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Article(id=1319291185022222354, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.09.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473129754, onlineDateStr=2026-10-20, pubDate=1788969600000, pubDateStr=2026-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473129754, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473129754, creator=13701087609, updateTime=1792473129754, updator=13701087609, issue=Issue{id=1319291166823142311, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1788969600000', pubDateStr='2026-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792473125414, creator='13701087609', updateTime=1792473357559, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292140618896016, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292140618896017, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291166823142311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=47, endPage=52, ext={EN=ArticleExt(id=1319291185215160339, articleId=1319291185022222354, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Buyang Huanwu Decoction (补阳还五汤) Attenuates H2O2 Induced Apoptosis of PC12 Cells Through JNK/c-Jun Signaling Pathway, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the effect and mechanism of water extract of Buyang Huanwu Decoction (补阳还五汤, BHD) on H2O2-induced apoptosis in PC12 cells based on the JNK/c-Jun signaling pathway.

Methods

An oxidative stress cell model was established by treating PC12 cells with H2O2 at an optimal concentration of 200 μmol/L. The experiment was divided into a normal group, a model group, low-, middle-and high-dose BHD groups, and an SP600125 group. PC12 cells were treated with SP600125 and different concentrations of BHD medium. The cell proliferation was detected using a real-time cell analysis (RTCA) system and the CCK-8 method. Intracellular reactive oxygen species (ROS) levels and apoptosis were measured by immunofluorescence and flow cytometry. The protein expression levels of Bax, Caspase-3, Bcl-2, c-Jun, p-c-Jun, p-JNK and JNK were detected by Western blotting.

Results

Compared with the normal group, the model group showed significantly increased ROS levels, apoptosis rate, protein expressions of Bax and Caspase-3 and ratios of p-JNK/JNK and p-c-Jun/c-Jun, while the expression of Bcl-2 protein was significantly decreased (P<0.01). Compared with the model group, high-dose BHD intervention significantly reduced ROS levels, apoptosis rate, protein expressions of Bax and Caspase-3 and ratios of p-JNK/JNK and p-c-Jun/c-Jun (P<0.01), while significantly increasing the expression of Bcl-2 protein (P<0.01).

Conclusion

The water extract of Buyang Huanwu Decoction can inhibit oxidative stress-mediated apoptosis in PC12 cells through the JNK/c-Jun signaling pathway, revealing a potential mechanism by which Buyang Huanwu Decoction may improve refractory erectile dysfunction by promoting nerve injury repair.

, authors=Quhua WEN1, 2, Miaoyong YE3, Ziqin ZHAO4, Jiyu WANG4, Wentao YANG5, Limin MA2, Fan ZHAO2, authorsList=Quhua WEN, Miaoyong YE, Ziqin ZHAO, Jiyu WANG, Wentao YANG, Limin MA, Fan ZHAO, authorCompany=null, correspAuthors=Limin MA, Fan ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291185559093268, articleId=1319291185022222354, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=补阳还五汤水提物通过JNK/c-Jun信号通路减轻H2O2诱导的PC12细胞凋亡, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

基于c-Jun氨基末端激酶（c-Jun N-terminal kinase，JNK）/c-Jun信号通路探讨补阳还五汤水提物对H2O2诱导的PC12细胞凋亡的影响及其作用机制。

方法

采用最佳浓度200 μmol/L的H2O2处理PC12细胞构建氧化应激体外细胞模型。设正常组、模型组、补阳还五汤（BHD）低、中、高剂量组、SP600125组，采用SP600125和不同浓度的BHD培养基对PC12细胞进行处理。利用实时细胞分析（RTCA）系统及CCK-8法检测细胞增殖情况；免疫荧光及流式细胞仪检测细胞内活性氧水平及细胞凋亡情况；蛋白质印迹检测细胞内促凋亡蛋白Bcl-2相关X蛋白（BCL-2-associated X protein，Bax）、促凋亡蛋白半胱氨酸依赖性天冬氨酸特异性蛋白酶-3（Cysteine-dependent aspartate-specific protease-3，Caspase-3）、抗凋亡蛋白Bcl-2、c-Jun、p-c-Jun、p-JNK、JNK蛋白的表达情况。

结果

与正常组比较，模型组活性氧水平、细胞凋亡率、Bax和Caspase-3蛋白表达、p-JNK/JNK和p-c-Jun/c-Jun明显升高，Bcl-2蛋白表达明显降低（P<0.01）。与模型组比较，高剂量BHD干预后活性氧水平、细胞凋亡率、Bax和Caspase-3蛋白表达、p-JNK/JNK和p-c-Jun/c-Jun显著降低（P<0.01），Bcl-2蛋白表达明显升高（P<0.01）。

结论

补阳还五汤水提物可通过JNK/c-Jun信号通路抑制氧化应激介导的PC12细胞凋亡，揭示了补阳还五汤可通过促进神经损伤修复而改善难治性勃起功能障碍的潜在作用机制。

