Article(id=1319291316417180396, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.032, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473161080, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473161080, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473161080, creator=13701087609, updateTime=1792473161080, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=176, endPage=180, ext={EN=ArticleExt(id=1319291316698198765, articleId=1319291316417180396, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Tonifying Kidney Efficacy Enhances Antidepressant Effect of Shanzhuyu (Corni Fructus) After Processing, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the differences in antidepressant effects and mechanisms between the crude and wine products of Shanzhuyu (Corni Fructus), evaluating the assistance of tonifying kidney efficacy in potentiating the antidepressant effect of Shanzhuyu (Corni Fructus) after processing.
Method The commonly used classic chronic unpredictable mild stress (CUMS) mouse depression model was used to evaluate the antidepressant effect of water extract of Shanzhuyu (Corni Fructus) through routine behavioral testing indicators such as sugar water preference and immobility time. Further, under the guidance of the traditional Chinese medicine theory of “kidney connected to brain”, the antidepressant mechanism was explored by detecting and analyzing oxidative/antioxidant related indicators in mice.
Result The water extract of crude and wine products of Shanzhuyu (Corni Fructus) (150 mg/kg) administered orally for 35 days, significantly improved depression-like behaviors induced by CUMS in mice, such as reduced sugar water preference and prolonged forced swimming and tail suspension time (P<0.01), and the effect of Shanzhuyu (Corni Fructus) wine products was significantly better than that of crude products (P<0.01). Crude and wine products of Shanzhuyu (Corni Fructus) significantly improved the increase of CUMS-induced lipid peroxidation malondialdehyde and ferrous ions, as well as the decrease of total superoxide dismutase and glutathione peroxidase levels (P<0.01) in hippocampus and kidney, while crude products of Shanzhuyu (Corni Fructus) were far inferior to its wine products in this regard (P<0.01).
Conclusion The tonifying kidney efficacy enhances the antidepressant effect of wine products of Shanzhuyu (Corni Fructus) compared to its crude products, and the mechanism may involved enhancing the antioxidant defense ability and inhibiting lipid peroxidation damage in the kidneys and brain to improve the theory of “kidney connected to brain”.
, authors=Mingzhu GONG
1, Yueyue ZHANG
1, Lingling SONG
1, Xiaohui WU
1, Junming WANG
1, 2, 3, Yanmei WANG
1, Lijie JI
1, Qingwen HE
1, Tianzhu ZHANG
1, authorsList=Mingzhu GONG, Yueyue ZHANG, Lingling SONG, Xiaohui WU, Junming WANG, Yanmei WANG, Lijie JI, Qingwen HE, Tianzhu ZHANG, authorCompany=null, correspAuthors=Junming WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291317000188654, articleId=1319291316417180396, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=补肾功效助力山茱萸抗抑郁的炮制增效作用研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 观测补肾中药山茱萸生品与其酒制品抗抑郁作用及其机制的差异，评价补肾功效对山茱萸抗抑郁的炮制增效作用的助力。
方法 采用经典的慢性不可预知温和应激（CUMS）小鼠抑郁模型，通过糖水偏爱、不动时间等常规行为测试指标评价山茱萸水提物的抗抑郁作用，进一步在中医“肾通于脑”理论的指导下通过对小鼠氧化/抗氧化相关指标的检测分析以初探其抗抑郁机制。
结果 山茱萸生品及其酒制品的水提物（150 mg/kg）灌服35 d均能够显著改善CUMS诱导的小鼠糖水偏爱的降低及强迫游泳和悬尾的不动时间的延长（P<0.01）等抑郁样行为，且山茱萸酒制品的作用显著优于生品（P<0.01）；山茱萸生品与其酒制品能显著改善CUMS诱导的海马、肾过高的脂质过氧化产物丙二醛、亚铁离子以及过低的总超氧化物歧化酶和谷胱甘肽过氧化物酶水平（P<0.01），而山茱萸生品对此远不及其酒制品（P<0.01）。
结论 补肾功效助力山茱萸酒制品比其生品具有更强的抗抑郁作用，其机制可能与增强肾与脑的抗氧化防御能力及抑制脂质过氧化损伤以提升“肾通于脑”有关。
, authors=弓明珠
1, 张月月
1, 宋玲玲
1, 巫晓慧
1, 王君明
1, 2, 3, 王彦嵋
1, 纪丽婕
1, 何庆文
1, 张天柱
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弓明珠（1995-），女，河南郑州人，博士在读，研究方向：中药药性药效机理与安全性评价。
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弓明珠（1995-），女，河南郑州人，博士在读，研究方向：中药药性药效机理与安全性评价。
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1.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
2.Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
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2.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心，河南 郑州 450046
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