Article(id=1317115148796543324, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.04.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954322289, onlineDateStr=2026-10-14, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954322289, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954322289, creator=13701087609, updateTime=1791954322289, updator=13701087609, issue=Issue{id=1317115107243573307, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='4', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791954312382, creator='13701087609', updateTime=1791958738709, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133672680116252, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133672680116253, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317115107243573307, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=66, endPage=71, ext={EN=ArticleExt(id=1317115150470070621, articleId=1317115148796543324, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Mechanism of Icariin Regulating BMSCs for Treating Osteoporosis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Osteoporosis（OP）is a kind of systemic bone disease characterized by decreased bone mass and degeneration of bone microstructure, and its incidence is increasing with the increase of population aging. Because of the limitations of the current treatment methods, the search for safer and more effective treatment strategies has become a research hotspot. Bone marrow mesenchymal stem cells（BMSCs）play an important role in the pathogenesis of osteoporosis, and their abnormal function is closely related to the occurrence of osteoporosis. Icariin（ICA）, as a commonly used Chinese medicine for tonifying kidney and strengthening bone, has the potential to regulate BMSCs. In this review, ICA regulates the mechanism of BMSCs in the treatment of osteoporosis. ICA can promote the differentiation of BMSCs into osteoblasts, inhibit their differentiation into adipocytes, and improve their migration and homing ability through various ways, thus promoting bone formation and inhibiting bone resorption. The mechanism of ICA involves a variety of signaling pathways, including Wnt/β-catenin, BMP-2/RunX2/OSX, PPARγ, etc. By regulating these signaling pathways, ICA can affect the gene expressions of BMSCs, and thus affect bone metabolic balance. In addition, ICA also has the effects of promoting osteoblast proliferation, inhibiting osteoclast function and anti-inflammation, which together exert the effect of anti-osteoporosis, and is expected to become a new choice for treating OP.

, authors=Zelin LIU^{1, 2}, Ji LI¹, Tuozi WANG², Tianqi REN², authorsList=Zelin LIU, Ji LI, Tuozi WANG, Tianqi REN, authorCompany=null, correspAuthors=Ji LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317115150788837726, articleId=1317115148796543324, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=淫羊藿苷调节BMSCs治疗骨质疏松症的机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

骨质疏松症（Osteoporosis，OP）是一种以骨量减少和骨组织微结构退化为特征的全身性骨病，随着人口老龄化加剧，其发病率不断上升。目前的治疗手段存在局限性，寻找更安全有效的治疗策略成为研究热点。骨髓间充质干细胞（Bone marrow mesenchymal stem cells，BMSCs）在骨质疏松症的发病机制中扮演着重要角色，其功能异常与骨质疏松症的发生密切相关。淫羊藿苷（Icariin，ICA）作为一种常用的补肾壮骨中药，具有调控BMSCs的潜力。综述了ICA调控BMSCs治疗骨质疏松症的机制，ICA能够通过多种途径促进BMSCs向成骨细胞分化，抑制其向脂肪细胞分化，并改善其迁移和归巢能力，从而促进骨形成并抑制骨吸收。ICA的作用机制涉及多种信号通路，包括Wnt/β-catenin、BMP-2/RunX2/OSX、PPARγ等，通过调节这些信号通路，ICA能够影响BMSCs的基因表达，进而影响骨代谢平衡。此外，ICA还具有促进成骨细胞增殖、抑制破骨细胞功能和抗炎等作用，共同发挥抗骨质疏松的作用，有望成为治疗OP的新选择。

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刘泽霖（1986-），男，黑龙江林口人，主治医师，博士在读，研究方向：中医治疗骨病及骨关节疾病。

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刘泽霖（1986-），男，黑龙江林口人，主治医师，博士在读，研究方向：中医治疗骨病及骨关节疾病。

