Article(id=1317115087991718810, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954307792, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954307792, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954307792, creator=13701087609, updateTime=1791954307792, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=204, endPage=210, ext={EN=ArticleExt(id=1317115088251765659, articleId=1317115087991718810, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Progress of Rhubarb and its Drug Pair, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Rhubarb is one of the commonly used drugs in clinic, which is a good medicine for purging fire and laxative, cooling blood and detoxification. This paper summarizes the effective components of anthraquinones, anthrones, rhein, emodin and chrysophanol. In clinical application, rhubarb and its drug pairs have different mechanisms in the treatment of various diseases. It has pharmacological effects such as regulating gastrointestinal tract, anti-tumor, anti-fibrosis, anti-inflammation and anti-oxidation, involving Wnt1/β-catenin, AMPK/TXNIP/NLRP3, TLR4/NF-κB/c-myc and other signaling pathways. In clinical application, rhubarb is often combined with Danshen, Taoren, Huanglian, Huangqi, Mahuang, Fuzi and other drugs, which has a certain effect on chronic kidney disease, adenomyosis, diabetes, pneumonia and other diseases. According to the different processing methods, the pharmacological effects of rhubarb change with the content of anthraquinone glycosides and monomer tannins. Modern research shows that the chemical composition of rhubarb before and after compatibility has a significant change. When the ratio of rhubarb to Salvia miltiorrhiza, Gardenia jasminoides, Centella asiatica, and Astragalus is 1∶2, 1∶1, 1∶5, 1∶1, respectively, it can maximize the drug efficacy, reduce toxic and side effects, and improve the effectiveness and safety of medication. This article focuses on the pharmacological effects of rhubarb and its compatibility research in network pharmacology, clinical compatibility application, and chemical composition changes before and after compatibility, in order to provide reference for the further development and utilization of rhubarb and its drug pairs, in order to better play the clinical value of traditional Chinese medicine rhubarb.

, authors=Yunfei ZHENG^{1, 2}, Zeshan CHEN³, Xin DENG¹, authorsList=Yunfei ZHENG, Zeshan CHEN, Xin DENG, authorCompany=null, correspAuthors=Xin DENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115088478258076, articleId=1317115087991718810, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=大黄及其药对的研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

大黄是临床上常用药物之一，为泻火通便、凉血解毒的良药，含有蒽醌类、蒽酮类、大黄酸、大黄素及大黄酚等多种有效成分。在临床应用中，大黄及其药对在治疗各种疾病时有着不同机制，其具有调节胃肠道、抗肿瘤、抗纤维化、抗炎、抗氧化等药理作用，涉及分泌型糖蛋白1/β-连环蛋白（Wnt1/β-catenin）、腺苷单磷酸活化蛋白激酶/硫氧还蛋白互作蛋白/核苷酸结合寡聚化结构域样受体蛋白3（AMPK/TXNIP/NLRP3）、TOLL样受体4（Toll-like receptor 4，TLR4）/核因子-κB（Nuclear factor kappa-B，NF-κB）/MYC癌基因（c-myc）等信号通路。在临床应用方面，大黄常与丹参、桃仁、黄连、黄芪、麻黄、附子等药物进行配伍，对慢性肾病、子宫腺肌病、糖尿病、肺炎等疾病具有一定疗效。根据炮制的方式不同，大黄的药理作用随着蒽醌苷及单体鞣质含量的变化而发生改变。现代研究表明，大黄配伍前后的化学成分有着显著变化，当大黄与丹参、栀子、积雪草、黄芪比例分别为1∶2、1∶1、1∶5、1∶1时，能够最大程度上提高药物疗效，减少不良反应，提高用药的有效性、安全性。重点对大黄的药理作用及其药对在网络药理学中的配伍研究、临床配伍应用以及配伍前后化学成分变化进行总结归纳，以期为大黄及其药对进一步的开发利用提供参考，更好发挥中药大黄的临床价值。

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