Article(id=1317115193742705329, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.030, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954333005, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954333005, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954333005, creator=13701087609, updateTime=1791954333005, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=143, endPage=148, ext={EN=ArticleExt(id=1317115195185545907, articleId=1317115193742705329, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Quercetin, as an active ingredient in traditional Chinese medicine, shows remarkable potential in the treatment of acute myeloid leukemia(AML). Quercetin inhibits AML cell proliferation by regulating cell cycle proteins and indirectly regulates the cell cycle through heat shock proteins(HSP)and others. Quercetin induces apoptosis in AML cells by various mechanisms, such as regulating apoptotic protein expression, affecting mitochondrial function, inhibiting the phosphatidylin-ositol-3-kinase(PI3K)/protein kinase B(AKT)pathway and modulating the ERK and AMPK signaling pathways. Quercetin can affect AML through vascular endothelial growth factor(VEGF)expression.in AML cells, quercetin promotes cellular autophagy and affects autophagy key junctions and signaling pathways such as PI3K, hypoxia inducible factor-1 α(HIF-1 α)and mammalian target of rapamycin(mTOR), but exhibits a protective effect in MV4-11. Quercetin exerts antioxidant damage and affects oxidative stress in AML by regulating nuclear factor erythroid 2-related factor 2(Nrf2), nuclear factor kappa-B(NF-κB)and PI3K/AKT pathways. In addition, quercetin has epigenetic regulatory effects, inducing DNA demethylation, inhibiting HDAC activity and promoting histone H3 and H4 acetylation, thus inhibiting AML. This paper reviewed the therapeutic effects of quercetin on AML through multiple mechanisms, providing new strategies and directions for traditional Chinese medicine in the field of AML treatment.

, authors=Man ZHANG1, Qiuling MA1, 2, 3, 4, Mingxin LIU1, Jiayuan GUO1, Yajing SU1, Wenqing LIU1, Jue GUO1, Mingwei LI1, Bo WANG1, Wenbo DONG1, Dongdong LI2, Yi WU2, 3, 4, authorsList=Man ZHANG, Qiuling MA, Mingxin LIU, Jiayuan GUO, Yajing SU, Wenqing LIU, Jue GUO, Mingwei LI, Bo WANG, Wenbo DONG, Dongdong LI, Yi WU, authorCompany=null, correspAuthors=Qiuling MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115195458175668, articleId=1317115193742705329, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=槲皮素抗急性髓系白血病作用机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

槲皮素作为中药的有效成分,在治疗急性髓系白血病(acute myeloid leukemia,AML)中展现出显著潜力。槲皮素通过调控细胞周期蛋白抑制AML细胞增殖,并间接通过热休克蛋白(heat shock protein,HSP)等调控细胞周期。槲皮素诱导AML细胞凋亡的机制多样,如调节凋亡蛋白表达、影响线粒体功能、抑制磷脂酰肌醇3激酶(phosphatidylin-ositol-3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)通路,及调控细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)和腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路。槲皮素可以通过调控血管内皮生长因子(vascular endothelial growth factor,VEGF)表达影响AML。在AML细胞中,槲皮素促进细胞自噬,影响自噬关键结点及PI3K、缺氧诱导因子-1 α(hypoxia inducible factor-1 α,HIF-1 α)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)等信号通路,但在MV4-11中却表现出保护作用。槲皮素通过调节核因子NF-E2相关因子(nuclear factor erythroid 2-related factor 2,Nrf2)、胞核中核因子κB(nuclear factor κB,NF-κB)及PI3K/AKT通路,发挥抗氧化损伤作用,影响AML的氧化应激。此外,槲皮素还具有表观遗传调控作用,能诱导脱氧核糖核酸(deoxyribonucleic acid,DNA)去甲基化,抑制组蛋白去乙酰化酶(histone deacetylase,HDAC)活性,促进组蛋白H3和H4乙酰化,从而抑制AML。综述槲皮素通过多种机制对AML发挥治疗作用,为中医药在AML治疗领域提供了新的策略和方向。

, authors=张曼1, 马秋玲1, 2, 3, 4, 刘洺欣1, 郭家缘1, 苏雅静1, 刘文卿1, 郭珏1, 李明蔚1, 王博1, 董文博1, 李东东2, 吴艺2, 3, 4, authorsList=张曼, 马秋玲, 刘洺欣, 郭家缘, 苏雅静, 刘文卿, 郭珏, 李明蔚, 王博, 董文博, 李东东, 吴艺, authorCompany=null, correspAuthors=马秋玲, authorNote=

张曼(1998-),女,河南郑州人,硕士在读,研究方向:中西医结合防治血液病。

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马秋玲(1975-),女,河南郑州人,副教授,硕士研究生导师,博士,研究方向:中西医结合防治血液病临床、科研和教学。E-mail: 。
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Acute myeloid leukaemia[J]. Lancet, 2018, 392(10147): 593-606., articleTitle=null, refAbstract=null), Reference(id=1319630764241699514, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=XIA C F, DONG X S, LI H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J, 2022, 135(5): 584-590., articleTitle=null, refAbstract=null), Reference(id=1319630764363334331, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=SIEGEL R L, GIAQUINTO A N, JEMAL A. Cancer statistics, 2024[J]. CA A Cancer J Clinicians, 2024, 74(1): 12-49., articleTitle=null, refAbstract=null), Reference(id=1319630766003307196, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=GUERRA M, ALOUANI E, HUESO T, et al. Relevance, risks, and benefits of early-phases clinical trials participations for patients with hematological malignancies from 2008 to 2023 [J]. European J Haematology, 2025, 114(1): 89-97., articleTitle=null, refAbstract=null), Reference(id=1319630766078804669, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=LI Y, YAO J Y, HAN C Y, et al. Quercetin, inflammation and immunity[J]. Nutrients, 2016, 8(3): 167., articleTitle=null, refAbstract=null), Reference(id=1319630766200439486, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=甄英鹏,刘淑玲,孙茜.槲皮素通过SIRT1/FoxO3信号通路对柯萨奇B3病毒诱导的病毒性心肌炎小鼠的治疗作用及机制研究[J].病毒学报,2024,40(6):1307-1315., articleTitle=null, refAbstract=null), Reference(id=1319630766284325567, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=孔露娇,鲁华,王心,等.