Article(id=1319291275476578563, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.036, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473151320, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473151320, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473151320, creator=13701087609, updateTime=1792473151320, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=202, endPage=205, ext={EN=ArticleExt(id=1319291275669516548, articleId=1319291275476578563, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Study on Anti-SARS-CoV-2 Mechanism of Emodin and Prediction of Antiviral Activity of Anthraquinone Compounds, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the inhibitory effect of emodin on SARS-CoV-2 RNA polymerase (RdRp) and main protease (Mpro) and predict the anti-SARS-CoV-2 activity of anthraquinone compounds.
Methods A cell-level SARS-CoV-2 RNA polymerase catalytic reaction system was used to detect the inhibitory activity of emodin against RdRp. An in vitro fluorescence polarization model was used to test the inhibitory activity of emodin against SARS-CoV-2 Mpro. Molecular docking technology was used to study the binding mode of anthraquinone compounds at the active site of RdRp.
Results The experiment showed that emodin inhibited RdRp with inhibition rates of 42.01%±3.43%, 47.28%±11.20% and 84.28%±4.34% at concentrations of 10, 25, 50 μmol/L, respectively. It did not show significant inhibitory activity against Mpro at drug concentrations of 25, 50, 100 μmol/L. Anthraquinone compounds can occupy the NTPs channel of the target enzyme, thereby hindering the entry of substrate molecules.
Conclusion This experiment confirmed that emodin has a significant inhibitory effect on SARS-CoV-2 RNA polymerase. The small molecule anthraquinone compounds in this paper should have strong anti-SARS-CoV-2 activity.
, authors=Jingfang LIU
1, Qian LIU
2, Yingnan ZHAO
3, Lei YANG
3, Yujia WANG
4, Jianyuan ZHAO
4, Yanlei SU
3, Dianxing SUN
3, Shan CEN
4, authorsList=Jingfang LIU, Qian LIU, Yingnan ZHAO, Lei YANG, Yujia WANG, Jianyuan ZHAO, Yanlei SU, Dianxing SUN, Shan CEN, authorCompany=null, correspAuthors=Yanlei SU, Shan CEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291275996672261, articleId=1319291275476578563, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=大黄素抗新型冠状病毒机制研究及蒽醌类化合物抗病毒活性预测, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 研究大黄素对新型冠状病毒RNA聚合酶、主蛋白酶的抑制作用，并预测蒽醌类化合物抗新型冠状病毒活性。
方法 利用细胞水平的新型冠状病毒RNA聚合酶催化反应体系检测大黄素对靶酶的抑制活性；利用体外荧光偏振模型测试大黄素对于新型冠状病毒主蛋白酶的抑制活性；应用分子对接技术研究蒽醌类化合物在RNA聚合酶活性位点处的结合方式。
结果 实验显示，大黄素在10、25、50 μmol/L浓度对RNA聚合酶抑制率分别为42.01%±3.43%、47.28%±11.20%、84.28%±4.34%；在25、50、100 μmol/L药物浓度并未表现出对主蛋白酶的显著抑制活性；蒽醌类化合物可占据靶酶NTPs通道从而阻碍底物分子的进入。
结论 实验证实大黄素对新型冠状病毒RNA聚合酶具有明显的抑制作用；小分子蒽醌类化合物应具有较强的抗新型冠状病毒活性。
, authors=刘京芳
1, 刘倩
2, 赵英男
3, 杨雷
3, 王宇佳
4, 赵建元
4, 苏彦雷
3, 孙殿兴
3, 岑山
4, authorsList=刘京芳, 刘倩, 赵英男, 杨雷, 王宇佳, 赵建元, 苏彦雷, 孙殿兴, 岑山, authorCompany=null, correspAuthors=苏彦雷, 岑山, authorNote=
刘京芳（1979-），女，河北石家庄人，副主任医师，硕士，研究方向：中医临床及方剂。
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=rHMk9WrgK8auId6WciAkLw==, magXml=saEN2oJbm+SLlyA13F3vlg==, pdfUrl=null, pdf=3LSIk9+vu05rw52H3YHueQ==, pdfFileSize=2747063, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=bYM46tAfDqxBsQ2uoG11TQ==, mapNumber=null, fund=null)}, authors=[Author(id=1319291277783445779, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291277879914773, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291277783445779, language=EN, stringName=Jingfang LIU, firstName=Jingfang, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291277947023638, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291277783445779, language=CN, stringName=刘京芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.河北省中医药科学院，河北 石家庄 050030, bio={"content":"
刘京芳（1979-），女，河北石家庄人，副主任医师，硕士，研究方向：中医临床及方剂。
"}, bioImg=null, bioContent=
刘京芳（1979-），女，河北石家庄人，副主任医师，硕士，研究方向：中医临床及方剂。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276218970374, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=1., ext=[AuthorCompanyExt(id=1319291276231553287, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276218970374, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China), AuthorCompanyExt(id=1319291276239941896, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276218970374, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.河北省中医药科学院，河北 石家庄 050030)])]), Author(id=1319291278014132504, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291278081241370, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278014132504, language=EN, stringName=Qian LIU, firstName=Qian, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291278152544539, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278014132504, language=CN, stringName=刘倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.河北省优抚医院，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276340605193, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=2., ext=[AuthorCompanyExt(id=1319291276348993802, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276340605193, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China), AuthorCompanyExt(id=1319291276357382411, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276340605193, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.