中华中医药学刊

黄芩苷防治糖尿病肾病作用机制研究进展

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张小年 , 刘爱军 , 赵杰 , 刁远明

中华中医药学刊 | 国家项目点击 2026,44(4): 24-27

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中华中医药学刊 |国家项目点击 2026 , 44 (4) : 24 -27

黄芩苷防治糖尿病肾病作用机制研究进展

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张小年, 刘爱军, 赵杰, 刁远明

作者信息

广州中医药大学基础医学院，广东广州 510006

通讯作者:

刁远明（1980-），女，广东梅州人，副教授，硕士研究生导师，博士，研究方向：中医药调控干细胞防治肿瘤。E-mail: zsdym@gzucm.edu.cn。

作者简介:

张小年（1984-），女，江西吉安人，高级实验师，硕士，研究方向：中医药治疗重大疾病。

Research Progress on Mechanism of Baicalin in Preventing and Treating Diabetic Nephropathy

Xiaonian ZHANG, Aijun LIU, Jie ZHAO, Yuanming DIAO

Affiliations

School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China

出版时间: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.006

文章导航

摘要

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糖尿病肾病（Diabetic nephropathy，DN）是糖尿病的主要微血管并发症之一，其发生机制复杂，与高糖环境诱导的肾脏组织细胞凋亡、相关酶类异常激活、炎症和氧化应激、蛋白非酶糖化、细胞外基质异常沉积及脂代谢异常等有关。黄芩苷（Baicalin）是从中药材黄芩根中提取分离出来的一种黄酮类化合物，具有广泛的药理作用。近年来，随着对传统中药新用途的开发不断深入，发现黄芩苷具有防治DN的作用。为此总结综述了近年来黄芩苷防治DN作用机制的研究进展，以期为今后黄芩苷防治DN的深入研究提供一定的理论基础和依据。

关键词

黄芩苷 / 防治 / 糖尿病肾病 / 作用机制 / 研究进展

Abstract

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Diabetic nephropathy（DN）is one of the major microvascular complications of diabetes, and its pathogenesis is complex, involving apoptosis of renal tissue cells induced by hyperglycemic environment, abnormal activation of related enzymes, inflammation and oxidative stress, non-enzymatic glycosylation of proteins, abnormal deposition of extracellular matrix and abnormal lipid metabolism. Baicalin, a flavonoid compound extracted and isolated from the root of the traditional Chinese medicinal herb Huangqin（Scutellariae Radix）, possesses a wide range of pharmacological effects. In recent years, with the continuous exploration of new applications for traditional Chinese medicine, baicalin has been found to have apreventive and therapeutic effect on DN. Therefore, this article summarized and reviewed the research progress in the mechanism of baicalin preventing and treating DN in recent years, aiming to provide a theoretical basis and foundation for further research on the prevention and treatment of DN with baicalin in the future.

Key words

baicalin / prevention and treatment / diabetic nephropathy / mechanism of action / research progress

引用本文

张小年, 刘爱军, 赵杰, 刁远明. 黄芩苷防治糖尿病肾病作用机制研究进展. 中华中医药学刊, 2026 , 44 (4) : 24 -27 . DOI: 10.13193/j.issn.1673-7717.2026.04.006

Xiaonian ZHANG, Aijun LIU, Jie ZHAO, Yuanming DIAO. Research Progress on Mechanism of Baicalin in Preventing and Treating Diabetic Nephropathy[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 24 -27 . DOI: 10.13193/j.issn.1673-7717.2026.04.006

基金

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国家自然科学基金项目(82174368)
广州中医药大学校院联合科技创新基金项目(GZYDG2024G01)

参考文献

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2026年第44卷第4期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.04.006

首发时间：2026-10-14
出版时间：2026-04-10

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基金

国家自然科学基金项目(82174368)

广州中医药大学校院联合科技创新基金项目(GZYDG2024G01)

作者信息

广州中医药大学基础医学院，广东广州 510006

通讯作者:

刁远明（1980-），女，广东梅州人，副教授，硕士研究生导师，博士，研究方向：中医药调控干细胞防治肿瘤。E-mail: zsdym@gzucm.edu.cn。

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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.04.006

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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