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Repurposing drugs for the treatment of osteoarthritis [J]. Osteoarthritis and Cartilage, 2024, 32（8）: 886-895., articleTitle=null, refAbstract=null), Reference(id=1319630626928570802, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=ALI M, KIMY S. A comprehensive review and advanced biomolecule-based therapies for osteoporosis[J]. Journal of Advanced Research, 2024, 71: 337-354., articleTitle=null, refAbstract=null), Reference(id=1319630626999873971, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=PIVONKA P, CALVO-GALLEGO J L, SCHMIDT S, et al. Advances in mechanobiological pharmacokinetic-pharmacodynamic models of osteoporosis treatment-Pathways to optimise and exploit existing therapies [J]. Bone, 2024, 2024: 117140., articleTitle=null, refAbstract=null), Reference(id=1319630627075371444, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=BUTTGEREIT F, PALMOWSKI A, BOND M, et al. Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases [J]. Nature Reviews, Rheumatology, 2024, 20（7）: 417-431., articleTitle=null, refAbstract=null), Reference(id=1319630627150868917, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=邱晓萍，刘铠婕，林宇慧，等.骨质疏松症的流行病学、管理与防治研究进展[J].山东医药，2023，63（21）：107-111., articleTitle=null, refAbstract=null), Reference(id=1319630627209589174, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=原发性骨质疏松症诊疗指南（2022）[J].中华骨质疏松和骨矿盐疾病杂志，2022，15（6）：573-611., articleTitle=null, refAbstract=null), Reference(id=1319630627276698039, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG X C, ZHANG C, ZHAO G, et al. Obesity and lipid metabolism in the development of osteoporosis[J]. International Journal of Molecular Medicine, 2024, 54（1）: 45-51., articleTitle=null, refAbstract=null), Reference(id=1319630627339612600, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=ABDUL Q, LIANG S J, WU Z X, et al. Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells[J]. International Journal of Molecular Sciences, 2020, 21（1）: 349., articleTitle=null, refAbstract=null), Reference(id=1319630627410915769, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU J J, AN J Y, JIANG N, et al. Codonopsis pilosula polysaccharides promote osteogenic differentiation and inhibit lipogenic differentiation of rat bone marrow stem cells by activating β-catenin [J]. Chemico-Biological Interactions, 2023, 385: 110721., articleTitle=null, refAbstract=null), Reference(id=1319630627473830330, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=FENG K, YANG M Y, LOU X Y, et al. Multi-omics analysis of bone marrow mesenchymal stem cell differentiation differences in osteoporosis[J]. Genomics, 2023, 115（5）: 110668., articleTitle=null, refAbstract=null), Reference(id=1319630627540939195, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG Y H, SUN Y, MAO W W, et al. Oxidative stress induces downregulation of TP53INP2 and suppresses osteogenic differentiation of BMSCs during osteoporosis through the autophagy degradation pathway [J]. Free Radical Biology and Medicine, 2021, 166: 226-237., articleTitle=null, refAbstract=null), Reference(id=1319630627620630972, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=HUAN J, XIAOXIA S, BO G, et al. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis[J]. Cell Death & Disease, 2018, 9（2）: 176., articleTitle=null, refAbstract=null), Reference(id=1319630627700322749, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=LI J Y, CHEN Y S, ZHA D S, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism[J]. Lipids in Health and Disease, 2024, 23（1）: 88., articleTitle=null, refAbstract=null), Reference(id=1319630627759043006, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=蒋国鹏，李晶，马小愉，等.