中华中医药学刊

麻黄细辛附子汤化裁对阳虚水泛型心力衰竭患者心功能、运动耐力、NT-proBNP的影响

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崔竞宇 , 任素华 , 李雪倩 , 魏晓

中华中医药学刊 | 省级项目平台 2026,44(5): 234-238

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中华中医药学刊 |省级项目平台 2026 , 44 (5) : 234 -238

麻黄细辛附子汤化裁对阳虚水泛型心力衰竭患者心功能、运动耐力、NT-proBNP的影响

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崔竞宇, 任素华, 李雪倩, 魏晓

作者信息

新乡市中心医院，新乡医学院第四临床医学院，河南新乡 453000

作者简介:

崔竞宇（1992-），女，河南新乡人，主治医师，硕士，研究方向：中医心血管病。

Effects of Mahuang Xixin Fuzi Decoction (麻黄细辛附子汤) on Cardiac Function, Exercise Tolerance and NT-proBNP in Patients with Yang Deficiency and Water Diffusion Type of Heart Failure

Jingyu CUI, Suhua REN, Xueqian LI, Xiao WEI

Affiliations

Xinxiang Central Hospital, The Fourth Clinical Medical College of Xinxiang Medical College, Xinxiang 453000, Henan, China

出版时间: 2026-05-10 doi: 10.13193/j.issn.1673-7717.2026.05.043

文章导航

摘要

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目的

探讨麻黄细辛附子汤化裁对阳虚水泛型心力衰竭患者心功能、运动耐力、氨基末端脑利尿钠肽前体（N-terminal pro-B-type natriuretic peptide，NT-proBNP）的影响。

方法

选取82例阳虚水泛型心力衰竭患者，按照随机数字表法1∶1分为对照组和治疗组。对照组在一般治疗的基础上，给予常规西药以及中药安慰剂进行治疗，治疗组在一般治疗和常规西药治疗的基础上，采用麻黄细辛附子汤化裁颗粒进行治疗，共治疗4周。观察两组患者在治疗前后的临床疗效、中医证候积分、不良反应、心功能指标［左心房内径（Left atrial diameter，LAD）、左室舒张末期内径（Left ventricular end-diastolic dimension，LVEDD）、左室收缩末期内径（Left ventricular end-systolic dimension，LVESD），以及左室射血分数（Left ventricular ejection fractions，LVEF）］、运动耐力情况［6 min步行试验（6MWT）］、生物标志物［白细胞介素-6（Interleukin-6，IL-6）、超敏C反应蛋白（Hypersensitive C-reactive protein，hs-CRP）、NT-proBNP］、明尼苏达心力衰竭生活质量表（MLHFQ）的变化情况。

结果

两组患者在治疗前各项观察指标差异比较均无统计学意义（P>0.05）。在接受治疗后，较对照组而言治疗组的临床疗效显著提高（P<0.05）；两组患者在治疗后心悸、胸闷、乏力、畏寒、水肿等中医证候积分均有所改善，且治疗组改善更明显（P<0.05），但对照组胸闷症状较治疗前相比，差异不具有统计意义（P>0.05）。较对照组而言，治疗组的不良反应更低（P<0.05）。治疗组的心功能（LAD、LVEDD、LVESD、LVEF）明显改善、步行距离（6MWT）也比对照组更远（P<0.05）。在治疗后，治疗组的炎症因子（IL-6、hs-CRP）和NT-proBNP水平较对照组降低；而且，治疗组较对照组而言生活质量评分（MLHFQ）也有所改善（P<0.05）。

结论

麻黄细辛附子汤化裁能显著改善阳虚水泛型心力衰竭患者心功能水平、运动耐力以及NT-proBNP含量，可有效提高生活质量。

关键词

麻黄细辛附子 / 阳虚水泛 / 心力衰竭 / 心功能

Abstract

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Objective

To investigate the effects of Mahuang Xixin Fuzi Decoction (麻黄细辛附子汤) on cardiac function, exercise tolerance and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with heart failure with Yang deficiency and water diffusion type.

Methods

Eighty-two patients with heart failure of Yang deficiency and water diffusion type were selected and divided into the control group and treatment group according to the randomized numerical table method with the ratio of 1∶1. The control group was treated with conventional western medicines as well as herbal placebo on the basis of the general treatment, and the treatment group was treated with Mahuang Xixin Fuzi Decoction on the basis of the general treatment and conventional western medicines. The two groups were treated for 4 weeks. The changes of clinical efficacy, TCM syndrome points, adverse reactions, cardiac function indicators［left atrial diameter (LAD), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), left ventricular ejection fractions (LVEF) ］, exercise endurance profile (6MWT), biomarkers［interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), NT-proBNP］, and Minnesota Heart Failure Life Quality Questionnaire (MLHFQ) before and after the treatment of the two groups were observed.

Results

The differences between the two groups in the pre-treatment observation indicators were not statistically significant (P>0.05) . After receiving treatment, the clinical efficacy of the treatment group was significantly improved compared with that of the control group (P<0.05) . After treatment, the TCMsyndrome scores of the two groups, such as palpitations, chest tightness, fatigue, chills and edema, were improved, and the improvement in the treatment group was more obvious (P<0.05), but the difference in chest tightness symptoms in the control group was not obvious compared with that before treatment, and was not statistically significant (P>0.05). The treatment group showed significant improvement in cardiac function (LAD, LVEDD, LVESD, LVEF) and greater walking distance (6MWT) than the control group (P<0.05) . After the treatment, the levels of inflammatory factors (IL-6, hs-CRP) and NT-proBNP were reduced in the treatment group compared to those in the control group (P<0.05). The MLHFQ scores also improved in the treatment group compared to those in the control group (P<0.05) .

Conclusion

Mahuang Xixin Fuzi Decoction can significantly improve the cardiac function, exercise tolerance and NT-proBNP content of the patients with heart failure of Yang deficiency and water diffusion type, which can effectively improve the quality of life.

Key words

Mahuang Xixin Fuzi Decoction (麻黄细辛附子汤) / Yang deficiency and water diffusion / heart failure / cardiac function

引用本文

崔竞宇, 任素华, 李雪倩, 魏晓. 麻黄细辛附子汤化裁对阳虚水泛型心力衰竭患者心功能、运动耐力、NT-proBNP的影响. 中华中医药学刊, 2026 , 44 (5) : 234 -238 . DOI: 10.13193/j.issn.1673-7717.2026.05.043

Jingyu CUI, Suhua REN, Xueqian LI, Xiao WEI. Effects of Mahuang Xixin Fuzi Decoction (麻黄细辛附子汤) on Cardiac Function, Exercise Tolerance and NT-proBNP in Patients with Yang Deficiency and Water Diffusion Type of Heart Failure[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (5) : 234 -238 . DOI: 10.13193/j.issn.1673-7717.2026.05.043

基金

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河南省医学科技攻关计划项目(LHGJ20210748)

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2026年第44卷第5期

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doi: 10.13193/j.issn.1673-7717.2026.05.043

首发时间：2026-10-14
出版时间：2026-05-10

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河南省医学科技攻关计划项目(LHGJ20210748)

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新乡市中心医院，新乡医学院第四临床医学院，河南新乡 453000

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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