Article(id=1317125468839596049, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.038, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956782779, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956782779, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956782779, creator=13701087609, updateTime=1791956782779, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=206, endPage=209, ext={EN=ArticleExt(id=1317125469024145426, articleId=1317125468839596049, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Efficacy and Safety of Shenling Baizhu Powder（参苓白术散）Combined with Methalazine in Treatment of Ulcerative Colitis with Spleen Deficiency and Dampness Syndrome, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of Shenling Baizhu Powder（参苓白术散）combined with methalazine in the treatment of ulcerative colitis with spleen deficiency and dampness syndrome.
Methods A total of 82 ulcerative colitis patients with spleen deficiency and dampness syndrome admitted from March 2021 to March 2024 were divided into groups by random number table method. According to different treatment methods, the patients were divided into the methalazine group treated solely with methalazine and the combined TCM group treated with Shenling Baizhu Powder combined with methalazine, with 41 cases in each group. The therapeutic effect, the symptom remission time（mucous, pus and blood stools, abdominal pain and diarrhea）, the changes of TCM syndrome scores such as mucous, pus and blood stools, loose stool diarrhea, abdominal distension, abdominal pain and fatigue before and after treatment, as well as the improved Mayo SCore（Mayo）and disease activity index（DAI）were observed in two groups. The changes in DAI scores, tumor necrosis factor-α（TNF-α）, interleukin-8（IL-8）and interleukin-17（IL-17）, and the quality of life of the two groups were assessed by inflammatory bowel disease quality of life questionnaire（IBDQ）, and the adverse reactions were compared between the two groups.
Results The total effective rate of the combined TCM group was significantly higher than that of the mesalazine group, and the symptom remission time（mucous, pus and blood stools, abdominal pain and diarrhea）was shorter than that of the mesalazine group（P < 0.05）. The TCM syndrome scores such as mucous, pus and blood stools, loose stool diarrhea, abdominal distension, abdominal pain and fatigue of the two groups before treatment were not significant（P > 0.05）. After treatment, the scores of TCM symptoms such as mucus, abscess, blood stool, loose stool diarrhea, abdominal distension, abdominal pain and fatigue, Mayo and DAI scores, the levels of TNF-α, IL-8 and IL-17, and IBDQ scores were improved in two groups. And these scores and levels in combined Chinese medicine group were better than those in mesalazine group（P < 0.05）. The adverse reaction rate of the combined TCM group was lower than that of the mesalazine group（P < 0.05）.
Conclusion The combination of Shenling Baizhu Powder and methalazine in the treatment of ulcerative colitis with spleen deficiency and dampness has a good effect, and the clinical symptoms and quality of life of the patients have been significantly improved after treatment, which can better promote the recovery of the patients, and the treatment is safe and reliable.
, authors=Yuanyuan LI, Ling CHANG, Qihua XU, Ying ZHOU, Qilin ZHANG, authorsList=Yuanyuan LI, Ling CHANG, Qihua XU, Ying ZHOU, Qilin ZHANG, authorCompany=null, correspAuthors=Qilin ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125469342912531, articleId=1317125468839596049, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=参苓白术散联合美沙拉秦治疗脾虚湿蕴证溃疡性结肠炎临床及安全性观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察脾虚湿蕴证溃疡性结肠炎患者应用参苓白术散联合美莎拉嗪治疗的疗效以及用药安全性。
方法 研究合计纳入82例脾虚湿蕴证溃疡性结肠炎患者（2021年3月—2024年3月收治），采取随机数字表法进行分组，根据治疗方法不同将患者分为单纯采取美沙拉秦治疗的美沙拉秦组以及采取参苓白术散联合美沙拉秦治疗的联合中医组，各组41例，观察两组疗效、症状消失时间（黏液脓血便、腹痛及腹泻）、治疗前后黏液脓血便、便溏腹泻、腹胀、腹痛、神疲肢倦等中医证候积分变化及改良梅奥评分（Mayo SCore，Mayo）及疾病活动指数（disease activity index，DAI）评分变化、肿瘤坏死因子α（tumor necrosis factor，TNF-α）、白细胞介素-8（interleukin-8，IL-8）及白细胞介素-17（interleukin-17，IL-17）指标变化，采取炎症性肠病生活质量量表（inflammatory bowel disease questionnaire，IBDQ）评估两组患者生活质量情况，对比两组患者治疗不良反应。
结果 联合中医组患者治疗总有效率明显高于美沙拉秦组，症状消失时间（黏液脓血便、腹泻、腹痛）均比美沙拉秦组更短，P < 0.05；两组患者治疗前黏液脓血便、便溏腹泻、腹胀、腹痛、神疲肢倦等中医证候积分、Mayo以及DAI评分、TNF-α及IL-8、IL-17、IBDQ评分比较，均P > 0.05，两组患者治疗后黏液脓血便、便溏腹泻、腹胀、腹痛、神疲肢倦等中医证候积分、Mayo以及DAI评分、TNF-α及IL-8、IL-17、IBDQ评分均改善，联合中医组患者治疗后黏液脓血便、便溏腹泻、腹胀、腹痛、神疲肢倦等中医证候积分、Mayo以及DAI评分、TNF-α及IL-8、IL-17、IBDQ评分均优于美沙拉秦组，P < 0.05；联合中医组患者不良反应率低于美沙拉秦组，P < 0.05。
结论 脾虚湿蕴证溃疡性结肠炎患者应用参苓白术散与美沙拉秦联合方案治疗作用良好，治疗后患者临床症状及生活质量明显改善，可较好促进患者恢复，治疗安全可靠。
, authors=李园园, 常玲, 许琦华, 周颖, 张旗林, authorsList=李园园, 常玲, 许琦华, 周颖, 张旗林, authorCompany=null, correspAuthors=张旗林, authorNote=
李园园（1992 -），女，山东菏泽人，医师，学士，研究方向：消化道肿瘤，炎症性肠病。
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张旗林（1976 -），男，上海人，副主任医师，学士，研究方向：消化道肿瘤。
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李园园（1992 -），女，山东菏泽人，医师，学士，研究方向：消化道肿瘤，炎症性肠病。
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李园园（1992 -），女，山东菏泽人，医师，学士，研究方向：消化道肿瘤，炎症性肠病。
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