中华中医药学刊

八角莲抗肿瘤作用的研究进展及发展思考

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雷艳 ¹ , 唐张甜 ¹ , 王艳红 ² , 李丁 ³ , 孔宪斌 ⁴ , 刘传鑫 ⁵ , 贾红燕 ¹

中华中医药学刊 | 国家项目点击 2026,44(7): 79-85

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中华中医药学刊 |国家项目点击 2026 , 44 (7) : 79 -85

八角莲抗肿瘤作用的研究进展及发展思考

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雷艳¹, 唐张甜¹, 王艳红², 李丁³, 孔宪斌⁴, 刘传鑫⁵, 贾红燕¹

作者信息

^1.山西医科大学第一医院，山西　太原　030001

^2.山西医科大学基础医学院，山西　太原　030001

^3.郑州大学附属肿瘤医院，河南省肿瘤医院，河南　郑州　450008

^4.天津中医药大学中医学院，天津　301617

^5.河南科技大学临床医学院，河南科技大学第一附属医院内分泌代谢中心，河南省罕见病重点实验室，洛阳市临床多组学与转化医学重点实验室，河南　洛阳　471003

通讯作者:

刘传鑫（1990-），男，山东郓城人，主管药师，硕士研究生导师，博士，研究方向：体质毒理学与个体化药学监护。E-mail：15222003775@163.com。

贾红燕（1974-），女，山西太原人，主任医师，博士研究生导师，博士后，研究方向：乳腺癌的诊断与治疗。E-mail：swallow_jhy@163.com。

作者简介:

雷艳（1996-），女，山西朔州人，助理研究员，博士，研究方向：中药药效物质与机制。

Research Progress and Development Thinking on Anti-Tumor Mechanism of Bajiaolian (Dysosma versipellis)

Yan LEI¹, Zhangtian TANG¹, Yanhong WANG², Ding LI³, Xianbin KONG⁴, Chuanxin LIU⁵, Hongyan JIA¹

Affiliations

^1.The First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China

^2.Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan 030001, Shanxi, China

^3.The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, Henan, China

^4.College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

^5.Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China

出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.016

文章导航

摘要

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近年来，中药八角莲因其独特的毒理和药理作用，成为抗肿瘤研究的重要方向之一。研究表明，八角莲及其活性成分能够抑制乳腺癌、肺癌、结直肠癌、肝癌和胃癌等多种癌症的发展。其作用机制主要包括抑制肿瘤细胞增殖、侵袭和迁移，诱导肿瘤细胞凋亡，以及干扰肿瘤细胞周期。这些特性使八角莲在抗肿瘤治疗领域具有广阔的应用前景。综述八角莲及其活性成分的抗肿瘤作用及机制，旨在为未来八角莲的药用开发提供理论依据，同时为抗肿瘤药物的研究与创新贡献新的思路和方向。

关键词

八角莲 / 抗肿瘤 / 鬼臼毒素 / 作用机制 / 体质毒理学 / 毒理证据链

Abstract

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In recent years, Bajiaolian (Dysosma versipellis), a traditional Chinese medicine, has emerged as a significant focus in anti-tumor research due to its distinctive toxicological and pharmacological properties. Evidence from various studies indicates that Bajiaolian (Dysosma versipellis) and its active constituents possess the ability to inhibit the development of multiple cancer types, including breast, lung, colorectal, liver and gastric cancers. The proposed mechanisms of action primarily involve the suppression of tumor cell proliferation, invasion and migration, the induction of apoptosis in tumor cells, and the disruption of the tumor cell cycle. These attributes suggest that Bajiaolian (Dysosma versipellis) holds considerable promise for application in anti-tumor therapy. This review aimed to elucidate the anti-tumor effects and underlying mechanisms of Bajiaolian (Dysosma versipellis) and its active components, thereby providing a theoretical foundation for the future medicinal development of Bajiaolian (Dysosma versipellis) and contributing novel insights and directions for the research and innovation of anti-tumor agents.

Key words

Bajiaolian (Dysosma versipellis) / anti-tumor / podophyllotoxin / mechanism of action / constitution-based toxicology / toxicological evidence chain

引用本文

雷艳, 唐张甜, 王艳红, 李丁, 孔宪斌, 刘传鑫, 贾红燕. 八角莲抗肿瘤作用的研究进展及发展思考. 中华中医药学刊, 2026 , 44 (7) : 79 -85 . DOI: 10.13193/j.issn.1673-7717.2026.07.016

Yan LEI, Zhangtian TANG, Yanhong WANG, Ding LI, Xianbin KONG, Chuanxin LIU, Hongyan JIA. Research Progress and Development Thinking on Anti-Tumor Mechanism of Bajiaolian (Dysosma versipellis)[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 79 -85 . DOI: 10.13193/j.issn.1673-7717.2026.07.016

基金

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国家自然科学基金青年科学基金项目(82204938; 82204962; 82404736)
山西省高等教育“百亿工程”科技引导专项(2024)

参考文献

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文献

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参考文献引证文献

排序方式：

[1]

FILHO A M, LAVERSANNE M, FERLAY J, et al. The GLOBOCAN 2022 cancer estimates: Data sources, methods, and a snapshot of the cancer burden worldwide[J]. Int J Cancer, 2025, 156(7): 1336-1346.

