Article(id=1319291298482339874, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.029, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473156804, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473156804, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473156804, creator=13701087609, updateTime=1792473156804, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=152, endPage=159, ext={EN=ArticleExt(id=1319291298708832291, articleId=1319291298482339874, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress in Prevention and Treatment of Colorectal Cancer in Banxia Xiexin Decoction (半夏泻心汤), columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Colorectal cancer is a common malignant tumor of the digestive tract with high incidence and mortality, and the existing treatment methods can prolong the survival of the patients to a certain extent, but it faces challenges such as high recurrence rate, strong drug resistance and serious adverse reactions, which cannot fully meet the overall needs of patients. Banxia Xiexin Decoction (半夏泻心汤) created by the medical saint ZHANG Zhongjing is a classic prescription for the treatment of cold and heat syndrome, and is often used for the prevention and treatment of colorectal cancer in modern clinical practice. A large number of studies have found that Banxia Xiexin Decoction can treat precancerous lesions in the early stage, by inhibiting inflammatory response, regulating a variety of signaling pathways, improving intestinal flora dysbiosis, effectively treating ulcerative colitis and colorectal adenoma, blocking the process of precancerous lesion transformation, and reducing the incidence of colorectal cancer. In the medium term, it can be combined with chemotherapy to reduce the adverse reactions of delayed diarrhea, nausea and vomiting, bone marrow suppression, peripheral neuropathy and oral ulcers caused by chemotherapy, alleviate intestinal injury, improve bone marrow hematopoietic function and relieve pain caused by chemotherapy, and adjuvant chemotherapy can be carried out smoothly to improve the overall efficacy. In the later stage, it can inhibit recurrence and metastasis, promote colorectal cancer cell apoptosis by regulating protein expression, and induce ferroptosis to inhibit cell proliferation and migration through multiple pathways, thereby reducing the rate of colorectal cancer metastasis and recurrence, and is widely used in the whole treatment of the disease. This article reviewed the relevant research progress on the prevention and treatment of colorectal cancer using Banxia Xiexin Decoction through literature retrieval, including theoretical foundations, pharmacological basis and various aspects of prevention and treatment applications. It also addressed the shortcomings and improvement measures of current research, aiming to provide new ideas for the development of new drugs and clinical applications for the prevention and treatment of colorectal cancer in the future.

, authors=Ge ZHANG¹, Pingsheng ZHOU^{1, 2}, Qingling ZHANG¹, Jianfeng Yi³, Shiping CHENG^{1, 4}, authorsList=Ge ZHANG, Pingsheng ZHOU, Qingling ZHANG, Jianfeng Yi, Shiping CHENG, authorCompany=null, correspAuthors=Pingsheng ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291299073736740, articleId=1319291298482339874, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=半夏泻心汤防治结直肠癌的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

结直肠癌是消化道常见恶性肿瘤，具有高发病率和高病死率，现有西医疗法一定程度上能够延长患者生存期，但面临着复发率高、耐药性强、药物不良反应大等挑战，不能完全满足患者整体需求。医圣张仲景所创的半夏泻心汤是治疗寒热错杂之痞证的经典名方，现代临床上常用于防治结直肠癌。大量研究发现半夏泻心汤前期可以治疗癌前病变，通过抑制炎症反应，调控多种信号通路，改善肠道菌群失调，有效治疗溃疡性结肠炎和结直肠腺瘤，阻断癌前病变转化的进程，降低结直肠癌的发病率；中期可以协同化疗减毒，减轻化疗所致的延迟性腹泻、恶心呕吐、骨髓抑制、周围神经病变和口腔溃疡不良反应，缓解肠道损伤，提高骨髓造血机能，缓解化疗引起的疼痛，辅助化疗顺利进行，提高整体疗效；后期可以抑制复发转移，通过调控蛋白表达，促进结直肠癌细胞凋亡，多途径诱导铁死亡抑制细胞增殖迁移，从而降低结直肠癌转移率和复发率，广泛用于疾病的全程治疗。通过检索文献，对半夏泻心汤防治结直肠癌的相关研究进展进行综述，包括理论基础、药效物质基础和防治应用等多方面的研究，并针对目前研究提出了不足与改进措施，以期为今后防治结直肠癌的新药研发和临床应用提供新思路。

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张格（2001-），女，湖南岳阳人，硕士在读，研究方向：经方防治肿瘤疾病。

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张格（2001-），女，湖南岳阳人，硕士在读，研究方向：经方防治肿瘤疾病。

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