Article(id=1317115146523234421, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.06.040, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954321746, onlineDateStr=2026-10-14, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954321746, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954321746, creator=13701087609, updateTime=1791954321746, updator=13701087609, issue=Issue{id=1317114999827452826, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954286772, creator='13701087609', updateTime=1791958677365, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133415753831385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133415753831386, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=215, endPage=218, ext={EN=ArticleExt(id=1317115146732949622, articleId=1317115146523234421, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Observation of Modified Longdan Xiegan Decoction (龙胆泻肝汤加减) Combined with Hepatic Artery Chemoembolization in Treatment of Primary Liver Cancer Complicated with Portal Vein Cancer Thrombus, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the clinical effect of Modified Longdan Xiegan Decoction (龙胆泻肝汤加减) combined with hepatic artery chemoembolization in the treatment of primary liver cancer complicated with portal vein cancer thrombus.

Methods

A total of 64 patients with primary liver cancer complicated with portal vein cancer thrombus admitted from January 2020 to January 2023 were included in the study and divided into into chemoembolization group (32 cases) and combined Chinese medicine group (32 cases) by random number table method. The patients in the chemoembolization group were treated with hepatic artery chemoembolization. Those in the combined Chinese medicine group were treated with Longdan Xiegan Decoction combined with hepatic artery chemoembolization, and the data of the patients in each group was observed, including the clinical efficacy, the changes in the total scores of TCM symptoms and the changes in the quality of life (QOL) before and after treatment, Eastern Cooperative Oncology Group (ECOG) scores, the changes of tumor markers such as Alpha-Feto protein (AFP), carcinoembryonic antigen (CEA), immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM), adverse reactions and 1-year survival rate.

Results

The total effective rate of the combined Chinese medicine group was higher than that of the chemoembolization group (P<0.05). The total TCM syndrome scores, QOL score, ECOG score, tumor markers (AFP and CEA), immune function indexes (IgA, IgG, IgM) and other indexes were not significant between the two groups before treatment (P>0.05). After treatment, the total TCM syndrome scores, QOL score, ECOG score, tumor markers (AFP and CEA), immune function indexes (IgA, IgG, IgM) and other indexes were improved in both groups. These indexes in the combined Chinese medicine group were better than those in the chemoembolization group (P<0.05). The incidence of gastrointestinal discomfort and alopecia in the combined Chinese medicine group was lower than that in the chemoembolization group (P<0.05). The 1-year survival rate in the combined Chinese medicine group was higher than that in the chemoembolization group (P<0.05).

Conclusion

Modified Longdan Xiegan Decoction combined with hepatic artery chemoembolization has good clinical effect in the treatment of primary liver cancer complicated with portal vein cancer embolus, which can improve the patients'quality of life, immune ability and physical condition, reduce the rate of chemotherapy adverse reactions to a certain extent, and improve the 1-year survival rate of the patients.

, authors=Yuanbo GUOHAI1, Yufen XU1, Fang WU2, Ping FENG2, Jiaqi TANG2, authorsList=Yuanbo GUOHAI, Yufen XU, Fang WU, Ping FENG, Jiaqi TANG, authorCompany=null, correspAuthors=Yufen XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115146967830647, articleId=1317115146523234421, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的

探讨龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果。

方法

研究合计纳入64例原发性肝癌合并门静脉癌栓患者(2020年1月—2023年1月收治)进行分组,采取随机数字表法将患者分为化疗栓塞组(32例)以及联合中药组(32例),化疗栓塞组患者均采取肝动脉化疗栓塞术治疗,联合中药组患者采取龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗,观察各组患者数据:临床疗效、治疗前后中医证候总积分变化及生活质量评分(Quality of Life,QOL)变化、美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)评分变化、甲胎蛋白(Alpha-FetoProtein,AFP)及癌胚抗原(Carcinoembryonic antigen,CEA)等肿瘤标志物变化、免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白M(Immunoglobulin M,IgM)等免疫功能指标变化、不良反应及1年生存率情况。

