Article(id=1317115099190506229, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954310462, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954310462, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954310462, creator=13701087609, updateTime=1791954310462, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=73, endPage=77, ext={EN=ArticleExt(id=1317115099383444214, articleId=1317115099190506229, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Jiawei Guipi Decoction (加味归脾合剂) on Immune Balance in Immune Thrombocytopenia Mice via JAK2/STAT3 Signaling Pathway, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the mechanism of Jiawei Guipi Decoction (加味归脾合剂) in regulating the Janus inases 2 (JAK2) /signal transducer and activator of transcription 3 (STAT3) signaling pathway to improve T helper cell 17 (Th17) /regulatory T cells (Treg) immune balance in primary immune thrombocytopenia (ITP) mice.
Methods Sixty female BALB/c mice were randomly assigned to six groups: normal group, model group, Jiawei Guipi Decoction low, medium and high dose groups, and prednisone group, with 10 mice in each group. Except for the normal group, the other five groups were administered intraperitoneal injection of MWReg30 antibody to establish the ITP model. After successful modeling, the corresponding treatments were administered. The blank control and model groups were given an equivalent volume of sterile drinking water by gavage, while the Jiawei Guipi Decoction low, medium and high dose groups received the administration with the corresponding doses［13.49, 26.99, 53.97 g/ (kg·d), respectively］. The prednisone group was administered prednisone 9.25 g/ (kg·d). The treatments lasted for 14 consecutive days, and after this period, the samples were collected. The effects of Jiawei Guipi Decoction on platelet count, splenic pathology, the number of Th17 and Treg cells in peripheral blood and spleen, the expression levels of interleukin (IL) -17, IL-21, IL-22, IL-10 in peripheral blood, and the protein expressions of p-JAK2, p-STAT3, retinoic acid receptor-related orphan receptor γt (RORγt) and forkhead transcription factor p3 (Foxp3) in the spleen were evaluated.
Result Compared with those in the normal group, the mice in the model group exhibited a significant decrease in peripheral blood platelet count, marked histopathological alterations in splenic tissue, a reduced number of Treg cells and an increased number of Th17 cells in both peripheral blood and spleen. Furthermore, the expression levels of splenic p-JAK2, p-STAT3 and RORγt protein were significantly up-regulated, accompanied by elevated concentrations of IL-17, IL-21 and IL-22, and a decreased level of IL-10 in peripheral blood (P<0.01) . Compared with the model group, all treatment groups significantly increased the peripheral blood platelet count, improved the pathological status of the spleen, markedly reduced the number of Th17 cells, and elevated the number of Treg cells in both peripheral blood and spleen, substantially decreased the levels of IL-17, IL-21 and IL-22 in peripheral blood and increased the level of IL-10 (P<0.05, P<0.01) . Among the treatment groups, the high-dose group showed superior efficacy compared to the low-dose, medium-dose as well as the prednisone groups (P<0.05) . Moreover, Jiawei Guipi Decoction significantly down-regulated the protein expression levels of splenic p-JAK2, p-STAT3 and RORγt (P<0.05, P<0.01), while up-regulated the protein expression of Foxp3 (P<0.05, P<0.01). The high dose group exhibited a more pronounced reduction in the protein expressions of p-JAK2, p-STAT3 and RORγt compared with the low dose group (P<0.05) .
Conclusion Jiawei Guipi Decoction exhibits significant therapeutic effects in ITP mice. The mechanism may involve the inhibition of the JAK2/STAT3 signaling pathway, regulation of RORγt and Foxp3 protein expression and modulation of the Th17/Treg balance.
