中华中医药学刊

活血通窍汤加减方联合高压氧疗法对动脉瘤性蛛网膜下腔出血患者临床预后及外周血miR-193b-3p、HIF-1 α水平的影响

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邢星 , 郝烘玉 , 褚红珊

中华中医药学刊 | 省级项目平台 2026,44(5): 221-225

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中华中医药学刊 |省级项目平台 2026 , 44 (5) : 221 -225

活血通窍汤加减方联合高压氧疗法对动脉瘤性蛛网膜下腔出血患者临床预后及外周血miR-193b-3p、HIF-1 α水平的影响

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邢星, 郝烘玉, 褚红珊

作者信息

河北省人民医院，河北石家庄 050000

作者简介:

邢星（1984-），女，河北石家庄人，副主任医师，博士，研究方向：重症脑血管病、癫痫持续状态等。

Effect of Modified Huoxue Tongqiao Decoction (活血通窍汤加减方) Combined with Hyperbaric Oxygen Therapy on Clinical Prognosis and Peripheral Blood Levels of miR-193b-3p and HIF-1 αin Patients with aSAH

Xing XING, Hongyu HAO, Hongshan CHU

Affiliations

Hebei Provincial People's Hospital, Shijiazhuang 050000, Hebei, China

出版时间: 2026-05-10 doi: 10.13193/j.issn.1673-7717.2026.05.040

文章导航

摘要

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目的

观察活血通窍汤加减方联合高压氧疗法对动脉瘤性蛛网膜下腔出血（Aneurysmal subarachnoid haemorrhage，aSAH）患者临床预后及外周血微小核糖核酸-193b-3p（MicroRNA-193b-3p，miR-193b-3p）、缺氧诱导因子-1 α（Hypoxia-inducible factor-1 α，HIF-1 α）水平的影响。

方法

选取2022年1月—2024年2月收治的aSAH患者94例，采用抽签法分为高压氧组47例和中医组47例。两组均给予血管内介入术或开颅夹闭手术治疗，高压氧组术后给予高压氧疗法治疗，中医组在高压氧组基础上给予活血通窍汤加减方治疗。比较两组血栓弹力图参数、miR-193b-3p相对表达量、miR-27a相对表达量、HIF-1 α、氧化应激指标、美国国立卫生研究院卒中量表（National institutes of health stroke scale，NIHSS）评分、中医症状评分、Barthel（BI）指数及短期预后情况。

结果

治疗后，高压氧组与中医组最大振幅（Maximum amplitude，MA）、凝血指数（Coagulation index，CI）、α角均低于治疗前，中医组低于高压氧组（P<0.05）。治疗后，高压氧组与中医组miR-193b-3p低于治疗前，中医组高于高压氧组（P<0.05）；高压氧组与中医组miR-27a相对表达量高于高压氧组（P<0.05），中医组高于高压氧组（P<0.05）。治疗后，高压氧组与中医组HIF-1 α、丙二醛（Malondialdehyde，MDA）低于治疗前，中医组低于高压氧组（P<0.05）；高压氧组与中医组超氧化物歧化酶（Superoxide dismutase，SOD）、总抗氧化能力（Total antioxidant capacity，T-AOC）高于高压氧组，中医组高于高压氧组（P<0.05）。治疗后，高压氧组与中医组NIHSS评分、中医症状评分低于治疗前，中医组低于高压氧组（P<0.05）；高压氧组与中医组BI指数高于治疗前，中医组高于高压氧组（P<0.05）。中医组短期预后情况优于高压氧组（P<0.05）。两组不良反应比较，差异无统计学意义（P>0.05）。

结论

活血通窍汤加减方联合高压氧疗法可减轻aSAH患者氧化应激损伤，改善神经功能和短期预后。

关键词

活血通窍汤加减方 / 高压氧 / 动脉瘤性蛛网膜下腔出血 / 氧化应激 / 预后

Abstract

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Objective

To observe the effect of Modified Huoxue Tongqiao Decoction (活血通窍汤加减方) combined with hyperbaric oxygen therapy on the clinical prognosis and peripheral blood levels of microRNA-193b-3p (miR-193b-3p) and hypoxia-inducible factor-1 α (HIF-1 α) in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods

Ninety-four patients with aSAH admitted from January 2022 to February 2024 were selected and divided into a hyperbaric oxygen group (47 cases) and a traditional Chinese medicine group (47 cases) using a lottery method. Both groups were treated with endovascular intervention or craniotomy clipping surgery. The hyperbaric oxygen group was treated with hyperbaric oxygen therapy after surgery, while the traditional Chinese medicine group was treated with Modified Huoxue Tongqiao Decoction on the basis of hyperbaric oxygen therapy. The thromboelastography parameters, relative expression levels of miR-193b-3p and miR-27a, HIF-1 α, oxidative stress markers, National Institutes of Health Stroke Scale (NIHSS) scores, traditional Chinese medicine symptom scores, Barthel (BI) index and short-term prognosis of two groups were compared.

