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Article(id=1319291446209925360, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473192026, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473192026, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473192026, creator=13701087609, updateTime=1792473192026, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=116, endPage=125, ext={EN=ArticleExt(id=1319291446419640561, articleId=1319291446209925360, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Guipi Decoction (归脾汤) is a classic formula used throughout history for treating deficiency of both Qi and blood in heart and spleen, as well as spleen failure to control blood. Its modern applications primarily focus on the neuroendocrine system, commonly addressing conditions like insomnia or hypersomnia. This decoction is known to improve immune function, exhibit anti-inflammatory and anti-tumor effects, regulate gastrointestinal function, and enhance psychological well-being. Referring to the five principles of core quality concept of traditional Chinese medicine quality markers (Q-markers) proposed by Academician LIU Changxiao in 2016, the prediction and analysis of Q-markers of Guipi Decoction were carried out, and the Q-markers were finally determined to be astragaloside Ⅳ, calycosin, quercetin, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, atractylenolide Ⅰ, atractylolactone Ⅱ, atractylolactone Ⅲ, ferulic acid, ligustilide, pachymic acid, dehydrotumulosic acid, dehydropachymic acid, jujuboside A, costunolide, dehydrocostus, tenuifolin, polygalaxanthone Ⅲ,3,6-disinapyryl sucrose, disinapoylsucrose, betulinic acid, oleanolic acid, liquiritin and glycyrrhizic acid.

, authors=Yamin KONG1, 2, Lyuyuan LIANG1, 2, 3, Jialei CAO1, 2, 3, Yifang SHEN1, 2, Shengjia DING1, 2, Fengzhen GUO1, 2, Yujie CHANG1, 2, Yihan LI1, 2, Jingwen LI1, 2, Qing TANG1, 2, Bingqi WEI1, 2, 3, Bingxiang MA1, 2, Wenli SHI4, authorsList=Yamin KONG, Lyuyuan LIANG, Jialei CAO, Yifang SHEN, Shengjia DING, Fengzhen GUO, Yujie CHANG, Yihan LI, Jingwen LI, Qing TANG, Bingqi WEI, Bingxiang MA, Wenli SHI, authorCompany=null, correspAuthors=Bingxiang MA, Wenli SHI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291446771962098, articleId=1319291446209925360, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=经典名方归脾汤现代应用和药理作用研究进展及其质量标志物预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

归脾汤是历代治疗心脾气血两虚、脾不统血的经典名方，其现代用法多集中于神经内分泌系统，以失眠症/多寐为多见，具有改善免疫功能、抗炎、抗肿瘤、调节胃肠功能、改善心理状态的作用。参考2016年刘昌孝院士所提出的中药质量标志物（Q-Marker）核心质量概念五原则，进行归脾汤质量标志物预测分析，最终确定其质量标志物为黄芪甲苷、毛蕊异黄酮、槲皮素、人参皂苷Rg1、人参皂苷Rb1、人参皂苷Re、白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ、阿魏酸、藁本内酯、茯苓酸、去氢土莫酸、去氢茯苓酸、酸枣仁皂苷A、木香烃内酯、去氢木香内酯、细叶远志皂苷、远志山酮Ⅲ、3，6-二芥子酰基蔗糖、白桦脂酸、齐墩果酸、甘草苷、甘草酸24种。

, authors=孔亚敏1, 2, 梁绿圆1, 2, 3, 曹佳蕾1, 2, 3, 沈艺芳1, 2, 丁圣家1, 2, 郭凤真1, 2, 常雨洁1, 2, 李懿涵1, 2, 李静雯1, 2, 唐箐1, 2, 魏炳琦1, 2, 3, 马丙祥1, 2, 史文丽4, authorsList=孔亚敏, 梁绿圆, 曹佳蕾, 沈艺芳, 丁圣家, 郭凤真, 常雨洁, 李懿涵, 李静雯, 唐箐, 魏炳琦, 马丙祥, 史文丽, authorCompany=null, correspAuthors=马丙祥, 史文丽, authorNote=

孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

, correspAuthorsNote=
马丙祥（1963-），男，河南开封人，主任医师、教授，博士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
史文丽（1985-），女，北京人，副主任医师，硕士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
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孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

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孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

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经典名方归脾汤现代应用和药理作用研究进展及其质量标志物预测分析
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孔亚敏 1, 2 , 梁绿圆 1, 2, 3 , 曹佳蕾 1, 2, 3 , 沈艺芳 1, 2 , 丁圣家 1, 2 , 郭凤真 1, 2 , 常雨洁 1, 2 , 李懿涵 1, 2 , 李静雯 1, 2 , 唐箐 1, 2 , 魏炳琦 1, 2, 3 , 马丙祥 1, 2 , 史文丽 4
中华中医药学刊 | 国家项目点击 2026,44(8): 116-125
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中华中医药学刊 |国家项目点击 2026 , 44 (8) : 116 -125
经典名方归脾汤现代应用和药理作用研究进展及其质量标志物预测分析
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孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

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孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

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孔亚敏1, 2, 梁绿圆1, 2, 3, 曹佳蕾1, 2, 3, 沈艺芳1, 2, 丁圣家1, 2, 郭凤真1, 2, 常雨洁1, 2, 李懿涵1, 2, 李静雯1, 2, 唐箐1, 2, 魏炳琦1, 2, 3, 马丙祥1, 2 , 史文丽4
作者信息
  • 1.河南中医药大学第一附属医院儿科医院，河南　郑州　450099
  • 2.河南中医药大学儿科医学院，河南　郑州　450046
  • 3.河南梁济时中医药科技研究院经典名方研究与开发中心，河南　郑州　450000
  • 4.中国中医科学院西苑医院，北京　100091
通讯作者:
马丙祥（1963-），男，河南开封人，主任医师、教授，博士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
史文丽（1985-），女，北京人，副主任医师，硕士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
作者简介:

孔亚敏（1992-），女，河南周口人，医师，博士，研究方向：中医药防治神经系统疾病临床及基础。

Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis
Yamin KONG1, 2, Lyuyuan LIANG1, 2, 3, Jialei CAO1, 2, 3, Yifang SHEN1, 2, Shengjia DING1, 2, Fengzhen GUO1, 2, Yujie CHANG1, 2, Yihan LI1, 2, Jingwen LI1, 2, Qing TANG1, 2, Bingqi WEI1, 2, 3, Bingxiang MA1, 2 , Wenli SHI4
Affiliations
  • 1.Hospital of Pediatrics of The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099, Henan, China
  • 2.School of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
  • 3.Research and Development Center of Classical Prescriptions, Henan Liang Jishi Research Institute of Chinese Medicine, Zhengzhou 450000, Henan, China
  • 4.Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China
出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.025
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摘要
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归脾汤是历代治疗心脾气血两虚、脾不统血的经典名方，其现代用法多集中于神经内分泌系统，以失眠症/多寐为多见，具有改善免疫功能、抗炎、抗肿瘤、调节胃肠功能、改善心理状态的作用。参考2016年刘昌孝院士所提出的中药质量标志物（Q-Marker）核心质量概念五原则，进行归脾汤质量标志物预测分析，最终确定其质量标志物为黄芪甲苷、毛蕊异黄酮、槲皮素、人参皂苷Rg1、人参皂苷Rb1、人参皂苷Re、白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ、阿魏酸、藁本内酯、茯苓酸、去氢土莫酸、去氢茯苓酸、酸枣仁皂苷A、木香烃内酯、去氢木香内酯、细叶远志皂苷、远志山酮Ⅲ、3，6-二芥子酰基蔗糖、白桦脂酸、齐墩果酸、甘草苷、甘草酸24种。