槲皮素对心肾综合征大鼠心肾功能的保护作用及机制[J].中国药房,2024,35(13):1612-1617., articleTitle=null, refAbstract=null), Reference(id=1319630766368211648, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=邓娜,高议雁,李佳瑞,等.楝酰胺对急性髓系白血病细胞线粒体功能的影响[J].天然产物研究与开发,2025,37(3):537-543., articleTitle=null, refAbstract=null), Reference(id=1319630766452097729, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=朱陆姣,王海波,姜宁祖,等.槲皮素对胃癌的抑制作用及免疫调节机理研究[J].西部中医药,2024,37(11):6-12., articleTitle=null, refAbstract=null), Reference(id=1319630766535983810, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=高博,李芳.槲皮素抗乳腺癌作用机制研究进展[J].中国中医药信息杂志,2024,31(6):193-196., articleTitle=null, refAbstract=null), Reference(id=1319630766611481283, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=王静芳,李珂,刘金海,等.天然抗氧化剂——槲皮素[J].化学与粘合,2024,46(6):611-615., articleTitle=null, refAbstract=null), Reference(id=1319630766691173060, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=林晓霞,朱莉,马静怡,等.槲皮素杜仲多糖纳米颗粒的表征、抗氧化及抗炎活性[J].食品工业科技,2025,46(15):126-134., articleTitle=null, refAbstract=null), Reference(id=1319630766754087621, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=李雪,李博,谈彬,等.槲皮素预处理ALI大鼠肺组织损伤、炎症/氧化应激反应、铁死亡及Nrf2/HO-1信号通路激活情况观察[J].山东医药,2024,64(15):13-18., articleTitle=null, refAbstract=null), Reference(id=1319630766825390790, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=耿嘉逸,王嫣然,王闯,等.槲皮素调控KCa3.1和NLRP3表达对大鼠PAH右心衰竭的保护作用[J].蚌埠医学院学报,2024,49(6):711-716., articleTitle=null, refAbstract=null), Reference(id=1319630766888305351, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=EASTHAML L, HOWARD C M, BALACHANDRAN P, et al. Eating green: shining light on the use of dietary phytochemicals as a modern approach in the prevention and treatment of head and neck cancers[J]. Curr Top Med Chem, 2018, 18(3): 182-191., articleTitle=null, refAbstract=null), Reference(id=1319630766972191432, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=CHOI J A, KIM J Y, LEE J Y, et al. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin[J]. Int J Oncol, 2001: 837-844., articleTitle=null, refAbstract=null), Reference(id=1319630767047688905, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=BENISTON R G, CAMPO MS. Quercetin elevates p27Kip1 and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 [J]. Oncogene, 2003, 22(35): 5504-5514., articleTitle=null, refAbstract=null), Reference(id=1319630767131574986, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=ONG C, TRAN E, NGUYEN T, et al. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions[J]. Oncol Rep, 2004, 2004: 727-733., articleTitle=null, refAbstract=null), Reference(id=1319630767236432587, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=李华洋,许婧,那辉,等.槲皮素通过STAT3信号通路抑制肺癌A549细胞迁移和侵袭[J].国际药学研究杂志,2017,44(3):262-266., articleTitle=null, refAbstract=null), Reference(id=1319630767320318668, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=殷雪琴,张夏炎,高雅茹,等.槲皮素对缺氧诱导的乳腺癌细胞增殖及干性的影响[J].中南药学,2019,17(11):1809-1813., articleTitle=null, refAbstract=null), Reference(id=1319630767395816141, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=HISAKA T, SAKAI H, SATO T, et al. Quercetin suppresses proliferation of liver cancer cell LinesIn vitro[J]. Anticancer Res, 2020, 40(8): 4695-4700., articleTitle=null, refAbstract=null), Reference(id=1319630767475507918, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=QIU D, YAN X X, XIAO X Q, et al. To explore immune synergistic function of Quercetin in inhibiting breast cancer cells[J]. Cancer Cell Int, 2021, 21(1): 632., articleTitle=null, refAbstract=null), Reference(id=1319630767551005391, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=马静,霍飞霞.基于PI3K/AKT信号通路研究槲皮素对宫颈癌细胞增殖和凋亡的影响[J].中国老年学杂志,2024,44(8):1957-1959., articleTitle=null, refAbstract=null), Reference(id=1319630767626502864, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=LAROCCA L M, TEOFILI L, SICA S, et al. Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells[J]. Blood, 1995, 85(12): 3654-3661., articleTitle=null, refAbstract=null), Reference(id=1319630767697806033, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=LAROCCA L M, TEOFILI L, MAGGIANO N, et al. Quercetin and the growth of leukemic progenitors[J]. Leuk Lymphoma, 1996, 23(1-2): 49-53., articleTitle=null, refAbstract=null), Reference(id=1319630767756526290, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=黄应桂,李岩松,康铁帮.槲皮素对HL-60细胞中c-myc和cyclin D1基因表达的影响[J].癌症,2000(8):832., articleTitle=null, refAbstract=null), Reference(id=1319630767823635155, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=CHANG J L, CHOW J M, CHANG J H, et al. Quercetin simultaneously induces G0/G1-phase arrest and Caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells: CHANG et al[J]. Environ Toxicol, 2017, 32(7): 1857-1868., articleTitle=null, refAbstract=null), Reference(id=1319630767894938324, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=LEE T J, KIMO H, KIMY H, et al. Quercetin arrests G2/Mphase and induces Caspase-dependent cell death in U937 cells [J]. Cancer Lett, 2006, 240(2): 234-242., articleTitle=null, refAbstract=null), Reference(id=1319630767966241493, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=王振振.槲皮素对白血病THP-1细胞株端粒结合蛋白TRF1、TRF2、POT1表达影响的初步探究[D].济南:山东中医药大学,2016., articleTitle=null, refAbstract=null), Reference(id=1319630768045933270, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=RONG Y, YANG E B, ZHANG K, et al. Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression.[J]. Anticancer research, 2000, 20(6B): 4339-4345., articleTitle=null, refAbstract=null), Reference(id=1319630768125625047, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN X, DONG X S, GAO H Y, et al. Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells[J]. Mol Med Rep, 2016, 13(1): 689-696., articleTitle=null, refAbstract=null), Reference(id=1319630768222094040, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=CALGAROTTO A K, MASO V, JUNIOR G C F, et al. Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells[J]. Sci Rep, 2018, 8: 3459., articleTitle=null, refAbstract=null), Reference(id=1319630768280814297, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG Y, CHEN L, TANG J M, et al. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt[J]. Mol Biol Rep, 2012, 39(7): 7785-7793., articleTitle=null, refAbstract=null), Reference(id=1319630768347923162, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=NIU G M, YIN S M, XIE S F, et al. Quercetin induces apoptosis by activating Caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells[J]. Acta Biochim Biophys Sin, 2011, 43(1): 30-37., articleTitle=null, refAbstract=null), Reference(id=1319630768419226331, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=SENG T. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells[J]. Oncol Rep, 2011, 25(2): 583., articleTitle=null, refAbstract=null), Reference(id=1319630768490529500, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=CHENG S P, GAO N, ZHANG Z, et al. Quercetin induces tumor-selective apoptosis through downregulation of mcl-1 and activation of bax[J]. Clin Cancer Res, 2010, 16(23): 5679-5691., articleTitle=null, refAbstract=null), Reference(id=1319630768570221277, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=SPAGNUOLO C, CERELLA C, RUSSO M, et al. Quercetin down-regulates Mcl-1 by acting on mRNA stability and protein degradation[J]. Br J Cancer, 2011, 105(2): 221-230., articleTitle=null, refAbstract=null), Reference(id=1319630768628941534, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=DE BLAS E, ESTAÑM C, DEL CARMEN GÓMEZ DE FRUTOS M, et al. Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities[J]. Cancer Cell Int, 2016, 16(1): 70., articleTitle=null, refAbstract=null), Reference(id=1319630768700244703, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=SHI H, LI X Y, CHEN Y, et al. Quercetin induces apoptosis via downregulation of vascular endothelial growth factor/akt signaling pathway in acute myeloid leukemia cells[J]. Frontiers in Pharmacology, 2020, 11: 534171., articleTitle=null, refAbstract=null), Reference(id=1319630768767353568, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=周云龙,林智敏,易小玉,等. PI3K/Akt信号通路调控急性髓系白血病机制及中医药治疗研究进展[J].中国现代医学杂志,2024,34(13):63-70., articleTitle=null, refAbstract=null), Reference(id=1319630768842851041, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=RAMOS A M, ALLER P. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines[J]. Biochem Pharmacol, 2008, 75(10): 1912-1923., articleTitle=null, refAbstract=null), Reference(id=1319630768922542818, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=沈明月,吴晓龙,崔思远,等.基于线粒体动力学探讨三氧化二砷联合槲皮素诱导人急性髓系白血病Kasumi-1细胞凋亡的作用机制[J].中华中医药杂志,2019,34(12):5637-5641., articleTitle=null, refAbstract=null), Reference(id=1319630770596070115, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=LEE W J, HSIAO M, CHANG J L, et al. Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft[J]. Arch Toxicol, 2015, 89(7): 1103-1117., articleTitle=null, refAbstract=null), Reference(id=1319630770658984676, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=GERMANO C A, CLEMENTE G, STORNIOLO A, et al.mTORC1/ERK1/2 interplay regulates protein synthesis and survival in acute myeloid leukemia cell lines[J]. Biology, 2023, 12(5): 676., articleTitle=null, refAbstract=null), Reference(id=1319630770721899237, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=肖洁,尹松梅,谢双锋,等.槲皮素调控AMPK活性诱导HL-60细胞自噬与凋亡[J].中山大学学报(医学科学版),2018,39(4):501-509., articleTitle=null, refAbstract=null), Reference(id=1319630770809979622, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=宦瑞华.槲皮素调控细胞能量代谢杀伤急性髓系白血病细胞的实验研究[D].呼和浩特:内蒙古医科大学,2022., articleTitle=null, refAbstract=null), Reference(id=1319630770885477095, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=null, journalName=null, refType=null, unstructuredReference=肖洁,牛国敏,尹松梅,等.槲皮素抑制HL-60细胞增殖与诱导凋亡机制探讨[J].中华肿瘤防治杂志,2014,21(21):1685-1690., articleTitle=null, refAbstract=null), Reference(id=1319630770965168872, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=null, journalName=null, refType=null, unstructuredReference=DIAS S, HATTORI K, HEISSIG B, et al. Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias[J]. Proc Natl Acad Sci U S A, 2001, 98(19): 10857-10862., articleTitle=null, refAbstract=null), Reference(id=1319630771049054953, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=null, journalName=null, refType=null, unstructuredReference=JAYSON G C, KERBEL R, ELLIS L M, et al. Antiangiogenic therapy in oncology: current status and future directions[J]. Lancet, 2016, 388(10043): 518-529., articleTitle=null, refAbstract=null), Reference(id=1319630771120358122, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=null, journalName=null, refType=null, unstructuredReference=PAPAEMMANUIL E, GERSTUNG M, BULLINGER L, et al. Genomic classification and prognosis in acute myeloid leukemia[J]. N Engl J Med, 2016, 374(23): 2209-2221., articleTitle=null, refAbstract=null), Reference(id=1319630771200049899, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=null, journalName=null, refType=null, unstructuredReference=何璇,彭文希.