels of ET and EGF in both groups were lower than those before treatment (P<0.05), which in the observation group were lower than those in the control group (P<0.05). After treatment, the serum levels of CGRP and the blood flow of the anterior and posterior walls of the gastric antrum, the greater curvature of the gastric antrum and the lesser curvature of the gastric antrum in both groups were higher than those before treatment (P<0.05), which in the observation group were higher than those in the control group (P<0.05). The total effective rate of the observation group (91.1%, 41/45) was higher than that of the control group (73.3%, 33/45) (P<0.05). There were no adverse reactions related to medication during the treatment in both groups.
Conclusion The application of Wenzhong Jianpi Decoction can regulate the serum levels of CGRP, EGF and ET in the patients with chronic atrophic gastritis with deficiency of spleen and stomach syndrome and increase the gastric mucosal blood flow, which help to improve gastric pathological status and enhance the treatment effectiveness.
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目的 观察温中健脾汤治疗慢性萎缩性胃炎（脾胃虚弱证）疗效及对降钙素基因相关肽（calcitonin gene related peptide，CGRP）、表皮生长因子（epidermal growth factor，EGF）、胃肠激素内皮素（endothelin，ET）水平的影响。
方法 将符合研究入选标准的90例慢性萎缩性胃炎（脾胃虚弱证）患者按随机数字表法分成两组。对照组予常规西医对症治疗，观察组另外联合温中健脾汤口服。连续治疗8周后，比较两组胃镜下病理积分（萎缩、肠上皮化生、异型增生、慢性炎症、活动性）、胃黏膜血流量（胃窦前壁、胃窦后壁、胃窦大弯、胃窦小弯）、血清胃肠激素（ET、CGRP、EGF）水平变化，并比较两组治疗总有效率及药物安全性。
结果 两组治疗后萎缩、肠上皮化生、异型增生、慢性炎症及活动性积分，血清ET和EGF水平均低于治疗前（P<0.05），且观察组均低于对照组（P<0.05）；两组治疗后血清CGRP水平，胃窦前壁、胃窦后壁、胃窦大弯、胃窦小弯血流量均高于治疗前（P<0.05），且观察组均高于对照组（P<0.05）；观察组总有效率（91.1%，41/45）高于对照组（73.3%，33/45）（P<0.05）；两组用药期间均未出现与用药相关的不良反应。
结论 温中健脾汤能够调节慢性萎缩性胃炎（脾胃虚弱证）患者血清CGRP、EGF、ET水平，提高患者胃黏膜血流量，有助于改善胃病理状态，提升治疗效果。
, authors=魏瑞瑶, 戴木根, authorsList=魏瑞瑶, 戴木根, authorCompany=null, correspAuthors=null, authorNote=
魏瑞瑶（1983-），女，浙江丽水人，主治中医师，学士，研究方向：中医消化系统疾病诊治。
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魏瑞瑶（1983-），女，浙江丽水人，主治中医师，学士，研究方向：中医消化系统疾病诊治。
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魏瑞瑶（1983-），女，浙江丽水人，主治中医师，学士，研究方向：中医消化系统疾病诊治。
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