[2]

KHORANA A A, KUDERER N M, CULAKOVA E, et al. Development and validation of a predictive model for chemotherapy-associated thrombosis[J]. Blood, 2008, 111(10): 4902-4907.

[3]

HERRMANN J. Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia[J]. Nat Rev Cardiol, 2020, 17(8): 474-502.

[4]

HESKETH P J, KRIS M G, BASCH E, et al. Antiemetics: American society of clinical oncology clinical practice guideline update[J]. J Clin Oncol, 2017, 35(28): 3240-3261.

[5]

邹晓雨, 李娟, 李金田, 等. 中药干预肿瘤微环境相关细胞抗肿瘤耐药的作用机制[J]. 中医学报, 2025, 40(2): 357-365.

[6]

宋中旭, 胡娇娇, 金艳, 等. 十六种壮药毒性药材抗肿瘤活性评价及筛选[J]. 中国药物警戒, 2025, 22(5): 539-546.

[7]

秦小波. 中国八角莲属植物的研究进展[J]. 资源开发与市场, 2012, 28(11): 1018-1019, 1043.

[8]

马君, 江露, 陈虎, 等. 中药八角莲的研究进展[J]. 湖北医药学院学报, 2020, 39(1): 96-100.

[9]

吕敏, 苏艳芳, 郭增军, 等. 八角莲属植物化学成分及生物活性研究概况[J]. 西北药学杂志, 2007, 22(3): 152-153.

[10]

魏明月, 杨思怡, 马瑜瑾, 等. 基于CiteSpace的八角莲研究动态与发展趋势分析[J]. 世界科学技术-中医药现代化, 2025, 27(2): 522-532.

[11]

张欣. 新型鬼臼毒素衍生物的抗肿瘤活性及其作用机制的探究[D]. 上海: 上海师范大学, 2022.

[12]

GORDALIZA M, GARCÍA P A, MIGUEL DEL CORRAL J M, et al. Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives[J]. Toxicon, 2004, 44(4): 441-459.

[13]

朱怀蝶. 卡铂联合依托泊苷治疗小细胞肺癌的近期疗效[J]. 临床合理用药, 2024, 17(28): 72-74.

[14]

XU W Z, LU H, YUAN Y, et al. The antioxidant and anti-inflammatory effects of flavonoids from propolis via Nrf2 and NF-κB pathways[J]. Foods, 2022, 11(16): 2439.

[15]

林启炫, 杜灿凯, 林稚凯, 等. 黄酮类化合物的生物活性及应用研究[J]. 现代食品, 2024, 30(2): 92-97.

[16]

GIAQUINTO A N, SUNG H, MILLER K D, et al. Breast cancer statistics, 2022[J]. CA A Cancer J Clin, 2022, 72(6): 524-541.

[17]

SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.

[18]

KAMAL A, TAMBOLI J R, RAMAIAH M J, et al. Quinazolino linked 4β-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation[J]. Bioorg Med Chem, 2013, 21(21): 6414-6426.

[19]

ZHANG W F, LIU C, LI J, et al. Target analysis and mechanism of podophyllotoxin in the treatment of triple-negative breast cancer[J]. Front Pharmacol, 2020, 11: 1211.

[20]

WANG Y J, SUN H, XIAO Z Y, et al. DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer[J]. Cell Commun Signal, 2018, 16(1): 52.

[21]

WANG Y J, SUN H, XIAO Z Y, et al. XWL-1-48 exerts antitumor activity via targeting topoisomerase Ⅱ and enhancing degradation of Mdm2 in human hepatocellular carcinoma[J]. Sci Rep, 2017, 7: 9989.

[22]

HAN H W, QIU H Y, HU C, et al. Design, synthesis and anticancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs[J]. Bioorg Med Chem Lett, 2016, 26(14): 3237-3242.

[23]

CHOI J Y, HONG W G, CHO J H, et al. Podophyllotoxin acetate triggers anticancer effects against non-small cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy[J]. Int J Oncol, 2015, 47(4): 1257-1265.

[24]

OH H N, KWAK A W, LEE M H, et al. Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells[J]. Phytomedicine, 2021, 80: 153355.

[25]

CHEN J Y, TANG Y A, LI W S, et al. A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models[J]. PLoS One, 2013, 8(4): e62082.

[26]

BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA A Cancer J Clin, 2024, 74(3): 229-263.

[27]

BHAT B A, REDDY P B, AGRAWAL S K, et al. Studies on novel 4β-[(4-substituted)-1, 2, 3-triazol-1-yl] podophyllotoxins as potential anticancer agents[J]. Eur J Med Chem, 2008, 43(10): 2067-2072.