单味中药提取物及有效成分对骨髓间充质干细胞增殖和分化的研究进展[J].辽宁中医杂志，2023，50（6）：247-250., articleTitle=null, refAbstract=null), Reference(id=1319630627821957567, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=李志文，刘元禄，杨永菊，等.补肾阳中药有效成分治疗骨质疏松症作用机制研究进展[J].辽宁中医药大学学报，2023，25（10）：135-141., articleTitle=null, refAbstract=null), Reference(id=1319630627889066432, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=曹天媛，倪志明，刘新宇，等.中医药调控BMSCs成骨分化防治骨质疏松症的研究进展[J].中国骨质疏松杂志，2023，29（11）：1669-1674., articleTitle=null, refAbstract=null), Reference(id=1319630627960369601, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=姜涛，凌翠敏，陈庆真，等.淫羊藿苷通过提高自噬促进成骨细胞分化防治骨质疏松[J].中国组织工程研究，2021，25（17）：2643-2649., articleTitle=null, refAbstract=null), Reference(id=1319630628031672770, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=訾慧，郑洪新，蒋宁，等.淫羊藿素通过BMP/Runx2/Osx信号通路促进大鼠骨髓间充质干细胞成骨分化研究[J].中华中医药学刊，2020，38（7）：212-215，270., articleTitle=null, refAbstract=null), Reference(id=1319630628102975939, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=王大伟.基于Wnt3a/β-catenin信号通路探究补肾益气活血方对绝经后骨质疏松症疗效机制研究[D].沈阳：辽宁中医药大学，2019., articleTitle=null, refAbstract=null), Reference(id=1319630628182667716, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=黄俊明.淫羊藿苷经Wnt/β-catenin信号通路调控骨髓间充质干细胞的成骨—成脂双向分化[D].武汉：华中科技大学，2017., articleTitle=null, refAbstract=null), Reference(id=1319630629860389317, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=韩月，王雨菲，刘婉晴，等.淫羊藿苷在炎症环境下对MC3T3-E1细胞增殖分化的影响[J].中国组织工程研究，2024，28（23）：3709-3714., articleTitle=null, refAbstract=null), Reference(id=1319630629940081094, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=颜荣耀，曾志远，王浩，等.淫羊藿苷对白细胞介素-1 β刺激的软骨细胞增殖、自噬和炎症反应的影响[J].中国临床药理学杂志，2023，39（22）：3301-3305., articleTitle=null, refAbstract=null), Reference(id=1319630630036550087, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=薛春阳，王秀会.淫羊藿苷调节酸性微环境减轻绝经后老年骨质疏松性疼痛[J].中国组织工程研究，2024，28（28）：4461-4468., articleTitle=null, refAbstract=null), Reference(id=1319630630103658952, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=乔鲁卉，马子雨，郭浩宇，等.葛根素与淫羊藿苷对小鼠前成骨细胞生物学性能影响的比较[J].中国组织工程研究，2023，27（6）：872-877., articleTitle=null, refAbstract=null), Reference(id=1319630630170767817, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=付殷，刘宇洲，胡晓阳，等.基于铁死亡通路研究淫羊藿苷对大鼠成骨细胞增殖分化的影响[J].时珍国医国药，2022，33（9）：2100-2103., articleTitle=null, refAbstract=null), Reference(id=1319630630246265290, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=何丽君，黄巧文，马黄璜，等.淫羊藿苷通过自噬与凋亡途径保护去卵巢大鼠骨质疏松的机制探究[J].中药新药与临床药理，2023，34（2）：149-155., articleTitle=null, refAbstract=null), Reference(id=1319630630409843147, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=朱晔，温黎明，李任，等.不同浓度锶与淫羊藿苷联合应用对MC3T3-E1细胞增殖及骨向分化的影响[J].安徽医科大学学报，2021，56（5）：828-831., articleTitle=null, refAbstract=null), Reference(id=1319630630481146316, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=杨冰璇，姜涛，贾敏，等.淫羊藿苷增强自噬促进小鼠前成骨细胞的分化[J].中国组织工程研究，2022，26（1）：64-69., articleTitle=null, refAbstract=null), Reference(id=1319630630560838093, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=王宥涵，孔令擘，贺宝荣.淫羊藿苷调控破骨细胞分化治疗骨质疏松症的机制研究进展[J].中华创伤杂志，2020，36（4）：377-382., articleTitle=null, refAbstract=null), Reference(id=1319630630833467854, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=冯萌，党院霞，刘芬，等.基于分子对接探究知母皂苷BⅡ对破骨细胞分化过程中的影响[J].中国实验方剂学杂志，2020，26（19）：146-152., articleTitle=null, refAbstract=null), Reference(id=1319630630892188111, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=沈燚，祝峥，张奇，等.淫羊藿苷对UMR-106成骨细胞和RAW264.7细胞诱导的破骨细胞蛋白质组学的影响[J].中国药学杂志，2019，54（4）：268-273., articleTitle=null, refAbstract=null), Reference(id=1319630631244509648, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=李伟娟，谢保平，石丽颖，等.