, authors=温瞿华1, 2, 叶妙勇3, 赵梓钦4, 王继禹4, 杨文涛5, 马利民2, 赵凡2, authorsList=温瞿华, 叶妙勇, 赵梓钦, 王继禹, 杨文涛, 马利民, 赵凡, authorCompany=null, correspAuthors=马利民, 赵凡, authorNote=

温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

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赵凡（1989-），男，江苏南通人，主治医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
马利民（1975-），男，江苏南通人，主任医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
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温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

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温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

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补阳还五汤水提物通过JNK/c-Jun信号通路减轻H2O2诱导的PC12细胞凋亡
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温瞿华 1, 2 , 叶妙勇 3 , 赵梓钦 4 , 王继禹 4 , 杨文涛 5 , 马利民 2 , 赵凡 2
中华中医药学刊 | 国家项目点击 2026,44(9): 47-52
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中华中医药学刊 |国家项目点击 2026 , 44 (9) : 47 -52
补阳还五汤水提物通过JNK/c-Jun信号通路减轻H2O2诱导的PC12细胞凋亡
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温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

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温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

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温瞿华1, 2, 叶妙勇3, 赵梓钦4, 王继禹4, 杨文涛5, 马利民2 , 赵凡2
作者信息
  • 1.广西中医药大学，广西　南宁　530200
  • 2.南通大学附属医院泌尿外科（国家中西医协同“旗舰”建设科室），江苏　南通　226001
  • 3.温州医科大学附属温岭医院，浙江　温岭　317599
  • 4.云南中医药大学，云南　昆明　650011
  • 5.广西中医药大学附属瑞康医院，广西　南宁　530012
通讯作者:
赵凡（1989-），男，江苏南通人，主治医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
马利民（1975-），男，江苏南通人，主任医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
作者简介:

温瞿华（1996-），男，江西赣州人，医师，博士在读，研究方向：泌尿男科疾病的中西医结合基础与临床。

Buyang Huanwu Decoction (补阳还五汤) Attenuates H2O2 Induced Apoptosis of PC12 Cells Through JNK/c-Jun Signaling Pathway
Quhua WEN1, 2, Miaoyong YE3, Ziqin ZHAO4, Jiyu WANG4, Wentao YANG5, Limin MA2 , Fan ZHAO2
Affiliations
  • 1.Guangxi University of Chinese Medicine, Nanning 530022, Guangxi, China
  • 2.Affiliated Hospital of Nantong University (National Flagship Construction Department of Collaboration between Traditional Chinese Medicine and Western Medicine), Nantong 226001, Jiangsu, China
  • 3.The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling 317599, Zhejiang, China
  • 4.Yunnan University of Chinese Medicine, Kunming 650011, Yunnan, China
  • 5.Ruikang Hospital, Guangxi University of Chinese Medicine Affiliated Hospital, Nanning 530012, Guangxi, China
出版时间: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.009
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摘要
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目的

基于c-Jun氨基末端激酶（c-Jun N-terminal kinase，JNK）/c-Jun信号通路探讨补阳还五汤水提物对H2O2诱导的PC12细胞凋亡的影响及其作用机制。

方法

采用最佳浓度200 μmol/L的H2O2处理PC12细胞构建氧化应激体外细胞模型。设正常组、模型组、补阳还五汤（BHD）低、中、高剂量组、SP600125组，采用SP600125和不同浓度的BHD培养基对PC12细胞进行处理。利用实时细胞分析（RTCA）系统及CCK-8法检测细胞增殖情况；免疫荧光及流式细胞仪检测细胞内活性氧水平及细胞凋亡情况；蛋白质印迹检测细胞内促凋亡蛋白Bcl-2相关X蛋白（BCL-2-associated X protein，Bax）、促凋亡蛋白半胱氨酸依赖性天冬氨酸特异性蛋白酶-3（Cysteine-dependent aspartate-specific protease-3，Caspase-3）、抗凋亡蛋白Bcl-2、c-Jun、p-c-Jun、p-JNK、JNK蛋白的表达情况。

结果

与正常组比较，模型组活性氧水平、细胞凋亡率、Bax和Caspase-3蛋白表达、p-JNK/JNK和p-c-Jun/c-Jun明显升高，Bcl-2蛋白表达明显降低（P<0.01）。与模型组比较，高剂量BHD干预后活性氧水平、细胞凋亡率、Bax和Caspase-3蛋白表达、p-JNK/JNK和p-c-Jun/c-Jun显著降低（P<0.01），Bcl-2蛋白表达明显升高（P<0.01）。

结论

补阳还五汤水提物可通过JNK/c-Jun信号通路抑制氧化应激介导的PC12细胞凋亡，揭示了补阳还五汤可通过促进神经损伤修复而改善难治性勃起功能障碍的潜在作用机制。

补阳还五汤  /  神经损伤  /  细胞凋亡  /  氧化应激  /  c-Jun氨基末端激酶/c-Jun信号通路  /  难治性勃起功能障碍
Objective

To investigate the effect and mechanism of water extract of Buyang Huanwu Decoction (补阳还五汤, BHD) on H2O2-induced apoptosis in PC12 cells based on the JNK/c-Jun signaling pathway.