Results

After treatment, the levels of maximal amplitude (MA) and coagulation index (CI) and alpha angle of the hyperbaric oxygen group and traditional Chinese medicine group were lower than those before treatment, and these indexes of the traditional Chinese medicine group were lower than those of hyperbaric oxygen group (P<0.05) . After treatment, the miR-193b-3p levels were lower in the hyperbaric oxygen group and traditional Chinese medicine group than those before treatment, and the level in the traditional Chinese medicine group was higher than that in the hyperbaric oxygen group (P<0.05). The relative expression of miR-27a was higher in the hyperbaric oxygen group and traditional Chinese medicine group than those before treatment and the expression in the traditional Chinese medicine group was higher than that in the hyperbaric oxygen group (P<0.05) . After treatment, the levels of HIF-1 αand malondialdehyde (MDA) in the hyperbaric oxygen group and traditional Chinese medicine group were lower than those before treatment, and the levels of the traditional Chinese medicine group were lower than those of the hyperbaric oxygen group (P<0.05). The levels of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) in the hyperbaric oxygen group and traditional Chinese medicine group were higher than those in the hyperbaric oxygen group, and the levels of the traditional Chinese medicine group were higher than those of the hyperbaric oxygen group (P<0.05) . After treatment, NIHSS scores and traditional Chinese medicine symptom scores of the hyperbaric oxygen group and traditional Chinese medicine group were lower than those before treatment, and the scores of the traditional Chinese medicine group were lower than those of the hyperbaric oxygen group (P<0.05) . BI indexes of the hyperbaric oxygen group and traditional Chinese medicine group were higher than those before treatment, and the index of the traditional Chinese medicine group was higher than that of the hyperbaric oxygen group (P<0.05). The short-term prognosis of the traditional Chinese medicine group was better than that of the hyperbaric oxygen group (P<0.05) . Comparison of adverse reactions between the two groups showed no difference (P>0.05) .

Conclusion

The combination of Modified Huoxue Tongqiao Decoction and hyperbaric oxygen therapy can alleviate the oxidative stress damage and improve the neurological function and short-term prognosis in patients with aSAH.

Key words

Modified Huoxue Tongqiao Decoction (活血通窍汤加减方) / hyperbaric oxygen / aneurysmal subarachnoid haemorrhage / oxidative stress / prognosis

引用本文

邢星, 郝烘玉, 褚红珊. 活血通窍汤加减方联合高压氧疗法对动脉瘤性蛛网膜下腔出血患者临床预后及外周血miR-193b-3p、HIF-1 α水平的影响. 中华中医药学刊, 2026 , 44 (5) : 221 -225 . DOI: 10.13193/j.issn.1673-7717.2026.05.040

Xing XING, Hongyu HAO, Hongshan CHU. Effect of Modified Huoxue Tongqiao Decoction (活血通窍汤加减方) Combined with Hyperbaric Oxygen Therapy on Clinical Prognosis and Peripheral Blood Levels of miR-193b-3p and HIF-1 αin Patients with aSAH[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (5) : 221 -225 . DOI: 10.13193/j.issn.1673-7717.2026.05.040

基金

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河北省卫生健康委员会医学科学研究项目(20241853)
河北省科学技术厅河北省脑网络与认知障碍疾病重点实验室项目(SZX2022006)

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罗泽鹏，罗忠平，邬娜，等．颅内动脉瘤夹闭术联合rHu-EPO、依达拉奉对动脉瘤性SAH患者氧化应激、神经损伤的影响［J］．临床和实验医学杂志，2023，22（2）：179-183.

2026年第44卷第5期

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doi: 10.13193/j.issn.1673-7717.2026.05.040

首发时间：2026-10-14
出版时间：2026-05-10

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河北省卫生健康委员会医学科学研究项目(20241853)

河北省科学技术厅河北省脑网络与认知障碍疾病重点实验室项目(SZX2022006)

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河北省人民医院，河北石家庄 050000

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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