中华中医药学刊

迈之灵治疗急性膝关节创伤性滑膜炎的疗效及对血清OPG、TGF-β1、IL-6水平的影响

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张茂文 ¹ , 李广亮 ² , 张玺娴 ¹ , 章慧 ²

中华中医药学刊 | 国家项目点击 2026,44(9): 181-184

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中华中医药学刊 |国家项目点击 2026 , 44 (9) : 181 -184

迈之灵治疗急性膝关节创伤性滑膜炎的疗效及对血清OPG、TGF-β1、IL-6水平的影响

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张茂文¹, 李广亮², 张玺娴¹, 章慧²

作者信息

^1.青岛黄海学院，山东　青岛　266555

^2.山东第二医科大学附属医院，山东　潍坊　261000

通讯作者:

李广亮（1988-），男，山东临沂人，副教授，硕士，研究方向：外科学、中医康复。

作者简介:

张茂文（1988-），男，山东青岛人，副教授，硕士，研究方向：老年学、中医康复。

Efficacy of Aescuven Forte in Treatment of Acute Traumatic Knee Synovitis and Influence on Serum Levels of OPG, TGF-β1 and IL-6

Maowen ZHANG¹, Guangliang LI², Xixian ZHANG¹, Hui ZHANG²

Affiliations

^1.Teaching and Research Office of Qingdao Huanghai University, Qingdao 266555, Shandong, China

^2.Shandong Second Medical University Affiliated Hospital, Weifang 261000, Shandong, China

出版时间: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.033

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摘要

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目的

探讨迈之灵治疗急性膝关节创伤性滑膜炎的疗效及对血清骨保护素（osteoprotegerin，OPG）、转化生长因子-β1（transforming growth factor-β1，TGF-β1）、白细胞介素6（interleukin 6，IL-6）水平的影响。

方法

选取100例急性膝关节创伤性滑膜炎患者，随机分为对照组与观察组，每组50例，对照组常规治疗，观察组在对照组治疗基础上加用迈之灵口服治疗，疗程14 d，采用视觉模拟评分法（Visual analogue scale，VAS）、麦克马斯特大学骨关节炎指数（Western Ontario and McMaster Universities osteoarthritis index，WOMAC）及膝关节Lysholm评分、滑膜厚度、积液深度、膝关节周径差值及血清OPG、TGF-β1、IL-6水平变化。

结果

两组治疗前的VAS评分、WOMAC评分、Lysholm评分、滑膜厚度、积液深度、膝关节周径差值比较差异均无统计学意义（P>0.05），治疗后VAS评分、WOMAC评分、滑膜厚度、积液深度、膝关节周径差值与治疗前比较下降（P<0.05），且观察组低于对照组（P<0.05），Lysholm评分与治疗前比较升高（P<0.05），且观察组高于对照组（P<0.05）；两组治疗前的血清OPG、TGF-β1、IL-6水平比较差异均无统计学意义（P>0.05），治疗后血清OPG、TGF-β1与治疗前比较升高（P<0.05），且观察组高于对照组（P<0.05），IL-6与治疗前比较下降（P<0.05），且观察组低于对照组（P<0.05）；观察组疗效优于对照组（P<0.05）；对照组及观察组不良反应发生率分别为14.00%、18.00%，比较差异无统计学意义（P>0.05）。

结论

迈之灵治疗急性膝关节创伤性滑膜炎可提高疗效，改善OPG、TGF-β1、IL-6水平，其作用可能与改善患者膝关节骨代谢、促进创伤修复及减轻炎性反应等途径有关。

关键词

迈之灵 / 急性膝关节创伤性滑膜炎 / 疗效 / 骨保护素 / 转化生长因子-β1 / 白细胞介素6

Abstract

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Objective

To explore the effects of Aescuven forte in the treatment of acute traumatic knee synovitis and influence on serum levels of osteoprotegerin (OPG), transforming growth factor-β1 (TGF-β1) and interleukin 6 (IL-6).

Methods

A total of 100 patients with acute traumatic knee synovitis induced were selected and divided into the control group (50 cases) and the observation group (50 cases) by random number table method. The control group received routine treatment, and the observation group received oral treatment with Aescuven forte on the basis of the control group, the course of treatment was 14 days. Visual analogue scale (VAS) score, Western Ontario and McMaster Universities osteoarthritis index (WOMAC) score, knee Lysholm score, synovial thickness, effusion depth, depth of fluid accumulation and difference of knee diameter, and the levels of serum OPG, TGF-β1 and IL-6 were compared.

Results

There was no significant difference in VAS score, WOMAC score, Lysholm score, synovial thickness, effusion depth or peri-diameter difference of knee joint between the observation group and the control group (P>0.05). After treatment, VAS scores, WOMAC scores, synovial thickness, effusion depth and peri-diameter difference of knee joint decreased compared with those before treatment (P<0.05). The results of the observation group were lower than those of the control group (P<0.05). The Lysholm scores in two groups were higher than those before treatment (P<0.05), and the score of the observation group was higher than that of the control group (P<0.05). There was no statistically significant difference in the levels of serum OPG, TGF-β1 or IL-6 between the two groups before treatment (P>0.05). The levels of serum OPG and TGF-β1 elevated after treatment compared with those before treatment (P<0.05). The serum IL-6 levels decreased after treatment compared with those before treatment (P<0.05) and the level of the observation group was lower than that of the control group (P<0.05). The therapeutic effect of the observation group was better than that of the control group (P<0.05). The incidence of adverse reactions in the control group and the observation group was 14.00% and 18.00%, respectively, with no statistical significance (P>0.05).

Conclusion

Aescuven forte in the treatment of acute traumatic knee synovitis can improve the therapeutic effect, the levels of OPG, TGF-β1 and IL-6. Its effect may be related to improving knee bone metabolism, promoting wound repair and alleviating inflammatory response.

Key words

Aescuven forte / acute traumatic knee synovitis / efficacy / OPG / TGF-β1 / IL-6

引用本文

张茂文, 李广亮, 张玺娴, 章慧. 迈之灵治疗急性膝关节创伤性滑膜炎的疗效及对血清OPG、TGF-β1、IL-6水平的影响. 中华中医药学刊, 2026 , 44 (9) : 181 -184 . DOI: 10.13193/j.issn.1673-7717.2026.09.033

Maowen ZHANG, Guangliang LI, Xixian ZHANG, Hui ZHANG. Efficacy of Aescuven Forte in Treatment of Acute Traumatic Knee Synovitis and Influence on Serum Levels of OPG, TGF-β1 and IL-6[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 181 -184 . DOI: 10.13193/j.issn.1673-7717.2026.09.033

基金

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国家中医药管理局项目(20172029)

参考文献

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2026年第44卷第9期

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doi: 10.13193/j.issn.1673-7717.2026.09.033

首发时间：2026-10-20
出版时间：2026-09-10

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基金

国家中医药管理局项目(20172029)

作者信息

^1.青岛黄海学院，山东　青岛　266555

^2.山东第二医科大学附属医院，山东　潍坊　261000

通讯作者:

李广亮（1988-），男，山东临沂人，副教授，硕士，研究方向：外科学、中医康复。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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