Article(id=1319291524093948374, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.050, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473210595, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473210595, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473210595, creator=13701087609, updateTime=1792473210595, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=241, endPage=245, ext={EN=ArticleExt(id=1319291524282692055, articleId=1319291524093948374, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Study of Modified Ditan Decoction (涤痰汤加减) on Regulation of Neurotransmitters in Brain of Elderly Dementia Patients with Phlegm-Turbidity Obstructing Orifices Type, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the regulatory effect of Modified Ditan Decoction (涤痰汤加减) on brain neurotransmitters in elderly dementia patients with phlegm-turbidity obstructing orifices type.
Method A total of 122 elderly dementia patients in the hospital from January 2021 to December 2024 divided into control group (61 cases) and an observation group (61 cases) according to the medication plan. The control group took orally donepezil hydrochloride tablets and vitamin E soft capsules, while the observation group Modified Ditan Decoction on the basis of control group. Two groups were evaluated for 12 weeks of treatment. It compared the therapeutic effects of two groups, the changes in cognitive function, daily living ability, traditional Chinese medicine syndrome, brain neurotransmitters and quality of life before and after treatment and safety evaluation.
Result The effective rate of the observation group (91.80%) was higher than that of the control group (77.05%) (P<0.05). After treatment, Alzheimer's disease assessment scale-cognitive (ADAS-cog) score [(19.86±3.78) points] of the observation group was lower that of the control group [(28.74±4.69) points], while the mini-mental state examination (MMSE) score [(23.42±2.14) points] and Montreal cognitive assessment (MoCA) score [(23.19±2.45) points] were higher than those of the control group [(20.16±2.53) points and (20.08±2.76) points] (P<0.05). After treatment, activity daily living (ADL) score of the observation group [(64.52±6.84) points] was higher than that of the control group [(56.79±7.17) points], while the TCM syndrome score [(7.74±2.13) points] was lower than that of the control group [13.28±2.97) points] (P<0.05). After treatment, the serum levels of dopamine (DA) [(245.13±29.47) pg/mL], acetylcholine (ACh) [(323.15±35.47) pmol/mL] and gamma-aminobutyric acid (GABA) [(169.35±16.54) pg/mL] of the observation group were higher than those of the control group [(210.35±26.52) pg/mL, (282.56±26.26) pmol/mL and (145.29±14.67) pg/mL] (P<0.05). After treatment, interpersonal environment score [(12.38±2.43) points], physiological function score [(10.07±1.56) points], psychological state score [(9.42±1.43) points] and behavioral ability score [(9.86±1.63) points] of the observation groupwere higher than those of the control group [(9.97±2.31) points, (8.32±1.42) points, (7.48±1.56) points and (7.94±1.54) points] (P<0.05). Neither group experienced significant adverse reactions.
Conclusion Modified Ditan Decoction has a good therapeutic effect on the elderly dementia patients with phlegm-turbidity obstructing orifices type, and its mechanism may be related to the regulation of brain neurotransmitter levels, which has important clinical research value.
, authors=Yezhi XIA, Jiehong SHEN, Ying LI, Haiyan HUANG, Xiaojing LI, authorsList=Yezhi XIA, Jiehong SHEN, Ying LI, Haiyan HUANG, Xiaojing LI, authorCompany=null, correspAuthors=Xiaojing LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291524563710424, articleId=1319291524093948374, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=涤痰汤加减治疗对痰浊阻窍型阿尔茨海默病患者脑神经递质调控作用研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探讨涤痰汤加减治疗对痰浊阻窍型阿尔茨海默病患者脑神经递质的调控作用。
方法 选取医院于2021年1月—2024年12月收治的阿尔茨海默病患者122例，依据用药方案将其分为对照组61例与观察组61例。对照组口服盐酸多奈哌齐片和维生素E软胶囊，观察组在对照组治疗基础上服用涤痰汤加减方。两组治疗12周评价。比较两组治疗疗效；治疗前后认知功能，日常生活能力，中医证候，脑神经递质和生活质量变化及安全性评价。
结果 观察组治疗总有效率（91.80%）高于对照组（77.05%）（P<0.05）。治疗后，观察组阿尔茨海默病评估量表-认知量表（Alzheimer's Disease Assessment Scale-Cognitive，ADAS-cog）评分（19.86±3.78）分低于对照组（28.74±4.69）分，而简易精神状态检查量表（Mini-Mental State Examination，MMSE）评分（23.42±2.14）分和蒙特利尔认知评估量表（Montreal Cognitive Assessment，MoCA）评分（23.19±2.45）分高于对照组（20.16±2.53）分和（20.08±2.76）分（P<0.05）。治疗后，观察组日常生活活动能力量表（Activity Daily Living，ADL）评分（64.52±6.84）分高于对照组（56.79±7.17）分，而中医证候积分（7.74±2.13）分低于对照组（13.28±2.97）分（P<0.05）。治疗后，观察组血清多巴胺（dopamine，DA）（245.13±29.47）pg/mL、乙酰胆碱（acetylcholine，ACh）（323.15±35.47）pmol/mL和γ-氨基丁酸（gamma-aminobutyric acid，GABA）（169.35±16.54）pg/mL高于对照组（210.35±26.52）pg/mL、（282.56±26.26）pmol/mL和（145.29±14.67）pg/mL（P<0.05）。治疗后，观察组人际环境（12.38±2.43）分、生理功能（10.07±1.56）分、心理状态（9.42±1.43）分和行为能力（9.86±1.63）分高于对照组（9.97±2.31）分、（8.32±1.42）分、（7.48±1.56）分和（7.94±1.54）分（P<0.05）。两组均未发生明显不良反应。
结论 涤痰汤加减治疗对痰浊阻窍型阿尔茨海默病患者疗效良好，其机制可能与调控脑神经递质水平有关，具有重要临床研究价值。
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夏叶子（1985-），女（回族），山东泰安人，主治医师，硕士，研究方向：阿尔茨海默病的综合治疗。
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夏叶子（1985-），女（回族），山东泰安人，主治医师，硕士，研究方向：阿尔茨海默病的综合治疗。
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