培门冬酶联合VDCP方案治疗急性淋巴细胞白血病的效果及其对外周血sFas、VEGF等的影响[J].临床和实验医学杂志,2024,23(1):20-24., articleTitle=null, refAbstract=null), Reference(id=1319630771271353068, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=null, journalName=null, refType=null, unstructuredReference=KAMPEN K R, TER ELST A, DE BONT ESJM. Vascular endothelial growth factor signaling in acute myeloid leukemia[J]. Cell Mol Life Sci, 2013, 70(8): 1307-1317., articleTitle=null, refAbstract=null), Reference(id=1319630771338461933, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=null, journalName=null, refType=null, unstructuredReference=何昊,郑克春,周友根,等.血清sICAM-1、VEGF、sFsa水平在急性白血病中的变化及临床价值[J].国际检验医学杂志,2024,45(12):1487-1490., articleTitle=null, refAbstract=null), Reference(id=1319630771397182190, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=null, journalName=null, refType=null, unstructuredReference=张岱,梅书豪,尹振东.“干白沙”方案对急性髓系白血病患者血管内皮生长因子、白细胞介素-6及肿瘤坏死因子-α水平的影响[J].癌症进展,2023,21(18):2066-2068., articleTitle=null, refAbstract=null), Reference(id=1319630771468485359, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=null, journalName=null, refType=null, unstructuredReference=王晨,钟璐,陈芳源,等.槲皮素对HL-60细胞形态及血管内皮生长因子表达的影响[J].诊断学理论与实践,2004(6):36-38., articleTitle=null, refAbstract=null), Reference(id=1319630771539788528, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[56], rfOrder=55, authorNames=null, journalName=null, refType=null, unstructuredReference=徐新荣,于海涛,李敏,等.槲皮素磷脂复合物固体分散体增强对氧化损伤小鼠视网膜的保护作用[J].中华中医药学刊,2018,36(4):775-778., articleTitle=null, refAbstract=null), Reference(id=1319630771627868913, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=null, journalName=null, refType=null, unstructuredReference=钟璐,陈芳源,王海嵘,等.槲皮素对K562细胞生长及血管内皮生长因子分泌的影响[J].白血病·淋巴瘤,2006(3):161-163., articleTitle=null, refAbstract=null), Reference(id=1319630771707560690, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=null, journalName=null, refType=null, unstructuredReference=钟璐,陈芳源,王海嵘,等.槲皮素在体外对NB4细胞形态及VEGF分泌的影响[J].中华肿瘤杂志,2006(1):25-27., articleTitle=null, refAbstract=null), Reference(id=1319630771783058163, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=null, journalName=null, refType=null, unstructuredReference=石欢.槲皮素介导VEGF/AKT通路诱导急性髓系白血病细胞凋亡的机制研究[D].南宁:广西医科大学,2020., articleTitle=null, refAbstract=null), Reference(id=1319630771854361332, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=null, journalName=null, refType=null, unstructuredReference=HOWITZ K T, BITTERMAN K J, COHEN H Y, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan[J]. Nature, 2003, 425(6954): 191-196., articleTitle=null, refAbstract=null), Reference(id=1319630771929858805, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[61], rfOrder=60, authorNames=null, journalName=null, refType=null, unstructuredReference=MERTENS-TALCOTT S U, BOMSER J A, ROMERO C, et al. Ellagic acid potentiates the effect of quercetin on p21 waf1/cip1, p53, and map-Kinases without affecting intracellular generation of reactive oxygen species in vitro[J]. J Nutr, 2005, 135(3): 609-614., articleTitle=null, refAbstract=null), Reference(id=1319630771988579062, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[62], rfOrder=61, authorNames=null, journalName=null, refType=null, unstructuredReference=李云飞,庞利君,束龙武,等.芪黄健脾滋肾颗粒可改善小鼠系统性红斑狼疮血小板减少:基于Ca2+/CaMK2/AMPK/mTOR信号通路介导的自噬[J].南方医科大学学报,2024,44(12):2327-2334., articleTitle=null, refAbstract=null), Reference(id=1319630772055687927, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[63], rfOrder=62, authorNames=null, journalName=null, refType=null, unstructuredReference=NGUYEN T T T. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells[J]. Carcinogenesis, 2003, 25(5): 647-659., articleTitle=null, refAbstract=null), Reference(id=1319630772122796792, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[64], rfOrder=63, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG K, LIU R, LI J Y, et al. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR-and hypoxia-induced factor 1 α-mediated signaling [J]. Autophagy, 2011, 7(9): 966-978., articleTitle=null, refAbstract=null), Reference(id=1319630772194099961, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[65], rfOrder=64, authorNames=null, journalName=null, refType=null, unstructuredReference=KLAPPAN A K, HONES S, MYLONAS I, et al. Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity[J]. Histochem Cell Biol, 2012, 137(1): 25-36., articleTitle=null, refAbstract=null), Reference(id=1319630772273791738, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[66], rfOrder=65, authorNames=null, journalName=null, refType=null, unstructuredReference=XIAO J, ZHANG B, YIN S M, et al. Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway[J]. Acta Biochim Biophys Sin, 2022: 1244-1256., articleTitle=null, refAbstract=null), Reference(id=1319630772340900603, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[67], rfOrder=66, authorNames=null, journalName=null, refType=null, unstructuredReference=BOOTS A W, HAENEN G R MM, BAST A. Health effects of quercetin: From antioxidant to nutraceutical [J]. Eur J Pharmacol, 2008, 585(2-3): 325-337., articleTitle=null, refAbstract=null), Reference(id=1319630772416398076, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[68], rfOrder=67, authorNames=null, journalName=null, refType=null, unstructuredReference=李怡,陈其章,范临夏,等.槲皮素协同影响DNA修复和ROS水平提高NSCLC细胞的放疗敏感性[J].中药药理与临床,2023,39(11):62-67., articleTitle=null, refAbstract=null), Reference(id=1319630772491895549, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[69], rfOrder=68, authorNames=null, journalName=null, refType=null, unstructuredReference=陈秀楠,王瑞琦,单红英,等.槲皮素通过抑制p38 MAPK/NOX4信号通路减轻H2O2诱导的人子宫内膜基质细胞氧化应激损伤[J].四川大学学报(医学版),2024,55(3):552-558., articleTitle=null, refAbstract=null), Reference(id=1319630772554810110, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115193742705329, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[70], rfOrder=69, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG M, SWARTS S G, YIN L J, et al. 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槲皮素抗急性髓系白血病作用机制研究进展
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张曼 1 , 马秋玲 1, 2, 3, 4 , 刘洺欣 1 , 郭家缘 1 , 苏雅静 1 , 刘文卿 1 , 郭珏 1 , 李明蔚 1 , 王博 1 , 董文博 1 , 李东东 2 , 吴艺 2, 3, 4
中华中医药学刊 | 国家项目点击 2026,44(4): 143-148
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中华中医药学刊 |国家项目点击 2026 , 44 (4) : 143 -148
槲皮素抗急性髓系白血病作用机制研究进展
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张曼(1998-),女,河南郑州人,硕士在读,研究方向:中西医结合防治血液病。

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3.Institute of Hematology, Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan, China
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3.河南中医药大学血液病研究所,河南 郑州 450002
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3.河南中医药大学血液病研究所,河南 郑州 450002
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张曼1, 马秋玲1, 2, 3, 4 , 刘洺欣1, 郭家缘1, 苏雅静1, 刘文卿1, 郭珏1, 李明蔚1, 王博1, 董文博1, 李东东2, 吴艺2, 3, 4
作者信息
  • 1.河南中医药大学第二临床医学院,河南 郑州 450002
  • 2.河南省中医院,河南中医药大学第二附属医院,河南 郑州 450002
  • 3.河南中医药大学血液病研究所,河南 郑州 450002
  • 4.河南省中西医结合防治血液病工程研究中心,河南 郑州 450002
通讯作者:
马秋玲(1975-),女,河南郑州人,副教授,硕士研究生导师,博士,研究方向:中西医结合防治血液病临床、科研和教学。E-mail: 。
作者简介:

张曼(1998-),女,河南郑州人,硕士在读,研究方向:中西医结合防治血液病。

Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia
Man ZHANG1, Qiuling MA1, 2, 3, 4 , Mingxin LIU1, Jiayuan GUO1, Yajing SU1, Wenqing LIU1, Jue GUO1, Mingwei LI1, Bo WANG1, Wenbo DONG1, Dongdong LI2, Yi WU2, 3, 4
Affiliations
  • 1.The Second Clinical College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
  • 2.Henan Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
  • 3.Institute of Hematology, Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan, China
  • 4.Henan Engineering Research Center of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Blood Diseases, Zhengzhou 450002, Henan, China
出版时间: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.030
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槲皮素作为中药的有效成分,在治疗急性髓系白血病(acute myeloid leukemia,AML)中展现出显著潜力。槲皮素通过调控细胞周期蛋白抑制AML细胞增殖,并间接通过热休克蛋白(heat shock protein,HSP)等调控细胞周期。槲皮素诱导AML细胞凋亡的机制多样,如调节凋亡蛋白表达、影响线粒体功能、抑制磷脂酰肌醇3激酶(phosphatidylin-ositol-3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)通路,及调控细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)和腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路。槲皮素可以通过调控血管内皮生长因子(vascular endothelial growth factor,VEGF)表达影响AML。在AML细胞中,槲皮素促进细胞自噬,影响自噬关键结点及PI3K、缺氧诱导因子-1 α(hypoxia inducible factor-1 α,HIF-1 α)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)等信号通路,但在MV4-11中却表现出保护作用。槲皮素通过调节核因子NF-E2相关因子(nuclear factor erythroid 2-related factor 2,Nrf2)、胞核中核因子κB(nuclear factor κB,NF-κB)及PI3K/AKT通路,发挥抗氧化损伤作用,影响AML的氧化应激。此外,槲皮素还具有表观遗传调控作用,能诱导脱氧核糖核酸(deoxyribonucleic acid,DNA)去甲基化,抑制组蛋白去乙酰化酶(histone deacetylase,HDAC)活性,促进组蛋白H3和H4乙酰化,从而抑制AML。综述槲皮素通过多种机制对AML发挥治疗作用,为中医药在AML治疗领域提供了新的策略和方向。

急性髓系白血病  /  槲皮素  /  研究进展

Quercetin, as an active ingredient in traditional Chinese medicine, shows remarkable potential in the treatment of acute myeloid leukemia(AML). Quercetin inhibits AML cell proliferation by regulating cell cycle proteins and indirectly regulates the cell cycle through heat shock proteins(HSP)and others. Quercetin induces apoptosis in AML cells by various mechanisms, such as regulating apoptotic protein expression, affecting mitochondrial function, inhibiting the phosphatidylin-ositol-3-kinase(PI3K)/protein kinase B(AKT)pathway and modulating the ERK and AMPK signaling pathways. Quercetin can affect AML through vascular endothelial growth factor(VEGF)expression.in AML cells, quercetin promotes cellular autophagy and affects autophagy key junctions and signaling pathways such as PI3K, hypoxia inducible factor-1 α(HIF-1 α)and mammalian target of rapamycin(mTOR), but exhibits a protective effect in MV4-11. Quercetin exerts antioxidant damage and affects oxidative stress in AML by regulating nuclear factor erythroid 2-related factor 2(Nrf2), nuclear factor kappa-B(NF-κB)and PI3K/AKT pathways. In addition, quercetin has epigenetic regulatory effects, inducing DNA demethylation, inhibiting HDAC activity and promoting histone H3 and H4 acetylation, thus inhibiting AML. This paper reviewed the therapeutic effects of quercetin on AML through multiple mechanisms, providing new strategies and directions for traditional Chinese medicine in the field of AML treatment.

