Article(id=1317115128630326224, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.05.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954317481, onlineDateStr=2026-10-14, pubDate=1778342400000, pubDateStr=2026-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954317481, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954317481, creator=13701087609, updateTime=1791954317481, updator=13701087609, issue=Issue{id=1317115025307845060, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1778342400000', pubDateStr='2026-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954292847, creator='13701087609', updateTime=1791958713604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133567340171275, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133567340171276, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115025307845060, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=68, endPage=72, ext={EN=ArticleExt(id=1317115128861012945, articleId=1317115128630326224, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Therapeutic Effect and Its Mechanism of Acupuncture and Moxibustion Combined with Modified Shaoyao Gancao Decoction (加味芍药甘草汤) on Trigeminal Neuralgia with Syndrome of Wind-Cold Invading Superficies, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the efficacy and safety of acupuncture and moxibustion combined with Modified Shaoyao Gancao Decoction (加味芍药甘草汤) in the treatment of primary trigeminal neuralgia with syndrome of wind-cold invading superficies.
Methods A total of 96 patients with primary trigeminal neuralgia and syndrome of wind-cold invading superficies who visited Department Neurology of Sinopharm Tongmei General Hospital from Dec. 2020 to Nov. 2023 were included in the study and randomly divided into two groups using block randomization. Forty-eight patients in the observation group were treated with acupuncture and moxibustion combined with Modified Shaoyao Gancao Decoction, while 48 patients in the control group were treated with carbamazepine. The total effective rate, pain symptoms, Pittsburgh sleep quality index (PSQI), the improvements in pain-related neuropeptides (substance P and β-endorphin) and adverse events were compared between the two groups.
Results A total of 94 patients completed the trial, with one dropout in each group. The total effective rate in the observation group was 93.62% (44/47), which was significantly higher than 70.21% (33/47) in the control group (P<0.05) . After treatment, the frequency and duration of pain attacks and visual analogue scale (VAS) scores were significantly lower in the observation group (P<0.05), compared to those in the control group. The scores for all dimensions and the total PSQI score were also significantly lower in the observation group than those in the control group (P<0.05) . After treatment, the plasma concentration of substance P in the external jugular vein decreased more significantly in the observation group compared to that of the control group (P<0.05), while the plasma concentration of β-endorphin increased more significantly (P<0.05). The incidence of adverse reactions in the observation group was 2.1%, which was significantly lower than 14.6% in the control group (P<0.05). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.05) .
Conclusion Acupuncture and moxibustion combined with Modified Shaoyao Gancao Decoction for the treatment of primary trigeminal neuralgia with wind-cold invading syndrome exhibits high total effectiveness and low incidence of adverse reactions, and then effectively improves the symptoms such as pain and sleep quality.
, authors=Gaixia YAN
1, Ting XUE
1, Shuxia LIN
1, Zhenjun BAI
1, Meijun QIN
1, Lijuan SONG
2, Chunli FU
3, authorsList=Gaixia YAN, Ting XUE, Shuxia LIN, Zhenjun BAI, Meijun QIN, Lijuan SONG, Chunli FU, authorCompany=null, correspAuthors=Lijuan SONG, Chunli FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115129146225618, articleId=1317115128630326224, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=针灸联合加味芍药甘草汤治疗原发性三叉神经痛风寒袭表证的疗效及其机制研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探索针灸联合加味芍药甘草汤治疗原发性三叉神经痛（Trigeminal neuralgia，TN）风寒袭表证的疗效与安全性。
方法 选取2020年12月—2023年11月在国药同煤总医院神经内科就诊的原发性TN风寒袭表证患者96例，按照区组化随机的方法分成两组，观察组48例接受针灸与加味芍药甘草汤的联合治疗，对照组48例接受卡马西平治疗。比较两组总有效率、疼痛症状、匹兹堡睡眠质量指数、疼痛相关神经肽P物质（Substance P，SP）与β-内啡肽（β-endorphin，β-EP）的改善情况，以及不良事件。
结果 共94例患者完成试验，观察组与对照组均脱失1例，两组脱失率差异无统计学意义（P>0.05）。观察组总有效率为93.62%（44/47），显著高于对照组的70.21%（33/47）（P<0.05）。治疗后观察组疼痛发作频率、持续时间、疼痛视觉模拟评分（Visual analogue scale，VAS）均显著低于对照组（P<0.05）。治疗后观察组匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）各维度评分、PSQI总分均显著低于对照组（P<0.05）。与对照组比较，治疗后观察组颈外静脉血浆SP浓度显著下降（P<0.05），颈外静脉血浆β-EP浓度显著升高（P<0.05）。观察组不良反应发生率2.1%（1/47），显著低于对照组的14.6%（7/47）（P<0.05），差异有统计学意义（P<0.05）。
结论 针灸联合加味芍药甘草汤治疗原发性TN风寒袭表证具有总有效率高、不良反应发生率低的特点，并能有效改善患者的疼痛和睡眠质量等症状。
, authors=闫改霞
1, 薛婷
1, 林淑霞
1, 白振军
1, 秦美君
1, 宋丽娟
2, 付春丽
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闫改霞（1977-），女，山西应县人，讲师、副主任医师，硕士，研究方向：针药结合治疗神经系统疾病的临床疗效及机制。
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宋丽娟（1985-），女，山西平遥人，副教授，博士，研究方向：中西医结合防治脑病的基础和临床。E-mail：songlijuan@sxtcm,edu.cn。
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