Article(id=1319291545434567249, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.08.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473215682, onlineDateStr=2026-10-20, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473215682, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473215682, creator=13701087609, updateTime=1792473215682, updator=13701087609, issue=Issue{id=1319291312826863771, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473160225, creator='13701087609', updateTime=1792473382588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292245547799195, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292245652656796, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291312826863771, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=33, endPage=35, ext={EN=ArticleExt(id=1319291545824637522, articleId=1319291545434567249, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Experimental Study on Inhibition of Novel Coronavirus RNA Polymerase by Glycycoumarin and Prediction of Enzyme Inhibitory Activity of Coumarin Small Molecules, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the inhibitory activity of glycycoumarin against the main RNA polymerase of the novel coronavirus and to predict the inhibitory activity of coumarin small molecules against this target enzyme.
Methods A cell-based novel coronavirus RNA polymerase catalytic reaction system was used to test the inhibitory activity of glycycoumarin against RNA polymerase. Molecular docking technology was used to study the interaction mode of glycycoumarin and coumarin small molecules with amino acids at the active site of the main RNA polymerase of the novel coronavirus.
Results In the RNA polymerase inhibition assay, glycycoumarin showed inhibition rates were (29.68±4.06)%, (58.30±7.65)% and (86.85±5.78)% at concentrations of 10, 25, 50 μmol/L, respectively. Glycycoumarin can enter the active site of RNA polymerase and interact with amino acids in the NTPs channel, releasing free energy of 7.6 kcal/mol during the binding process. Coumarin small molecules can bind to the active site of RNA polymerase and hinder the entry of normal substrate nucleotides.
Conclusion Glycycoumarin has significant inhibitory activity against RNA polymerase. Coumarin small molecules can occupy the NTPs channel and inhibit the biological function of RNA polymerase. Structural modification based on the coumarin parent nucleus is a potential pathway for the development of anti-novel coronavirus drugs.
, authors=Qiaona WU
1, Kun DI
1, Sha LIU
1, Jingfang LIU
2, Yanlei SU
3, Jianyuan ZHAO
4, Yujia WANG
4, Dianxing SUN
3, Shan CEN
4, Qian LIU
5, authorsList=Qiaona WU, Kun DI, Sha LIU, Jingfang LIU, Yanlei SU, Jianyuan ZHAO, Yujia WANG, Dianxing SUN, Shan CEN, Qian LIU, authorCompany=null, correspAuthors=Yanlei SU, Shan CEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291546176959059, articleId=1319291545434567249, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=甘草香豆素抑制新型冠状病毒RNA聚合酶的实验研究及香豆素小分子的酶抑制活性预测, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 研究甘草香豆素单体成分对新型冠状病毒RNA聚合酶的抑制活性，并预测香豆素类小分子对RNA聚合酶的抑制活性。
方法 应用细胞水平的新型冠状病毒RNA聚合酶催化反应体系测试甘草香豆素对RNA聚合酶的抑制活性；利用分子对接技术研究香豆素类小分子与新型冠状病毒RNA聚合酶活性位点处氨基酸的相互作用模式。
结果 在抑制RNA聚合酶的药理测试实验中，甘草香豆素在10、25、50 μmol/L浓度显示出对靶酶抑制率为（29.68±4.06）%、（58.30±7.65）%、（86.85±5.78）%。甘草香豆素可进入RNA聚合酶活性位点处并与NTPs通道氨基酸的发生分子间相互作用，结合过程释放的自由能为7.6 kcal/mol。香豆素类小分子均可结合于RNA聚合酶的活性位点处并阻碍正常底物核苷酸的进入。
结论 甘草香豆素对RNA聚合酶具有明显抑制活性，香豆素类小分子可占据NTPs通道而抑制RNA聚合酶的生物学功能，以香豆素母核结构为模板进行结构修饰是开发抗新型冠状病毒药物的一条路径。
, authors=吴巧娜
1, 邸琨
1, 刘莎
1, 刘京芳
2, 苏彦雷
3, 赵建元
4, 王宇佳
4, 孙殿兴
3, 岑山
4, 刘倩
5, authorsList=吴巧娜, 邸琨, 刘莎, 刘京芳, 苏彦雷, 赵建元, 王宇佳, 孙殿兴, 岑山, 刘倩, authorCompany=null, correspAuthors=苏彦雷, 岑山, authorNote=
吴巧娜（1984-），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=nkbLnMiYIieKvT7AQJiCWw==, magXml=o7UFkQSpRbsbJlx8YThbdA==, pdfUrl=null, pdf=TOsC6oYuRohDToYoekg82w==, pdfFileSize=3193829, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=RNALdK69/RwEIgnY+6SLHA==, mapNumber=null, fund=null)}, authors=[Author(id=1319291547087123044, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291547196174950, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291547087123044, language=EN, stringName=Qiaona WU, firstName=Qiaona, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291547355558503, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291547087123044, language=CN, stringName=吴巧娜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.石家庄市第三医院，河北 石家庄 050011, bio={"content":"
吴巧娜（1984-），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。
"}, bioImg=null, bioContent=
吴巧娜（1984-），女，河北石家庄人，副主任药师，硕士，研究方向：临床药理学及中药活性成分筛选。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546579612244, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=1., ext=[AuthorCompanyExt(id=1319291546592195157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China), AuthorCompanyExt(id=1319291546600583766, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.石家庄市第三医院，河北 石家庄 050011)])]), Author(id=1319291548920033899, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291548991337069, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291548920033899, language=EN, stringName=Kun DI, firstName=Kun, middleName=null, lastName=DI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291549062640238, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291548920033899, language=CN, stringName=邸琨, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.石家庄市第三医院，河北 石家庄 050011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546579612244, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=1., ext=[AuthorCompanyExt(id=1319291546592195157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China), AuthorCompanyExt(id=1319291546600583766, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.