从ERα/RANK通路探讨淫羊藿苷抑制破骨细胞分化作用[J].中国实验方剂学杂志，2017，23（7）：121-126., articleTitle=null, refAbstract=null), Reference(id=1319630631315812817, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=杨世超，宋慕格，李幸，等.淫羊藿苷修复骨缺损及其作用机制研究[J].中国骨质疏松杂志，2024，30（5）：720-724，744., articleTitle=null, refAbstract=null), Reference(id=1319630631395504594, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=陈浩，杜斌，刘锌，等.淫羊藿治疗糖皮质激素相关型股骨头坏死研究进展[J].中国中西医结合杂志，2021，41（11）：1401-1408., articleTitle=null, refAbstract=null), Reference(id=1319630631680717267, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=陈绎志，董忠，杨俊，等.淫羊藿苷对兔成骨细胞的调控[J].中国老年学杂志，2023，43（8）：1937-1939., articleTitle=null, refAbstract=null), Reference(id=1319630631768797652, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=黄云芬，赵林超，吴松南，等.基于化学指纹-细胞代谢组学相关性分析淫羊藿及巫山淫羊藿促成骨分化的药效物质基础[J].中国实验方剂学杂志，2024，30（17）：155-163., articleTitle=null, refAbstract=null), Reference(id=1319630631890432469, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=李明霞，杨谦，乔海霞，等.淫羊藿苷调控mTOR/Akt/CREB通路对高糖诱导的足细胞自噬及凋亡的影响[J].医药导报，2024，43（1）：19-25., articleTitle=null, refAbstract=null), Reference(id=1319630631957541334, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=吕娟，张云霞，白俊嫄，等.基于PTEN/PI3K/Akt/mTOR信号通路探讨淫羊藿苷联合地塞米松对阿霉素诱导足细胞损伤的保护作用及机制[J].中药新药与临床药理，2023，34（6）：739-746., articleTitle=null, refAbstract=null), Reference(id=1319630632037233111, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=刘迎节，侍才洪，陈凡平，等.淫羊藿苷对过载损伤后成骨细胞凋亡和骨架的影响[J].医用生物力学，2017，32（4）：325-330., articleTitle=null, refAbstract=null), Reference(id=1319630632137896408, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=XINGZHI J, TING D, KUN C, et al. Icariin protects against iron overload-induced bone loss via suppressing oxidative stress[J]. Journal of Cellular Physiology, 2019, 234（7）: 10123-10137., articleTitle=null, refAbstract=null), Reference(id=1319630632205005273, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=MA H P, MA X N, GE B F, et al. Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potential in vitro[J]. Cell Proliferation, 2014, 47（6）: 527-539., articleTitle=null, refAbstract=null), Reference(id=1319630632293085659, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=FENG R J, FENG L, YUAN Z N, et al. Icariin protects against glucocorticoid-induced osteoporosis in vitro and prevents glucocorticoid-induced osteocyte apoptosis in vivo [J]. Cell Biochemistry and Biophysics, 2013, 67（1）: 189-197., articleTitle=null, refAbstract=null), Reference(id=1319630632360194525, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=张庆宇，高福强，程立明，等.淫羊藿苷对骨微血管内皮细胞自噬及外泌体产生的影响[J].中国修复重建外科杂志，2019，33（5）：568-577., articleTitle=null, refAbstract=null), Reference(id=1319630632565715423, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=XU Y X, JIANG Y P, JIA B, et al. Icariin stimulates osteogenesis and suppresses adipogenesis of human bone mesenchymal stem cells via miR-23a-mediated activation of the Wnt/β-catenin signaling pathway[J]. Phytomedicine, 2021, 85: 153485., articleTitle=null, refAbstract=null), Reference(id=1319630632637018592, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=DENG S, ZENG Y Q, XIANG J J, et al. Icariin protects bone marrow mesenchymal stem cells in aplastic anemia by targeting MAPK pathway[J]. Molecular Biology Reports, 2022, 49（9）: 8317-8324., articleTitle=null, refAbstract=null), Reference(id=1319630632695738849, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=岳峥嵘，张悦，汤建成，等.淫羊藿苷经PI3K/Akt/mTOR通路调控激素对骨微血内皮细胞自噬的影响[J].