Article(id=1319291496260551316, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.045, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473203958, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473203958, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473203958, creator=13701087609, updateTime=1792473203958, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=219, endPage=223, ext={EN=ArticleExt(id=1319291496512209557, articleId=1319291496260551316, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Study on Improvement of Lower Limb Circulatory Disorders of Diabetic Foot by Mailuo Shutong Pill (脉络舒通丸) Based on Theory of “Dampness-Heat and Blood Stasis Obstruction”, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective Based on the theory of “dampness-heat and blood stasis obstruction” in traditional Chinese medicine, to investigate the improvement of blood supply of the lower limbs of the patients with diabetic foot combined with lower limb arterial occlusive disease and the effect on the healing of ulcerated surfaces by Mailuo Shutong Pill (脉络舒通丸).
Methods One hundred and twenty patients with diabetic foot combined with lower limb arterial occlusive disease who were treated in Harbin First Hospital from July 2023 to June 2024 were selected as the study subjects, and were randomly divided into the treatment group and the control group with 60 cases in each group. The control group received conventional western medical treatment, and the treatment group added Mailuo Shutong Pill on the basis of the control group. The treatment effects, blood glucose levels [fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 h PG)], glycated haemoglobin (HbA1c) levels, lipid levels [total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)], blood flow in the foot, sensory nerve conduction velocities and changes in the trauma area before and after the treatment in both groups were compared.
Results The total effective rate of the treatment group was 96.67% (58/60), which was significantly higher than that (83.33%, 50/60) of the control group (χ2=5.926, P<0.05). The levels of FPG, 2 h PG, HbA1c, TC, TG and LDL-C decreased and HDL-C levels increased in both groups after treatment (P<0.05), but the differences in blood glucose and lipid indexes between the two groups before and after treatment were not statistically significant. (P>0.05). After treatment, the internal diameter of the lumen of the dorsalis pedis artery increased, the blood flow increased, the peak arterial blood flow decreased in both groups, and the improvement of the treatment group was better than that of the control group (P<0.05). After treatment, the sensory nerve conduction velocity (SNCV) of the sural nerve increased and the foot trauma area decreased in both groups, and the improvement of the treatment group was better than that of the control group (P<0.05). There was no apparentt difference in rate of adverse events between the treatment group and the control group (P>0.05).
Conclusion Mailuo Shutong Pill can significantly improve the treatment efficiency of the patients with diabetic foot combined with lower limb arterial occlusive disease, relieve the lower limb circulatory disorders, promote the restoration of nerve conduction velocity and wound healing, and has a good safety profile.
, authors=Chen ZHAO, Fuming YANG, Chang TAN, Jing CHEN, Xiujuan LI, Linna LI, authorsList=Chen ZHAO, Fuming YANG, Chang TAN, Jing CHEN, Xiujuan LI, Linna LI, authorCompany=null, correspAuthors=Jing CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291496814199446, articleId=1319291496260551316, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于“湿热瘀阻”理论探讨脉络舒通丸改善下肢循环障碍治疗糖尿病足的临床研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 以中医“湿热瘀阻”理论为基础，探讨脉络舒通丸对糖尿病足合并下肢动脉闭塞症患者下肢血供的改善情况，以及对溃疡面愈合的影响。
方法 选取2023年7月—2024年6月于哈尔滨市第一医院接受治疗的120例糖尿病足合并下肢动脉闭塞症患者作为研究对象，随机分为治疗组和对照组各60例。对照组接受常规西医治疗，治疗组在对照组的基础上加用脉络舒通丸。比较两组患者的治疗效果、治疗前后的血糖水平[空腹血糖（fasting plasma glucose，FPG）、餐后2 h血糖（2h postprandial blood glucose，2hPG）]、糖化血红蛋白（hemoglobin A1c，HbA1c）水平、血脂水平[总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）]、足部血流情况、感觉神经传导速度及创面面积变化。
结果 治疗组患者的总有效率为96.67%（58/60），明显高于对照组患者的83.33%（50/60）（χ2=5.926，P<0.05）。两组患者治疗后的FPG、2hPG、HbA1c、TC、TG及LDL-C水平均下降，HDL-C水平升高（P<0.05），但治疗前、治疗后两组患者血糖、血脂指标比较差异均无统计学意义（P>0.05）。治疗后，两组患者足背动脉管腔内径增大、血流量升高，动脉血流峰值降低，且治疗组改善优于对照组（P<0.05）。治疗后，两组患者腓肠神经感觉神经传导速度（sensory nerve conduction velocity，SNCV）升高，足部创面面积减小，且治疗组改善优于对照组（P<0.05）。两组不良反应总发生率比较差异无统计学意义（P>0.05）。
结论 脉络舒通丸能够显著提高糖尿病足伴下肢动脉闭塞症患者的治疗有效率，改善下肢循环障碍，促进神经传导速度的恢复以及创面的愈合，且具有良好的安全性。
, authors=赵晨, 杨馥铭, 谭畅, 陈婧, 李秀娟, 李琳娜, authorsList=赵晨, 杨馥铭, 谭畅, 陈婧, 李秀娟, 李琳娜, authorCompany=null, correspAuthors=陈婧, authorNote=
赵晨（1989-），女，黑龙江哈尔滨人，主治医师，硕士，研究方向：糖尿病足。
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赵晨（1989-），女，黑龙江哈尔滨人，主治医师，硕士，研究方向：糖尿病足。
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