河北省优抚医院，河北 石家庄 050051)])]), Author(id=1319291278253207837, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291278345482527, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278253207837, language=EN, stringName=Yingnan ZHAO, firstName=Yingnan, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291278416785696, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278253207837, language=CN, stringName=赵英男, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276428685580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=3., ext=[AuthorCompanyExt(id=1319291276437074189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291276445462798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291278492283170, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291278584557860, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278492283170, language=EN, stringName=Lei YANG, firstName=Lei, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291278668443941, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278492283170, language=CN, stringName=杨雷, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276428685580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=3., ext=[AuthorCompanyExt(id=1319291276437074189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291276445462798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291278769107239, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291278844604713, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278769107239, language=EN, stringName=Yujia WANG, firstName=Yujia, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291278911713578, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291278769107239, language=CN, stringName=王宇佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276520960271, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=4., ext=[AuthorCompanyExt(id=1319291276533543184, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China), AuthorCompanyExt(id=1319291276541931793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])]), Author(id=1319291279138205996, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291279234674990, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279138205996, language=EN, stringName=Jianyuan ZHAO, firstName=Jianyuan, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291279301783855, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279138205996, language=CN, stringName=赵建元, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276520960271, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=4., ext=[AuthorCompanyExt(id=1319291276533543184, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China), AuthorCompanyExt(id=1319291276541931793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])]), Author(id=1319291279398252849, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=suyanlei0161@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1319291279503110451, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279398252849, language=EN, stringName=Yanlei SU, firstName=Yanlei, middleName=null, lastName=SU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291279591190836, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279398252849, language=CN, stringName=苏彦雷, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276428685580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=3., ext=[AuthorCompanyExt(id=1319291276437074189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291276445462798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291279658299702, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291279737991480, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279658299702, language=EN, stringName=Dianxing SUN, firstName=Dianxing, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291279805100345, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279658299702, language=CN, stringName=孙殿兴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276428685580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=3., ext=[AuthorCompanyExt(id=1319291276437074189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291276445462798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291279876403515, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=shancen@imb.pumc.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1319291279947706685, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279876403515, language=EN, stringName=Shan CEN, firstName=Shan, middleName=null, lastName=CEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291280019009854, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, authorId=1319291279876403515, language=CN, stringName=岑山, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291276520960271, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=4., ext=[AuthorCompanyExt(id=1319291276533543184, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China), AuthorCompanyExt(id=1319291276541931793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])])], keywords=[Keyword(id=1319291280144838975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=1, keyword=SARS-CoV-2), Keyword(id=1319291280224530752, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=2, keyword=RNA polymerase), Keyword(id=1319291280320999745, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=3, keyword=main