Article(id=1317115139401306162, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.06.039, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954320049, onlineDateStr=2026-10-14, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954320049, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954320049, creator=13701087609, updateTime=1791954320049, updator=13701087609, issue=Issue{id=1317114999827452826, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954286772, creator='13701087609', updateTime=1791958677365, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133415753831385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133415753831386, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=209, endPage=214, ext={EN=ArticleExt(id=1317115139611021363, articleId=1317115139401306162, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Quality Control Status and Predictive Analysis of Quality Markers of Qiancao (Rubiae Radix et Rhizoma), columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=

Qiancao (Rubiae Radix et Rhizoma) contains active ingredients such as quinones, cyclopeptides, terpenes and polysaccharides, which have the effects of promoting blood circulation, removing blood stasis, stopping bleeding and dredging meridians. It is widely used in traditional Chinese medicine clinical practice. However, there are problems with adulteration, excessive nonmedicinal parts and substandard content in Qiancao (Rubiae Radix et Rhizoma) currently, and the existing quality control indicators make it difficult to evaluate the quality of medicinal materials comprehensively. Based on research progress on quality control of Qiancao (Rubiae Radix et Rhizoma), its quality markers were predicted and analyzed from 7 aspects such as plant genetic relationship, traditional efficacy, different origins, compatibility of different compounds, new pharmacodynamic pathway and measurable chemical compounds. The results suggested that alizarin, purpurin, 6-hdroxyrubiadin, xnthopurpurin, rbiadin, mollugin, rbioncolin C, xyloidone, lpachol, isolariciresinol, RA-Ⅴ, RA-Ⅶ and β-sitosterol can be used as quality markers of Qiancao (Rubiae Radix et Rhizoma), providing a reference for its quality standard improvement and other research in the future.

, authors=Xiaoyan ZHANG1, Ziyao QIAO2, Kairu DING2, Kaihua LONG1, Tingting SUN1, Hong ZHANG1, 2, Ye LI1, 2, Yang LIU1, 2, authorsList=Xiaoyan ZHANG, Ziyao QIAO, Kairu DING, Kaihua LONG, Tingting SUN, Hong ZHANG, Ye LI, Yang LIU, authorCompany=null, correspAuthors=Yang LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115139866873908, articleId=1317115139401306162, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=茜草质量控制研究进展及质量标志物(Q-Marker)预测, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=

茜草含有醌类、环肽类、萜类和多糖类等活性成分,具有凉血、祛瘀、止血、通经的功效,临床应用广泛,但目前茜草饮片存在掺伪、非药用部位超标与含量不合格等问题,现有质量控制指标难以全面评价药材品质。对茜草的质量控制研究进展进行综述,并在此基础上,从植物亲缘学、传统药效、不同产地、复方配伍、新的药效用途、网络药理学和可测性化学成分等7个方面对茜草质量标志物(Q-marker)进行预测分析,初步确定茜草素、羟基茜草素、6-羟基茜草素、异茜草素、甲基异茜草素、大叶茜草素、钩毛茜草素C、去氢-α-拉杷醌、拉帕醇、异落叶松脂素、RA-Ⅴ、RA-Ⅶ、β-谷甾醇可作为茜草的潜在Q-Marker,为茜草的质量标准提升与后续研究提供参考。

, authors=张笑颜1, 乔子尧2, 丁凯茹2, 龙凯花1, 孙婷婷1, 张红1, 2, 李晔1, 2, 刘洋1, 2, authorsList=张笑颜, 乔子尧, 丁凯茹, 龙凯花, 孙婷婷, 张红, 李晔, 刘洋, authorCompany=null, correspAuthors=刘洋, authorNote=

张笑颜(1996-),女,陕西西安人,研究实习员,硕士,研究方向:中药质量分析。

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刘洋(1988-),女,陕西西安人,副研究员,硕士研究生导师,博士,研究方向:中药药效物质基础。E-mail:。
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张笑颜(1996-),女,陕西西安人,研究实习员,硕士,研究方向:中药质量分析。

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张笑颜(1996-),女,陕西西安人,研究实习员,硕士,研究方向:中药质量分析。

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茜草质量控制研究进展及质量标志物(Q-Marker)预测
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张笑颜 1 , 乔子尧 2 , 丁凯茹 2 , 龙凯花 1 , 孙婷婷 1 , 张红 1, 2 , 李晔 1, 2 , 刘洋 1, 2
中华中医药学刊 | 省级项目平台 2026,44(6): 209-214
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中华中医药学刊 |省级项目平台 2026 , 44 (6) : 209 -214
茜草质量控制研究进展及质量标志物(Q-Marker)预测
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张笑颜1, 乔子尧2, 丁凯茹2, 龙凯花1, 孙婷婷1, 张红1, 2, 李晔1, 2, 刘洋1, 2
作者信息
  • 1.陕西省中医药研究院,陕西 西安 710003
  • 2.西北大学生命科学学院,陕西 西安 710069
通讯作者:
刘洋(1988-),女,陕西西安人,副研究员,硕士研究生导师,博士,研究方向:中药药效物质基础。E-mail:。
作者简介:

张笑颜(1996-),女,陕西西安人,研究实习员,硕士,研究方向:中药质量分析。

Quality Control Status and Predictive Analysis of Quality Markers of Qiancao (Rubiae Radix et Rhizoma)
Xiaoyan ZHANG1, Ziyao QIAO2, Kairu DING2, Kaihua LONG1, Tingting SUN1, Hong ZHANG1, 2, Ye LI1, 2, Yang LIU1, 2
Affiliations
  • 1.Shaanxi Academy of Traditional Chinese Medicine, Xi'an 710003, Shaanxi, China
  • 2.College of Life Science, Northwest University, Xi'an 710069, Shaanxi, China
出版时间: 2026-06-10 doi: 10.13193/j.issn.1673-7717.2026.06.039
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茜草含有醌类、环肽类、萜类和多糖类等活性成分,具有凉血、祛瘀、止血、通经的功效,临床应用广泛,但目前茜草饮片存在掺伪、非药用部位超标与含量不合格等问题,现有质量控制指标难以全面评价药材品质。对茜草的质量控制研究进展进行综述,并在此基础上,从植物亲缘学、传统药效、不同产地、复方配伍、新的药效用途、网络药理学和可测性化学成分等7个方面对茜草质量标志物(Q-marker)进行预测分析,初步确定茜草素、羟基茜草素、6-羟基茜草素、异茜草素、甲基异茜草素、大叶茜草素、钩毛茜草素C、去氢-α-拉杷醌、拉帕醇、异落叶松脂素、RA-Ⅴ、RA-Ⅶ、β-谷甾醇可作为茜草的潜在Q-Marker,为茜草的质量标准提升与后续研究提供参考。

茜草  /  质量控制  /  质量标志物  /  醌类化合物  /  茜草科类型环肽类化合物

Qiancao (Rubiae Radix et Rhizoma) contains active ingredients such as quinones, cyclopeptides, terpenes and polysaccharides, which have the effects of promoting blood circulation, removing blood stasis, stopping bleeding and dredging meridians. It is widely used in traditional Chinese medicine clinical practice. However, there are problems with adulteration, excessive nonmedicinal parts and substandard content in Qiancao (Rubiae Radix et Rhizoma) currently, and the existing quality control indicators make it difficult to evaluate the quality of medicinal materials comprehensively. Based on research progress on quality control of Qiancao (Rubiae Radix et Rhizoma), its quality markers were predicted and analyzed from 7 aspects such as plant genetic relationship, traditional efficacy, different origins, compatibility of different compounds, new pharmacodynamic pathway and measurable chemical compounds. The results suggested that alizarin, purpurin, 6-hdroxyrubiadin, xnthopurpurin, rbiadin, mollugin, rbioncolin C, xyloidone, lpachol, isolariciresinol, RA-Ⅴ, RA-Ⅶ and β-sitosterol can be used as quality markers of Qiancao (Rubiae Radix et Rhizoma), providing a reference for its quality standard improvement and other research in the future.

Qiancao (Rubiae Radix et Rhizoma)  /  quality control  /  quality markers  /  quinones  /  Rubiaceae-type cyclopeptides
张笑颜, 乔子尧, 丁凯茹, 龙凯花, 孙婷婷, 张红, 李晔, 刘洋. 茜草质量控制研究进展及质量标志物(Q-Marker)预测. 中华中医药学刊, 2026 , 44 (6) : 209 -214 . DOI: 10.13193/j.issn.1673-7717.2026.06.039
Xiaoyan ZHANG, Ziyao QIAO, Kairu DING, Kaihua LONG, Tingting SUN, Hong ZHANG, Ye LI, Yang LIU. Quality Control Status and Predictive Analysis of Quality Markers of Qiancao (Rubiae Radix et Rhizoma)[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (6) : 209 -214 . DOI: 10.13193/j.issn.1673-7717.2026.06.039
  • 陕西省重点研发计划项目(2021ZDLSF04-06)
  • 陕西省中医药管理局科研项目(SZY-KJCYC-2023-014)
  • 陕西省自然科学基础研究计划项目(2023-JC-QN-0820)
  • 陕西省中医药管理局“秦药”质量提升工程项目(2021-QYZL-01)
  • 陕西省“秦药”研发重点实验室项目(2021-QYPT-001)
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2026年第44卷第6期
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doi: 10.13193/j.issn.1673-7717.2026.06.039
  • 首发时间:2026-10-14
  • 出版时间:2026-06-10
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陕西省重点研发计划项目(2021ZDLSF04-06)
陕西省中医药管理局科研项目(SZY-KJCYC-2023-014)
陕西省自然科学基础研究计划项目(2023-JC-QN-0820)
陕西省中医药管理局“秦药”质量提升工程项目(2021-QYZL-01)
陕西省“秦药”研发重点实验室项目(2021-QYPT-001)
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    1.陕西省中医药研究院,陕西 西安 710003
    2.西北大学生命科学学院,陕西 西安 710069

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刘洋(1988-),女,陕西西安人,副研究员,硕士研究生导师,博士,研究方向:中药药效物质基础。E-mail:。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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