acute myeloid leukemia  /  quercetin  /  research progress
张曼, 马秋玲, 刘洺欣, 郭家缘, 苏雅静, 刘文卿, 郭珏, 李明蔚, 王博, 董文博, 李东东, 吴艺. 槲皮素抗急性髓系白血病作用机制研究进展. 中华中医药学刊, 2026 , 44 (4) : 143 -148 . DOI: 10.13193/j.issn.1673-7717.2026.04.030
Man ZHANG, Qiuling MA, Mingxin LIU, Jiayuan GUO, Yajing SU, Wenqing LIU, Jue GUO, Mingwei LI, Bo WANG, Wenbo DONG, Dongdong LI, Yi WU. Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 143 -148 . DOI: 10.13193/j.issn.1673-7717.2026.04.030
  • 国家自然科学基金青年科学基金项目(82204981)
  • 河南省中医药科学研究专项(2024ZY1010; 2022ZY1056)
参考文献 引证文献
排序方式:
[1]
SHORT N J, RYTTING ME, CORTES J E. Acute myeloid leukaemia[J]. Lancet, 2018, 392(10147): 593-606.
[2]
XIA C F, DONG X S, LI H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J, 2022, 135(5): 584-590.
[3]
SIEGEL R L, GIAQUINTO A N, JEMAL A. Cancer statistics, 2024[J]. CA A Cancer J Clinicians, 2024, 74(1): 12-49.
[4]
GUERRA M, ALOUANI E, HUESO T, et al. Relevance, risks, and benefits of early-phases clinical trials participations for patients with hematological malignancies from 2008 to 2023 [J]. European J Haematology, 2025, 114(1): 89-97.
[5]
LI Y, YAO J Y, HAN C Y, et al. Quercetin, inflammation and immunity[J]. Nutrients, 2016, 8(3): 167.
[6]
甄英鹏,刘淑玲,孙茜.槲皮素通过SIRT1/FoxO3信号通路对柯萨奇B3病毒诱导的病毒性心肌炎小鼠的治疗作用及机制研究[J].病毒学报,2024,40(6):1307-1315.
[7]
孔露娇,鲁华,王心,等.槲皮素对心肾综合征大鼠心肾功能的保护作用及机制[J].中国药房,2024,35(13):1612-1617.
[8]
邓娜,高议雁,李佳瑞,等.楝酰胺对急性髓系白血病细胞线粒体功能的影响[J].天然产物研究与开发,2025,37(3):537-543.
[9]
朱陆姣,王海波,姜宁祖,等.槲皮素对胃癌的抑制作用及免疫调节机理研究[J].西部中医药,2024,37(11):6-12.
[10]
高博,李芳.槲皮素抗乳腺癌作用机制研究进展[J].中国中医药信息杂志,2024,31(6):193-196.
[11]
王静芳,李珂,刘金海,等.天然抗氧化剂——槲皮素[J].化学与粘合,2024,46(6):611-615.
[12]
林晓霞,朱莉,马静怡,等.槲皮素杜仲多糖纳米颗粒的表征、抗氧化及抗炎活性[J].食品工业科技,2025,46(15):126-134.
[13]
李雪,李博,谈彬,等.槲皮素预处理ALI大鼠肺组织损伤、炎症/氧化应激反应、铁死亡及Nrf2/HO-1信号通路激活情况观察[J].山东医药,2024,64(15):13-18.
[14]
耿嘉逸,王嫣然,王闯,等.槲皮素调控KCa3.1和NLRP3表达对大鼠PAH右心衰竭的保护作用[J].蚌埠医学院学报,2024,49(6):711-716.
[15]
EASTHAML L, HOWARD C M, BALACHANDRAN P, et al. Eating green: shining light on the use of dietary phytochemicals as a modern approach in the prevention and treatment of head and neck cancers[J]. Curr Top Med Chem, 2018, 18(3): 182-191.
[16]
CHOI J A, KIM J Y, LEE J Y, et al. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin[J]. Int J Oncol, 2001: 837-844.
[17]
BENISTON R G, CAMPO MS. Quercetin elevates p27Kip1 and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 [J]. Oncogene, 2003, 22(35): 5504-5514.
[18]
ONG C, TRAN E, NGUYEN T, et al. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions[J]. Oncol Rep, 2004, 2004: 727-733.
[19]
李华洋,许婧,那辉,等.槲皮素通过STAT3信号通路抑制肺癌A549细胞迁移和侵袭[J].国际药学研究杂志,2017,44(3):262-266.
