Article(id=1319291330757509451, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.042, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473164499, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473164499, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473164499, creator=13701087609, updateTime=1792473164499, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=228, endPage=231, ext={EN=ArticleExt(id=1319291330942058828, articleId=1319291330757509451, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Study on Mechanism of Qingre Jiedu Formula (清热解毒方) Against Human Papillomavirus, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective

The purpose of this study was to explore the mechanism of Qingre Jiedu Formula (清热解毒方) against human papillomavirus (HPV), specifically investigating its immunomodulatory effects at the molecular and cellular levels.

Methods

At the molecular level, macromolecular interaction analysis was employed to investigate the binding capacity between Qingre Jiedu Formula and HPV virus. The experimental groups were designed as follows. (1) Blank control group: The equal volume of complete medium was added. (2) Lipopolysaccharide (LPS) positive control group (LPS group): The final concentration was 1 μg/mL. (3) Qingre Jiedu Formula groups: There were four concentration gradients (20, 100, 500, 1000 μg/L). At the cellular level, Raw 264.7 and Jurkat cell lines were used, and the expression levels of cytokines such as tumor necrosis factor-alpha (TNF-α) in cell supernatants were measured by RT-PCR.

Results

Qingre Jiedu Formula could bind HPV at the molecular level. The purgative formula had the effect of activating macrophages, enhancing their ability to phagocytose neutrophilic red and promoting the secretion of nitric oxide (NO), TNF-α, interleukin-1β (IL-1β) and interferon-beta (IFN-β) in macrophages.

Conclusion

Qingre Jiedu Formula exerts anti-HPV effects through two mechanisms, directly binding to the HPV and enhancement of immune cell activity.

, authors=Jia LYU, Yao LU, Deyan WANG, Xuemeng RAN, authorsList=Jia LYU, Yao LU, Deyan WANG, Xuemeng RAN, authorCompany=null, correspAuthors=Xuemeng RAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291331235660109, articleId=1319291330757509451, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=清热解毒方抗人乳头瘤病毒的作用机制研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的

探究清热解毒方对人乳头瘤病毒(Human Papillomavirus,HPV)的作用机制,主要从分子水平及细胞水平探索其在免疫调节作用机制。

方法

在分子水平上,采用大分子相互作用方式探索清热解毒方与HPV病毒的结合能力;本研究设置以下实验组别:(1)空白对照组:加入等体积完全培养基。(2)LPS组:终浓度1 μg/mL。(3)清热解毒方:20、100、500、1000 μg/L 4个浓度梯度。细胞水平上采用Raw 264.7及Jurkat细胞,并通过RT-PCR的方法测定细胞上清中TNF-α等细胞因子的表达水平。

结果

清热解毒方可在分子水平结合HPV病毒;清热解毒方具有激活巨噬细胞的作用,增强其吞噬中性红的能力,且促进巨噬细胞中一氧化氮(Nitric Oxide,NO)、肿瘤坏死因子α(Tumor Necrosis Factor-alpha,TNF-α)、白细胞介素-1β(Interleukin-1 beta,IL-1β)、干扰素β(Interferon-beta,IFN-β)的分泌。

结论

清热解毒方通过直接结合HPV病毒和增强免疫细胞活性两种机制起到抗HPV作用。

结论

研究证实清热解毒方通过直接结合HPV病毒蛋白和双向调节免疫细胞功能双重机制发挥抗HPV作用。

, authors=吕佳, 路瑶, 王德彦, 冉雪梦, authorsList=吕佳, 路瑶, 王德彦, 冉雪梦, authorCompany=null, correspAuthors=冉雪梦, authorNote=

吕佳(1982-),女,山东青岛人,副主任医师,硕士,研究方向:中西医结合治疗妇产科相关疾病。

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冉雪梦(1973-),女,山东青岛人,主任医师,博士,研究方向:中西医结合妇科疾病临床及基础研究。E-mail:。
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吕佳(1982-),女,山东青岛人,副主任医师,硕士,研究方向:中西医结合治疗妇产科相关疾病。

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清热解毒方抗人乳头瘤病毒的作用机制研究
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吕佳 , 路瑶 , 王德彦 , 冉雪梦
中华中医药学刊 | 省级项目平台 2026,44(9): 228-231
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中华中医药学刊 |省级项目平台 2026 , 44 (9) : 228 -231
清热解毒方抗人乳头瘤病毒的作用机制研究
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吕佳, 路瑶, 王德彦, 冉雪梦
作者信息
  • 青岛市中医医院、青岛大学附属青岛市海慈医院,山东 青岛 266033
通讯作者:
冉雪梦(1973-),女,山东青岛人,主任医师,博士,研究方向:中西医结合妇科疾病临床及基础研究。E-mail:。
作者简介:

吕佳(1982-),女,山东青岛人,副主任医师,硕士,研究方向:中西医结合治疗妇产科相关疾病。

Study on Mechanism of Qingre Jiedu Formula (清热解毒方) Against Human Papillomavirus
Jia LYU, Yao LU, Deyan WANG, Xuemeng RAN
Affiliations
  • Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated to Qingdao University, Qingdao 266033, Shandong, China
出版时间: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.042
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目的

探究清热解毒方对人乳头瘤病毒(Human Papillomavirus,HPV)的作用机制,主要从分子水平及细胞水平探索其在免疫调节作用机制。

方法

在分子水平上,采用大分子相互作用方式探索清热解毒方与HPV病毒的结合能力;本研究设置以下实验组别:(1)空白对照组:加入等体积完全培养基。(2)LPS组:终浓度1 μg/mL。(3)清热解毒方:20、100、500、1000 μg/L 4个浓度梯度。细胞水平上采用Raw 264.7及Jurkat细胞,并通过RT-PCR的方法测定细胞上清中TNF-α等细胞因子的表达水平。

结果

清热解毒方可在分子水平结合HPV病毒;清热解毒方具有激活巨噬细胞的作用,增强其吞噬中性红的能力,且促进巨噬细胞中一氧化氮(Nitric Oxide,NO)、肿瘤坏死因子α(Tumor Necrosis Factor-alpha,TNF-α)、白细胞介素-1β(Interleukin-1 beta,IL-1β)、干扰素β(Interferon-beta,IFN-β)的分泌。

结论

清热解毒方通过直接结合HPV病毒和增强免疫细胞活性两种机制起到抗HPV作用。

结论

研究证实清热解毒方通过直接结合HPV病毒蛋白和双向调节免疫细胞功能双重机制发挥抗HPV作用。

抗人乳头瘤病毒  /  清热解毒方  /  免疫调节  /  作用机制
Objective

The purpose of this study was to explore the mechanism of Qingre Jiedu Formula (清热解毒方) against human papillomavirus (HPV), specifically investigating its immunomodulatory effects at the molecular and cellular levels.

Methods

At the molecular level, macromolecular interaction analysis was employed to investigate the binding capacity between Qingre Jiedu Formula and HPV virus. The experimental groups were designed as follows. (1) Blank control group: The equal volume of complete medium was added. (2) Lipopolysaccharide (LPS) positive control group (LPS group): The final concentration was 1 μg/mL. (3) Qingre Jiedu Formula groups: There were four concentration gradients (20, 100, 500, 1000 μg/L). At the cellular level, Raw 264.7 and Jurkat cell lines were used, and the expression levels of cytokines such as tumor necrosis factor-alpha (TNF-α) in cell supernatants were measured by RT-PCR.

Results

Qingre Jiedu Formula could bind HPV at the molecular level. The purgative formula had the effect of activating macrophages, enhancing their ability to phagocytose neutrophilic red and promoting the secretion of nitric oxide (NO), TNF-α, interleukin-1β (IL-1β) and interferon-beta (IFN-β) in macrophages.

Conclusion

Qingre Jiedu Formula exerts anti-HPV effects through two mechanisms, directly binding to the HPV and enhancement of immune cell activity.

anti-human papillomavirus  /  Qingre Jiedu Formula (清热解毒方)  /  immunomodulation  /  action mechanism
吕佳, 路瑶, 王德彦, 冉雪梦. 清热解毒方抗人乳头瘤病毒的作用机制研究. 中华中医药学刊, 2026 , 44 (9) : 228 -231 . DOI: 10.13193/j.issn.1673-7717.2026.09.042
Jia LYU, Yao LU, Deyan WANG, Xuemeng RAN. Study on Mechanism of Qingre Jiedu Formula (清热解毒方) Against Human Papillomavirus[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 228 -231 . DOI: 10.13193/j.issn.1673-7717.2026.09.042
  • 山东省中医药科技项目(Z-2022007)
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2026年第44卷第9期
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doi: 10.13193/j.issn.1673-7717.2026.09.042
  • 首发时间:2026-10-20
  • 出版时间:2026-09-10
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山东省中医药科技项目(Z-2022007)
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    青岛市中医医院、青岛大学附属青岛市海慈医院,山东 青岛 266033

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冉雪梦(1973-),女,山东青岛人,主任医师,博士,研究方向:中西医结合妇科疾病临床及基础研究。E-mail:。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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