归脾汤  /  经典名方  /  现代应用  /  质量标志物  /  药理作用

Guipi Decoction (归脾汤) is a classic formula used throughout history for treating deficiency of both Qi and blood in heart and spleen, as well as spleen failure to control blood. Its modern applications primarily focus on the neuroendocrine system, commonly addressing conditions like insomnia or hypersomnia. This decoction is known to improve immune function, exhibit anti-inflammatory and anti-tumor effects, regulate gastrointestinal function, and enhance psychological well-being. Referring to the five principles of core quality concept of traditional Chinese medicine quality markers (Q-markers) proposed by Academician LIU Changxiao in 2016, the prediction and analysis of Q-markers of Guipi Decoction were carried out, and the Q-markers were finally determined to be astragaloside Ⅳ, calycosin, quercetin, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, atractylenolide Ⅰ, atractylolactone Ⅱ, atractylolactone Ⅲ, ferulic acid, ligustilide, pachymic acid, dehydrotumulosic acid, dehydropachymic acid, jujuboside A, costunolide, dehydrocostus, tenuifolin, polygalaxanthone Ⅲ,3,6-disinapyryl sucrose, disinapoylsucrose, betulinic acid, oleanolic acid, liquiritin and glycyrrhizic acid.

Guipi Decoction (归脾汤)  /  classic prescriptions  /  modern applications  /  quality markers  /  pharmacological effect
孔亚敏, 梁绿圆, 曹佳蕾, 沈艺芳, 丁圣家, 郭凤真, 常雨洁, 李懿涵, 李静雯, 唐箐, 魏炳琦, 马丙祥, 史文丽. 经典名方归脾汤现代应用和药理作用研究进展及其质量标志物预测分析. 中华中医药学刊, 2026 , 44 (8) : 116 -125 . DOI: 10.13193/j.issn.1673-7717.2026.08.025
Yamin KONG, Lyuyuan LIANG, Jialei CAO, Yifang SHEN, Shengjia DING, Fengzhen GUO, Yujie CHANG, Yihan LI, Jingwen LI, Qing TANG, Bingqi WEI, Bingxiang MA, Wenli SHI. Research Progress on Modern Applications and Pharmacological Effects of Guipi Decoction (归脾汤) and Its Quality Marker Predictive Analysis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 116 -125 . DOI: 10.13193/j.issn.1673-7717.2026.08.025
基金
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  • 国家自然科学基金项目(81973904)
  • 国家自然科学基金青年科学基金项目(81904252)
  • 河南省卫生健康委国家中医药传承创新中心科研专项(2023ZXZX1060)
  • 河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202144; STG-ZYXKY-2020023)
  • 河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-2-08)
  • 河南省中医药科学研究专项(2023ZY2057)
  • 河南省重点研发与推广专项（科技攻关项目）(232102311208)
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2026年第44卷第8期
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doi: 10.13193/j.issn.1673-7717.2026.08.025
  • 首发时间：2026-10-20
  • 出版时间：2026-08-10
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基金
国家自然科学基金项目(81973904)
国家自然科学基金青年科学基金项目(81904252)
河南省卫生健康委国家中医药传承创新中心科研专项(2023ZXZX1060)
河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202144; STG-ZYXKY-2020023)
河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-2-08)
河南省中医药科学研究专项(2023ZY2057)
河南省重点研发与推广专项（科技攻关项目）(232102311208)
作者信息
    1.河南中医药大学第一附属医院儿科医院，河南　郑州　450099
    2.河南中医药大学儿科医学院，河南　郑州　450046
    3.河南梁济时中医药科技研究院经典名方研究与开发中心，河南　郑州　450000
    4.中国中医科学院西苑医院，北京　100091

通讯作者:

马丙祥（1963-），男，河南开封人，主任医师、教授，博士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
史文丽（1985-），女，北京人，副主任医师，硕士研究生导师，博士，研究方向：中医药防治儿童神经系统疾病。E-mail：。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.08.025
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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