protease), Keyword(id=1319291280396497218, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=4, keyword=molecular docking), Keyword(id=1319291280501354819, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=5, keyword=activity test), Keyword(id=1319291280572657988, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=6, keyword=emodin), Keyword(id=1319291280643961157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=EN, orderNo=7, keyword=anthraquinone), Keyword(id=1319291280715264326, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=1, keyword=新型冠状病毒), Keyword(id=1319291280782373191, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=2, keyword=RNA聚合酶), Keyword(id=1319291280849482056, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=3, keyword=主蛋白酶), Keyword(id=1319291280929173833, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=4, keyword=分子对接), Keyword(id=1319291281000477002, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=5, keyword=活性测试), Keyword(id=1319291281080168779, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=6, keyword=大黄素), Keyword(id=1319291281155666252, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, language=CN, orderNo=7, keyword=蒽醌)], refs=[Reference(id=1319291281503793488, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=戚运, 陈苏宁. 大黄素改善肠屏障机制研究进展[J]. 中华中医药学刊, 2024, 42(11): 103-108., articleTitle=null, refAbstract=null), Reference(id=1319291281570902353, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=谢蓉, 张民权, 李莹, 等. 大黄素药理作用及新剂型研究进展[J]. 中华中医药学刊, 2023, 41(12): 120-125., articleTitle=null, refAbstract=null), Reference(id=1319291281663177042, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU W, QAED E, ZHU Y L, et al. Research progress and new perspectives of anticancer effects of emodin[J]. Am J Chin Med, 2023, 51(7): 1751-1793., articleTitle=null, refAbstract=null), Reference(id=1319291281734480211, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=吴丛宇, 周悦, 上官璐茜, 等. 大黄素的药理作用机制研究进展[J]. 中国药科大学学报, 2023, 54(5): 634-643., articleTitle=null, refAbstract=null), Reference(id=1319291281797394772, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=陈浪, 余武汉, 陈海乐, 等. 大黄素对肺部炎症性疾病的保护作用[J]. 生命的化学, 2023, 43(3): 428-434., articleTitle=null, refAbstract=null), Reference(id=1319291281856115029, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=张茸祯. 大黄素在心血管疾病中的应用[J]. 国际心血管病杂志, 2023, 50(2): 92-94., articleTitle=null, refAbstract=null), Reference(id=1319291281910640982, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=陈鹏, 王琛, 罗瑞熙, 等. 大黄素通过调节血清代谢改善神经病理性疼痛的机制研究[J]. 中国中药杂志, 2022, 47(8): 2187-2194., articleTitle=null, refAbstract=null), Reference(id=1319291281981944151, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=石凯歌, 段志军. 大黄素修复肠屏障的研究进展[J]. 中华中医药学刊, 2021, 39(9): 130-133., articleTitle=null, refAbstract=null), Reference(id=1319291282061635928, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=熊轲, 张昊, 胡图强. 大黄素通过调节自噬抑制口腔鳞状细胞癌细胞的增殖[J]. 口腔医学, 2024, 44(8): 602-608., articleTitle=null, refAbstract=null), Reference(id=1319291282128744793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=黄伟, 胡中柱, 张雅琪, 等. 大黄素抑制维罗非尼耐药黑色素瘤细胞增殖[J]. 南昌大学学报(医学版), 2024, 64(3): 33-37., articleTitle=null, refAbstract=null), Reference(id=1319291282187465050, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=蔡箫杨, 张丽敏, 肖寒. 大黄素防治动脉粥样硬化作用机制的研究进展[J]. 现代药物与临床, 2024, 39(5): 1360-1364., articleTitle=null, refAbstract=null), Reference(id=1319291282262962523, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=陶纯立, 冯春艳, 陶柏楠. 大黄素抗类风湿关节炎的作用机制研究进展[J]. 风湿病与关节炎, 2024, 13(1): 67-70, 80., articleTitle=null, refAbstract=null), Reference(id=1319291282321682780, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHENG Q, LI S, LI X, et al. Advances in the study of emodin: an update on pharmacological properties and mechanistic basis[J]. Chin Med, 2021, 16(1): 102., articleTitle=null, refAbstract=null), Reference(id=1319291282380403037, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=陈家琪, 刘佳琪, 胡会龙, 等. 大黄素甲醚、大黄酸的研究进展[J]. 中国兽药杂志, 2023, 57(8): 79-87., articleTitle=null, refAbstract=null), Reference(id=1319291282443317598, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=张进宇, 张少波, 徐红, 等. 大黄素甲醚改善小鼠非酒精性脂肪性肝病的研究[J]. 药学学报, 2024, 59(4): 939-947., articleTitle=null, refAbstract=null), Reference(id=1319291282510426463, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=郭浩林, 姚杰凝, 董璐, 等. 大黄素甲醚对酒精性肝纤维化小鼠NLRP3信号通路及肠道菌群的影响[J]. 中国药理学通报, 2024, 40(5): 999-1000., articleTitle=null, refAbstract=null), Reference(id=1319291282594312544, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=梁瑞峰, 宋献美, 葛文静, 等. 大黄素甲醚通过调控Keap1/Nrf2信号通路抗大鼠肝纤维化的作用[J]. 中药药理与临床, 2024, 40(10): 46-51., articleTitle=null, refAbstract=null), Reference(id=1319291282657227105, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=邢志华, 徐志远, 申光焕, 等. 大黄素结构修饰及其生物活性研究进展[J]. 中国药学杂志, 2022, 57(16): 1316-1322., articleTitle=null, refAbstract=null), Reference(id=1319291282720141666, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=王洁, 张启立, 赵磊, 等. 大黄素及衍生物的合成与抗肿瘤活性的研究进展[J]. 华西药学杂志, 2023, 38(2): 214-221., articleTitle=null, refAbstract=null), Reference(id=1319291282791444835, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=常红, 刘倩, 李方龙, 等. 大黄素抗奥密克戎毒株BA.2.2药理活性的研究[J]. 