, authors=Huajie TIAN, Hui YANG, Xiaoying HU, Weiying QU, Zhou FENG, Yingjia LU, Zhongdi HUANG, Pei CHEN, Lin ZHAO, Xiaoqin ZHU, authorsList=Huajie TIAN, Hui YANG, Xiaoying HU, Weiying QU, Zhou FENG, Yingjia LU, Zhongdi HUANG, Pei CHEN, Lin ZHAO, Xiaoqin ZHU, authorCompany=null, correspAuthors=Xiaoqin ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115101220549367, articleId=1317115099190506229, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=加味归脾合剂通过JAK2/STAT3信号通路对免疫性血小板减少症小鼠免疫平衡的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨加味归脾合剂调控Janus激酶2（Janus inases 2，JAK2）/信号传导及转录激活蛋白3（Signal transducer and activator of transcription 3，STAT3）信号通路，改善免疫性血小板减少症（Primary immune thrombocytopenia，ITP）小鼠辅助性T细胞17（T helper cell 17，Th17）/调节性T细胞（Regulatory T cells，Treg）免疫平衡的作用机制。
方法 BALB/c雌性小鼠60只，随机分为正常组，模型组，加味归脾合剂低、中、高剂量组及泼尼松组，每组10只。除正常组外，其余5组均采用腹腔注射MWReg30抗体的方法构建ITP小鼠模型。造模成功后分别给予相应的药物，加味归脾合剂低、中、高剂量分别按13.49、26.99、53.97 g/（kg·d）给小鼠灌胃，泼尼松组按9.25 g/（kg·d）给小鼠灌胃，正常组、模型组予等量无菌饮用水灌胃，14 d后取材。观察加味归脾合剂对ITP小鼠血小板计数，脾脏病理，外周血及脾脏Th17、Treg细胞数量，外周血白细胞介素（Interleukin，IL）-17、IL-21、IL-22、IL-10的表达及脾脏p-JAK2、p-STAT3、维A酸相关孤儿受体γt（Retinoic acid receptor-related orphan receptorγt，RORγt）、叉头转录因子（Forkhead transcription factor p3，Foxp3）蛋白表达的影响。
结果 与正常组比较，模型组小鼠外周血血小板计数明显降低，脾脏组织病理明显改变，外周血和脾脏Treg细胞数量降低、Th17细胞数量升高，脾脏p-JAK2、p-STAT3及RORγt蛋白表达显著升高，外周血IL-17、IL-21、IL-22含量显著升高，IL-10含量显著降低（P<0.01）。与模型组相比，各用药组可以明显升高ITP小鼠外周血血小板计数，改善脾脏病理状态，显著降低外周血和脾脏Th17细胞数量，升高外周血和脾Treg细胞数量，明显降低外周血IL-17、IL-21、IL-22的含量，升高IL-10的含量（P<0.05，P<0.01），且加味归合剂高剂量组优于低、中剂量组和泼尼松组（P<0.05）。此外，加味归脾合剂可以显著降低ITP模型小鼠脾脏p-JAK2、p-STAT3和RORγt蛋白表达水平（P<0.05，P<0.01），升高Foxp3蛋白表达水平（P<0.05，P<0.01），且高剂量组降低脾脏p-JAK2、p-STAT3和RORγt蛋白表达优于低剂量组（P<0.05）。
结论 加味归脾合剂治疗ITP小鼠疗效显著，其机制可能通过抑制JAK2/STAT3信号通路活化，调节RORγt和Foxp3蛋白表达水平，进而调控Th17/Treg平衡发挥作用。
, authors=田华捷, 杨辉, 胡晓莹, 瞿玮颖, 封舟, 陆颖佳, 黄中迪, 陈珮, 赵琳, 朱小勤, authorsList=田华捷, 杨辉, 胡晓莹, 瞿玮颖, 封舟, 陆颖佳, 黄中迪, 陈珮, 赵琳, 朱小勤, authorCompany=null, correspAuthors=朱小勤, authorNote=
田华捷（1990-），女，河南南阳人，主治医师，博士，研究方向：中医药治疗血液病。
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田华捷（1990-），女，河南南阳人，主治医师，博士，研究方向：中医药治疗血液病。
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田华捷（1990-），女，河南南阳人，主治医师，博士，研究方向：中医药治疗血液病。
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