石家庄市第三医院，河北 石家庄 050011)])]), Author(id=1319291549146526320, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291549217829490, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549146526320, language=EN, stringName=Sha LIU, firstName=Sha, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291549284938355, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549146526320, language=CN, stringName=刘莎, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.石家庄市第三医院，河北 石家庄 050011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546579612244, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=1., ext=[AuthorCompanyExt(id=1319291546592195157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China), AuthorCompanyExt(id=1319291546600583766, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.石家庄市第三医院，河北 石家庄 050011)])]), Author(id=1319291549368824437, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291549461099127, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549368824437, language=EN, stringName=Jingfang LIU, firstName=Jingfang, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291549557568120, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549368824437, language=CN, stringName=刘京芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.河北省中医药科学院，河北 石家庄 050030, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546684469847, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=2., ext=[AuthorCompanyExt(id=1319291546692858456, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546684469847, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China), AuthorCompanyExt(id=1319291546697052761, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546684469847, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.河北省中医药科学院，河北 石家庄 050030)])]), Author(id=1319291549624676986, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=suyanlei0161@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1319291549721145980, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549624676986, language=EN, stringName=Yanlei SU, firstName=Yanlei, middleName=null, lastName=SU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980thHospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291549796643453, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549624676986, language=CN, stringName=苏彦雷, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546776744538, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=3., ext=[AuthorCompanyExt(id=1319291546789327451, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980thHospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291546797716060, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291549888918143, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291549968609921, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549888918143, language=EN, stringName=Jianyuan ZHAO, firstName=Jianyuan, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291550065078914, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291549888918143, language=CN, stringName=赵建元, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546881602141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=4., ext=[AuthorCompanyExt(id=1319291546889990750, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1319291546898379359, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])]), Author(id=1319291550144770692, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291550216073862, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550144770692, language=EN, stringName=Yujia WANG, firstName=Yujia, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291550278988423, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550144770692, language=CN, stringName=王宇佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546881602141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=4., ext=[AuthorCompanyExt(id=1319291546889990750, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1319291546898379359, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])]), Author(id=1319291550346097289, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291550425789067, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550346097289, language=EN, stringName=Dianxing SUN, firstName=Dianxing, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.The 980thHospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291550497092236, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550346097289, language=CN, stringName=孙殿兴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.联勤保障部队第九八〇医院，河北 石家庄 050082, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546776744538, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=3., ext=[AuthorCompanyExt(id=1319291546789327451, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980thHospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291546797716060, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)])]), Author(id=1319291550560006798, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=shancen@imb.pumc.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1319291550631309968, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550560006798, language=EN, stringName=Shan CEN, firstName=Shan, middleName=null, lastName=CEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291550698418833, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550560006798, language=CN, stringName=岑山, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
4, address=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546881602141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=4., ext=[AuthorCompanyExt(id=1319291546889990750, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1319291546898379359, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)])]), Author(id=1319291550761333395, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319291550841025173, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550761333395, language=EN, stringName=Qian LIU, firstName=Qian, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