结果

联合中药组患者治疗总有效率高于化疗栓塞组,P<0.05;治疗前两组患者中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标比较,P>0.05,治疗后各组患者中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标改善,联合中药组患者治疗后中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标均优于化疗栓塞组患者,P<0.05;联合中药组患者治疗胃肠道不适发生率及脱发发生率低于化疗栓塞组患者,P<0.05;联合中药组患者1年生存率高于化疗栓塞组患者,P<0.05。

结论

龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果良好,可较好改善患者生活质量、免疫能力、体力状况,还可一定程度降低患者化疗不良反应率,提升患者1年生存率。

, authors=郭海渊博1, 徐玉芬1, 吴芳2, 冯娉2, 汤加奇2, authorsList=郭海渊博, 徐玉芬, 吴芳, 冯娉, 汤加奇, authorCompany=null, correspAuthors=徐玉芬, authorNote=

郭海渊博(1988-),男,江苏淮安人,副主任医师,学士,研究方向:肿瘤内科。

, correspAuthorsNote=
徐玉芬(1984-),女,江西上饶人,副主任医师,博士,研究方向:肿瘤内科。
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郭海渊博(1988-),男,江苏淮安人,副主任医师,学士,研究方向:肿瘤内科。

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郭海渊博(1988-),男,江苏淮安人,副主任医师,学士,研究方向:肿瘤内科。

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龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果观察
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郭海渊博 1 , 徐玉芬 1 , 吴芳 2 , 冯娉 2 , 汤加奇 2
中华中医药学刊 | 省级项目平台 2026,44(6): 215-218
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中华中医药学刊 |省级项目平台 2026 , 44 (6) : 215 -218
龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果观察
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郭海渊博1, 徐玉芬1, 吴芳2, 冯娉2, 汤加奇2
作者信息
  • 1.浙江中医药大学,浙江 杭州 310053
  • 2.嘉兴市第一医院,浙江 嘉兴 314001
通讯作者:
徐玉芬(1984-),女,江西上饶人,副主任医师,博士,研究方向:肿瘤内科。
作者简介:

郭海渊博(1988-),男,江苏淮安人,副主任医师,学士,研究方向:肿瘤内科。

Clinical Observation of Modified Longdan Xiegan Decoction (龙胆泻肝汤加减) Combined with Hepatic Artery Chemoembolization in Treatment of Primary Liver Cancer Complicated with Portal Vein Cancer Thrombus
Yuanbo GUOHAI1, Yufen XU1, Fang WU2, Ping FENG2, Jiaqi TANG2
Affiliations
  • 1.Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
  • 2.Jiaxing First Hospital, Jiaxing 314001, Zhejiang, China
出版时间: 2026-06-10 doi: 10.13193/j.issn.1673-7717.2026.06.040
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目的

探讨龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果。

方法

研究合计纳入64例原发性肝癌合并门静脉癌栓患者(2020年1月—2023年1月收治)进行分组,采取随机数字表法将患者分为化疗栓塞组(32例)以及联合中药组(32例),化疗栓塞组患者均采取肝动脉化疗栓塞术治疗,联合中药组患者采取龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗,观察各组患者数据:临床疗效、治疗前后中医证候总积分变化及生活质量评分(Quality of Life,QOL)变化、美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)评分变化、甲胎蛋白(Alpha-FetoProtein,AFP)及癌胚抗原(Carcinoembryonic antigen,CEA)等肿瘤标志物变化、免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白M(Immunoglobulin M,IgM)等免疫功能指标变化、不良反应及1年生存率情况。

结果

联合中药组患者治疗总有效率高于化疗栓塞组,P<0.05;治疗前两组患者中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标比较,P>0.05,治疗后各组患者中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标改善,联合中药组患者治疗后中医证候总积分、QOL评分及ECOG评分、肿瘤标志物(AFP及CEA)、免疫功能指标(IgA、IgG、IgM)等指标均优于化疗栓塞组患者,P<0.05;联合中药组患者治疗胃肠道不适发生率及脱发发生率低于化疗栓塞组患者,P<0.05;联合中药组患者1年生存率高于化疗栓塞组患者,P<0.05。

结论

龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果良好,可较好改善患者生活质量、免疫能力、体力状况,还可一定程度降低患者化疗不良反应率,提升患者1年生存率。

原发性肝癌合并门静脉癌栓  /  肝动脉化疗栓塞术  /  龙胆泻肝汤加减  /  疗效  /  不良反应  /  肿瘤标志物  /  免疫功能
Objective

To investigate the clinical effect of Modified Longdan Xiegan Decoction (龙胆泻肝汤加减) combined with hepatic artery chemoembolization in the treatment of primary liver cancer complicated with portal vein cancer thrombus.