中国实验方剂学杂志，2024，30（15）：73-80., articleTitle=null, refAbstract=null), Reference(id=1319630634612535779, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=null, journalName=null, refType=null, unstructuredReference=GAO L F, ZHANG S Q. Antiosteoporosis effects, pharmacokinetics, and drug delivery systems of icaritin: advances and prospects[J]. Pharmaceuticals, 2022, 15（4）: 397., articleTitle=null, refAbstract=null), Reference(id=1319630634717393380, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG X, HAN N, LI G, et al. Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis[J]. International Journal of Oral Science, 2018, 10（2）: 1-6., articleTitle=null, refAbstract=null), Reference(id=1319630635065520613, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=null, journalName=null, refType=null, unstructuredReference=XIANG S Y, ZHAO L L, TANG C, et al. Icariin inhibits osteoblast ferroptosis via Nrf2/HO-1 signaling and enhances healing of osteoporotic fractures [J]. European Journal of Pharmacology, 2024, 965: 176244., articleTitle=null, refAbstract=null), Reference(id=1319630635157795302, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG X Y, CHEN Y P, ZHANG C, et al. Effects of icariin on the fracture healing in young and old rats and its mechanism[J]. Pharmaceutical biology, 2021, 59（1）: 1245-1255., articleTitle=null, refAbstract=null), Reference(id=1319630635443007975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU G Y, CAO G L, TIAN F M, et al. Parathyroid hormone（1-34）promotes fracture healing in ovariectomized rats with type 2 diabetes mellitus [J]. Osteoporosis International, 2017, 28（10）: 3043-3053., articleTitle=null, refAbstract=null), Reference(id=1319630635505922536, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=null, journalName=null, refType=null, unstructuredReference=XU C H, ZHANG C, HAN J, et al. Icariin accelerates fracture healing；activation of the Wnt1/β-catenin osteogenic signaling pathway[J]. Current Pharmaceutical Biotechnology, 2020, 21（15）: 1645-1653., articleTitle=null, refAbstract=null), Reference(id=1319630635573031402, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=null, journalName=null, refType=null, unstructuredReference=SUN X D, WEI J, LYU J Y, et al. Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis [J]. Journal of Nanobiotechnology, 2019, 17（1）: 10., articleTitle=null, refAbstract=null), Reference(id=1319630635933741548, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=null, journalName=null, refType=null, unstructuredReference=KAАН G, MÜKERREM B Y, PERIHAN G, et al. Icariin promotes early and late stages of fracture healing in rats[J]. Joint Diseases & Related Surgery, 2019, 30（3）: 282-288., articleTitle=null, refAbstract=null), Reference(id=1319630636294451694, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=null, journalName=null, refType=null, unstructuredReference=YOU Y H, LIU J C, ZHANG L, et al. WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis[J]. Cell Death & Disease, 2023, 14（1）: 33., articleTitle=null, refAbstract=null), Reference(id=1319630636407697903, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[56], rfOrder=55, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO Y, RUAN B J, WANG S, et al. RNA-binding protein QKI inhibits osteogenic differentiation via suppressing wnt pathway[J]. Archives of Medical Research, 2023, 54（5）: 102853., articleTitle=null, refAbstract=null), Reference(id=1319630636755825136, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=null, journalName=null, refType=null, unstructuredReference=WU Z X, ZHU J Y, WEN Y X, et al. Hmga1-overexpressing lentivirus protects against osteoporosis by activating the Wnt/β-catenin pathway in the osteogenic differentiation of BMSCs [J]. FASEB Journal, 2023, 37（9）: e22987., articleTitle=null, refAbstract=null), Reference(id=1319630636818739697, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=null, journalName=null, refType=null, unstructuredReference=JINGQIONG X, CHAN L, MEILU L, et al. Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo[J]. Stem Cell Research & Therapy, 2021, 12（1）: 424., articleTitle=null, refAbstract=null), Reference(id=1319630637120729586, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=null, journalName=null, refType=null, unstructuredReference=LI T, JIANG H X, LI Y, et al. Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis[J]. Molecular and Cellular Endocrinology, 2021, 527（prepublish）: 111171., articleTitle=null, refAbstract=null), Reference(id=1319630637204615667, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=null, journalName=null, refType=null, unstructuredReference=LI J Y, WEI X, SUN Q, et al. MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2[J]. European Review for Medical and Pharmacological Sciences, 2019, 23（15）: 6394-6403., articleTitle=null, refAbstract=null), Reference(id=1319630638832005620, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[61], rfOrder=60, authorNames=null, journalName=null, refType=null, unstructuredReference=HU Y, LI X Q, ZHANG Q, et al. Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss[J]. Bioactive Materials, 2021, 6（9）: 2905-2913., articleTitle=null, refAbstract=null), Reference(id=1319630638907503093, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[62], rfOrder=61, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU Q, ZHANG X, JIAO Y, et al. In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats[J]. International Journal of Molecular Medicine, 2018, 41（2）: 669-678., articleTitle=null, refAbstract=null), Reference(id=1319630638978806262, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[63], rfOrder=62, authorNames=null, journalName=null, refType=null, unstructuredReference=REN H H, CHEN S Z, JIN Y A, et al. A traceable and bone-targeted nanoassembly based on defect-related luminescent mesoporous silica for enhanced osteogenic differentiation[J]. Journal of Materials Chemistry B, 2017, 5（8）: 1585-1593., articleTitle=null, refAbstract=null), Reference(id=1319630639054303735, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[64], rfOrder=63, authorNames=null, journalName=null, refType=null, unstructuredReference=KOU Y Y, RONG X, TANG R, et al. Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal [J]. Frontiers in Pharmacology, 2023, 14: 1067085., articleTitle=null, refAbstract=null), Reference(id=1319630639201104376, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[65], rfOrder=64, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU F, YUAN Y J, BAI L, et al. LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss[J]. Redox Biology, 2021, 43: 101963., articleTitle=null, refAbstract=null), Reference(id=1319630639289184761, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[66], rfOrder=65, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHU C Y, SHEN S W, ZHANG S H, et al. Autophagy in bone remodeling: a regulator of oxidative stress[J]. Frontiers in Endocrinology, 2022, 13: 898634., articleTitle=null, refAbstract=null), Reference(id=1319630639377265146, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[67], rfOrder=66, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU B L, GAN X Q, ZHAO Y W, et al. Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions [J]. Journal of Physiology and Biochemistry, 2021, 77（2）: 1-9., articleTitle=null, refAbstract=null), Reference(id=1319630639452762619, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[68], rfOrder=67, authorNames=null, journalName=null, refType=null, unstructuredReference=HU S W, WANG S S. The Role of SIRT3 in the Osteoporosis[J]. Frontiers in Endocrinology, 2022, 13: 893678., articleTitle=null, refAbstract=null), Reference(id=1319630639540843004, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[69], rfOrder=68, authorNames=null, journalName=null, refType=null, unstructuredReference=李烨，肖亚平，李晶晶，等.淫羊藿对骨髓间充质干细胞影响的研究进展[J].中国药学杂志，2017，52（24）：2137-2140., articleTitle=null, refAbstract=null), Reference(id=1319630639641506301, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[70], rfOrder=69, authorNames=null, journalName=null, refType=null, unstructuredReference=李烨，童杰，周衍晶，等.补肾壮骨中药抗骨质疏松有效成分及其药理作用研究进展[J].中国中药杂志，2015，40（6）：1038-1043., articleTitle=null, refAbstract=null), Reference(id=1319630639708615166, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[71], rfOrder=70, authorNames=null, journalName=null, refType=null, unstructuredReference=梁广胜，陈伟才，殷嫦嫦，等.淫羊藿总黄酮对大鼠骨髓间充质干细胞成骨分化过程BMP-2/RunX2/OSX通路的影响[J].中国中西医结合杂志，2016，36（5）：614-618., articleTitle=null, refAbstract=null), Reference(id=1319630639784112639, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[72], rfOrder=71, authorNames=null, journalName=null, refType=null, unstructuredReference=刘海全，秦佳佳，吴倩.淫羊藿对骨质疏松MSCs成脂分化PPARγmRNA表达的影响[J].中药新药与临床药理，2013，24（4）：382-385., articleTitle=null, refAbstract=null), Reference(id=1319630639872193024, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[73], rfOrder=72, authorNames=null, journalName=null, refType=null, unstructuredReference=秦佳佳，刘海全，杨海韵.淫羊藿含药血清对绝经后骨质疏松症大鼠MSCs成脂分化干预作用研究[J].药物分析杂志，2010，30（6）：1096-1099., articleTitle=null, refAbstract=null), Reference(id=1319630639939301889, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[74], rfOrder=73, authorNames=null, journalName=null, refType=null, unstructuredReference=刘海全，吴梅剑宗，蒙祖玉.淫羊藿诱导ADSCs成骨分化作用于骨质疏松症防治的研究进展[J].医学新知，2023，33（5）：381-388., articleTitle=null, refAbstract=null), Reference(id=1319630640060936706, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[75], rfOrder=74, authorNames=null, journalName=null, refType=null, unstructuredReference=汪盛玉，陈超，张文财，等.淫羊藿含药血清对骨质疏松大鼠BMSCs的Sirt1及PPARγmRNA表达的影响[J].中药新药与临床药理，2019，30（3）：296-300., articleTitle=null, refAbstract=null), Reference(id=1319630640149017091, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[76], rfOrder=75, authorNames=null, journalName=null, refType=null, unstructuredReference=金垚，徐鹏辉，卞泗善，等.淫羊藿苷调节PTEN激活成骨基因表达缓解大鼠骨质疏松症的实验研究[J].中医药信息，2023，40（6）：38-43，53., articleTitle=null, refAbstract=null), Reference(id=1319630640228708868, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[77], rfOrder=76, authorNames=null, journalName=null, refType=null, unstructuredReference=金垚，徐鹏辉，卞泗善，等.淫羊藿通过ICA-miR-335-5p轴缓解骨质疏松症的生物信息学分析及实验研究[J].中医药导报，2023，29（2）：1-7，13., articleTitle=null, refAbstract=null), Reference(id=1319630640300012037, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[78], rfOrder=77, authorNames=null, journalName=null, refType=null, unstructuredReference=刘佩，梁润英.中医药防治原发性骨质疏松症研究进展[J].中医学报，2022，37（10）：2122-2130., articleTitle=null, refAbstract=null), Reference(id=1319630640367120902, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[79], rfOrder=78, authorNames=null, journalName=null, refType=null, unstructuredReference=徐家宁.淫羊藿苷延缓骨髓间充质干细胞衰老的机制研究[D].上海：中国人民解放军海军军医大学，2023., articleTitle=null, refAbstract=null), Reference(id=1319630640430035463, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[80], rfOrder=79, authorNames=null, journalName=null, refType=null, unstructuredReference=朱元超.淫羊藿苷/多孔镁合金支架通过SIRT1-Wnt/β-catenin信号通路修复骨质疏松大鼠骨缺损的实验研究[D].