Article(id=1317115014004191350, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.06.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954290152, onlineDateStr=2026-10-14, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954290152, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954290152, creator=13701087609, updateTime=1791954290152, updator=13701087609, issue=Issue{id=1317114999827452826, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954286772, creator='13701087609', updateTime=1791958677365, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133415753831385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133415753831386, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317114999827452826, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=74, endPage=78, ext={EN=ArticleExt(id=1317115014184546423, articleId=1317115014004191350, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Anti-osteoporosis of Duzhong (Cortex Eucommiae) and Its Components, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mass and deterioration of bone tissue microstructure. With the global aging population, the incidence of OP is progressively increasing. Current Western medical treatments primarily rely on bone-forming agents and bone resorption inhibitors, which often exhibit significant side effects and are unsuitable for long-term use. OP is a condition where traditional Chinese medicine (TCM) demonstrates therapeutic advantages, and Duzhong (Cortex Eucommiae) is a commonly used traditional Chinese herb for treating OP. This article reviewed Duzhong (Cortex Eucommiae) and its primary active components, such as pinoresinol diglucoside, aucubin and geniposidic acid, focusing on their multi-pathway regulatory mechanisms against OP. Duzhong (Cortex Eucommiae) and its components promote bone formation by modulating the Wnt/β-catenin and bone morphogenetic protein (BMP) /Smad signaling pathways, while inhibiting bone resorption through the mitogen activated protein kinase (MAPK) and osteoprotegerin (OPG) /receptor activator of nuclear factor-κB ligand (RANKL) /nuclear factor-κB receptor activating factor receptor (RANK) signaling pathways. Additionally, they regulate the coupling of bone formation and resorption by influencing the phosphoinositide 3-kinase (PI3K) /protein kinase B (AKT) and estrogen signaling pathways. Furthermore, Duzhong (Cortex Eucommiae) and its components can regulate bone angiogenesis by stimulating the expression of vascular factors in bone marrow mesenchymal stem cells via the BMP/Smad pathway or by modulating the secretion of platelet-derived growth factor in osteoclast precursor cells through the mitogenactivated protein kinase (MAPK) /nuclear factor kappa-B (NF-κB) pathway. Moreover, Duzhong (Cortex Eucommiae) and its components can modulate the polarization state of macrophages, alter the expression of inflammatory factors and improve the bone immune-inflammatory microenvironment, thereby maintaining bone homeostasis. In summary, Duzhong (Cortex Eucommiae) exerts anti-OP effects through multiple mechanisms and pathways, providing valuable insights and references for its clinical application and development.

, authors=Yuang LIU, Yifei DONG, Xinyi TU, Yanqiu LIU, authorsList=Yuang LIU, Yifei DONG, Xinyi TU, Yanqiu LIU, authorCompany=null, correspAuthors=Yanqiu LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115014406844536, articleId=1317115014004191350, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=杜仲及其成分抗骨质疏松的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

骨质疏松症（Osteoporosis，OP）是一种以骨量减少及骨组织微观结构退化为特征的代谢性骨病。由于全球老龄化，OP发病率日益升高。当前，西医治疗以骨形成制剂及骨吸收抑制剂为主，但药物不良反应明显且不能长期服用。OP是中医药治疗优势病种，传统中药杜仲是治疗OP常用药物，综述了杜仲及其主要成分，如松脂醇二葡萄糖苷、桃叶珊瑚苷、京尼平苷酸等，及抗OP的多通路调节机制。杜仲及其成分可促进骨形成，调控Wnt/β-catenin、BMP/Smad信号通路；抑制骨吸收，调控MAPK、OPG/RANKL/RANK信号通路，并可通过调节PI3K/AKT、雌激素信号通路调控骨形成与骨吸收耦联。另外，杜仲及其成分能调控骨血管生成，其机制为通过刺激骨髓间充质干细胞BMP/Smad途径促进血管因子表达或调控破骨前体细胞MAPK/NF-κB途径分泌血小板衍生生长因子发挥作用。此外，杜仲及其成分可调节巨噬细胞的极化状态，改变炎症因子的表达，改善骨免疫炎症微环境，维持骨稳态。总之，杜仲可从多环节、多途径发挥抗OP作用效果，为杜仲及其成分的临床应用与开发提供思路和借鉴。

, authors=刘玉昂, 董一霏, 涂心怡, 刘艳秋, authorsList=刘玉昂, 董一霏, 涂心怡, 刘艳秋, authorCompany=null, correspAuthors=刘艳秋, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=4CTit6TBx/BGDv6nHlWFSQ==, magXml=D+v14T4YOKvniF9m4TSCRA==, pdfUrl=null, pdf=sROJsNwnLypqBZI20S8yKQ==, pdfFileSize=2356316, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=K7qYtd6hO1GvJBqVqZBzyg==, mapNumber=null, fund=null)}, authors=[Author(id=1319631041044787529, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115014004191350, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319631041116090699, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115014004191350, authorId=1319631041044787529, language=EN, stringName=Yuang LIU, firstName=Yuang, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319631041187393868, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115014004191350, authorId=1319631041044787529, language=CN, stringName=刘玉昂, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学，山东 济南 250355, bio={"content":"

刘玉昂（2001-），男，山东德州人，硕士在读，研究方向：肾藏象理论的方药基础。

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刘玉昂（2001-），男，山东德州人，硕士在读，研究方向：肾藏象理论的方药基础。

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