中华中医药学刊

加味四妙勇安汤联合针刺敏化穴用于急性冠脉综合征PCI术后对血小板功能参数和血清凋亡因子水平的影响研究

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朝力根 ¹^,² , 王莹 ³ , 焦琳 ¹

中华中医药学刊 | 国家项目点击 2026,44(7): 68-72

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中华中医药学刊 |国家项目点击 2026 , 44 (7) : 68 -72

加味四妙勇安汤联合针刺敏化穴用于急性冠脉综合征PCI术后对血小板功能参数和血清凋亡因子水平的影响研究

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朝力根¹^,², 王莹³, 焦琳¹

作者信息

^1.江西中医药大学，江西　南昌　330004

^2.内蒙古民族大学附属医院，内蒙古　通辽　028005

^3.通辽市职业学院，内蒙古　通辽　028006

通讯作者:

焦琳（1977-），女，山东莱芜人，主任医师、教授，博士研究生导师，博士，研究方向：腧穴敏化规律及针灸临床。E-mail：524677683@qq.com。

作者简介:

朝力根（1991-），男（蒙古族），内蒙古通辽人，主治医师，博士在读，研究方向：腧穴敏化规律及针灸临床。

Research on Effect of Modified Simiao Yong'an Decoction (加味四妙勇安汤) Combined with Acupuncture at Sensitized Acupoints on Platelet Function Parameters and Serum Apoptosis Factor Levels After PCI for Acute Coronary Syndrome

Ligen CHAO¹^,², Ying WANG³, Lin JIAO¹

Affiliations

^1.Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China

^2.Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028005, Inner Mongolia, China

^3.Tongliao Vocational College, Tongliao 028006, Inner Mongolia, China

出版时间: 2026-07-10 doi: 10.13193/j.issn.1673-7717.2026.07.014

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摘要

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目的

分析加味四妙勇安汤联合针刺敏化穴用于急性冠脉综合征经皮冠状动脉介入（PCI）术后对血小板功能参数和血清凋亡因子水平的影响。

方法

纳入2022年1月—2024年12月医院收治的急性冠脉综合征经PCI术后患者226例进行研究，按照随机数字表法分为两组，113例对照组术后应用常规西药进行治疗，113例观察组术后在此基础上应用加味四妙勇安汤联合针刺敏化穴治疗，对比两组治疗效果、证候积分、血小板功能参数、血清凋亡因子水平、血管内皮功能变化情况等。

结果

观察组治疗总有效率为93.81%（106/113），远高于对照组（77.88%，88/113），组间比较差异有统计学意义（P<0.05）。治疗后两组证候积分均有所降低（P<0.05），且相较于对照组，观察组降低更为明显（P<0.05）。两组血小板聚集率（PagT）、平均血小板体积（MPV）、血小板分布宽度（PDW）指标水平均有降低，血小板计数（PLT）提高，且较于对照组，观察组改善更为显著（P<0.05）。治疗后两组胱天蛋白酶3（Caspase-3）、BCL2关联X蛋白（Bax）水平降低，B细胞淋巴瘤-2（Bcl-2）水平提高，且较于对照组，观察组改善更为显著（P<0.05）。治疗后两组内皮素-1（ET-1）水平较治疗前降低，一氧化氮（NO）水平均有提高，且较于对照组，观察组改善更为显著（P<0.05）。

结论

对急性冠脉综合征PCI术后患者应用加味四妙勇安汤联合针刺敏化穴治疗能有效改善患者胸闷气短等相关症状，抑制血栓形成，改善血小板功能，减轻血管内皮损伤，同时抑制心肌凋亡因子表达异常，对预后起到改善作用。

关键词

急性冠脉综合征 / 经皮冠状动脉介入术 / 四妙勇安汤 / 针刺 / 中西医结合疗法 / 血小板功能 / 血清凋亡因子

Abstract

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Objective

To analyze the effect of Modified Simiao Yong'an Decoction (加味四妙勇安汤) combined with acupuncture at sensitized acupoints on platelet function parameters and serum apoptosis factor levels after percutaneous coronary intervention (PCI) for acute coronary syndrome.

Methods

A total of 226 patients with acute coronary syndrome who underwent PCI and were admitted to the hospital from January 2022 to December 2024 were included in the study. They were divided into two groups by the random number table method. The patients (113 cases) in the control group were treated with conventional Western medicine after surgery, and those (113 cases) in the observation group were treated with Modified Simiao Yong'an Decoction combined with acupuncture at sensitized acupoints on this basis. The treatment effects, syndrome scores, platelet function parameters, serum apoptosis factor levels and changes in vascular endothelial function were compared between the two groups.

Results

The total effective rate in the observation group was 93.81%(106/113), which was significantly higher than that (77.88%, 88/113) in the control group, and the difference between the two groups was significant (P<0.05). After treatment, the syndrome scores of both groups decreased (P<0.05), and the decrease in the observation group was more significant compared with that in the control group (P<0.05). The levels of platelet aggregation test (PagT), mean platelet volume (MPV) and platelet distribution width (PDW) in both groups decreased, and the platelet count (PLT) increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05). After treatment, the levels of cysteinyl aspartate specific proteinase-3 (Caspase-3) and Bcl-2 associated X protein (Bax) in both groups decreased, and the level of B-cell lymphoma-2 (Bcl-2) increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05). After treatment, the ET-1 level in both groups decreased compared with that before treatment, and the nitric oxide (NO) level increased. The improvement in the observation group was more significant compared with that in the control group (P<0.05).

Conclusion

The application of Modified Simiao Yong'an Decoction combined with acupuncture at sensitized acupoints in the patients with acute coronary syndrome after PCI can effectively improve the related symptoms such as chest tightness and shortness of breath, inhibit the thrombosis, improve the platelet function, reduce the vascular endothelial damage and at the same time inhibit the abnormal expressions of myocardial apoptosis factors, playing a role in improving the prognosis.

Key words

acute coronary syndrome / percutaneous coronary intervention / Simiao Yong'an Decoction (四妙勇安汤) / acupuncture / integrated traditional Chinese and western medicine therapy / platelet function / serum apoptosis factor

引用本文

朝力根, 王莹, 焦琳. 加味四妙勇安汤联合针刺敏化穴用于急性冠脉综合征PCI术后对血小板功能参数和血清凋亡因子水平的影响研究. 中华中医药学刊, 2026 , 44 (7) : 68 -72 . DOI: 10.13193/j.issn.1673-7717.2026.07.014

Ligen CHAO, Ying WANG, Lin JIAO. Research on Effect of Modified Simiao Yong'an Decoction (加味四妙勇安汤) Combined with Acupuncture at Sensitized Acupoints on Platelet Function Parameters and Serum Apoptosis Factor Levels After PCI for Acute Coronary Syndrome[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (7) : 68 -72 . DOI: 10.13193/j.issn.1673-7717.2026.07.014

基金

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国家重点研发计划项目(2022YFC3500701)

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2026年第44卷第7期

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doi: 10.13193/j.issn.1673-7717.2026.07.014

首发时间：2026-10-20
出版时间：2026-07-10

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出版历史

基金

国家重点研发计划项目(2022YFC3500701)

作者信息

^1.江西中医药大学，江西　南昌　330004

^2.内蒙古民族大学附属医院，内蒙古　通辽　028005

^3.通辽市职业学院，内蒙古　通辽　028006

通讯作者:

焦琳（1977-），女，山东莱芜人，主任医师、教授，博士研究生导师，博士，研究方向：腧穴敏化规律及针灸临床。E-mail：524677683@qq.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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