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Article(id=1317125468365631833, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956782665, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956782665, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956782665, creator=13701087609, updateTime=1791956782665, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=81, endPage=84, ext={EN=ArticleExt(id=1317125468755702106, articleId=1317125468365631833, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Jianpi Huatan Formula（健脾化痰方）Alleviates Atherosclerosis via Inhibiting Inflammasome in vitro, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

This study observed the effects of Jianpi Huatan Formula（健脾化痰方, JPHTF）on oxidized low-density lipoprotein（ox-LDL）induced vascular smooth muscle cell viability, proliferation, phenotype transformation and inflammatory factors in vitro.

Methods

Smooth muscle cells were isolated from the thoracic aorta of C57BL/6J mice. The 6-8 week old Sprague Dawley rats were orally administered, and the blood samples were collected from the abdominal aorta to prepare the drug containing serum. The DMEM medium culture was the control group. The ox-LDL induction（100 μg/mL）was the ox-LDL group. The atorvastatin group were the serum containing ox-LDL and atorvastatin（0.4 μM）. JPHTF low, middle and high dose groups were the serum containing ox-LDL and JPHTF（5%, 10%, 15%）. The identification of the first generation vascular smooth muscle cells？（VSMCs）was carried out by using immunofluorescence staining with α-smooth muscle actin（α-SMA）antibody. The cell counting kit-8（CCK-8）method was used to detect the cell viability. Transwell assay was used to observe the cell migration. Western Blot was used to detect the expressions of α-SMA, Calponin, SM22α, proliferating cell nuclear antigen（PCNA）, osteopontin（OPN）, ASC, NOD-like receptor family pyrin domain containing 3（NLRP3）and cleaved caspase-1 in cells, and enzyme-linked immunosorbent assay（ELISA）was used to detect the levels of interleukin-1β（IL-1β）, interleukin -18（IL-18）, tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）in cell supernatant.

Results

JPHTF inhibited ox-LDL induced VSMCs proliferation and phenotype transition. JPHTF reduced the protein expression levels of NLRP3, ASC and cleaved caspase-1. ELISA results showed that JPHTF significantly reduced the levels of IL-1β and IL-18, as well as the levels of TNF-α and IL-6.

Conclusion

The effect of JPHTF in vitro can inhibit the conversion of VSMCs induced by ox-LDL from contractile phenotype to synthetic phenotype, reduce the ability of cell proliferation and migration, lower the levels of NL-RP3, ASC and cleaved caspase-1, and inhibit the activation of inflammasome, thereby inhibiting the development of atherosclerosis.

, authors=Miao TIAN1, 2, Lianqun JIA2, Nan SONG2, Dongyu MIN1, Yang WANG1, Le GUAN1, Yetao JU1, Fengrong WANG1, authorsList=Miao TIAN, Lianqun JIA, Nan SONG, Dongyu MIN, Yang WANG, Le GUAN, Yetao JU, Fengrong WANG, authorCompany=null, correspAuthors=Fengrong WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125469242241371, articleId=1317125468365631833, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=健脾化痰方抑制炎症小体改善小鼠主动脉粥样硬化的体外作用机制, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

研究通过体外实验观察健脾化痰方对ox-LDL诱导的血管平滑肌细胞活力、增殖、表型转换及炎症因子的影响。

方法

C57BL/6J小鼠分离胸主动脉制备平滑肌细胞。6～8周龄SD（Sprague Dawley）大鼠灌胃给药，腹主动脉取血制备含药血清。DMEM培养基培养，ox-LDL：100 μg/mL ox-LDL诱导，Atorvastatin：ox-LDL +阿托伐他汀（0.4 μM）含药血清，JPHTF-L/M/H：ox-LDL + JPHTF含药血清（5%，10%，15%）。免疫荧光染色α-SMA抗体鉴定初代VSMCs。CCK-8法检测细胞活力，Transwell实验观察细胞迁移情况，Western Blot检测细胞中α-SMA、Calponin、SM22α、PCNA、OPN、ASC、NLRP3、cleaved Caspase-1表达，ELISA检测细胞上清中IL-1β、IL-18、TNF-α和IL-6的含量。

结果

JPHTF抑制ox-LDL诱导的VSMCs增殖和表型转换，JPHTF处理可降低NLRP3、ASC和cleaved Caspase-1蛋白表达水平，ELISA结果提示JPHTF处理能显著降低IL-1β和IL-18含量，降低TNF-α和IL-6炎症因子的水平。

结论

健脾化痰方体外作用可抑制ox-LDL诱导的VSMCs从收缩表型向合成表型转换，降低细胞增殖和细胞迁移能力，减少NLRP3、ASC和cleaved Caspase-1水平，抑制炎症小体的激活，从而延缓动脉粥样硬化发展。

