Article(id=1317125460174160806, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.040, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956780713, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956780713, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956780713, creator=13701087609, updateTime=1791956780713, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=214, endPage=219, ext={EN=ArticleExt(id=1317125460375487399, articleId=1317125460174160806, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Prediction Research of Quality Markers for Different Efficacies of Jiangzhizi（Gardeniae Fructus）, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=

Jiangzhizi（Gardeniae Fructus）is the dry and mature fruit of Zhizi（Gardenia jasminoides Ellis）. It is a famous authentic medicinal herb with diverse chemical components, mainly including iridoids, monoterpenoid glycoside, diterpenoids, triterpenoids, organic ester, flavone and volatile oil. In this study, 600 targets of Jiangzhizi（Gardeniae Fructus）were obtained based on the prediction of chemical structure similarity, and the top 20 highly related diseases of Jiangzhizi（Gardeniae Fructus）were obtained through disease enrichment analysis. The disease classification obtained from the enrichment was mapped to the traditional Chinese medicine diseases treated with Jiangzhizi（Gardeniae Fructus）, and the network topology model was used to analyze and predict the corresponding quality markers（Q-Markers）of different traditional Chinese medicine diseases treated with Jiangzhizi（Gardeniae Fructus）. The results showed that geniposide, crocin-1, barbinervic acid, rotundic acid, methyl linoleate and crocusatin-C were the candidate Q-Markers for the treatment of fever and restlessness with Jiangzhizi（Gardeniae Fructus）. Barbinervic acid, rotundic acid, methyl linoleate, geniposide, hederagenin, clethric acid, myrianthic acid, pentyl hexanoate, quercetin and crocin-1 were the candidate Q-Markers for the treatment of damp-heat jaundice with Jiangzhizi（Gardeniae Fructus）. Geniposide, barbinervic acid, rotundic acid, pentyl hexanoate, methyl linoleate, quercetin and crocin-1 were the candidate Q-Markers for the treatment of stranguria with astringent pain and hematemesis due to blood heat with Jiangzhizi（Gardeniae Fructus）.While quercetin, methyl linoleate and geniposide were the candidate Q-Markers for the treatment of fire sores and sprains contusions pain with Jiangzhizi（Gardeniae Fructus）. The significance of this study is to provide a theoretical basis for the precise quality control and in-depth development of Jiangzhizi（Gardeniae Fructus）.

, authors=Fangzhou LIU, Yang YANG, Meng LI, Yu DU, Yihao LI, Yuanbai LI, authorsList=Fangzhou LIU, Yang YANG, Meng LI, Yu DU, Yihao LI, Yuanbai LI, authorCompany=null, correspAuthors=Yuanbai LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125460685865896, articleId=1317125460174160806, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=道地药材江栀子发挥不同功效的质量标志物预测研究, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=

江栀子为茜草科植物栀子Gardenia jasminoides Ellis的干燥成熟果实，是著名的道地药材。其化学成分多样，主要包括环烯醚萜类、单萜苷类、二萜类、三萜类、有机酸酯类、黄酮类和挥发油类等化合物。研究在综合分析江栀子化学成分的基础上，基于化学结构相似性预测得到江栀子作用靶点600个，通过疾病富集分析得到江栀子前20种高相关性疾病，并将富集得到的疾病分类与江栀子传统中医主治疾病进行映射分析，基于网络拓扑模型分析预测江栀子不同中医主治疾病对应的质量标志物（quality marker，Q-Marker），研究结果显示栀子苷、西红花苷-1、马尾柴酸、铁冬青酸、亚油酸甲酯、（7R）-6-羟甲基-1，1，5-三甲基环己-3-烯酮为江栀子治疗热病心烦的候选Q-Marker，马尾柴酸、铁冬青酸、亚油酸甲酯、栀子苷、常春藤皂苷元、氯氰菊酸、肉豆蔻酸、己酸戊酯、槲皮素、西红花苷-1为江栀子治疗湿热黄疸和的候选Q-Marker，栀子苷、马尾柴酸、铁冬青酸、己酸戊酯、亚油酸甲酯、槲皮素、西红花苷-1为江栀子治疗淋证涩痛和血热吐衄的候选Q-Marker，槲皮素、亚油酸甲酯、栀子苷为江栀子治疗火毒疮疡和扭挫伤痛的候选Q-Marker。研究旨在为道地药材江栀子后续的精准质量控制及深入开发提供理论基础。

, authors=刘方舟, 杨阳, 李萌, 杜昱, 李逸豪, 李园白, authorsList=刘方舟, 杨阳, 李萌, 杜昱, 李逸豪, 李园白, authorCompany=null, correspAuthors=李园白, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=9OoPkj/d80q8ftP47vlw7A==, magXml=cNnePLJlK9c9ut0DmrSu1Q==, pdfUrl=null, pdf=5u8nmqOUNa+leEy0B4Ps+Q==, pdfFileSize=4858288, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=d9uFBKTfO1zGsK90BfHqRQ==, mapNumber=null, fund=null)}, authors=[Author(id=1319724662146318652, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125460174160806, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724662234399038, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125460174160806, authorId=1319724662146318652, language=EN, stringName=Fangzhou LIU, firstName=Fangzhou, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724662309896511, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125460174160806, authorId=1319724662146318652, language=CN, stringName=刘方舟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国中医科学院中医药信息研究所，北京 100700, bio={"content":"

刘方舟（1985 -），女，黑龙江伊春人，副研究员，博士，研究方向：基于中医药信息学技术支撑的中药资源学与药理学跨领域研究。

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刘方舟（1985 -），女，黑龙江伊春人，副研究员，博士，研究方向：基于中医药信息学技术支撑的中药资源学与药理学跨领域研究。

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