Article(id=1317115281219113239, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.035, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954353860, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954353860, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954353860, creator=13701087609, updateTime=1791954353860, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=189, endPage=192, ext={EN=ArticleExt(id=1317115281428828440, articleId=1317115281219113239, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Spacetime-Medicine Theory Illustrates Non-alcoholic Fatty Liver Disease on Traditional Chinese Medicine, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

The pathology of non-alcoholic fatty liver disease (NAFLD) is a dynamic process characterized by temporal and spatial dimensions. In the temporal dimension, NAFLD begins with liver dysfunction due to blockage by phlegm-dampness, progressing over time to the generation of pathological products such as blood stasis and turbid toxins, ultimately resulting in liver deficiency. In the spatial dimension, NAFLD evolves from affecting the liver and spleen to involving the liver, spleen, and kidneys, and may eventually spread to other organs in the body. The“multiple strikes”theory of NAFLD pathogenesis aligns with the spatial and temporal integration observed in traditional Chinese medicine (TCM) . The“first strike”of obesity and insulin resistance corresponds to spleen deficiency, dampness, and mitochondrial dysfunction. The“second strike”involves oxidative stress, lipid peroxidation in hepatocytes, turbid toxins accumulation in the liver, and endoplasmic reticulum stress, leading to liver-kidney yin deficiency. This paper aims to use the spacetime-medicine theory as a guide to bridge TCMwith modern life science, elucidating the TCMperspective on NAFLD's pathologic mechanism.

, authors=Xinru SHEN¹, Chenyun MIAO¹, Dongcheng LI², Lin CHEN¹, Xiaobing DOU¹, authorsList=Xinru SHEN, Chenyun MIAO, Dongcheng LI, Lin CHEN, Xiaobing DOU, authorCompany=null, correspAuthors=Xiaobing DOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115281663709465, articleId=1317115281219113239, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=从中医时空医学理论探究非酒精性脂肪性肝病, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）的疾病进程是一个动态的过程，该过程具有有序性、循环性的时空医学特点。在时间维度上，NAFLD病机之始为痰湿阻滞所致的肝体失用，后期瘀血、浊毒等病理产物随时间推移逐渐产生，致使肝体虚损。在空间维度上，NAFLD经历了肝、脾→肝、脾、肾，最后有可能波及全身脏腑器官的病位演变。现代医学中，NAFLD发病机制的“多重打击”学说同样符合中医时空一体化：“第一次打击”——肥胖和胰岛素抵抗即为脾虚湿盛，线粒体功能障碍和肠道菌群紊乱为肝用失调；“第二次打击”——肝细胞发生氧化应激和脂质过氧化即为浊毒积聚于肝，肝细胞内质网应激即为肝肾阴虚。以时空医学理论为指导，将传统中医学与现代生命科学相联系，阐明其病理机制的中医内涵。

, authors=沈昕如¹, 缪晨韵¹, 李东成², 陈林¹, 窦晓兵¹, authorsList=沈昕如, 缪晨韵, 李东成, 陈林, 窦晓兵, authorCompany=null, correspAuthors=窦晓兵, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=41BWSjAFOgsOTtl3gpX4cw==, magXml=btBonsV8jXCjdBjABpdSMg==, pdfUrl=null, pdf=xPh65QiAxxLz2jdjzM/OFg==, pdfFileSize=1671205, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=U0r7R4PZjKx7M2YRUiEmbA==, mapNumber=null, fund=null)}, authors=[Author(id=1319630522070970989, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115281219113239, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630522150662767, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115281219113239, authorId=1319630522070970989, language=EN, stringName=Xinru SHEN, firstName=Xinru, middleName=null, lastName=SHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1. School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630522263908976, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115281219113239, authorId=1319630522070970989, language=CN, stringName=沈昕如, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．浙江中医药大学生命科学学院，浙江 杭州 310053, bio={"content":"

沈昕如（1999-），女，浙江杭州人，硕士在读，研究方向：中医药防治代谢性疾病。

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沈昕如（1999-），女，浙江杭州人，硕士在读，研究方向：中医药防治代谢性疾病。

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