Article(id=1319291770941325326, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.07.041, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792473269447, onlineDateStr=2026-10-20, pubDate=1783612800000, pubDateStr=2026-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792473269447, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792473269447, creator=13701087609, updateTime=1792473269447, updator=13701087609, issue=Issue{id=1319291472856338924, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1783612800000', pubDateStr='2026-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792473198379, creator='13701087609', updateTime=1792473406504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319292345858773669, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319292345858773670, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1319291472856338924, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=230, endPage=233, ext={EN=ArticleExt(id=1319291772757458959, articleId=1319291770941325326, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Ningshen Wendan Decoction (宁神温胆汤) on Auditory Hallucination and Cognitive Function in Schizophrenia Patients with Psychiatric Disabilities, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the clinical efficacy of Ningshen Wendan Decoction (宁神温胆汤) on auditory hallucination symptoms and cognitive function in schizophrenia patients with psychiatric disabilities.
Methods A total of 98 schizophrenia patients with psychiatric disabilities treated at the hospital from January 2022 to January 2023 were selected and randomly assigned to the reference group (49 cases, receiving risperidone treatment) and the herbal medicine group (49 cases, receiving Ningshen Wendan Decoction in addition to risperidone). The treatment period was 4 weeks. The clinical efficacy, clinical symptoms [Positive and Negative Syndrome Scale (PANSS), Auditory Hallucination Rating Scale (AHRS), Symptom Checklist-90 (SCL-90)], cognitive function [Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA)], neurobiochemical indicators and adverse events were compared between the two groups.
Results After 4 weeks of treatment, the total efficacy rate in the herbal medicine group was higher than that in the reference group (P<0.05). After treatment, PANSS and AHRS scores in the herbal medicine group were lower than those in the reference group, while MMSE and MoCA scores were higher (P<0.05). Additionally, the brain-derived neurotrophic factor (BDNF) levels were higher, while the levels of γ-aminobutyric acid (GABA) and acetylcholine (ACh) were lower in the herbal medicine group than those in the reference group (P<0.05). The incidence of adverse events was not statistically different between the two groups (P>0.05).
Conclusion Ningshen Wendan Decoction combined with conventional antipsychotic medication significantly alleviates the auditory hallucination symptoms and improves the cognitive function in schizophrenia patients with psychiatric disabilities, demonstrating good safety and clinical applicability.
, authors=Kang FU, Xinxin JIANG, Xinli WANG, Kewei TAO, authorsList=Kang FU, Xinxin JIANG, Xinli WANG, Kewei TAO, authorCompany=null, correspAuthors=Xinxin JIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319291773021700112, articleId=1319291770941325326, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=宁神温胆汤对发生精神残疾的精神分裂症听幻觉及认知功能的影响分析, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探讨宁神温胆汤对发生精神残疾的精神分裂症患者听幻觉症状和认知功能的临床疗效。
方法 选取2022年1月—2023年1月在医院就诊的98例发生精神残疾的精神分裂症患者，采用随机数字表法分为参照组（49例，接受利培酮治疗）和中药组（49例，在参照组基础上联合宁神温胆汤治疗）。治疗周期为4周。比较两组患者的临床疗效、临床症状[阳性与阴性症状量表（Positive and Negative Syndrome Scale，PANSS）、听幻觉评分量表（Auditory Hallucinations Rating Scale，AHRS）、症状自评量表（Symptom Checklist-90，SCL-90）]、认知功能[简易精神状态检查（Mini-Mental State Examination，MMSE）、蒙特利尔认知评估量表（Montreal Cognitive Assessment，MoCA）]、神经生化指标以及不良反应发生情况。
结果 经过4周的治疗，中药组的总有效率高于参照组（P<0.05）。治疗后中药组患者的PANSS、AHRS评分均低于参照组，MMSE、MoCA评分均高于参照组（P<0.05）。治疗后中药组患者的脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）水平高于参照组，γ-氨基丁酸（γ-aminobutyric acid，GABA）、乙酰胆碱（acetylcholine，ACh）水平低于参照组（P<0.05）。中药组的不良事件发生率与参照组比较差异无统计学意义（P>0.05）。
结论 宁神温胆汤联合常规抗精神病药物治疗可显著减轻发生精神残疾的精神分裂症患者的听幻觉症状，改善认知功能，且安全性良好，具有临床推广价值。
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付康（1985-），男，陕西城固人，副主任中医师，硕士，研究方向：中医脑科疾病治疗与康复。
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付康（1985-），男，陕西城固人，副主任中医师，硕士，研究方向：中医脑科疾病治疗与康复。
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付康（1985-），男，陕西城固人，副主任中医师，硕士，研究方向：中医脑科疾病治疗与康复。
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