5, address=
5.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319291550899745430, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, authorId=1319291550761333395, language=CN, stringName=刘倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
5, address=
5.河北省优抚医院，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319291546994848352, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=5., ext=[AuthorCompanyExt(id=1319291547003236961, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546994848352, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China), AuthorCompanyExt(id=1319291547011625570, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546994848352, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.河北省优抚医院，河北 石家庄 050051)])])], keywords=[Keyword(id=1319291550983631511, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=1, keyword=novel coronavirus), Keyword(id=1319291551063323288, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=2, keyword=RNA polymerase), Keyword(id=1319291551138820761, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=3, keyword=glycycoumarin), Keyword(id=1319291551193346714, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=4, keyword=activity assay), Keyword(id=1319291551294010011, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=5, keyword=molecular docking), Keyword(id=1319291551365313180, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=EN, orderNo=6, keyword=coumarin small molecules), Keyword(id=1319291551432422045, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=1, keyword=新型冠状病毒), Keyword(id=1319291551499530910, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=2, keyword=RNA聚合酶), Keyword(id=1319291551575028383, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=3, keyword=甘草香豆素), Keyword(id=1319291551650525856, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=4, keyword=活性测试), Keyword(id=1319291551709246113, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=5, keyword=分子对接), Keyword(id=1319291551772160674, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, language=CN, orderNo=6, keyword=香豆素类小分子)], refs=[Reference(id=1319291553672180391, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=PENG T, LONG B, YANG X L, et al. Total syntheses and anti-inflammatory studies of three natural coumarins: glycycoumarin, glycyrin, and 3-O-methylglycyrol[J]. Molecules, 2024, 29(16): 3942., articleTitle=null, refAbstract=null), Reference(id=1319291553751872168, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=YUMEI T, SHUIPING O, LINHU Y, et al. Pharmacological Activities and Pharmacokinetics of Glycycoumarin[J]. Revista brasileira de farmacognosia: orgao oficial da Sociedade Brasileira de Farmacognosia, 2022, 33(3): 11-13., articleTitle=null, refAbstract=null), Reference(id=1319291553823175337, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=吴新玉, 成蕾, 邓艳, 等. 异戊烯基香豆素类化合物抑制A549细胞增殖作用及其构效关系[J]. 现代药物与临床, 2022, 37(10): 2190-2196., articleTitle=null, refAbstract=null), Reference(id=1319291553898672810, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=宋鑫华. 甘草香豆素预防和治疗肝癌的作用及机制研究[D]. 北京: 中国农业大学, 2018., articleTitle=null, refAbstract=null), Reference(id=1319291553953198763, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=彭安堂, 苏彦雷, 刘倩, 等. 基于分子对接技术精细分析中药化学成分与新型冠状病毒RNA聚合酶之间的结合模式[J]. 中华中医药学刊, 2021, 39(4): 94-101, 280-285., articleTitle=null, refAbstract=null), Reference(id=1319291554007724716, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=邸琨, 谢小华, 赵田华, 等. 根皮素对新型冠状病毒RNA聚合酶抑制活性的实验研究及类似物活性预测[J]. 中华中医药学刊, 2025, 43(11): 28-31, 263., articleTitle=null, refAbstract=null), Reference(id=1319291554074833581, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO J Y, GUO S S, YI D R, et al. A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase[J]. Antivir Res, 2021, 190: 105078., articleTitle=null, refAbstract=null), Reference(id=1319291554146136750, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=苏彦雷, 刘倩, 王君平, 等. 黄芩素抗奥密克戎毒株BA.2.2活性的研究[J]. 中华中医药学刊, 2022, 40(8): 14-16, 259., articleTitle=null, refAbstract=null), Reference(id=1319291554225828527, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=王利华, 刘军, 邸琨, 等. 木犀草苷抗奥密克戎毒株药理活性的研究[J]. 中华中医药学刊, 2023, 41(7): 26-28., articleTitle=null, refAbstract=null), Reference(id=1319291554318103216, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=海洋, 谢建平. SARS-CoV-2 NSP7和NSP8的研究进展[J]. 生物信息学, 2021, 19(3): 149-158., articleTitle=null, refAbstract=null), Reference(id=1319291554523624113, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=SARMA H, JAMIR E, SASTRY G N. Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: a comparison between SARS-CoV-2 and SARS-CoV[J]. J Mol Struct, 2022, 1257: 132602., articleTitle=null, refAbstract=null), Reference(id=1319291554590732978, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=RONA G, ZEKE A, MIWATANI-MINTER B, et al. The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target[J]. Cell Death Differ, 2022, 29(2): 285-292., articleTitle=null, refAbstract=null), Reference(id=1319291554683007667, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=STEINER S, KRATZEL A, BARUT G T, et al. SARS-CoV-2 biology and host interactions[J]. Nat Rev Microbiol, 2024, 22(4): 206-225., articleTitle=null, refAbstract=null), Reference(id=1319291554775282356, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=VANDERSMISSEN G, VERBEECK J, HENCKENS P, et al. Sick leave due to SARS-CoV-2 infection[J]. Occup Med, 2024, 74(7): 486-492., articleTitle=null, refAbstract=null), Reference(id=1319291554838196917, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=NESTERUK I. Should we ignore SARS-CoV-2 disease?