Article(id=1319291410663199683, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.046, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473183550, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473183550, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473183550, creator=13701087609, updateTime=1792473183550, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=224, endPage=228, ext={EN=ArticleExt(id=1319291410889692100, articleId=1319291410663199683, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Observational Study on Treatment of Degenerative Lumbar Spinal Stenosis with Modified Tongdu Huoxue Decoction (通督活血汤加减) and Conservative Protocol of Electroacupuncture Intervertebral Foraminal Stimulation, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the therapeutic efficacy of the addition and subtraction of Modified Tongdu Huoxue Decoction (通督活血汤加减) and the conservative protocol of electroacupuncture intervertebral foraminal stimulation in the treatment of degenerative lumbar spinal stenosis.
Methods A total of 108 patients with degenerative lumbar spinal stenosis admitted from January 2023 to October 2024 were prospectively selected and randomly divided into two groups using envelope method. Both groups were given celecoxib capsules and conventional Tuina treatment, the electrical stimulation group was combined with electroacupuncture intervertebral foraminal stimulation on its basis, and the comprehensive group was treated with Modified Tongdu Huoxue Decoction with electroacupuncture intervertebral foraminal stimulation on its basis. The TCM symptom scores, the changes of visual analogue scale (VAS) scores and Oswestry disability index (ODI) were assessed in the two groups, and the levels of interleukin-1β (IL-1β), silent information regulator 1 (SIRT1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), lumbar lordosis, Cobb angle and intervertebral space and blood rheology changes were observed. And painfree walking distance and incidence of adverse reactions were analyzed.
Results Comparing with those before treatment, there was no difference in TCM symptom scores, VAS scores, ODI scores or pain-free walking distance of the two groups after treatment (P>0.05). TCM symptom scores, VAS scores and ODI scores were lower in both groups, and lower in the comprehensive group after treatment (P<0.05). The pain-free walking distance was elevated in both groups, and higher in the comprehensive group (P<0.05) after treatment. Comparing with those before treatment, there was no difference in SIRT1, IL-1β, TNF-α or MCP-1 of the two groups after treatment (P>0.05). After treatment, SIRT1 was elevated in both groups, and was higher in the comprehensive group (P<0.05). The levels of IL-1β, TNF-α and MCP-1 were lower in both groups, and were lower in the comprehensive group after treatment (P<0.05). Comparing with those before treatment, there was no difference in lumbar lordosis Cobb angle or intervertebral space height of the two groups after treatment (P>0.05). After treatment, the lumbar anterior convex Cobb angle and intervertebral space height of the two groups were elevated, and higher in the comprehensive group (P<0.05). Comparing with those before treatment, there was no difference in blood rheology of the two groups after treatment (P>0.05). Comparing with those before treatment, hematocrit, fibrinogen, plasma viscosity and whole blood high cut viscosity were lower in the two groups, and lower in the comprehensive group (P<0.05). There was no difference in the incidence of total adverse reactions such as gastrointestinal reactions, skin injury, malaise and rash between the two groups (P>0.05).
Conclusion The treatment of degenerative lumbar spinal stenosis with a conservative regimen of Modified Tongdu Huoxue Decoction and electroacupuncture intervertebral foraminal stimulation reduces pain, improves blood rheology and reduces inflammatory stimuli.
, authors=Jian CAI, Linlin SHEN, Dong SUN, Jun TANG, Shuaizi YIN, Zeyang LI, authorsList=Jian CAI, Linlin SHEN, Dong SUN, Jun TANG, Shuaizi YIN, Zeyang LI, authorCompany=null, correspAuthors=Dong SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291411216847813, articleId=1319291410663199683, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=通督活血汤加减与电针椎间孔刺激保守方案治疗退行性腰椎管狭窄症疗效观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察通督活血汤加减与电针椎间孔刺激保守方案治疗退行性腰椎管狭窄症的疗效。
方法 前瞻性选取2023年1月—2024年10月收治的108例退行性腰椎管狭窄症患者，采用信封法随机分为两组。两组均给予塞来昔布胶囊+常规推拿治疗，电刺激组在其基础上联合电针椎间孔刺激治疗，综合组在其基础上采用通督活血汤加减与电针椎间孔刺激治疗。评估两组中医症状评分、视觉模拟评分（Visual analogue scale，VAS）、Oswestry功能障碍指数（Oswestry disability Index，ODI）变化，检测两组白细胞介素-1β（Interleukin-1β，IL-1β）、沉默信息调节因子（Silent information regulator1，SIRT1）、肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、单核细胞趋化蛋白1（Monocyte chemoattractant protein-1，MCP-1）、腰椎前凸Cobb角、椎间隙高度及血液流变学变化，统计两组无痛行走距离、不良反应发生率。
结果 治疗前比较，两组中医症状评分、VAS评分、ODI评分、无痛行走距离差异无统计学意义（P>0.05）。治疗前后比较，两组中医症状评分、VAS评分、ODI评分均降低，且综合组治疗后更低（P<0.05）；两组无痛行走距离升高，且综合组更高（P<0.05）。治疗前比较，两组SIRT1、IL-1β、TNF-α、MCP-1差异无统计学意义（P>0.05）。治疗前后比较，两组SIRT1升高，且综合组更高（P<0.05）；两组IL-1β、TNF-α、MCP-1均降低，且综合组治疗后更低（P<0.05）。治疗前比较，两组腰椎前凸Cobb角、椎间隙高度差异无统计学意义（P>0.05）。治疗前后比较，两组腰椎前凸Cobb角、椎间隙高度升高，且综合组更高（P<0.05）。治疗前比较，两组血液流变学指标差异无统计学意义（P>0.05）。治疗前后比较，两组血细胞比容、纤维蛋白原、血浆黏度、全血高切黏度均降低，且综合组更低（P<0.05）。两组胃肠道反应、皮肤损伤、乏力、皮疹等总不良反应发生率比较，差异无统计学意义（P>0.05）。
结论 通督活血汤加减与电针椎间孔刺激保守方案治疗退行性腰椎管狭窄症可减轻疼痛，改善血液流变学，减轻炎症刺激。
, authors=蔡健, 沈林林, 孙栋, 唐君, 尹帅子, 李泽阳, authorsList=蔡健, 沈林林, 孙栋, 唐君, 尹帅子, 李泽阳, authorCompany=null, correspAuthors=孙栋, authorNote=
蔡健（1990-），男，浙江台州人，主治中医师，硕士，研究方向：推拿治疗脊柱相关疾病。
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蔡健（1990-），男，浙江台州人，主治中医师，硕士，研究方向：推拿治疗脊柱相关疾病。
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蔡健（1990-），男，浙江台州人，主治中医师，硕士，研究方向：推拿治疗脊柱相关疾病。
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