Article(id=1317115045339841113, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954297622, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954297622, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954297622, creator=13701087609, updateTime=1791954297622, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=81, endPage=87, ext={EN=ArticleExt(id=1317115045557944922, articleId=1317115045339841113, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Correlation Analysis of Internal and External Quality of Nine Times Steamed and Processed Dihuang (Rehmanniae Radix) Based on Changes of Chroma and Viscosity and Study of Processing Endpoint, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the dynamic change of chroma and viscosity during the nine times steamed and processed Dihuang (Rehmanniae Radix) and the correlation with its intrinsic quality, and to explore the optimal processing end point by establishing a comprehensive quality index (QI), so as to provide reference for the quality control and processing end point judgment of Dihuang (Rehmanniae Radix).
Methods The chroma and viscosity of Dihuang (Rehmanniae Radix) samples were quantified objectively by thin layer imager, MATLAB and viscometer. The polysaccharide content was determined by ultraviolet spectrophotometry, and the contents of Rehmannium D, veronin, iso-veronin, motheronin and 5-hydroxymethylfurfural (5-HMF) were determined by high performance liquid chromatography (HPLC) . SPSS 26.0 and SIMCA software were used to conduct multivariate statistical analysis of the results, and the correlation and change rule of chroma, viscosity and their internal chemical composition were analyzed. Then, the QI of nine times steamed and processed Dihuang (Rehmanniae Radix) was established by triangle area method to predict the optimal processing end point.
Results During the process of steaming process of nine times steamed and processed Dihuang (Rehmanniae Radix), the color of the prepared product turned black and the viscosity increased. There were correlations between chroma and viscosity and different processing degrees, indicating that chroma and viscosity could be used as the evaluation indexes for processing end points. There was a correlation between the color of decoction pieces and the color of powder, and the first or second steaming may be the main stage of the color change of Dihuang (Rehmanniae Radix). The correlation between chroma, viscosity and intrinsic chemical composition can be established, and a better regression model can be established, and the change of chemical composition content in the processing process can be objectively predicted by measuring chroma value I and viscosity to a certain extent. The principal component analysis of intrinsic chemical composition showed that the first to fourth steaming may be the main stage of the change of chemical composition content of Dihuang (Rehmanniae Radix) . The quality index QI value was the highest when the seven-steaming system was used, which suggested that the seven-steaming system might be the best processing end point of Dihuang (Rehmanniae Radix) .
Conclusion The color and appearance of Dihuang (Rehmanniae Radix) can be quantified objectively based on chroma and viscosity, and the correlation between them and component content is analyzed and a regression model is established, which can objectively predict the changes of internal chemical component content in the processing of Dihuang (Rehmanniae Radix) to a certain extent. The establishment of comprehensive quality index QI can predict the optimal processing endpoint. It provided reference for the quality control and processing end point determination of Dihuang (Rehmanniae Radix) processing process.
, authors=Lanlan YU
1, 2, Yudie WEI
1, 2, Meng’en LI
1, 2, Hongmin YAN
1, 2, Tianchao CHEN
3, authorsList=Lanlan YU, Yudie WEI, Meng’en LI, Hongmin YAN, Tianchao CHEN, authorCompany=null, correspAuthors=Hongmin YAN, Tianchao CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115046065455707, articleId=1317115045339841113, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于色度与黏度变化的九蒸九制地黄内在质量的相关性分析及炮制终点研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 以九蒸九制地黄为研究对象，探究九蒸九制地黄炮制过程中色度、黏度的动态变化规律及与内在质量的相关性，并通过建立品质综合指数（QI）探究其最佳炮制终点，为九蒸九制地黄的质量控制和炮制终点判断提供参考。
方法 采用薄层成像仪及MATLAB、黏度计对九蒸九制地黄样品色度、黏度进行客观量化，紫外分光光度法测定多糖含量，HPLC法测定地黄苷D、毛蕊花糖苷、异毛蕊花糖苷、益母草苷、5-羟甲基糠醛（5-HMF）含量，运用SPSS 26.0、SIMCA软件对结果进行多元统计分析，分析色度、黏度与其内在化学成分的相关性及变化规律，再采用三角形面积法建立九蒸九制地黄的QI，以推测其最佳炮制终点。
结果 地黄九蒸九制过程中，炮制品颜色变黑，黏度升高；色度、黏度与不同炮制程度之间存在相关性，表明色度和黏度可作为炮制终点的评价指标；饮片色度与粉末色度之间存在相关性，一蒸或二蒸可能是地黄颜色变化的主要阶段；色度、黏度与内在化学成分之间存在相关性，可建立较好回归模型，并通过测定色度值I、黏度在一定程度上客观预测其炮制过程中化学成分的含量变化，内在化学成分的主成分分析表明，一蒸到四蒸可能是地黄化学成分含量变化的主要阶段；品质综合指数QI值七蒸七制时最大，推测七蒸七制可能为地黄最佳炮制终点。
结论 基于色度、黏度可实现九蒸九制地黄颜色与外观质地的客观量化，分析其与成分含量的相关性并建立回归模型，在一定程度上可客观预测其炮制过程中的内在化学成分含量变化，综合品质指数QI的建立可预测地黄九蒸九制的最佳炮制终点，为九蒸九制地黄炮制过程的质量控制和炮制终点判定提供参考。
, authors=于兰兰
1, 2, 位玉蝶
1, 2, 李蒙恩
1, 2, 闫红敏
1, 2, 陈天朝
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于兰兰（1991-），女，河南许昌人，主管药师，硕士，研究方向：中药炮制及中药新剂型。
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1. The Third People's Hospital of Henan Province, Zhengzhou 450007, Henan, China
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