[J]. Epidemiol Infect, 2024, 152: e57., articleTitle=null, refAbstract=null), Reference(id=1319291554976608950, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=ULUDAĞ M, INCITTI R, GAO X, et al. Global surveillance of emerging SARS-CoV-2 variants[J]. Bull World Health Organ, 2024, 102(6): 374., articleTitle=null, refAbstract=null), Reference(id=1319291555047912119, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=MACHKOVECH H M, HAHN A M, GARONZIK WANG J, et al. Persistent SARS-CoV-2 infection: significance and implications[J]. Lancet Infect Dis, 2024, 24(7): e453-e462., articleTitle=null, refAbstract=null), Reference(id=1319291555110826680, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=NOORUZZAMAN M, JOHNSON KEE, RANI R, et al. Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections[J]. Nat Commun, 2024, 15: 7999., articleTitle=null, refAbstract=null), Reference(id=1319291555169546937, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=HIROTSU Y, KOBAYASHI H, KAKIZAKI Y, et al. Multidrug-resistant mutations to antiviral and antibody therapy in an immuno-compromised patient infected with SARS-CoV-2[J]. Med, 2023, 4(11): 813-824., articleTitle=null, refAbstract=null), Reference(id=1319291555224072890, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=IKETANI S, MOHRI H, CULBERTSON B, et al. Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir[J]. Nature, 2023, 613(7944): 558-564., articleTitle=null, refAbstract=null), Reference(id=1319291555307958971, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=CHAKRABORTY C, BHATTACHARYA M, SHARMA AR. Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance[J]. Curr Opin Pharmacol, 2022, 62: 64-73., articleTitle=null, refAbstract=null), Reference(id=1319291555366679229, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=TAMURA T J, CHOUDHARY M C, DEO R, et al. Emerging SARS-CoV-2 resistance after antiviral treatment[J]. JAMA Netw Open, 2024, 7(9): e2435431., articleTitle=null, refAbstract=null), Reference(id=1319291555433788094, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=STEVENS L J, PRUIJSSERS A J, LEE H W, et al. Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms[J]. Sci Transl Med, 2022, 14(656): eabo0718., articleTitle=null, refAbstract=null), Reference(id=1319291555505091263, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=SHIMAZU H, WADA D, MARUYAMA S, et al. Clinical experience of treatment of immunocompromised individuals with persistent SARS-CoV-2 infection based on drug resistance mutations determined by genomic analysis: a descriptive study[J]. BMC Infect Dis, 2023, 23(1): 780., articleTitle=null, refAbstract=null)], funds=[Fund(id=1319291553437299364, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, awardId=81672041, language=CN, fundingSource=国家自然科学基金项目(81672041), fundOrder=null, country=null), Fund(id=1319291553500213925, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, awardId=20231303; 20241370, language=CN, fundingSource=河北省卫生健康委重点科研攻关计划项目(20231303; 20241370), fundOrder=null, country=null), Fund(id=1319291553554739878, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, awardId=2024256, language=CN, fundingSource=河北省中医药管理局科研计划项目(2024256), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1319291546579612244, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=1., ext=[AuthorCompanyExt(id=1319291546592195157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China), AuthorCompanyExt(id=1319291546600583766, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546579612244, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.石家庄市第三医院，河北 石家庄 050011)]), AuthorCompany(id=1319291546684469847, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=2., ext=[AuthorCompanyExt(id=1319291546692858456, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546684469847, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Hebei Province Academy of Chinese Medicine Sciences, Shijiazhuang 050030, Hebei, China), AuthorCompanyExt(id=1319291546697052761, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546684469847, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.河北省中医药科学院，河北 石家庄 050030)]), AuthorCompany(id=1319291546776744538, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=3., ext=[AuthorCompanyExt(id=1319291546789327451, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.The 980thHospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Shijiazhuang 050082, Hebei, China), AuthorCompanyExt(id=1319291546797716060, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546776744538, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.联勤保障部队第九八〇医院，河北 石家庄 050082)]), AuthorCompany(id=1319291546881602141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=4., ext=[AuthorCompanyExt(id=1319291546889990750, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1319291546898379359, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546881602141, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.中国医学科学院、北京协和医学院医药生物技术研究所，北京 100050)]), AuthorCompany(id=1319291546994848352, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, xref=5., ext=[AuthorCompanyExt(id=1319291547003236961, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546994848352, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.Youfu Hospital of Hebei Province, Shijiazhuang 050051, Hebei, China), AuthorCompanyExt(id=1319291547011625570, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1319291545434567249, companyId=1319291546994848352, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.河北省优抚医院，河北 石家庄 050051)])], figs=null, attaches=null, journal=Journal(id=1255846881855815682, delFlag=0, nameCn=中华中医药学刊, nameEn=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1673-7717, eissn=null, cn=21-1546/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=v4T+dd+NLAnioIpGAbkcEQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Archives of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1777346829146, updatedTime=1788949222391, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=v4T+dd+NLAnioIpGAbkcEQ==, picEn=RAy5vuC40hwJB+Y0pEARug==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510846391050374, language=CN, name=中华中医药学刊, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222419, updatedTime=1788949222419, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510846449770631, language=EN, name=Chinese Archives of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949222433, updatedTime=1788949222433, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://zyhs.