Article(id=1317125473310720019, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.044, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956783844, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956783844, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956783844, creator=13701087609, updateTime=1791956783844, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=231, endPage=235, ext={EN=ArticleExt(id=1317125473545601044, articleId=1317125473310720019, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Tongxinluo Capsule（通心络胶囊）Combined with Atorvastatin Calcium in Treatment of Patients with Angina Pectoris of Coronary Heart Disease with Qi Deficiency and Blood Stasis and Its Effect on Blood Rheology Index and Inflammatory Factor Levels, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the clinical efficacy of Tongxinluo Capsule（通心络胶囊）combined with atorvastatin calcium in the treatment of patients with angina pectoris of coronary heart disease with Qi deficiency and blood stasis.
Methods A total of 302 patients with angina pectoris of coronary heart disease with Qi deficiency and blood stasis were selected and randomly divided into an observation group（152 cases）and a control group（150 cases）. The control group was treated with atorvastatin calcium tablets and the observation group was treated with Tongxinluo Capsule on the basis of the control group. Both groups were treated for 4 weeks. The clinical efficacy, the TCM symptom scores and angina attacks before and after treatment, cardiac enzyme parameters［creatine kinase-MB（CK-MB）, creatine kinase（CK）, lactate dehydrogenase（LDH）］, platelet aggregation rate, plasma viscosity, four hemorheological parameters of whole blood low shear and whole blood shear, interleukin-6（IL-6）, interleukin -18（IL-18）, C-reactive protein（CRP）, tumour necrosis factor-α（TNF-α）as well as adverse reactions that occurred during the study were observed.
Results After four weeks of treatment, the total effective rate of the observation group was 96.05%（146/152）, which was significantly higher than that of the control group（P < 0.05）. The symptom scores of the observation group were significantly reduced（P < 0.05）, the frequency, duration and dosage of angina pectoris were significantly reduced（P < 0.05）, the levels of CK-MB, CK and LDH were significantly reduced（P < 0.05）, the platelet aggregation rate, plasma viscosity, whole blood low shear and whole blood high shear parameters were also significantly reduced（P < 0.05）, the levels of IL-6, IL-18, CRP and TNF-α were also significantly reduced（P < 0.05）, and the improvement in the observation group was more obvious than that in the control group（P < 0.05）. In addition, both groups showed good safety during the research process.
Conclusion Tongxinluo Capsule combined with atorvastatin calcium has a good clinical efficacy in the treatment of angina pectoris of coronary heart disease with Qi deficiency and blood stasis, can significantly improve the clinical symptoms and myocardial function, reduce the blood viscosity, weaken the body＇s inflammatory response, and has good safety.
, authors=Jiliang WANG, Jing XUE, Lijie LIU, Feng CHEN, Huawei LI, authorsList=Jiliang WANG, Jing XUE, Lijie LIU, Feng CHEN, Huawei LI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125473780482069, articleId=1317125473310720019, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=通心络胶囊联合阿托伐他汀钙治疗气虚血瘀型冠心病心绞痛及对血流变指数、炎性因子水平的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 评价通心络胶囊联合阿托伐他汀钙治疗气虚血瘀型冠心病心绞痛患者的疗效。
方法 选取医院收治的气虚血瘀型冠心病心绞痛患者302例，并采用随机数字表法将其分为观察组（152例），对照组（150例），对照组口服阿托伐他汀钙片进行治疗，观察组在对照组的基础上加服通心络胶囊，两组均治疗4周。观察两组患者临床疗效，以及治疗前后中医症状积分、心绞痛发作情况，肌酸激酶同工酶（Creatine Kinase-MB，CK-MB）、肌酸激酶（Creatine Kinase，CK）与乳酸脱氢酶（Lactate Dehydrogenase，LDH）3项心肌酶指标，血小板聚集率、血浆黏度、全血低切及全血高切四项血流变学指标参数，白细胞介素-6（Interleukin-6，IL-6）、白细胞介素-18（Interleukin-6，IL-18）、C反应蛋白（C-Reactive Protein，CRP）、肿瘤坏死因子-α（Tumor Necrosis Factor-alpha，TNF-α）4项血清炎性因子水平，以及研究过程中发生的不良反应。
结果 经过4周治疗后，观察组患者总有效率（96.05%，146/152）明显高于对照组（P < 0.05），观察组各项症状积分明显降低（P < 0.05），心绞痛发作频率、持续时间、硝酸甘油用量明显减少（P < 0.05），CK-MB、CK与LDH水平明显降低（P < 0.05），血小板聚集率、血浆黏度、全血低切、全血高切参数水平同样明显降低（P < 0.05），IL-6、IL-18、CRP与TNF-α 4项血清炎性因子水平亦明显降低（P < 0.05），且观察组改善情况较对照组更为明显（P < 0.05），两组在研究过程中均显示出较好安全性。
结论 通心络胶囊联合阿托伐他汀钙治疗气虚血瘀型冠心病心绞痛具有较好的临床疗效，能够明显改善临床症状与心肌功能、降低血液黏度、减弱机体炎性反应，并且具有较好的安全性。
, authors=王计亮, 薛静, 刘黎洁, 陈凤, 李华伟, authorsList=王计亮, 薛静, 刘黎洁, 陈凤, 李华伟, authorCompany=null, correspAuthors=null, authorNote=
王计亮（1983 -），男，河北临西人，副主任医师，硕士，研究方向：临床医学心内科。
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王计亮（1983 -），男，河北临西人，副主任医师，硕士，研究方向：临床医学心内科。
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王计亮（1983 -），男，河北临西人，副主任医师，硕士，研究方向：临床医学心内科。
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