Article(id=1319291457568096590, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.036, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473194734, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473194734, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473194734, creator=13701087609, updateTime=1792473194734, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=177, endPage=180, ext={EN=ArticleExt(id=1319291459413590351, articleId=1319291457568096590, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Fresh, Raw and Processed Dihuang (Rehmanniae Radix) and Predictive Analysis of Its Quality Markers, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

As one of the local medicinal herbs in Henan Province, the fresh product of Dihuang (Rehmanniae Radix) has the function of clearing heat and generating fluids, cooling blood and stopping bleeding. The raw product has the effect of clearing heat and cooling blood, nourishing Yin and generating fluids and the processed product has the function of replenishing blood and nourishing Yin and benefiting the essence and filling in the marrow. Currently, there is a single method for quality evaluation of Dihuang (Rehmanniae Radix), therefore, based on the traditional Chinese medicine theory that “the raw product is especially good”, “combination of raw and processed products”, the studies on the chemical composition and pharmacological effects of Dihuang (Rehmanniae Radix) before and after processing were summarized. Combined with the quality marker (Q-Marker) prediction analysis from the aspects of plant affinity and chemical constituents, traditional efficacy and clinical compatibility, traditional medicinal properties and material basis, concoction method and auxiliary material differences, blood components and pharmacokinetics, dihuangoside A, mauritiana glycoside, catalpol, stachyose, quercetin, baicalein, sanguinarol, polysaccharide, hesperidin, digitonin and dihuangoside D can be regarded as the most important chemical constituents in the traditional Chinese medicine, which can be used for the quality evaluation of Dihuang (Rehmanniae Radix), with the aim of providing a reference for the quality control study of Dihuang (Rehmanniae Radix), the guidance of clinical use and the development of new drugs.

, authors=Mengqing YAN¹, Hongwei ZHANG^{1, 2}, Mengyun LIU^{1, 2}, Hongwei LI^{1, 2}, Mingsan MIAO^{2, 3}, Jianguang ZHU^{1, 2, 3}, Kai LI^{1, 2}, Le KANG^{1, 2, 3}, authorsList=Mengqing YAN, Hongwei ZHANG, Mengyun LIU, Hongwei LI, Mingsan MIAO, Jianguang ZHU, Kai LI, Le KANG, authorCompany=null, correspAuthors=Jianguang ZHU, Le KANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291459749134672, articleId=1319291457568096590, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=地黄鲜用、生用、熟用研究进展及其质量标志物（Q-Marker）的预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

地黄作为河南的道地药材之一，鲜品有清热生津、凉血、止血之功；生品有清热凉血、养阴生津之效；熟品有补血滋阴、益精填髓之用。目前，对于地黄的质量评价方法较单一，故基于“生者尤良”“生熟异用”传统中医药理论，结合质量标志物（Q-Marker）从植物亲缘学与化学成分特有性、传统功效与临床配伍、传统药性与物质基础、炮制方法与辅料差异、入血成分及药动学等方面对Q-Marker预测分析，得出地黄苷A、毛蕊花糖苷、梓醇、水苏糖、槲皮素、汉黄芩素、山柰酚、多糖、橙皮苷、地黄苦苷元、地黄苷、地黄苷D可作为地黄的Q-Marker，以期为地黄的质量控制研究、临床用药指导和新药开发提供参考。

, authors=燕梦晴¹, 张宏伟^{1, 2}, 刘梦云^{1, 2}, 李红伟^{1, 2}, 苗明三^{2, 3}, 朱建光^{1, 2, 3}, 李凯^{1, 2}, 康乐^{1, 2, 3}, authorsList=燕梦晴, 张宏伟, 刘梦云, 李红伟, 苗明三, 朱建光, 李凯, 康乐, authorCompany=null, correspAuthors=朱建光, 康乐, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=K/qZHNDpQLts/NyKVrJZtQ==, magXml=4B1SgIY9PeSZE8XAfo+gZw==, pdfUrl=null, pdf=tZul9M1PF4tCTP13NnH3YQ==, pdfFileSize=2380876, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=4Idwqid2ZzAJTtrgKuQ9vg==, mapNumber=null, fund=null)}, authors=[Author(id=1319291460252451163, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291457568096590, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291460353114461, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291457568096590, authorId=1319291460252451163, language=EN, stringName=Mengqing YAN, firstName=Mengqing, middleName=null, lastName=YAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291460432806238, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291457568096590, authorId=1319291460252451163, language=CN, stringName=燕梦晴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.河南中医药大学药学院，河南　郑州　450046, bio={"content":"

燕梦晴（1997-），女，河南周口人，硕士在读，研究方向：中药炮制物质基础及炮制机制。

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燕梦晴（1997-），女，河南周口人，硕士在读，研究方向：中药炮制物质基础及炮制机制。

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