Methods

An oxidative stress cell model was established by treating PC12 cells with H2O2 at an optimal concentration of 200 μmol/L. The experiment was divided into a normal group, a model group, low-, middle-and high-dose BHD groups, and an SP600125 group. PC12 cells were treated with SP600125 and different concentrations of BHD medium. The cell proliferation was detected using a real-time cell analysis (RTCA) system and the CCK-8 method. Intracellular reactive oxygen species (ROS) levels and apoptosis were measured by immunofluorescence and flow cytometry. The protein expression levels of Bax, Caspase-3, Bcl-2, c-Jun, p-c-Jun, p-JNK and JNK were detected by Western blotting.

Results

Compared with the normal group, the model group showed significantly increased ROS levels, apoptosis rate, protein expressions of Bax and Caspase-3 and ratios of p-JNK/JNK and p-c-Jun/c-Jun, while the expression of Bcl-2 protein was significantly decreased (P<0.01). Compared with the model group, high-dose BHD intervention significantly reduced ROS levels, apoptosis rate, protein expressions of Bax and Caspase-3 and ratios of p-JNK/JNK and p-c-Jun/c-Jun (P<0.01), while significantly increasing the expression of Bcl-2 protein (P<0.01).

Conclusion

The water extract of Buyang Huanwu Decoction can inhibit oxidative stress-mediated apoptosis in PC12 cells through the JNK/c-Jun signaling pathway, revealing a potential mechanism by which Buyang Huanwu Decoction may improve refractory erectile dysfunction by promoting nerve injury repair.

Buyang Huanwu Decoction (补阳还五汤)  /  nerve injury  /  apoptosis  /  oxidative stress  /  JNK/c-Jun signaling pathway  /  refractory erectile function
温瞿华, 叶妙勇, 赵梓钦, 王继禹, 杨文涛, 马利民, 赵凡. 补阳还五汤水提物通过JNK/c-Jun信号通路减轻H2O2诱导的PC12细胞凋亡. 中华中医药学刊, 2026 , 44 (9) : 47 -52 . DOI: 10.13193/j.issn.1673-7717.2026.09.009
Quhua WEN, Miaoyong YE, Ziqin ZHAO, Jiyu WANG, Wentao YANG, Limin MA, Fan ZHAO. Buyang Huanwu Decoction (补阳还五汤) Attenuates H2O2 Induced Apoptosis of PC12 Cells Through JNK/c-Jun Signaling Pathway[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 47 -52 . DOI: 10.13193/j.issn.1673-7717.2026.09.009
基金
收起
  • 国家自然科学基金项目(82004360)
  • 国家中医药管理局国家中西医协同“旗舰”科室（泌尿外科）建设项目(国中医药综结合函〔2024〕221号)
  • 中华中医药学会青年人才托举工程项目(CACM-2023-QNRC2-B21)
  • 江苏省研究型医院资助基金项目(YJXYY202204-YSA05; YJXYY202204-XKB08)
  • 南通市卫生健康委员会科研项目(MS2023020)
  • 南通大学附属医院“青蓝工程”项目
文献
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2026年第44卷第9期
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doi: 10.13193/j.issn.1673-7717.2026.09.009
  • 首发时间：2026-10-20
  • 出版时间：2026-09-10
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文章信息
作者
出版历史
基金
国家自然科学基金项目(82004360)
国家中医药管理局国家中西医协同“旗舰”科室（泌尿外科）建设项目(国中医药综结合函〔2024〕221号)
中华中医药学会青年人才托举工程项目(CACM-2023-QNRC2-B21)
江苏省研究型医院资助基金项目(YJXYY202204-YSA05; YJXYY202204-XKB08)
南通市卫生健康委员会科研项目(MS2023020)
南通大学附属医院“青蓝工程”项目
作者信息
    1.广西中医药大学，广西　南宁　530200
    2.南通大学附属医院泌尿外科（国家中西医协同“旗舰”建设科室），江苏　南通　226001
    3.温州医科大学附属温岭医院，浙江　温岭　317599
    4.云南中医药大学，云南　昆明　650011
    5.广西中医药大学附属瑞康医院，广西　南宁　530012

通讯作者:

赵凡（1989-），男，江苏南通人，主治医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
马利民（1975-），男，江苏南通人，主任医师，博士，研究方向：泌尿男科疾病的中西医结合基础与临床。E-mail：。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.09.009
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2种不同金属材料的力学参数
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species		 占总种数比例
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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