中华中医药学刊

针灸在膝关节骨性关节炎治疗中作用并对关节功能及血清炎症因子IL-1β、TNF-α、hs-CRP的影响

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高国强 ¹ , 崔华峰 ² , 冯亚男 ³

中华中医药学刊 | 国家项目点击 2026,44(8): 45-48

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中华中医药学刊 |国家项目点击 2026 , 44 (8) : 45 -48

针灸在膝关节骨性关节炎治疗中作用并对关节功能及血清炎症因子IL-1β、TNF-α、hs-CRP的影响

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高国强（1981-），男，山东滕州人，副主任医师，学士，研究方向：脑血管病的针灸治疗。

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高国强¹, 崔华峰², 冯亚男³

作者信息

^1.济宁医学院附属滕州市中心人民医院，山东　滕州　277599

^2.山东中医药大学附属医院，山东　济南　250014

^3.滕州市中医医院，山东　滕州　277599

通讯作者:

崔华峰（1980-），男，山东平原人，主任医师，博士，研究方向：脑血管病的针灸治疗。E-mail：cuihuafeng@139.com。

作者简介:

高国强（1981-），男，山东滕州人，副主任医师，学士，研究方向：脑血管病的针灸治疗。

Effect of Acupuncture and Moxibustion in Treatment of Knee Osteoarthritis and Its Effect on Joint Function and Serum Inflammatory Factors IL-1β, TNF-α and hs-CRP

Guoqiang GAO¹, Huafeng CUI², Yanan FENG³

Affiliations

^1.Tengzhou Central People's Hospital Affiliated to Jining Medical College, Tengzhou 277599, Shandong, China

^2.Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China

^3.Tengzhou Traditional Chinese Medicine Hospital, Tengzhou 277599, Shandong, China

出版时间: 2026-08-10 doi: 10.13193/j.issn.1673-7717.2026.08.010

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摘要

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目的

研究针灸辅助治疗膝关节骨性关节炎对关节功能及血清炎症因子白介素-1β（Interleukin-1β，IL-1β）、肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、超敏C反应蛋白（Hypersensitive C-reactive protein，hs-CRP）的影响。

方法

选取2022年3月—2024年3月于医院治疗的膝关节骨性关节炎患者102例进行研究，按照入院顺序奇、偶数分成观察组和对照组。对照组51例采用常规西药治疗，观察组51例在对照组基础上增加针灸辅助治疗，疗程4周。比较两组患者的治疗总有效率、中医证候积分、膝关节功能、炎症因子及治疗安全性情况。

结果

观察组总有效率98.04%（50/51）、对照组84.31%（43/51），观察组高于对照组（P<0.05）。治疗后，观察组关节疼痛、腰膝酸软、屈伸不利证候积分显著低于对照组[（2.13±0.44）、（2.07±0.45）、（1.74±0.50）分vs（2.72±0.51）、（2.30±0.38）、（1.98±0.26）分]，观察组Lysholm膝关节功能量表（Lysholmknee scale，LKS）评分高于对照组[（87.25±9.03）分vs（82.30±7.56）分]，观察组血清炎症因子IL-1β、TNF-α、hs-CRP显著低于对照组[（17.25±3.68）pg/mL、（21.04±6.30）pg/mL、（8.12±1.43）μg/mL vs（21.38±3.40）pg/mL、（24.60±5.71）pg/mL、（9.27±1.18）μg/mL]（P<0.05）。两组均无严重不良反应发生。

结论

针灸辅助治疗膝关节骨性关节炎能够获得更佳疗效，其可以更好地缓解患者中医证候，改善关节功能，并减轻炎症反应，且安全性良好，具有良好的应用价值。

关键词

膝关节骨性关节炎 / 骨痹 / 针灸 / 关节功能 / 炎症因子

Abstract

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Objective

To study the effects of acupuncture and moxibustion on joint function and serum inflammatory factors interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) in adjuvant treatment of knee osteoarthritis.

Methods

A total of 102 patients with knee osteoarthritis who were treated in the hospital from March 2022 to March 2024 were selected for the study. They were randomly divided into observation group and control group according to the order of admission, with 51 patients in each group. The patients in the control group were treated with conventional western medicine, and those in the observation group were treated with acupuncture and moxibustion for 4 weeks. The total effective rate, TCM syndrome score, knee joint function, inflammatory factors and treatment safety were compared between the two groups.

Results

The total effective rate was 98.04% (50/51) in the observation group and 84.31% (43/51) in the control group. The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the scores of joint pain, soreness and weakness of waist and knees and unfavorable flexion and extension in the observation group were significantly lower than those in the control group [(2.13±0.44) points, (2.07±0.45) points, (1.74±0.50) points vs (2.72±0.51) points, (2.30±0.38) points, (1.98±0.26) points], the Lysholm knee scale (LKS) score of the observation group was higher than that of the control group [(87.25±9.03) points vs (82.30±7.56) points]. The levels of serum inflammatory factors IL-1β, TNF-α and hs-CRP in the observation group were significantly lower than those in the control group [(17.25±3.68) pg/mL, (21.04±6.30) pg/mL, (8.12±1.43) μg/mL vs (21.38±3.40) pg/mL, (24.60±5.71) pg/mL, (9.27±1.18) μg/mL] (P<0.05). No serious adverse reactions occurred in both groups.

Conclusion

Acupuncture and moxibustion can achieve better curative effect in the treatment of knee osteoarthritis. It can better alleviate the TCM syndromes, improve the joint function and reduce the inflammatory reaction of the patients. It has good safety and good application value.

Key words

knee osteoarthritis / bone Bi syndrome / acupuncture / joint function / inflammatory factors

引用本文

高国强, 崔华峰, 冯亚男. 针灸在膝关节骨性关节炎治疗中作用并对关节功能及血清炎症因子IL-1β、TNF-α、hs-CRP的影响. 中华中医药学刊, 2026 , 44 (8) : 45 -48 . DOI: 10.13193/j.issn.1673-7717.2026.08.010

Guoqiang GAO, Huafeng CUI, Yanan FENG. Effect of Acupuncture and Moxibustion in Treatment of Knee Osteoarthritis and Its Effect on Joint Function and Serum Inflammatory Factors IL-1β, TNF-α and hs-CRP[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (8) : 45 -48 . DOI: 10.13193/j.issn.1673-7717.2026.08.010

基金

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国家自然科学基金项目(82260757)

参考文献

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2026年第44卷第8期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.08.010

首发时间：2026-10-20
出版时间：2026-08-10

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出版历史

基金

国家自然科学基金项目(82260757)

作者信息

^1.济宁医学院附属滕州市中心人民医院，山东　滕州　277599

^2.山东中医药大学附属医院，山东　济南　250014

^3.滕州市中医医院，山东　滕州　277599

通讯作者:

崔华峰（1980-），男，山东平原人，主任医师，博士，研究方向：脑血管病的针灸治疗。E-mail：cuihuafeng@139.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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