Article(id=1317125425713755111, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956772496, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956772496, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956772496, creator=13701087609, updateTime=1791956772496, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=129, endPage=133, ext={EN=ArticleExt(id=1317125425910887400, articleId=1317125425713755111, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Carrier-free Nanoparticles Composed of Curcumin-Quercetin for Anti-Tumor Treatment, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To achieve the co-delivery of water insoluble anti-tumor herbal components and enhance their anti-tumor efficacy, the natural polyphenolic compounds curcumin（Cur）and quercetin（Que）were co-assembled into curcumin-quercetin nanoparticles by carrier-free drug self-assembly technology.
Methods The organic solution containing Cur and Que was added to an aqueous system by a drug liquid-phase self-assembly method to finally prepare curcumin-quercetin nanoparticles（Cur-Que NPs）. The morphology, particle size, phase properties and the stability of Cur-Que NPs were investigated by scanning electron microscopy（SEM）, X-ray powder diffraction（XRPD）and differential scanning calorimetry（DSC）. The self-assembly mechanism of Cur-Que was studied by Fourier transform infrared spectroscopy（FTIR）. The cytotoxicity of Cur-Que NPs on 4T1 cells was investigated by MTT assay. A 4T1 tumor-bearing mice model was established to study the combined anti-tumor efficacy of Cur-Que NPs in vivo.
Results The prepared Cur-Que NPs were amorphous and spherical with the particle size at（44.33 ± 12.18）nm. The lyophilized-treated Cur-Que NPs also remained spherical and the particle size was（44.53 ± 10.08）nm in SEM, indicating that the Cur-Que NPs had good stability. From the SEM, XRPD and DSC results, the morphology, particle size as well as existing forms of the lyophilized Cur-Que NPs remained unchanged for 6 months of storage at room temperature away from light, indicating that the Cur-Que NPs had good physical stability. From FTIR result, hydrogen bonding interaction was the driving force for the self-assembly of Cur-Que. Compared to other treatment groups, the Cur-Que NPs group showed significantly enhanced cytotoxicity（P < 0.001）. Also, the Cur-Que NPs group had the most significant inhibitory effect on tumor growth compared with the Cur API group or the Que API group（P < 0.05）.
Conclusion Carrier-free Cur-Que NPs for self-assembly could achieve co-delivery for drugs and significantly improve anti-tumor efficacy.
, authors=Mingyue RUAN, Jialing LI, Yunan DONG, Wanling CHEN, Haitong ZHANG, Yaqiu MIAO, Ning HAN, Shouying DU, Kai WU, authorsList=Mingyue RUAN, Jialing LI, Yunan DONG, Wanling CHEN, Haitong ZHANG, Yaqiu MIAO, Ning HAN, Shouying DU, Kai WU, authorCompany=null, correspAuthors=Shouying DU, Kai WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125427718632425, articleId=1317125425713755111, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=姜黄素-槲皮素无载体复合纳米颗粒用于抗肿瘤的实验研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 为了实现难溶性抗肿瘤中药成分的共同递送并提高其抗肿瘤效果，采用无载体药物自组装技术将天然多酚类物质姜黄素（Curcumin，Cur）和槲皮素（Quercetin，Que）制备成姜黄素-槲皮素复合纳米颗粒。
方法 利用药物液相自组装方法，将姜黄素-槲皮素复合溶液加入至水性体系中，二者共组装得到姜黄素-槲皮素复合纳米颗粒（Cur-Que NPs），通过扫描电子显微镜（Scanning electron microscopy，SEM）、X射线粉末衍射法（X-ray powder diffraction，XRPD）和差示扫描量热法（Differential scanning calorimetry，DSC）对Cur-Que NPs的形貌、粒径、物相性质及其稳定性进行研究；并进一步采用傅里叶变换红外光谱仪（Fourier transform infrared spectroscopy，FTIR）探究姜黄素与槲皮素的组装机制；在MTT法考察Cur-Que NPs对4T1细胞的毒性基础上，建立4T1荷瘤小鼠模型研究Cur-Que NPs在体内的联合抗肿瘤效果。
结果 Cur-Que NPs为无定型球形颗粒，粒径为（44.33 ± 12.18）nm。将Cur-Que NPs冻干粉体在水中进行再分散后，其颗粒仍为球形，粒径为（44.53 ± 10.08）nm，说明Cur-Que NPs水再分散性良好。SEM、XRPD与DSC结果表明，冻干后的纳米颗粒在6个月的储存过程中形貌、粒径以及存在状态均未发生明显变化，具有较好物理稳定性。FTIR结果表明，姜黄素和槲皮素自组装主要依靠氢键相互作用。细胞毒性实验表明，与其他治疗组相比，Cur-Que NPs组具有更强的细胞杀伤效果（P < 0.001）。体内药效实验结果表明，与姜黄素原料药组或槲皮素原料药组相比，Cur-Que NPs组对肿瘤生长的抑制效果最为显著（P < 0.05）。
结论 姜黄素-槲皮素无载体复合纳米颗粒能够实现药物的共同递送，显著提高抗肿瘤疗效。
, authors=阮明月, 李加玲, 董昱男, 陈宛灵, 张海桐, 苗雅秋, 韩宁, 杜守颖, 吴凯, authorsList=阮明月, 李加玲, 董昱男, 陈宛灵, 张海桐, 苗雅秋, 韩宁, 杜守颖, 吴凯, authorCompany=null, correspAuthors=杜守颖, 吴凯, authorNote=
阮明月（2000 -），女，湖北天门人，硕士在读，研究方向：中药学-中药新剂型与新技术。
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阮明月（2000 -），女，湖北天门人，硕士在读，研究方向：中药学-中药新剂型与新技术。
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