Article(id=1317115175178715670, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954328579, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954328579, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954328579, creator=13701087609, updateTime=1791954328579, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=120, endPage=123, ext={EN=ArticleExt(id=1317115175388430871, articleId=1317115175178715670, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Danggui Buxue Decoction（当归补血汤）Combined with Acupuncture on Levels of Hcy，NGF，IGF-1 and VEGF and Changes in Nerve Conduction Function in Diabetic Patients with Peripheral Neuropathy, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of Danggui Buxue Decoction（当归补血汤）combined with acupuncture on the levels of blood homocysteine（Hcy）, nerve growth factor（NGF）, insulin-like growth factor-1（IGF-1）and vascular endothelial growth factor（VEGF）and the changes in nerve conduction function in diabetic patients with peripheral neuropathy.
Methods This paper collected 120 diabetic patients with peripheral neuropathy admitted to the hospital between January 2022 and January 2024, and were randomly divided into test group and control group. The control group used conventional Western medicine treatment, and the test group used acupuncture and Danggui Buxue Decoction. TCMsyndrome scores, diabetic peripheral neuropathy scores, diabetic neuropathy score（DNS）, clinical efficacy, serum levels of Hcy, NGF, IGF-1 and VEGF and nerve conduction function were compared.
Results There was no significant difference in TCMsyndrome scores, DNS, the serum levels of Hcy, NGF, IGF-1 or VEGF, the conduction velocities of median nerve motor conduction（MCV）and tibial nerve sensory conduction（SCV）between the two groups before treatment（P>0.05）. The scores of TCMsyndromes and DNS in both groups were significantly lower after treatment and the scores and DNS in the test group were significantly lower than those in the control group（P<0.05）. The clinical effective rate in the test group was significantly higher than that in the control group（P<0.05）. After treatment, the serum levels of Hcy and VEGF in the two groups were significantly lower than those before treatment, the serum levels of NGF and IGF-1, conduction velocities of MCV and SCV on both sides were significantly higher than those before treatment, and the decrease/increase amplitude in the test group was significantly higher than that in the control group（P<0.05）.
Conclusion - Acupuncture and Danggui Buxue Decoction have obvious effect and can effectively improve the serum levels of Hcy, NGF, IGF-1 and VEGF and the nerve conduction function of the diabetic patients with peripheral neuropathy.
, authors=Wenwen ZHAO
1, Xiangyu HUANG
1, Ting LUO
1, Litao LI
2, Jiao YAN
1, Defang LIU
1, authorsList=Wenwen ZHAO, Xiangyu HUANG, Ting LUO, Litao LI, Jiao YAN, Defang LIU, authorCompany=null, correspAuthors=Defang LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115175711392280, articleId=1317115175178715670, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=当归补血汤联合针灸对伴有周围神经病变的糖尿病Hcy、NGF、IGF-1、VEGF水平及神经传导功能的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探究当归补血汤联合针灸对伴有周围神经病变的糖尿病患者的血同型半胱氨酸（Hcy）、神经生长因子（NGF）、胰岛素样生长因子-1（IGF-1）、血管内皮生长因子（VEGF）水平及神经传导功能变化情况的影响。
方法 收集医院2022年1月—2024年1月期间收治的120例糖尿病伴周围神经病变患者，随机分为试验组和对照组。对照组采用常规西医治疗，试验组采用针灸、当归补血汤联合治疗。对两组患者治疗前后中医证候积分、糖尿病周围神经病变积分（DNS）、临床疗效、血清Hcy、NGF、IGF-1、VEGF水平、神经传导功能进行比较。
结果 两组患者治疗前中医证候积分、DNS、血清Hcy、NGF、IGF-1、VEGF水平、左右两侧MCV、SCV传导速度比较差异无统计学意义（P>0.05）。两组患者治疗后中医证候积分、DNS较治疗前均明显下降，且试验组患者治疗后中医证候积分、DNS明显低于对照组（P<0.05）。试验组患者临床有效率较对照组明显提高（P<0.05）。两组患者治疗后血清Hcy、VEGF水平较治疗前明显降低，血清NGF、IGF-1水平、左右两侧MCV、SCV传导速度较治疗前明显上升，且试验组降低/上升幅度明显大于对照组（P<0.05）。
结论 针灸联合当归补血汤治疗效果明显，能够有效改善伴有周围神经病变的糖尿病患者血清Hcy、NGF、IGF-1、VEGF水平，提高患者神经传导功能。
, authors=赵雯雯
1, 黄湘玉
1, 罗婷
1, 李立涛
2, 晏姣
1, 刘德芳
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赵雯雯（1993-），女，四川成都人，主治医师，硕士，研究方向：中医内科学内分泌与代谢性疾病。
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