中华中医药学刊, 2022, 40(9): 17-19., articleTitle=null, refAbstract=null), Reference(id=1319291282866942308, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=CARUSO F, ROSSI M, PEDERSEN J Z, et al. Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone[J]. J Infect Public Health, 2020, 13(12): 1868-1877., articleTitle=null, refAbstract=null), Reference(id=1319291282946634085, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=JANG W D, JEON S, KIM S, et al. Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay[J]. Proc Natl Acad Sci USA, 2021, 118(30): e2024302118., articleTitle=null, refAbstract=null), Reference(id=1319291283013742950, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO J Y, GUO S S, YI D R, et al. A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase[J]. Antiviral Res, 2021, 190: 105078., articleTitle=null, refAbstract=null), Reference(id=1319291283085046119, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=邸琨, 谢小华, 赵田华, 等. 根皮素对新型冠状病毒RNA聚合酶抑制活性的实验研究及类似物活性预测[J]. 中华中医药学刊, 2025, 43(11): 28-31., articleTitle=null, refAbstract=null), Reference(id=1319291283147960680, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=王绛辉, 张晶, 段绪红, 等. 黄酮类化合物抑制新型冠状病毒主蛋白酶的研究[J]. 中华中医药学刊, 2023, 41(4): 13-16, 262., articleTitle=null, refAbstract=null), Reference(id=1319291283219263849, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=张培红, 赵洁, 张欣欣, 等. 桑辛素对新型冠状病毒主蛋白酶抑制作用的研究[J]. 中华中医药学刊, 2023, 41(10): 9-11., articleTitle=null, refAbstract=null), Reference(id=1319291283286372714, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=苏彦雷, 刘倩, 王君平, 等. 黄芩素抗奥密克戎毒株BA.2.2活性的研究[J]. 中华中医药学刊, 2022, 40(8): 14-16, 259., articleTitle=null, refAbstract=null), Reference(id=1319291283349287275, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=王利华, 刘军, 邸琨, 等. 木犀草苷抗奥密克戎毒株药理活性的研究[J]. 中华中医药学刊, 2023, 41(7): 26-28., articleTitle=null, refAbstract=null), Reference(id=1319291283412201836, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=海洋, 谢建平. SARS-CoV-2 NSP7和NSP8的研究进展[J]. 生物信息学, 2021, 19(3): 149-158., articleTitle=null, refAbstract=null), Reference(id=1319291283483505005, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=SARMA H, JAMIR E, SASTRY G N. Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: a comparison between SARS-CoV-2 and SARS-CoV[J]. J Mol Struct, 2022, 1257: 132602., articleTitle=null, refAbstract=null), Reference(id=1319291283554808174, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=MOELLER N H, SHI K, DEMIR Ö, et al. Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN[J]. Proc Natl Acad Sci USA, 2022, 119(9): e2106379119., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319291281252135245, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, awardId=81672041, language=CN, fundingSource=国家自然科学基金项目(81672041), fundOrder=null, country=null), Fund(id=1319291281331827022, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, awardId=20241370, language=CN, fundingSource=河北省卫生健康委员会重点科研攻关计划项目(20241370), fundOrder=null, country=null), Fund(id=1319291281403130191, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, awardId=2024256, language=CN, fundingSource=河北省中医药管理局科研计划项目(2024256), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319291276218970374, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=1., ext=[AuthorCompanyExt(id=1319291276231553287, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276218970374, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China), AuthorCompanyExt(id=1319291276239941896, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276218970374, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.河北省中医药科学院，河北 石家庄 050030)]), AuthorCompany(id=1319291276340605193, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=2., ext=[AuthorCompanyExt(id=1319291276348993802, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276340605193, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China), AuthorCompanyExt(id=1319291276357382411, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276340605193, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.河北省优抚医院，河北 石家庄 050051)]), AuthorCompany(id=1319291276428685580, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=3., ext=[AuthorCompanyExt(id=1319291276437074189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291276445462798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276428685580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)]), AuthorCompany(id=1319291276520960271, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, xref=4., ext=[AuthorCompanyExt(id=1319291276533543184, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Hebei, China), AuthorCompanyExt(id=1319291276541931793, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291275476578563, companyId=1319291276520960271, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])], figs=null, attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.09.036, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.09.036, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2026.09.036, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2026.09.036, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788969600000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
82
13
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
