中华中医药学刊

抗纤汤联合抗感染治疗对肺间质纤维化合并感染患者临床症状及肺纤维化的影响

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杨东明 , 任蔚 , 许东风

中华中医药学刊 | 省级项目平台 2026,44(9): 220-223

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中华中医药学刊 |省级项目平台 2026 , 44 (9) : 220 -223

抗纤汤联合抗感染治疗对肺间质纤维化合并感染患者临床症状及肺纤维化的影响

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杨东明, 任蔚, 许东风

作者信息

南阳医学高等专科学校第一附属医院，河南　南阳　473000

通讯作者:

许东风（1969-），男，河南南阳人，主任医师，学士，研究方向：肺间质病。

作者简介:

杨东明（1983-），男（回族），河南南阳人，主治医生，学士，研究方向：呼吸重症。

Effect of Kangxian Decoction (抗纤汤) Combined with Anti-Infective Therapy on Clinical Symptoms and Pulmonary Fibrosis in Patients with Idiopathic Pulmonary Fibrosis and Infection

Dongming YANG, Wei REN, Dongfeng XU

Affiliations

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan, China

出版时间: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.040

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摘要

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目的

探讨抗纤汤联合抗感染治疗对特发性肺间质纤维化（Idiopathic Pulmonary Fibrosis，IPF）合并感染患者临床症状及肺纤维化的影响。

方法

117例IPF合并感染患者均为2022年1月—2024年1月医院收治的符合纳入与排除标准的病例。根据随机数字表法分为59例观察组与58例对照组。对照组给予常规抗感染治疗，观察组给予抗纤汤联合抗感染治疗，比较两组治疗后疗效；比较两组治疗前后中医证候积分肺纤维化指标[层连黏蛋白（Laminin，LN）、透明质酸酶（Hyaluronidase，HA）、Ⅳ型胶原（Type Ⅳ collagen，Ⅳ-C）、Ⅲ型前胶原（Type Ⅲ procollagen，PC-Ⅲ）]、肺功能指标[第1秒用力呼气容积（Forced expiratory volume 1 second，FEV1）、呼出50%肺容积时呼气流量峰值（Peak expiratory flow，PEF）、用力肺活量（Forced expiratory vital capacity，FVC）、FEV1/FVC]、炎症因子指标[白细胞介素-1β（Interleukin-1β，IL-1β）、白细胞介素-6（Interleukin-6，IL-6）、肿瘤坏死因子-ɑ（Tumor Necrosis Factor-α，TNF-α）]；比较两组治疗期间不良反应情况。

结果

治疗后观察组临床疗效94.92%（56例）与对照组82.76%（48例）对比显著提升（P<0.05）；治疗后，观察组胸闷气短、咳嗽、神疲乏力、痰黄痰稠、自汗畏寒中医证候积分均比对照组低（P<0.05）；治疗后观察组肺纤维化指标LN、HA、Ⅳ-C、PC-Ⅲ水平均比对照组低（P<0.05）；治疗后观察组肺功能指标FEV1、PEF、FVC、FEV1/FVC水平均比对照组高（P<0.05）；治疗后观察组炎症因子指标IL-1β、IL-6、TNF-α水平均比对照组低（P<0.05）；两组均无明显不良反应发生。

结论

抗纤汤联合抗感染治疗IPF合并感染患者临床疗效较好，能有效促进临床症状改善，抑制肺纤维化，提升肺功能、减轻肺部炎症，且安全性较高，值得推广。

关键词

抗纤汤 / 抗感染 / 肺间质纤维化合并感染 / 临床症状 / 肺纤维化

Abstract

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Objective

To investigate the effect of Kangxian Decoction (抗纤汤) combined with anti-infective therapy on clinical symptoms and pulmonary fibrosis in the patients with idiopathic pulmonary fibrosis (IPF) and infection.

Methods

A total of 117 IPF patients with infection who admitted to the hospital between January 2022 and January 2024 and met the inclusion and exclusion criteria were enrolled, and assigned into two groups using the random number table method. The control group (58 cases) was given conventional anti-infection treatment, and the observation group (59 cases) was given Kangxian Decoction combined with anti-infective therapy. Then the comparison was conducted between two groups in clinical efficacy, TCM syndrome scores, pulmonary fibrosis indexes [laminin (LN), hyaluronidase (HA), type IV collagen (CIV), type Ⅲ procollagen (PC-Ⅲ)], pulmonary function indices [forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), forced vital capacity (FVC), FEV1/FVC], inflammatory factors [interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α)] and adverse reactions.

Results

The observation group reported a higher clinical efficacy rate compared to the control group [94.92% (56/59) vs 82.76% (48/58), P<0.05]. After treatment, the observation group scored lower on TCM syndromes including chest tightness, shortness of breath, cough, mental weariness, yellowish purulent sputum, spontaneous perspiration and aversion to cold compared to the control group (P<0.05). The levels of LN, HA, Ⅳ-C and PC-Ⅲ were notably decreased in the observation group compared to those in the control group after treatment (P<0.05). The levels of FEV1, PEF, FVC and FEV1/FVC were remarkably increase in the observation group compared to those of the control group after treatment (P<0.05). The observation group detected a lower levels of IL-1β, IL-6 and TNF-α than the control group (P<0.05). No significant adverse effects occurred in either group.

Conclusion

Kangxian Decoction combined with anti-infective therapy for IPF patients with infection can effectively ameliorate the clinical symptoms, inhibit pulmonary fibrosis, improve lung function and alleviate inflammation, which has a good safety profile and is worthy of promoting.

Key words

Kangxian Decoction / anti-infective therapy / idiopathic pulmonary fibrosis and infection / clinical symptoms / pulmonary fibrosis

引用本文

杨东明, 任蔚, 许东风. 抗纤汤联合抗感染治疗对肺间质纤维化合并感染患者临床症状及肺纤维化的影响. 中华中医药学刊, 2026 , 44 (9) : 220 -223 . DOI: 10.13193/j.issn.1673-7717.2026.09.040

Dongming YANG, Wei REN, Dongfeng XU. Effect of Kangxian Decoction (抗纤汤) Combined with Anti-Infective Therapy on Clinical Symptoms and Pulmonary Fibrosis in Patients with Idiopathic Pulmonary Fibrosis and Infection[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 220 -223 . DOI: 10.13193/j.issn.1673-7717.2026.09.040

基金

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河南省卫生健康委员会项目-河南省中医药科学研究专项(2024ZY3123)

参考文献

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2026年第44卷第9期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.09.040

首发时间：2026-10-20
出版时间：2026-09-10

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基金

河南省卫生健康委员会项目-河南省中医药科学研究专项(2024ZY3123)

作者信息

南阳医学高等专科学校第一附属医院，河南　南阳　473000

通讯作者:

许东风（1969-），男，河南南阳人，主任医师，学士，研究方向：肺间质病。

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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.09.040

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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