Article(id=1317115106849313594, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.06.031, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954312287, onlineDateStr=2026-10-14, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954312287, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954312287, creator=13701087609, updateTime=1791954312287, updator=13701087609, issue=Issue{id=1317114999827452826, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954286772, creator='13701087609', updateTime=1791958677365, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133415753831385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133415753831386, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=170, endPage=173, ext={EN=ArticleExt(id=1317115107050640187, articleId=1317115106849313594, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Huatan Huoxue Tongluo Decoction (化痰活血通络汤) on Unstable Angina Pectoris of Coronary Heart Disease and Its Effect on Serum Levels of cTnI and NT-proBNP, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the effect of Huatan Huoxue Tongluo Decoction (化痰活血通络汤) on unstable angina pectoris of coronary heart disease and its effect on the serum levels of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).
Methods From January 2022 to December 2023, 100 patients with unstable angina pectoris of coronary heart disease treated in the hospital were selected and randomly divided into two groups, with 50 cases in each group. The control group was treated with enteric-coated aspirin and isosorbide dinitrate, while the observation group was additionally treated with Huatan Huoxue Tongluo Decoction on the basis of the control group. After 4 weeks of treatment, the TCM syndrome scores, angina attack conditions, cardiac function indicators, the serum levels of cTnI and NT-proBNP and medication safety were compared between the two groups.
Results After treatment, the TCM syndrome scores for chest tightness and heartache, shortness of breath and wheezing and palpitations with easy sweating significantly decreased in both groups, with the observation group showing greater improvement than the control group (P<0.05). After treatment, the Seattle Angina Questionnaire scores, the frequency of angina attacks and the duration of attacks decreased in both groups, with the observation group outperforming the control group (P<0.05). After treatment, both groups showed a significant reduction in left ventricular systolic and diastolic diameters and a significant increase in left ventricular ejection fraction, with the observation group outperforming the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of cTnI and NT-proBNP decreased in both groups, with a more significant decrease in the observation group (P<0.05). No serious adverse reactions occurred in either group during the treatment process.
Conclusion The effect of Huatan Huoxue Tongluo Decoction in the treatment of unstable angina pectoris of coronary heart disease is satisfactory. It can effectively improve the main TCM syndromes of the patients, relieve the angina pectoris, improve the cardiac function and the serum levels of cTnI and NT-proBNP. It is a safe and effective medication plan.
, authors=Mingming ZHANG, Daimei NI, Qian CHEN, Xiaokui FU, Wenming BAN, authorsList=Mingming ZHANG, Daimei NI, Qian CHEN, Xiaokui FU, Wenming BAN, authorCompany=null, correspAuthors=Wenming BAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115107394573116, articleId=1317115106849313594, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=化痰活血通络汤治疗冠心病不稳定心绞痛效果及对血清cTnI、NT-proBNP水平的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 研究化痰活血通络汤治疗冠心病不稳定心绞痛的效果及对血清心肌肌钙蛋白I（cTnI）和N末端脑钠肽前体（NT-proBNP）水平的影响。
方法 选取2022年1月—2023年12月医院治疗的冠心病不稳定心绞痛患者100例，随机均分两组各50例。对照组予肠溶阿司匹林、硝酸异山梨酯治疗，观察组在此基础上增加化痰活血通络汤治疗。治疗4周后，比较两组中医证候积分，心绞痛发作情况，心功能指标，血清cTnI、NT-proBNP水平，用药安全性。
结果 治疗后，两组中医证候积分胸闷心痛、短气喘息、心悸易汗均显著下降，且观察组优于对照组（P<0.05）。治疗后，两组患者西雅图心绞痛量表评分及心绞痛发作次数、持续时间均降低，且观察组优于对照组（P<0.05）。治疗后，两组左室收缩及舒张末径显著降低，左室射血分数显著升高，且观察组优于对照组，差异有统计学意义（P<0.05）。治疗后，两组cTnI、NT-proBNP水平均下降，且观察组下降更显著（P<0.05）。治疗过程中两组均未发生严重不良反应。
结论 化痰活血通络汤治疗冠心病不稳定心绞痛的效果满意，能够有效改善患者的主要中医证候，缓解心绞痛发作，改善心功能及血清cTnI、NT-proBNP水平，是安全、有效的用药方案。
, authors=张明明, 倪代梅, 陈倩, 付小奎, 班文明, authorsList=张明明, 倪代梅, 陈倩, 付小奎, 班文明, authorCompany=null, correspAuthors=班文明, authorNote=
张明明（1987-），女，安徽太和人，副主任医师，硕士，研究方向：中西医结合老年心脑血管病。
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班文明（1972-），男，安徽太和人，主任医师，硕士，研究方向：中西医结合老年心脑血管病。
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张明明（1987-），女，安徽太和人，副主任医师，硕士，研究方向：中西医结合老年心脑血管病。
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张明明（1987-），女，安徽太和人，副主任医师，硕士，研究方向：中西医结合老年心脑血管病。
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