Article(id=1317125451596804302, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.030, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956778668, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956778668, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956778668, creator=13701087609, updateTime=1791956778668, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=164, endPage=168, ext={EN=ArticleExt(id=1317125452016234703, articleId=1317125451596804302, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress of Extraction，Purification，Structural Characteristics and Anti-Tumor Mechanism of Polysaccharides from Shihu（Dendrobium dendrobium）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

The Dendrobium polysaccharide（DP）is one of the main functional components of Shihu（Dendrobium dendrobium）, which has become a hot spot in current research because of its wide range of biological activities. This paper systematically expounded the research progress of the extraction, isolation and purification, content determination, structure identification and antitumor activity of DP at home and abroad in the past 10 years, analyzed the shortcomings in the current research of DP. For example, although DP are diverse, the extraction rate is affected by various factors, and the different extraction methods have an impact on the structure and activity of DP. The extraction, isolation and purification methods have not been standardized. In the stage of monosaccharides and molecular weight measurement, the relationship between the structure is not clear enough. At the same time, DP, especially small molecule DP, polysaccharide fragments in small molecules, inhibits the proliferation of tumor cells, promotes tumor cell apoptosis, autophagy, anti-metastasis and anti-invasion. And it looked forward to the future research directions of DP, established the quality standards for the extraction, isolation and purification of DP, further accurately identifed the structure of DP, promoted the research on advanced structures, applied the emerging omics technologies to study the relationship between the structure of DP and anti-tumor activity, and revealed its anti-tumor mechanism in order to provide a theoretical basis for the development and reasonable application of DP.

, authors=Jun Wu¹, Ting LE¹, Shangdian WANG¹, Zilu GUO¹, siya YANG¹, Jinrong FU², Jinhong FU², Jing ZHU¹, Wenting WU¹, authorsList=Jun Wu, Ting LE, Shangdian WANG, Zilu GUO, siya YANG, Jinrong FU, Jinhong FU, Jing ZHU, Wenting WU, authorCompany=null, correspAuthors=Jing ZHU, Wenting WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125452741849296, articleId=1317125451596804302, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=石斛多糖提取、分离纯化、结构鉴定和抗肿瘤机制研究进展, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

石斛多糖（Dendrobium polysaccharide，DP）是石斛主要功效成分之一，因其广泛的生物活性，成为当前研究的热点。系统阐述国内外近10年来有关石斛多糖的提取、分离纯化、含量测定、结构分析及抗肿瘤机制研究方面的进展，分析了目前石斛多糖研究中存在的不足，如石斛多糖虽提取方法多样，但提取率受多种因素影响，且不同提取方法对多糖的结构和活性有影响，而且提取、分离纯化方法尚未规范化、标准化，其结构研究仍处于一级结构中单糖组成及分子量测定的阶段，构效关系不够明确等。同时发现石斛多糖尤其是小分子量的石斛多糖片段通过增强免疫应答、抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、促进肿瘤细胞自噬、抗转移和抗侵袭以及抗氧化等机制发挥其独特的抗肿瘤作用。继而展望石斛多糖未来的研究方向，制定石斛多糖提取和分离纯化的质量标准，进一步精准鉴定石斛多糖结构，推动进入高级结构的研究，应用新兴的组学技术研究石斛多糖结构及抗肿瘤活性之间的关系，揭示其抗肿瘤机制等。以期为石斛多糖的深度开发及合理应用提供理论支持。

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吴俊（2001 -），男（苗族），湖南湘西人，硕士在读，研究方向：中药制剂。

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吴俊（2001 -），男（苗族），湖南湘西人，硕士在读，研究方向：中药制剂。

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