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1255847919539208197, websiteList=[Website(id=1255847989868900719, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN, language=CN, createTime=1777347093312, createBy=18614031015, updateTime=1777347427646, updateBy=18614031015, name=中华中医药学刊-中文, tplId=1146099689490845704, title=中华中医药学刊, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849512594170105, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=articleTextType, value=kx, createTime=1777347456358, updateTime=1777347456358, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512564809974, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=banner, value=null, createTime=1777347456352, updateTime=1777347456352, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512631918844, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=grayFlag, value=0, createTime=1777347456367, updateTime=1777347456367, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512552227061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347456348, updateTime=1777347456348, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512657084670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=minRunFlag, value=0, createTime=1777347456373, updateTime=1777347456373, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512589975800, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/file/pic, createTime=1777347456357, updateTime=1777347456357, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512648696061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=silenceFlag, value=0, createTime=1777347456371, updateTime=1777347456371, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512581587191, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1777347456355, updateTime=1777347456355, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512619335930, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeColor, value=null, createTime=1777347456364, updateTime=1777347456364, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849512627724539, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989868900719, code=themeStyle, value=null, createTime=1777347456366, updateTime=1777347456366, creator=18614031015, updator=18614031015)]), Website(id=1255847989944398211, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1255847919539208197, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN, language=EN, createTime=1777347093330, createBy=18614031015, updateTime=1777347417860, updateBy=18614031015, name=中华中医药学刊-英文, tplId=1146101810881728533, title=Chinese Archives of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1255849538993119491, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=articleTextType, value=kx, createTime=1777347462652, updateTime=1777347462652, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538972147968, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=banner, value=null, createTime=1777347462647, updateTime=1777347462647, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539047645446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=grayFlag, value=0, createTime=1777347462665, updateTime=1777347462665, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538930204927, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=logo, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic?fileId=uitCA2DBwhJaQSiSV07uhw==, createTime=1777347462637, updateTime=1777347462637, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539064422664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=minRunFlag, value=0, createTime=1777347462669, updateTime=1777347462669, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538988925186, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/file/pic, createTime=1777347462651, updateTime=1777347462651, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539060228359, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=silenceFlag, value=0, createTime=1777347462668, updateTime=1777347462668, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849538980536577, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1777347462649, updateTime=1777347462649, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539001508100, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeColor, value=null, createTime=1777347462654, updateTime=1777347462654, creator=18614031015, updator=18614031015), WebsiteProps(id=1255849539039256837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1255847989944398211, code=themeStyle, value=null, createTime=1777347462663, updateTime=1777347462663, creator=18614031015, updator=18614031015)])], journalTitle=中华中医药学刊, weixinUrl=null, journalUrl=https://castjournals.cast.org.cn/zhzyyxk, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Archives of Traditional Chinese Medicine, journalPhotoCn=v4T+dd+NLAnioIpGAbkcEQ==, journalPhotoEn=RAy5vuC40hwJB+Y0pEARug==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.08.007, detailUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.08.007, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/PDF/10.13193/j.issn.1673-7717.2026.08.007, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/PDF/10.13193/j.issn.1673-7717.2026.08.007, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1786291200000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
67
11
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
