Article(id=1317115058820334257, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.033, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954300837, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954300837, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954300837, creator=13701087609, updateTime=1791954300837, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=177, endPage=182, ext={EN=ArticleExt(id=1317115059017466546, articleId=1317115058820334257, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effects of Xingpi Capsules (醒脾胶囊) on Duodenal Mucosal Barrier and Gut Microbiota in Rats with Functional Dyspepsia, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the efficacy and possible mechanism of Xingpi Capsule (醒脾胶囊) in the treatment of functional dyspepsia (FD).
Methods Sixty SPF grade rats were randomly divided into normal group, model group, low-dose Xingpi Capsule group［0.135 g/ (kg·d) ］, high-dose Xingpi Capsule group［0.54 g/ (kg·d) ］and domperidone group［3 mg/ (kg·d) ］, with 12 rats in each group. Except for the normal group, which was given 0.2 mL of 2% sucrose by gavage, the other groups were used to prepare the functional dyspepsia rat models by gavage with iodoacetamide for 6 consecutive days. Then the rats were normally fed until the 8th week. Starting from the 8th week, the normal group and the model group were given the same volume of distilled water by gavage, while the treatment groups were given the corresponding medication by gavage for one week. The macroscopic signs, gastric emptying rate, small intestine propulsion rate, serum levels of vasoactive intestinal peptide (VIP) and substance P (SP) were detected by using enzyme-linked immunosorbent assay (ELISA). The morphology of gastric and duodenal tissues were observed using hematoxylin eosin staining (HE). The ZO-1 protein expression was observed using immunohistochemistry method. The mRNA expressions of ZO-1 and Occludin were detected using polymerase chain reaction (RT-PCR), and Occludin protein expression was detected using Western blot (WB). The changes in the types and abundance of gut microbiota were analyzed through 16S rRNA sequencing.
Results Compared with the normal group, the model group showed a decrease in body weight, rat fur withered and discolored, reduced grip, decreased open field total pathway, gastric emptying rate and small intestine propulsion rate (P<0.01). The HE staining site showed disordered arrangement of goblet cells. ELISA results showed an increase in VIP content and a decrease in SP content (P<0.01), while immunohistochemistry results showed a decrease in ZO-1 expression (P<0.01) . PCR results showed a decrease in mRNA expressions of ZO-1 and Occludin (P<0.01), and WB result showed a decrease in Occludin protein expression. Compared with those in the model group, the mental state of the rats in the Xingpi Capsule groups and the domperidone group was significantly improved, with increased gastric emptying rate and small intestinal emptying rate (P<0.05, P<0.01) . ELISA results showed a decrease in serum VIP content and an increase in SP content (P<0.05, P<0.01) . Immunohistochemistry results showed an increase in ZO-1 expression (P<0.05, P<0.01) . RT-PCR results showed an increase in mRNA expressions of ZO-1 and Occludin (P<0.05, P<0.01) . WB results showed an increase in Occludin protein expression (P<0.01), and high-dose Xingpi Capsule group had a significant therapeutic effect on the rats. 16S rRNA sequencing analysis showed significant changes in the overall structure of the gut microbiota in the model group compared to those in the normal group. Compared with that in the model group, the overall structure of gut microbiota in the high-dose Xingpi Capsule group and the domperidone group was closer to that in the normal group, with decreased Chao1 and Shannon indices (P<0.01) . Through species composition analysis, the relative abundance of Firmicutes phylum in the model group decreased compared to that in the normal group. Compared with that in the model group, the relative abundance of Firmicutes phylum increased in the high-dose Xingpi Capsule group and the domperidone group. The significant difference analysis among groups found that the high-dose Xingpi Capsule group had a positive effect on the homeostasis of intestinal microbiota.
Conclusion Xingpi Capsule can improve the damage of duodenal mucosal barrier and regulate the steady state of intestinal microbiota to achieve the effect of treating functional dyspepsia.