[28]

FAN H Y, ZHU Z L, XIAN H C, et al. Insight into the molecular mechanism of podophyllotoxin derivatives as anticancer drugs[J]. Front Cell Dev Biol, 2021, 9: 709075.

[29]

KATOCH A, NAYAK D, FAHEEM M M, et al. Natural podophyllotoxin analog 4DPG attenuates EMT and colorectal cancer progression via activation of checkpoint kinase 2[J]. Cell Death Discov, 2021, 7: 25.

[30]

CAI D S, LOU S Y, HUO S, et al. Synthesis and biological activity evaluation of podophyllotoxin-linked bile acid derivatives as potential anti-liver cancer agents[J]. Bioorg Chem, 2022, 128: 106066.

[31]

ZHANG L, LIU L, ZHENG C Y, et al. Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells[J]. Eur J Med Chem, 2017, 131: 81-91.

[32]

ZHANG L, WANG J, LIU L, et al. Synthesis and antiproliferative activity of novel all-trans-retinoic acid-podophyllotoxin conjugate towards human gastric cancer cells[J]. Molecules, 2017, 22(4): 628.

[33]

SADEGHI I, BEHMANESH M, AHMADIAN CHASHMI N, et al. 6-methoxy podophyllotoxin induces apoptosis via inhibition of TUBB3 and TOPIIA gene expressions in 5637 and K562 cancer cell lines[J]. Cell J, 2015, 17(3): 502-509.

[34]

WANG J, LONG L, CHEN Y Z, et al. Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents[J]. Bioorg Med Chem Lett, 2018, 28(10): 1817-1824.

[35]

CORTESE F, BHATTACHARYYA B, WOLFF J. Podophyllotoxin as a probe for the colchicine binding site of tubulin[J]. J Biol Chem, 1977, 252(4): 1134-1140.

[36]

KAMAL A, TAMBOLI J R, NAYAK V L, et al. Synthesis of a terphenyl substituted 4-aza-2, 3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers[J]. Bioorg Med Chem, 2014, 22(9): 2714-2723.

[37]

ZHANG L, ZHANG Z G, CHEN F, et al. Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways[J]. Eur J Med Chem, 2016, 123: 226-235.

[38]

刘传鑫, 孔娇. 体质毒理学: 中药安全性评价的新方向[J]. 世界科学技术-中医药现代化, 2023, 25(12): 3776-3784.

[39]

孔娇, 田悦, 刘传鑫, 等. “量-权-证”网络毒理学的提出与应用: 以八角莲醇提液致肝毒性为例[J]. 中国中药杂志, 2022, 47(2): 511-527.

[40]

JIANG T, SUN L, WANG Y M, et al. Podophyllotoxin via SIRT1/PPAR/NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept[J]. Phytomedicine, 2024, 130: 155655.

[41]

DUAN J J, SUN J X, JIANG T, et al. Podophyllotoxin-mediated neurotoxicity via the microbiota-gut-brain axis in SD rats based on the toxicological evidence chain (TEC) concept[J]. Sci Total Environ, 2024, 907: 168106.

[42]

LIU C X, ZHANG C N, HE T, et al. Study on potential toxic material base and mechanisms of hepatotoxicity induced by Dysosma versipellis based on toxicological evidence chain (TEC) concept[J]. Ecotoxicol Environ Saf, 2020, 190: 110073.

[43]

KONG J, HE T, LIU C X, et al. Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept[J]. Ecotoxicol Environ Saf, 2022, 231: 113157.

[44]

KONG J, KUI H Q, TIAN Y, et al. Nephrotoxicity assessment of podophyllotoxin-induced rats by regulating PI3K/Akt/mTORNrf2/HO1 pathway in view of toxicological evidence chain (TEC) concept[J]. Ecotoxicol Environ Saf, 2023, 264: 115392.

[45]

MA K Y, SUN L, JIA C X, et al. Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept[J]. Front Pharmacol, 2024, 15: 1378758.

[46]

LIU C X, HUANG X B, KONG J, et al. Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis[J]. Ecotoxicol Environ Saf, 2025, 289: 117441.

2026年第44卷第7期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.07.016

首发时间：2026-10-20
出版时间：2026-07-10

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基金

国家自然科学基金青年科学基金项目(82204938; 82204962; 82404736)

山西省高等教育“百亿工程”科技引导专项(2024)

作者信息

^1.山西医科大学第一医院，山西　太原　030001

^2.山西医科大学基础医学院，山西　太原　030001

^3.郑州大学附属肿瘤医院，河南省肿瘤医院，河南　郑州　450008

^4.天津中医药大学中医学院，天津　301617

通讯作者:

刘传鑫（1990-），男，山东郓城人，主管药师，硕士研究生导师，博士，研究方向：体质毒理学与个体化药学监护。E-mail：15222003775@163.com。

贾红燕（1974-），女，山西太原人，主任医师，博士研究生导师，博士后，研究方向：乳腺癌的诊断与治疗。E-mail：swallow_jhy@163.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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