中华中医药学刊

代谢性疾病的“肠源学说”

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姚海强 , 万瑾毅

中华中医药学刊 | 博士导师新论 2026,44(4): 7-10

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中华中医药学刊 |博士导师新论 2026 , 44 (4) : 7 -10

代谢性疾病的“肠源学说”

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姚海强, 万瑾毅

作者信息

北京中医药大学，北京 100029

通讯作者:

万瑾毅（1985-），女，山东即墨人，研究员，博士研究生导师、博士后合作导师，博士，研究方向：中医体质学。E-mail: wanjinyi1128@163.com。

作者简介:

姚海强（1986-），男，河南禹州人，研究员，博士研究生导师、博士后合作导师，博士，研究方向：中医体质学。

The “Intestinal Origin Theory”of Metabolic Diseases

Haiqiang YAO, Jinyi WAN

Affiliations

Beijing University of Chinese Medicine, Bejing 100029, China

出版时间: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.002

文章导航

摘要

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代谢性疾病近年来呈全球高发趋势，造成沉重的社会负担。在中医理论中，脾主运化，将水谷精微代谢输布至全身。若脾失健运，则水液停聚化生痰饮湿浊，导致机体代谢异常。然而关于脾失健运的微观机制目前尚不明确。肠道稳态是指宿主黏膜屏障和肠道微生态相互作用所构成的动态平衡状态，涉及肠道菌群及其代谢物、肠道屏障、肠道黏膜免疫以及宿主肠道功能等因素。根据藏象学说，肠道隶属于中医脾藏体系，肠道稳态的破坏与代谢性疾病密切相关。提出代谢性疾病的“肠源学说”为脾失健运这一传统中医理论提供新的科学解读，阐释其科学内涵，并为代谢性疾病的中医药防治提供新的干预靶点。

关键词

肠道稳态 / 脾失健运 / 代谢紊乱 / 肠道菌群 / 肠道屏障

Abstract

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Metabolic diseases have shown a global trend of high prevalence in recent years, causing a heavy social burden. In Chinese medical theory, the spleen is responsible for transporting water and grain throughout the whole body. The dysfunction of the spleen in transportation would affect the fluidity of the human body, resulting in phlegm and dampness, eventually leading to metabolic disturbance. However, the microscopic mechanism of the above phenomenon remains unclear. Intestinal homeostasis refers to the dynamic state of equilibrium formed by the interaction between the host mucosal barrier and the intestinal microecology. The factors such as intestinal flora and its metabolites, intestinal barrier, intestinal mucosal immunity and the host intestinal function are involved. According to the theory of visceral manifestations, the intestinal tract belongs to the spleen category in traditional Chinese medicine, and the destruction of intestinal homeostasis is closely related to metabolic diseases. This article proposes that the “intestinal origin theory”of metabolic diseases could provide a new scientific interpretation of the traditional Chinese medicine theory of spleen dysfunction in transportation, explain its scientific connotation and provide a novel intervention target for the prevention and treatment of metabolic diseases by traditional Chinese medicine.

Key words

intestinal homeostasis / dysfunction of spleen in transportation / metabolic disorder / intestinal flora / intestinal barrier

引用本文

姚海强, 万瑾毅. 代谢性疾病的“肠源学说”. 中华中医药学刊, 2026 , 44 (4) : 7 -10 . DOI: 10.13193/j.issn.1673-7717.2026.04.002

Haiqiang YAO, Jinyi WAN. The “Intestinal Origin Theory”of Metabolic Diseases[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 7 -10 . DOI: 10.13193/j.issn.1673-7717.2026.04.002

基金

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国家自然科学基金项目(82274379; 82474371)
北京市自然科学基金-大兴创新联合基金项目(L246067)
北京中医药大学-优莎纳联合研究中心基金项目(K23-900201-028)

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2026年第44卷第4期

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文章信息

doi: 10.13193/j.issn.1673-7717.2026.04.002

首发时间：2026-10-14
出版时间：2026-04-10

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基金

国家自然科学基金项目(82274379; 82474371)

北京市自然科学基金-大兴创新联合基金项目(L246067)

北京中医药大学-优莎纳联合研究中心基金项目(K23-900201-028)

作者信息

北京中医药大学，北京 100029

通讯作者:

万瑾毅（1985-），女，山东即墨人，研究员，博士研究生导师、博士后合作导师，博士，研究方向：中医体质学。E-mail: wanjinyi1128@163.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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