, authors=Mingyue HUANG
1, Rongxin ZHU
1, Gang WANG
1, Xiangning LIU
1, Fangfang RUI
1, Keyan WANG
1, Yinglan LYU
1, Chun LI
1, 2, authorsList=Mingyue HUANG, Rongxin ZHU, Gang WANG, Xiangning LIU, Fangfang RUI, Keyan WANG, Yinglan LYU, Chun LI, authorCompany=null, correspAuthors=Chun LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115059323650739, articleId=1317115058820334257, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=醒脾胶囊对功能性消化不良大鼠十二指肠黏膜屏障和肠道菌群的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨醒脾胶囊治疗功能性消化不良（Functional dyspepsia，FD）的药效研究。
方法 将60只SPF级大鼠随机分成正常组、模型组、醒脾胶囊低剂量组［0.135 g/（kg·d）］、醒脾胶囊高剂量组［0.54 g/（kg·d）］和多潘立酮组［3 mg/（kg·d）］，每组12只。除正常组灌胃2%蔗糖0.2 mL外，其余各组采用碘乙酰胺灌胃法制备功能性消化不良大鼠模型，连续6 d。后续正常饲养至第8周。第8周开始，正常组和模型组给予同体积蒸馏水灌胃，给药组给予相应药物灌胃，连续1周。检测各组大鼠宏观体征、胃排空率、小肠推进率；酶联免疫吸附测定法（Enzyme-linked immunosorbent assay，ELISA）检测血清中血管活性肠肽（Vasoactive intestinal peptide，VIP）和P物质（Substance P，SP）含量；苏木精-伊红染色法（Hematoxylin-eosin，HE）观察胃、十二指肠组织形态；免疫组化检测紧密连接蛋白（Zonula occludens-1，ZO-1）表达；聚合酶链式反应（Real-time reverse transcription-polymerase chain reaction，RT-PCR）检测ZO-1、紧密连接蛋白（Occludin）mRNA表达；蛋白质免疫印迹法（Western blot，WB）检测Occludin蛋白表达；通过16S rRNA测序分析肠道菌群的种类和丰度的变化。
结果 与正常组相比，模型组的体质量降低，大鼠皮毛枯泽，抓力减弱，旷场总路径、胃排空率、小肠推进率降低（P<0.01），HE染色部位可见杯状细胞排列紊乱，Elisa结果显示VIP含量升高，SP含量降低（P<0.01），免疫组化结果显示ZO-1表达降低（P<0.01），PCR结果显示ZO-1、Occludin mRNA表达降低（P<0.01），WB结果显示Occludin蛋白表达降低（P<0.01）；与模型组相比，醒脾胶囊组和多潘立酮组大鼠精神状态明显改善，胃排空率、小肠排空率升高（P<0.05，P<0.01），Elisa结果显示血清VIP含量降低，SP含量升高（P<0.05，P<0.01），免疫组化结果显示ZO-1表达升高（P<0.05，P<0.01），PCR结果显示ZO-1、Occludin mRNA表达升高（P<0.05，P<0.01），WB结果显示Occludin蛋白表达升高（P<0.01），且高剂量醒脾胶囊干预大鼠治疗效果显著；16S rRNA测序分析显示，与正常组相比，模型组肠道菌群整体结构发生显著变化；与模型组相比，醒脾胶囊高剂量组和多潘立酮组的肠道菌群整体结构更接近正常组，Chao1、Shannon指数降低（P<0.01）；通过物种组成分析，与正常组相比，模型组Firmicutes门相对丰度降低；与模型组相比，醒脾胶囊高剂量组和多潘立酮组Firmicutes门相对丰度升高；组间差异显著性分析发现醒脾胶囊高剂量组对肠道菌群稳态具有积极作用。
结论 醒脾胶囊通过改善十二指肠黏膜屏障受损情况并调控肠道菌群稳态，以达到治疗功能性消化不良的作用。
, authors=黄明月
1, 朱镕鑫
1, 王港
1, 刘相凝
1, 芮芳芳
1, 王可妍
1, 吕迎兰
1, 李春
1, 2, authorsList=黄明月, 朱镕鑫, 王港, 刘相凝, 芮芳芳, 王可妍, 吕迎兰, 李春, authorCompany=null, correspAuthors=李春, authorNote=
黄明月（2001-），女，四川广安人，硕士在读，研究方向：中西医结合防治心血管疾病。
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1．北京中医药大学中医学院，证候与方剂基础研究北京市重点实验室，证候与方剂基础研究教育部重点实验室，北京 100029, bio={"content":"
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