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Article(id=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956774040, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956774040, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956774040, creator=13701087609, updateTime=1791956774040, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=154, endPage=159, ext={EN=ArticleExt(id=1317125432655336188, articleId=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To optimize the process conditions for extracting polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）using water extraction and alcohol precipitation method.

Method

Water extraction and alcohol precipitation were used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, and a three-factor experiment was conducted. On this basis, a Box Benhnken（BBD）response surface experiment was designed, integrating the experimental results and fitting the data. A fitting model was established for the degree of influence between factors and response values, and its water extraction and alcohol precipitation process were optimized. And it preliminarily characterized the structure of its polysaccharides and determined their antioxidant activity.

Result

The optimal extraction conditions for water extraction and alcohol extraction of polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）were a solid-liquid ratio of 1∶22.11（g/mL）, reflux time of 129 min 36 s, 3 times. The average extraction rate of 5 times was 4.324%, which was close to the system＇s predicted value of 4.313%. After PMP derivatization and HPLC analysis, the results showed that the polysaccharides of Yejiaoteng（Tuber Fleeceflower Stem）were mainly composed of Man, Rha, Glc and Gal, with a molar ratio of 29.87∶3.36∶51.25∶39.98. The infrared spectrum showed characteristic peaks of polysaccharides at 3420, 1600, 1000 cm-1. The clearance rates of polysaccharides（Y-TD）on DPPH and ABTS free radicals were 78.2% and 85.4%, respectively.

Conclusion

Box-Behnken response surface design optimization of water extraction and alcohol precipitation extraction process is stable and reliable, and can be used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）with antioxidant activity.

, authors=Qimao HAN1, Zixin PANG2, Lu CHEN1, Shijia ZHANG2, Hongcai ZHANG2, authorsList=Qimao HAN, Zixin PANG, Lu CHEN, Shijia ZHANG, Hongcai ZHANG, authorCompany=null, correspAuthors=Hongcai ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125432915383037, articleId=1317125432189768443, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

优化水提醇沉法提取夜交藤多糖工艺条件。

方法

利用水提醇沉法提取夜交藤多糖，进行三因素实验。在此基础上，设计响应面实验（Box-Benhnken Design，BBD），进行数据拟合，优化其水提醇沉工艺。并对其多糖进行结构初步表征，抗氧化活性测定。

结果

夜交藤多糖水浸醇提的最佳提取条件∶料液比1∶22.11（g/mL），回流时间129 min 36 s，次数为3次。5次提取率的平均值为4.324%，与系统预测值4.313%相近。经PMP衍生后HPLC分析，结果表明，夜交藤多糖主要是由Man、Rha、Glc、Gal组成，其摩尔比为29.87∶3.36∶51.25∶39.98。红外光谱可见多糖3420、1600、1000 cm-1特征峰。多糖（Y-TD）对DPPH、ABTS自由基的清除率分别为78.2%和85.4% 。

结论

Box-Behnken响应面设计优化水提醇沉提取工艺稳定可靠，可用于提取具有抗氧化活性的夜交藤多糖。

, authors=韩其茂1, 庞子鑫2, 陈璐1, 张诗嘉2, 张洪财2, authorsList=韩其茂, 庞子鑫, 陈璐, 张诗嘉, 张洪财, authorCompany=null, correspAuthors=张洪财, authorNote=

韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

, correspAuthorsNote=
张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究
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韩其茂 1 , 庞子鑫 2 , 陈璐 1 , 张诗嘉 2 , 张洪财 2
中华中医药学刊 | 国家项目点击 2026,44(3): 154-159
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 154 -159
夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究
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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

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韩其茂1, 庞子鑫2, 陈璐1, 张诗嘉2, 张洪财2
作者信息
  • 1.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040
  • 2.黑龙江中医药大学，黑龙江 哈尔滨 150040
通讯作者:
张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
作者简介:

韩其茂（1984 -），男，黑龙江哈尔滨人，主治医师，博士，研究方向：中药治疗干燥综合征、类风湿关节炎的药效物质基础。

Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）
Qimao HAN1, Zixin PANG2, Lu CHEN1, Shijia ZHANG2, Hongcai ZHANG2
Affiliations
  • 1.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
  • 2.Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.028
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摘要
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目的