[20]
殷雪琴,张夏炎,高雅茹,等.槲皮素对缺氧诱导的乳腺癌细胞增殖及干性的影响[J].中南药学,2019,17(11):1809-1813.
[21]
HISAKA T, SAKAI H, SATO T, et al. Quercetin suppresses proliferation of liver cancer cell LinesIn vitro[J]. Anticancer Res, 2020, 40(8): 4695-4700.
[22]
QIU D, YAN X X, XIAO X Q, et al. To explore immune synergistic function of Quercetin in inhibiting breast cancer cells[J]. Cancer Cell Int, 2021, 21(1): 632.
[23]
马静,霍飞霞.基于PI3K/AKT信号通路研究槲皮素对宫颈癌细胞增殖和凋亡的影响[J].中国老年学杂志,2024,44(8):1957-1959.
[24]
LAROCCA L M, TEOFILI L, SICA S, et al. Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells[J]. Blood, 1995, 85(12): 3654-3661.
[25]
LAROCCA L M, TEOFILI L, MAGGIANO N, et al. Quercetin and the growth of leukemic progenitors[J]. Leuk Lymphoma, 1996, 23(1-2): 49-53.
[26]
黄应桂,李岩松,康铁帮.槲皮素对HL-60细胞中c-myc和cyclin D1基因表达的影响[J].癌症,2000(8):832.
[27]
CHANG J L, CHOW J M, CHANG J H, et al. Quercetin simultaneously induces G0/G1-phase arrest and Caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells: CHANG et al[J]. Environ Toxicol, 2017, 32(7): 1857-1868.
[28]
LEE T J, KIMO H, KIMY H, et al. Quercetin arrests G2/Mphase and induces Caspase-dependent cell death in U937 cells [J]. Cancer Lett, 2006, 240(2): 234-242.
[29]
王振振.槲皮素对白血病THP-1细胞株端粒结合蛋白TRF1、TRF2、POT1表达影响的初步探究[D].济南:山东中医药大学,2016.
[30]
RONG Y, YANG E B, ZHANG K, et al. Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression.[J]. Anticancer research, 2000, 20(6B): 4339-4345.
[31]
CHEN X, DONG X S, GAO H Y, et al. Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells[J]. Mol Med Rep, 2016, 13(1): 689-696.
[32]
CALGAROTTO A K, MASO V, JUNIOR G C F, et al. Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells[J]. Sci Rep, 2018, 8: 3459.
[33]
ZHANG Y, CHEN L, TANG J M, et al. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt[J]. Mol Biol Rep, 2012, 39(7): 7785-7793.
[34]
NIU G M, YIN S M, XIE S F, et al. Quercetin induces apoptosis by activating Caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells[J]. Acta Biochim Biophys Sin, 2011, 43(1): 30-37.
[35]
SENG T. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells[J]. Oncol Rep, 2011, 25(2): 583.
[36]
CHENG S P, GAO N, ZHANG Z, et al. Quercetin induces tumor-selective apoptosis through downregulation of mcl-1 and activation of bax[J]. Clin Cancer Res, 2010, 16(23): 5679-5691.
[37]
SPAGNUOLO C, CERELLA C, RUSSO M, et al. Quercetin down-regulates Mcl-1 by acting on mRNA stability and protein degradation[J]. Br J Cancer, 2011, 105(2): 221-230.
[38]
DE BLAS E, ESTAÑM C, DEL CARMEN GÓMEZ DE FRUTOS M, et al. Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities[J]. Cancer Cell Int, 2016, 16(1): 70.
[39]
SHI H, LI X Y, CHEN Y, et al. Quercetin induces apoptosis via downregulation of vascular endothelial growth factor/akt signaling pathway in acute myeloid leukemia cells[J]. Frontiers in Pharmacology, 2020, 11: 534171.
[40]
周云龙,林智敏,易小玉,等. PI3K/Akt信号通路调控急性髓系白血病机制及中医药治疗研究进展[J].中国现代医学杂志,2024,34(13):63-70.
[41]
RAMOS A M, ALLER P. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines[J]. Biochem Pharmacol, 2008, 75(10): 1912-1923.
[42]
沈明月,吴晓龙,崔思远,等.基于线粒体动力学探讨三氧化二砷联合槲皮素诱导人急性髓系白血病Kasumi-1细胞凋亡的作用机制[J].中华中医药杂志,2019,34(12):5637-5641.
[43]
LEE W J, HSIAO M, CHANG J L, et al. Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft[J]. Arch Toxicol, 2015, 89(7): 1103-1117.
[44]
GERMANO C A, CLEMENTE G, STORNIOLO A, et al.mTORC1/ERK1/2 interplay regulates protein synthesis and survival in acute myeloid leukemia cell lines[J]. Biology, 2023, 12(5): 676.
[45]
肖洁,尹松梅,谢双锋,等.槲皮素调控AMPK活性诱导HL-60细胞自噬与凋亡[J].中山大学学报(医学科学版),2018,39(4):501-509.
[46]
宦瑞华.槲皮素调控细胞能量代谢杀伤急性髓系白血病细胞的实验研究[D].呼和浩特:内蒙古医科大学,2022.
[47]
肖洁,牛国敏,尹松梅,等.槲皮素抑制HL-60细胞增殖与诱导凋亡机制探讨[J].中华肿瘤防治杂志,2014,21(21):1685-1690.
[48]
DIAS S, HATTORI K, HEISSIG B, et al. Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias[J]. Proc Natl Acad Sci U S A, 2001, 98(19): 10857-10862.
[49]
JAYSON G C, KERBEL R, ELLIS L M, et al. Antiangiogenic therapy in oncology: current status and future directions[J]. Lancet, 2016, 388(10043): 518-529.
