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Article(id=1317115182053179977, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.029, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954330217, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954330217, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954330217, creator=13701087609, updateTime=1791954330217, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=136, endPage=142, ext={EN=ArticleExt(id=1317115182271283786, articleId=1317115182053179977, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Wogonin in Suppressing Lung Metastasis of Breast Cancer After Myocardial Infarction by Regulating Macrophage Polarization, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

This study explored the pharmacological effect and mechanism of wogonin on lung metastasis of breast cancer after myocardial infarction, and provided potential drugs and experimental basis for the treatment of lung metastasis of breast cancer.

Methods

In the experiment, the mouse model of myocardial infarction and breast cancer was established by 6-7 weeks old female balb/c mice, and the effect of wogonin on lung metastasis of breast cancer after myocardial infarction and macrophages in mouse tumors was detected. THP-1, RAW264.7 and bone marrow-derived macrophages（BMDM）cells were induced in vitro to construct macrophage polarization model, and the effect of wogonin on macrophage polarization and the changes of key proteins regulating polarization were detected.

Results

The results showed that compared with those of the model group, the number of lung tumor metastasis, the weight of breast tumor, cardiac function and cardiac inflammation were significantly reduced, and the expression of M2 macrophages in tumor was significantly reduced in the wogonin group. In vitro experiments showed that wogonin significantly inhibited the M2 polarization of macrophages, reduced the phosphorylation of signal transducer and activator of transcription 6（STAT6）and inhibited the migration of MDA-MB 231 cells.

Conclusions

The above results indicate that wogonin can inhibit the lung metastasis of breast adenocarcinoma after myocardial infarction, and its mechanism may be realized by inhibiting the phosphorylation of STAT6 and then affecting the M2 polarization of macrophages in the tumor.

, authors=Zhenkun XU1, Wenjie YANG2, Hongyu LI1, Mengyao LI2, Xiuyun REN2, Xianhai CAO1, Xinyue LIU1, Lu CHEN1, Hong WANG2, authorsList=Zhenkun XU, Wenjie YANG, Hongyu LI, Mengyao LI, Xiuyun REN, Xianhai CAO, Xinyue LIU, Lu CHEN, Hong WANG, authorCompany=null, correspAuthors=Lu CHEN, Hong WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115182896235084, articleId=1317115182053179977, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=汉黄芩素通过调控巨噬细胞极化抑制心肌梗死后乳腺癌肺转移的作用研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

探讨汉黄芩素对心肌梗死（Myocardial infarction，MI）后乳腺癌肺转移的药理作用及其机制，为乳腺癌肺转移的治疗提供潜在药物以及实验基础。

方法

实验通过6～7周雌性BALB/c小鼠构建心肌梗死乳腺癌小鼠模型，检测汉黄苓素对心肌梗死后乳腺癌肺转移的影响及对小鼠肿瘤中巨噬细胞的影响。体外诱导THP-1、RAW264.7及骨髓来源巨噬细胞（Bone marrow-derived macrophages，BMDM）细胞构建巨噬细胞极化模型，检测汉黄苓素对巨噬细胞极化的影响及调控极化关键蛋白的变化。

结果

与模型组小鼠相比，汉黄芩素组小鼠肺部肿瘤转移灶数显著减少，乳腺肿瘤重量显著降低，心功能和心脏炎症明显改善，肿瘤中M2型巨噬细胞表达显著降低。体外实验显示，汉黄芩素显著抑制巨噬细胞M2极化，显著降低信号转导和转录激活剂6（Signal transducer and activator of transcription 6，STAT6）磷酸化；显著阻抑MDA-MB 231细胞迁移。

结论

汉黄芩素可以遏制心肌梗死后乳腺腺癌肺转移，其作用机制可能是通过抑制STAT6磷酸化进而影响肿瘤中巨噬细胞M2极化实现的。

, authors=许振坤1, 杨文杰2, 李宏宇1, 李梦瑶2, 任秀云2, 曹贤海1, 刘昕月1, 陈璐1, 王虹2, authorsList=许振坤, 杨文杰, 李宏宇, 李梦瑶, 任秀云, 曹贤海, 刘昕月, 陈璐, 王虹, authorCompany=null, correspAuthors=陈璐, 王虹, authorNote=

许振坤（1998-），男，山东泰安人，硕士在读，研究方向：中药药理。

, correspAuthorsNote=
陈璐（1989-），女，江西吉安人，副研究员，硕士研究生导师，博士，研究方向：中药药理。E-mail: 。
王虹（1974-），女，山东烟台人，教授，博士研究生导师，博士，研究方向：中药药理。E-mail: 。
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许振坤（1998-），男，山东泰安人，硕士在读，研究方向：中药药理。

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许振坤（1998-），男，山东泰安人，硕士在读，研究方向：中药药理。

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汉黄芩素通过调控巨噬细胞极化抑制心肌梗死后乳腺癌肺转移的作用研究
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许振坤 1 , 杨文杰 2 , 李宏宇 1 , 李梦瑶 2 , 任秀云 2 , 曹贤海 1 , 刘昕月 1 , 陈璐 1 , 王虹 2
中华中医药学刊 | 国家项目点击 2026,44(4): 136-142
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中华中医药学刊 |国家项目点击 2026 , 44 (4) : 136 -142
汉黄芩素通过调控巨噬细胞极化抑制心肌梗死后乳腺癌肺转移的作用研究
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许振坤1, 杨文杰2, 李宏宇1, 李梦瑶2, 任秀云2, 曹贤海1, 刘昕月1, 陈璐1 , 王虹2
作者信息
  • 1.天津中医药大学测试中心，天津 301617
  • 2.天津中医药大学医学技术学院，天津 301617
通讯作者:
陈璐（1989-），女，江西吉安人，副研究员，硕士研究生导师，博士，研究方向：中药药理。E-mail: 。
王虹（1974-），女，山东烟台人，教授，博士研究生导师，博士，研究方向：中药药理。E-mail: 。
作者简介:

许振坤（1998-），男，山东泰安人，硕士在读，研究方向：中药药理。

Effect of Wogonin in Suppressing Lung Metastasis of Breast Cancer After Myocardial Infarction by Regulating Macrophage Polarization
Zhenkun XU1, Wenjie YANG2, Hongyu LI1, Mengyao LI2, Xiuyun REN2, Xianhai CAO1, Xinyue LIU1, Lu CHEN1 , Hong WANG2
Affiliations
  • 1.Testing Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2.School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
出版时间: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.029
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摘要
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目的

探讨汉黄芩素对心肌梗死（Myocardial infarction，MI）后乳腺癌肺转移的药理作用及其机制，为乳腺癌肺转移的治疗提供潜在药物以及实验基础。

方法

实验通过6～7周雌性BALB/c小鼠构建心肌梗死乳腺癌小鼠模型，检测汉黄苓素对心肌梗死后乳腺癌肺转移的影响及对小鼠肿瘤中巨噬细胞的影响。体外诱导THP-1、RAW264.7及骨髓来源巨噬细胞（Bone marrow-derived macrophages，BMDM）细胞构建巨噬细胞极化模型，检测汉黄苓素对巨噬细胞极化的影响及调控极化关键蛋白的变化。

结果

与模型组小鼠相比，汉黄芩素组小鼠肺部肿瘤转移灶数显著减少，乳腺肿瘤重量显著降低，心功能和心脏炎症明显改善，肿瘤中M2型巨噬细胞表达显著降低。体外实验显示，汉黄芩素显著抑制巨噬细胞M2极化，显著降低信号转导和转录激活剂6（Signal transducer and activator of transcription 6，STAT6）磷酸化；显著阻抑MDA-MB 231细胞迁移。

结论

汉黄芩素可以遏制心肌梗死后乳腺腺癌肺转移，其作用机制可能是通过抑制STAT6磷酸化进而影响肿瘤中巨噬细胞M2极化实现的。

汉黄芩素  /  心肌梗死  /  乳腺癌  /  巨噬细胞极化
Objective

This study explored the pharmacological effect and mechanism of wogonin on lung metastasis of breast cancer after myocardial infarction, and provided potential drugs and experimental basis for the treatment of lung metastasis of breast cancer.

Methods

In the experiment, the mouse model of myocardial infarction and breast cancer was established by 6-7 weeks old female balb/c mice, and the effect of wogonin on lung metastasis of breast cancer after myocardial infarction and macrophages in mouse tumors was detected. THP-1, RAW264.7 and bone marrow-derived macrophages（BMDM）cells were induced in vitro to construct macrophage polarization model, and the effect of wogonin on macrophage polarization and the changes of key proteins regulating polarization were detected.

Results

The results showed that compared with those of the model group, the number of lung tumor metastasis, the weight of breast tumor, cardiac function and cardiac inflammation were significantly reduced, and the expression of M2 macrophages in tumor was significantly reduced in the wogonin group. In vitro experiments showed that wogonin significantly inhibited the M2 polarization of macrophages, reduced the phosphorylation of signal transducer and activator of transcription 6（STAT6）and inhibited the migration of MDA-MB 231 cells.

Conclusions

The above results indicate that wogonin can inhibit the lung metastasis of breast adenocarcinoma after myocardial infarction, and its mechanism may be realized by inhibiting the phosphorylation of STAT6 and then affecting the M2 polarization of macrophages in the tumor.

wogonin  /  myocardial infarction  /  breast cancer  /  macrophage polarization
许振坤, 杨文杰, 李宏宇, 李梦瑶, 任秀云, 曹贤海, 刘昕月, 陈璐, 王虹. 汉黄芩素通过调控巨噬细胞极化抑制心肌梗死后乳腺癌肺转移的作用研究. 中华中医药学刊, 2026 , 44 (4) : 136 -142 . DOI: 10.13193/j.issn.1673-7717.2026.04.029
Zhenkun XU, Wenjie YANG, Hongyu LI, Mengyao LI, Xiuyun REN, Xianhai CAO, Xinyue LIU, Lu CHEN, Hong WANG. Effect of Wogonin in Suppressing Lung Metastasis of Breast Cancer After Myocardial Infarction by Regulating Macrophage Polarization[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 136 -142 . DOI: 10.13193/j.issn.1673-7717.2026.04.029
基金
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  • 国家自然科学基金项目(82274135; 82174205)
  • 天津市科技计划项目(23ZYJDSS00020)
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2026年第44卷第4期
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doi: 10.13193/j.issn.1673-7717.2026.04.029
  • 首发时间：2026-10-14
  • 出版时间：2026-04-10
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基金
国家自然科学基金项目(82274135; 82174205)
天津市科技计划项目(23ZYJDSS00020)
作者信息
    1.天津中医药大学测试中心，天津 301617
    2.天津中医药大学医学技术学院，天津 301617

通讯作者:

陈璐（1989-），女，江西吉安人，副研究员，硕士研究生导师，博士，研究方向：中药药理。E-mail: 。
王虹（1974-），女，山东烟台人，教授，博士研究生导师，博士，研究方向：中药药理。E-mail: 。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.04.029
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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