Methods

A total of 64 patients with primary liver cancer complicated with portal vein cancer thrombus admitted from January 2020 to January 2023 were included in the study and divided into into chemoembolization group (32 cases) and combined Chinese medicine group (32 cases) by random number table method. The patients in the chemoembolization group were treated with hepatic artery chemoembolization. Those in the combined Chinese medicine group were treated with Longdan Xiegan Decoction combined with hepatic artery chemoembolization, and the data of the patients in each group was observed, including the clinical efficacy, the changes in the total scores of TCM symptoms and the changes in the quality of life (QOL) before and after treatment, Eastern Cooperative Oncology Group (ECOG) scores, the changes of tumor markers such as Alpha-Feto protein (AFP), carcinoembryonic antigen (CEA), immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM), adverse reactions and 1-year survival rate.

Results

The total effective rate of the combined Chinese medicine group was higher than that of the chemoembolization group (P<0.05). The total TCM syndrome scores, QOL score, ECOG score, tumor markers (AFP and CEA), immune function indexes (IgA, IgG, IgM) and other indexes were not significant between the two groups before treatment (P>0.05). After treatment, the total TCM syndrome scores, QOL score, ECOG score, tumor markers (AFP and CEA), immune function indexes (IgA, IgG, IgM) and other indexes were improved in both groups. These indexes in the combined Chinese medicine group were better than those in the chemoembolization group (P<0.05). The incidence of gastrointestinal discomfort and alopecia in the combined Chinese medicine group was lower than that in the chemoembolization group (P<0.05). The 1-year survival rate in the combined Chinese medicine group was higher than that in the chemoembolization group (P<0.05).

Conclusion

Modified Longdan Xiegan Decoction combined with hepatic artery chemoembolization has good clinical effect in the treatment of primary liver cancer complicated with portal vein cancer embolus, which can improve the patients'quality of life, immune ability and physical condition, reduce the rate of chemotherapy adverse reactions to a certain extent, and improve the 1-year survival rate of the patients.

primary liver cancer complicated with portal vein cancer thrombus  /  hepatic arterial chemoembolization  /  Modified Longdan Xiegan Decoction (龙胆泻肝汤加减)  /  curative effect  /  adverse reactions  /  tumor markers  /  immune function
郭海渊博, 徐玉芬, 吴芳, 冯娉, 汤加奇. 龙胆泻肝汤加减联合肝动脉化疗栓塞术治疗原发性肝癌合并门静脉癌栓临床效果观察. 中华中医药学刊, 2026 , 44 (6) : 215 -218 . DOI: 10.13193/j.issn.1673-7717.2026.06.040
Yuanbo GUOHAI, Yufen XU, Fang WU, Ping FENG, Jiaqi TANG. Clinical Observation of Modified Longdan Xiegan Decoction (龙胆泻肝汤加减) Combined with Hepatic Artery Chemoembolization in Treatment of Primary Liver Cancer Complicated with Portal Vein Cancer Thrombus[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (6) : 215 -218 . DOI: 10.13193/j.issn.1673-7717.2026.06.040
  • 浙江省医药卫生科研项目(2020KY974)
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2026年第44卷第6期
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doi: 10.13193/j.issn.1673-7717.2026.06.040
  • 首发时间:2026-10-14
  • 出版时间:2026-06-10
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基金
浙江省医药卫生科研项目(2020KY974)
作者信息
    1.浙江中医药大学,浙江 杭州 310053
    2.嘉兴市第一医院,浙江 嘉兴 314001

通讯作者:

徐玉芬(1984-),女,江西上饶人,副主任医师,博士,研究方向:肿瘤内科。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.06.040
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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