[50]
PAPAEMMANUIL E, GERSTUNG M, BULLINGER L, et al. Genomic classification and prognosis in acute myeloid leukemia[J]. N Engl J Med, 2016, 374(23): 2209-2221.
[51]
何璇,彭文希.培门冬酶联合VDCP方案治疗急性淋巴细胞白血病的效果及其对外周血sFas、VEGF等的影响[J].临床和实验医学杂志,2024,23(1):20-24.
[52]
KAMPEN K R, TER ELST A, DE BONT ESJM. Vascular endothelial growth factor signaling in acute myeloid leukemia[J]. Cell Mol Life Sci, 2013, 70(8): 1307-1317.
[53]
何昊,郑克春,周友根,等.血清sICAM-1、VEGF、sFsa水平在急性白血病中的变化及临床价值[J].国际检验医学杂志,2024,45(12):1487-1490.
[54]
张岱,梅书豪,尹振东.“干白沙”方案对急性髓系白血病患者血管内皮生长因子、白细胞介素-6及肿瘤坏死因子-α水平的影响[J].癌症进展,2023,21(18):2066-2068.
[55]
王晨,钟璐,陈芳源,等.槲皮素对HL-60细胞形态及血管内皮生长因子表达的影响[J].诊断学理论与实践,2004(6):36-38.
[56]
徐新荣,于海涛,李敏,等.槲皮素磷脂复合物固体分散体增强对氧化损伤小鼠视网膜的保护作用[J].中华中医药学刊,2018,36(4):775-778.
[57]
钟璐,陈芳源,王海嵘,等.槲皮素对K562细胞生长及血管内皮生长因子分泌的影响[J].白血病·淋巴瘤,2006(3):161-163.
[58]
钟璐,陈芳源,王海嵘,等.槲皮素在体外对NB4细胞形态及VEGF分泌的影响[J].中华肿瘤杂志,2006(1):25-27.
[59]
石欢.槲皮素介导VEGF/AKT通路诱导急性髓系白血病细胞凋亡的机制研究[D].南宁:广西医科大学,2020.
[60]
HOWITZ K T, BITTERMAN K J, COHEN H Y, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan[J]. Nature, 2003, 425(6954): 191-196.
[61]
MERTENS-TALCOTT S U, BOMSER J A, ROMERO C, et al. Ellagic acid potentiates the effect of quercetin on p21 waf1/cip1, p53, and map-Kinases without affecting intracellular generation of reactive oxygen species in vitro[J]. J Nutr, 2005, 135(3): 609-614.
[62]
李云飞,庞利君,束龙武,等.芪黄健脾滋肾颗粒可改善小鼠系统性红斑狼疮血小板减少:基于Ca2+/CaMK2/AMPK/mTOR信号通路介导的自噬[J].南方医科大学学报,2024,44(12):2327-2334.
[63]
NGUYEN T T T. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells[J]. Carcinogenesis, 2003, 25(5): 647-659.
[64]
WANG K, LIU R, LI J Y, et al. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR-and hypoxia-induced factor 1 α-mediated signaling [J]. Autophagy, 2011, 7(9): 966-978.
[65]
KLAPPAN A K, HONES S, MYLONAS I, et al. Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity[J]. Histochem Cell Biol, 2012, 137(1): 25-36.
[66]
XIAO J, ZHANG B, YIN S M, et al. Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway[J]. Acta Biochim Biophys Sin, 2022: 1244-1256.
[67]
BOOTS A W, HAENEN G R MM, BAST A. Health effects of quercetin: From antioxidant to nutraceutical [J]. Eur J Pharmacol, 2008, 585(2-3): 325-337.
[68]
李怡,陈其章,范临夏,等.槲皮素协同影响DNA修复和ROS水平提高NSCLC细胞的放疗敏感性[J].中药药理与临床,2023,39(11):62-67.
[69]
陈秀楠,王瑞琦,单红英,等.槲皮素通过抑制p38 MAPK/NOX4信号通路减轻H2O2诱导的人子宫内膜基质细胞氧化应激损伤[J].四川大学学报(医学版),2024,55(3):552-558.
[70]
ZHANG M, SWARTS S G, YIN L J, et al. Antioxidant properties of quercetin[M]//Oxygen Transport to Tissue XXXII. Boston, MA: Springer US, 2011: 283-289.
[71]
RUBIO V, GARCÍA-PÉREZ A I, HERRÁEZ A, et al. Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells[J]. Chem Biol Interact, 2018, 294: 158-166.
[72]
ALVAREZ M C, MASO V, TORELLO C O, et al. The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes [J]. Clin Epigenet, 2018, 10(1): 139.
[73]
杨旭.槲皮素对白血病表观遗传修饰的机制研究[D].武汉:武汉科技大学,2012.
2026年第44卷第4期
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doi: 10.13193/j.issn.1673-7717.2026.04.030
  • 首发时间:2026-10-14
  • 出版时间:2026-04-10
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国家自然科学基金青年科学基金项目(82204981)
河南省中医药科学研究专项(2024ZY1010; 2022ZY1056)
作者信息
    1.河南中医药大学第二临床医学院,河南 郑州 450002
    2.河南省中医院,河南中医药大学第二附属医院,河南 郑州 450002
    3.河南中医药大学血液病研究所,河南 郑州 450002
    4.河南省中西医结合防治血液病工程研究中心,河南 郑州 450002

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马秋玲(1975-),女,河南郑州人,副教授,硕士研究生导师,博士,研究方向:中西医结合防治血液病临床、科研和教学。E-mail: 。
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2种不同金属材料的力学参数
科
Family
属数
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genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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