优化水提醇沉法提取夜交藤多糖工艺条件。

方法

利用水提醇沉法提取夜交藤多糖，进行三因素实验。在此基础上，设计响应面实验（Box-Benhnken Design，BBD），进行数据拟合，优化其水提醇沉工艺。并对其多糖进行结构初步表征，抗氧化活性测定。

结果

夜交藤多糖水浸醇提的最佳提取条件∶料液比1∶22.11（g/mL），回流时间129 min 36 s，次数为3次。5次提取率的平均值为4.324%，与系统预测值4.313%相近。经PMP衍生后HPLC分析，结果表明，夜交藤多糖主要是由Man、Rha、Glc、Gal组成，其摩尔比为29.87∶3.36∶51.25∶39.98。红外光谱可见多糖3420、1600、1000 cm-1特征峰。多糖（Y-TD）对DPPH、ABTS自由基的清除率分别为78.2%和85.4% 。

结论

Box-Behnken响应面设计优化水提醇沉提取工艺稳定可靠，可用于提取具有抗氧化活性的夜交藤多糖。

夜交藤  /  多糖  /  设计响应面实验（BBD）  /  结构表征  /  抗氧化
Objective

To optimize the process conditions for extracting polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）using water extraction and alcohol precipitation method.

Method

Water extraction and alcohol precipitation were used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）, and a three-factor experiment was conducted. On this basis, a Box Benhnken（BBD）response surface experiment was designed, integrating the experimental results and fitting the data. A fitting model was established for the degree of influence between factors and response values, and its water extraction and alcohol precipitation process were optimized. And it preliminarily characterized the structure of its polysaccharides and determined their antioxidant activity.

Result

The optimal extraction conditions for water extraction and alcohol extraction of polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）were a solid-liquid ratio of 1∶22.11（g/mL）, reflux time of 129 min 36 s, 3 times. The average extraction rate of 5 times was 4.324%, which was close to the system＇s predicted value of 4.313%. After PMP derivatization and HPLC analysis, the results showed that the polysaccharides of Yejiaoteng（Tuber Fleeceflower Stem）were mainly composed of Man, Rha, Glc and Gal, with a molar ratio of 29.87∶3.36∶51.25∶39.98. The infrared spectrum showed characteristic peaks of polysaccharides at 3420, 1600, 1000 cm-1. The clearance rates of polysaccharides（Y-TD）on DPPH and ABTS free radicals were 78.2% and 85.4%, respectively.

Conclusion

Box-Behnken response surface design optimization of water extraction and alcohol precipitation extraction process is stable and reliable, and can be used to extract polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）with antioxidant activity.

Yejiaoteng（Tuber Fleeceflower Stem）  /  polysaccharide  /  Box-Behnken designed（BBD）surface response methodology  /  structural characterization  /  antioxidant
韩其茂, 庞子鑫, 陈璐, 张诗嘉, 张洪财. 夜交藤多糖提取工艺优化、结构表征及抗氧化活性研究. 中华中医药学刊, 2026 , 44 (3) : 154 -159 . DOI: 10.13193/j.issn.1673-7717.2026.03.028
Qimao HAN, Zixin PANG, Lu CHEN, Shijia ZHANG, Hongcai ZHANG. Optimization of Extraction Process，Structural Characterization and Antioxidant Activity of Polysaccharides from Yejiaoteng（Tuber Fleeceflower Stem）[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 154 -159 . DOI: 10.13193/j.issn.1673-7717.2026.03.028
基金
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  • 国家自然科学基金项目(81803711)
  • 黑龙江省自然科学基金项目(PL2024H210)
  • 黑龙江省中医药科研项目(ZHY2023-166)
  • 黑龙江中医药大学科研基金项目(2019MS08)
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文章信息
doi: 10.13193/j.issn.1673-7717.2026.03.028
  • 首发时间：2026-10-14
  • 出版时间：2026-03-10
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作者
出版历史
基金
国家自然科学基金项目(81803711)
黑龙江省自然科学基金项目(PL2024H210)
黑龙江省中医药科研项目(ZHY2023-166)
黑龙江中医药大学科研基金项目(2019MS08)
作者信息
    1.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040
    2.黑龙江中医药大学，黑龙江 哈尔滨 150040

通讯作者:

张洪财（1983 -），男，黑龙江绥芬河人，副研究员，硕士研究生导师，博士，研究方向：中药化学成分提取工艺优化及活性。E-mail：。
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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