遵义：遵义医科大学，2023., articleTitle=null, refAbstract=null), Reference(id=1319630640497144328, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[81], rfOrder=80, authorNames=null, journalName=null, refType=null, unstructuredReference=李少荣.载Icariin的海藻酸盐/矿化胶原体系联合3D打印支架修复大节段骨缺损的研究[D].长春：吉林大学，2023., articleTitle=null, refAbstract=null), Reference(id=1319630640576836105, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[82], rfOrder=81, authorNames=null, journalName=null, refType=null, unstructuredReference=吴玉琼.淫羊藿苷磷酸钙骨水泥控释给药系统应用于骨质疏松大鼠颅骨缺损修复的研究[C]//中华口腔医学会口腔医学科研管理分会第二次学术年会论文集.北京：中华口腔医学会，2017：63., articleTitle=null, refAbstract=null), Reference(id=1319630640648139274, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[83], rfOrder=82, authorNames=null, journalName=null, refType=null, unstructuredReference=吴玉琼，曹玲燕，夏伦果，等.淫羊藿苷磷酸钙骨水泥控释给药系统应用于骨质疏松大鼠颅骨缺损修复的研究[C]//中华口腔医学会口腔修复学专业委员会第十次全国口腔修复学术大会论文集.北京：中华口腔医学会，2016：191., articleTitle=null, refAbstract=null), Reference(id=1319630640732025355, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[84], rfOrder=83, authorNames=null, journalName=null, refType=null, unstructuredReference=SHI W G, GAO Y H, WANG Y Y, et al. The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts[J]. The Journal of Biological Chemistry, 2017, 292（51）: 20883-20896., articleTitle=null, refAbstract=null), Reference(id=1319630640803328524, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[85], rfOrder=84, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG D W, FONG C C, JIA Z B, et al. Icariin stimulates differentiation and suppresses adipocytic transdifferentiation of primary osteoblasts through estrogen receptor-mediated pathway[J]. Calcified tissue International, 2016, 99（2）: 187-198., articleTitle=null, refAbstract=null), Reference(id=1319630640870437389, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[86], rfOrder=85, authorNames=null, journalName=null, refType=null, unstructuredReference=梅杰，何强，孙欣，等.淫羊藿苷促进成骨细胞增殖分化的非核效应信号通路[J].中国组织工程研究，2023，27（20）：3129-3135., articleTitle=null, refAbstract=null), Reference(id=1319630640941740558, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[87], rfOrder=86, authorNames=null, journalName=null, refType=null, unstructuredReference=黄孝闻，王绪平，张扬，等.淫羊藿苷对脂多糖诱导成骨细胞骨架F-actin损伤的保护作用[J].中国现代应用药学，2019，36（13）：1612-1616., articleTitle=null, refAbstract=null), Reference(id=1319630641029820943, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[88], rfOrder=87, authorNames=null, journalName=null, refType=null, unstructuredReference=吕明波，陈克明，葛宝丰.淫羊藿苷对小鼠破骨细胞MMP-9、CK mRNA表达的影响[J].中国骨质疏松杂志，2014，20（8）：896-899., articleTitle=null, refAbstract=null), Reference(id=1319630641109512720, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[89], rfOrder=88, authorNames=null, journalName=null, refType=null, unstructuredReference=崔京福，徐耀增，朱世军，等.淫羊藿苷抑制钛颗粒诱导的破骨细胞活化[J].中华实验外科杂志，2014，31（1）：116., articleTitle=null, refAbstract=null), Reference(id=1319630641168232977, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[90], rfOrder=89, authorNames=null, journalName=null, refType=null, unstructuredReference=马小妮，葛宝丰，陈克明，等.淫羊藿苷调节成骨细胞骨形成和破骨细胞骨吸收的机制[J].中国医学科学院学报，2013，35（4）：432-438., articleTitle=null, refAbstract=null), Reference(id=1319630641247924754, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317115148796543324, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[91], rfOrder=90, authorNames=null, journalName=null, refType=null, unstructuredReference=刘兴炎，吕明波，葛宝丰，等.淫羊藿苷对小鼠破骨细胞β-肌动蛋白、抗酒石酸酸性磷酸酶、核因子-κB受体活化因子mRNA表达的影响[J].中华实验外科杂志，2007，24（8）：996-998，1027., articleTitle=null, refAbstract=null), Reference(id=1319630641310839315, tenantId=1146029695717560320, journalId=1255847919539208197, 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