Article(id=1317115031267951085, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954294268, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954294268, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954294268, creator=13701087609, updateTime=1791954294268, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=108, endPage=114, ext={EN=ArticleExt(id=1317115031477666286, articleId=1317115031267951085, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Latest Research Progress of Anti-Digestive System Tumor Active Components and Its Mechanism of Baihuasheshecao (Herba Hedyotidis Diffusae), columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Baihuasheshecao (Herba Hedyotidis Diffusae) belongs to the genus Baihuasheshecao (Hedyotis diffusa) of the family Rubiaceae. It was first recorded in Luchuan Bencao. This herb has the effects of clearing away heat and detoxifying, reducing swelling and relieving pain. Baihuasheshecao (Herba Hedyotidis Diffusae) is clinically used for treating bruises, venomous snake bites and so on. Modern studies indicate that Baihuasheshecao (Herba Hedyotidis Diffusae) also exhibits anti-tumor pharmacological effects. Clinically, it is often employed to treat liver cancer, lung cancer, breast cancer, intestinal cancer and gastric cancer, particularly for digestive system tumors. The terpenoids, flavonoids and anthraquinones in Baihuasheshecao (Herba Hedyotidis Diffusae) could inhibit the malignant proliferation, invasion and metastasis of tumor cells, induce the apoptosis of tumor cells, block the signal pathway conduction and inhibit the angiogenesis. Moreover, Baihuasheshecao (Herba Hedyotidis Diffusae) can play an anti-tumor role by enhancing the body's immunity. In this manuscript, the active ingredients, pharmacological mechanisms and clinical applications of drug combinations of Baihuasheshecao (Herba Hedyotidis Diffusae) in the treatment of digestive system tumors were briefly reviewed, laying a foundation for the research and development of new drugs of Baihuasheshecao (Herba Hedyotidis Diffusae) for treating digestive system tumors.

, authors=Sha ZENG¹, Hui ZHAO², Jingxing GAO¹, Ping LI¹, Juan WANG¹, authorsList=Sha ZENG, Hui ZHAO, Jingxing GAO, Ping LI, Juan WANG, authorCompany=null, correspAuthors=Juan WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115031788044783, articleId=1317115031267951085, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=白花蛇舌草抗消化系统肿瘤活性成分及其作用机制的最新研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

白花蛇舌草（Hedyotis diffusa willd.）为茜草科蛇舌草属植物白花蛇舌草，始载于《陆川本草》，具有清热解毒、消肿止痛的功效，临床用于跌打损伤、毒蛇咬伤等。现代研究认为白花蛇舌草还具有抗肿瘤的药理作用，临床上白花蛇舌草常用于治疗肝癌、肺癌、乳腺癌、肠癌、胃癌等，尤其是对消化系统肿瘤具有较高的临床应用价值。白花蛇舌草中的萜类、黄酮类和蒽醌类能抑制肿瘤细胞的恶性增殖、侵袭和转移，诱导肿瘤细胞发生凋亡，阻断信号通路传导，抑制血管生成，此外白花蛇舌草还可通过增强机体免疫来发挥抗肿瘤的作用。就白花蛇舌草抗消化系统肿瘤的活性成分、药理作用机制以及药对联合用药的临床应用进行简要综述，为白花蛇舌草抗消化系统肿瘤的新药研发奠定基础。

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曾沙（1997-），女，四川成都人，主管中药师，硕士，研究方向：中药药理与毒理学。

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曾沙（1997-），女，四川成都人，主管中药师，硕士，研究方向：中药药理与毒理学。

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