中华中医药学刊

加味黄连阿胶汤对中风后睡眠障碍中医证候积分、血浆IL-10、TNF-α、NSE水平及睡眠质量的影响

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金玥 , 王华强 , 刘芳雅

中华中医药学刊 | 国家项目点击 2026,44(6): 178-180

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中华中医药学刊 |国家项目点击 2026 , 44 (6) : 178 -180

加味黄连阿胶汤对中风后睡眠障碍中医证候积分、血浆IL-10、TNF-α、NSE水平及睡眠质量的影响

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金玥, 王华强, 刘芳雅

作者信息

浙江中医药大学附属丽水市中医院，浙江丽水 323000

通讯作者:

王华强（1980-），男，山东威海人，主任中医师，博士，研究方向：中西医结合神经病学。

作者简介:

金玥（1990-），女，浙江丽水人，主治中医师，学士，研究方向：认知，睡眠障碍。

Effect of Jiawei Huanglian Ejiao Decoction (加味黄连阿胶汤) on TCM Syndrome Scores, Plasma Levels of IL-10, TNF-α and NSE and Sleep Quality of Patients with Sleep Disorder After Stroke

Yue JIN, Huaqiang WANG, Fangya LIU

Affiliations

Lishui Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Lishui 323000, Zhejiang, China

出版时间: 2026-06-10 doi: 10.13193/j.issn.1673-7717.2026.06.033

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摘要

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目的

分析加味黄连阿胶汤对中风后睡眠障碍患者中医证候积分、血浆白细胞介素-10（Interleukin-10，IL-10）、肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、神经元特异性烯醇化酶（Neuron-specific enolase，NSE）水平及睡眠质量的影响。

方法

纳入医院2021年3月—2023年5月收治的120例中风后睡眠障碍患者，随机分为联合组（60例）、对照组（60例），两组常规药物治疗及经颅磁刺激治疗，联合组加用加味黄连阿胶汤，两组治疗均持续6周。对比两组治疗前后中医证候积分，血浆IL-10、TNF-α、NSE等指标以及睡眠质量变化，分析两种治疗方案的临床价值。

结果

两组治疗6周后腰膝酸软、五心烦热、口干咽燥、潮热盗汗证候积分均较治疗前下降；联合组治疗6周后各项中医证候积分均低于对照组，差异有统计学意义（P<0.05）。两组治疗6周后血浆IL-10较治疗前升高，TNF-α、NSE均较治疗前下降；联合组治疗6周后血浆IL-10高于对照组，TNF-α、NSE均低于对照组，差异有统计学意义（P<0.05）。两组治疗6周后匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）各因子评分及总分均较治疗前下降；联合组治疗6周PSQI量表各因子评分及总分均低于对照组，差异有统计学意义（P<0.05）。

结论

在常规药物治疗的基础上，给予加味黄连阿胶汤能够改善中风后睡眠障碍患者中医证候积分、调节炎症反应并促进神经功能恢复，对于患者睡眠质量的改善有积极影响。

关键词

加味黄连阿胶汤 / 中风 / 睡眠障碍 / 炎症因子 / 睡眠质量

Abstract

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Objective

To analyze the effects of Jiawei Huanglian Ejiao Decoction (加味黄连阿胶汤) on TCM syndrome scores, plasma levels of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), neuron-specific enolase (NSE) and sleep quality in the patients with sleep disorder after stroke.

Methods

One hundred and twenty patients with post-stroke sleep disorder admitted to the hospital from March 2021 to May 2023 were randomly divided into the combined group (60 cases) and the control group (60 cases). The two groups were treated with conventional drugs and transcranial magnetic stimulation, and the combined group was treated with Jiawei Huanglian Ejiao Decoction. Both groups were treated for 6 weeks. The TCM syndrome scores, plasma levels of IL-10, TNF-α and NSE and sleep quality of the two groups before and after treatment were compared, and the clinical value of the two treatment schemes was analyzed.

Results

After 6-week treatment, the scores of symptoms such as soreness and weakness of the lower back knee, feverish sensation, dry mouth and throat, hot flashes and night sweats in both groups decreased compared with those before treatment, the scores of TCM syndromes in the combined group were lower than those in the control group, and the difference was statistically significant (P<0.05). After 6 weeks of treatment, the plasma IL-10 levels in the two groups increased, while the levels of TNF-α and NSE decreased, and the plasma IL-10 in the combined group was higher than that in the control group, and the levels of TNF-α and NSE were lower than those in the control group, with statistical significance (P<0.05). After 6 weeks of treatment, the scores of each factor and the total score of Pittsburgh sleep quality index (PSQI) scale in both groups decreased compared with those before treatment. The scores of all factors and the total score of PSQI in the combined group were lower than those in the control group, and the difference was statistically significant (P<0.05).

Conclusion

On the basis of routine drug treatment, Jiawei Huanglian Ejiao Decoction can improve the TCM syndrome score of the patients with sleep disorder after stroke, regulate the inflammatory reaction and promote the recovery of neurological function, which has a positive impact on the improvement of sleep quality of patients.

Key words

Jiawei Huanglian Ejiao Decoction (加味黄连阿胶汤) / stroke / sleep disorder / inflammatory factors / sleep quality

引用本文

金玥, 王华强, 刘芳雅. 加味黄连阿胶汤对中风后睡眠障碍中医证候积分、血浆IL-10、TNF-α、NSE水平及睡眠质量的影响. 中华中医药学刊, 2026 , 44 (6) : 178 -180 . DOI: 10.13193/j.issn.1673-7717.2026.06.033

Yue JIN, Huaqiang WANG, Fangya LIU. Effect of Jiawei Huanglian Ejiao Decoction (加味黄连阿胶汤) on TCM Syndrome Scores, Plasma Levels of IL-10, TNF-α and NSE and Sleep Quality of Patients with Sleep Disorder After Stroke[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (6) : 178 -180 . DOI: 10.13193/j.issn.1673-7717.2026.06.033

基金

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国家中医药管理局中医标准化项目(ZYYBZ-2013)

参考文献

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2026年第44卷第6期

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doi: 10.13193/j.issn.1673-7717.2026.06.033

首发时间：2026-10-14
出版时间：2026-06-10

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基金

国家中医药管理局中医标准化项目(ZYYBZ-2013)

作者信息

浙江中医药大学附属丽水市中医院，浙江丽水 323000

通讯作者:

王华强（1980-），男，山东威海人，主任中医师，博士，研究方向：中西医结合神经病学。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
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红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
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				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
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