, authors=田苗1, 2, 贾连群2, 宋囡2, 闵冬雨1, 王洋1, 关乐1, 鞠业涛1, 王凤荣1, authorsList=田苗, 贾连群, 宋囡, 闵冬雨, 王洋, 关乐, 鞠业涛, 王凤荣, authorCompany=null, correspAuthors=王凤荣, authorNote=

田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

, correspAuthorsNote=
王凤荣（1962 -），女，辽宁沈阳人，主任医师，博士研究生导师，博士，研究方向：中西医结合心血管疾病。E-mail：。
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田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

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田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

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健脾化痰方抑制炎症小体改善小鼠主动脉粥样硬化的体外作用机制
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田苗 1, 2 , 贾连群 2 , 宋囡 2 , 闵冬雨 1 , 王洋 1 , 关乐 1 , 鞠业涛 1 , 王凤荣 1
中华中医药学刊 | 国家项目点击 2026,44(3): 81-84
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中华中医药学刊 |国家项目点击 2026 , 44 (3) : 81 -84
健脾化痰方抑制炎症小体改善小鼠主动脉粥样硬化的体外作用机制
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田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

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田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

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田苗1, 2, 贾连群2, 宋囡2, 闵冬雨1, 王洋1, 关乐1, 鞠业涛1, 王凤荣1
作者信息
  • 1.辽宁中医药大学附属医院，辽宁 沈阳 110032
  • 2.辽宁中医药大学，辽宁 沈阳 110847
通讯作者:
王凤荣（1962 -），女，辽宁沈阳人，主任医师，博士研究生导师，博士，研究方向：中西医结合心血管疾病。E-mail：。
作者简介:

田苗（1981 -），女，辽宁抚顺人，副主任医师，硕士，研究方向：从脾论治心血管疾病。

Jianpi Huatan Formula（健脾化痰方）Alleviates Atherosclerosis via Inhibiting Inflammasome in vitro
Miao TIAN1, 2, Lianqun JIA2, Nan SONG2, Dongyu MIN1, Yang WANG1, Le GUAN1, Yetao JU1, Fengrong WANG1
Affiliations
  • 1.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China
  • 2.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
出版时间: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.015
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摘要
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目的

研究通过体外实验观察健脾化痰方对ox-LDL诱导的血管平滑肌细胞活力、增殖、表型转换及炎症因子的影响。

方法

C57BL/6J小鼠分离胸主动脉制备平滑肌细胞。6～8周龄SD（Sprague Dawley）大鼠灌胃给药，腹主动脉取血制备含药血清。DMEM培养基培养，ox-LDL：100 μg/mL ox-LDL诱导，Atorvastatin：ox-LDL +阿托伐他汀（0.4 μM）含药血清，JPHTF-L/M/H：ox-LDL + JPHTF含药血清（5%，10%，15%）。免疫荧光染色α-SMA抗体鉴定初代VSMCs。CCK-8法检测细胞活力，Transwell实验观察细胞迁移情况，Western Blot检测细胞中α-SMA、Calponin、SM22α、PCNA、OPN、ASC、NLRP3、cleaved Caspase-1表达，ELISA检测细胞上清中IL-1β、IL-18、TNF-α和IL-6的含量。

结果

JPHTF抑制ox-LDL诱导的VSMCs增殖和表型转换，JPHTF处理可降低NLRP3、ASC和cleaved Caspase-1蛋白表达水平，ELISA结果提示JPHTF处理能显著降低IL-1β和IL-18含量，降低TNF-α和IL-6炎症因子的水平。

结论

健脾化痰方体外作用可抑制ox-LDL诱导的VSMCs从收缩表型向合成表型转换，降低细胞增殖和细胞迁移能力，减少NLRP3、ASC和cleaved Caspase-1水平，抑制炎症小体的激活，从而延缓动脉粥样硬化发展。

健脾化痰方  /  动脉粥样硬化  /  血管平滑肌细胞  /  表型转化  /  NLRP3
Objective

This study observed the effects of Jianpi Huatan Formula（健脾化痰方, JPHTF）on oxidized low-density lipoprotein（ox-LDL）induced vascular smooth muscle cell viability, proliferation, phenotype transformation and inflammatory factors in vitro.

Methods

Smooth muscle cells were isolated from the thoracic aorta of C57BL/6J mice. The 6-8 week old Sprague Dawley rats were orally administered, and the blood samples were collected from the abdominal aorta to prepare the drug containing serum. The DMEM medium culture was the control group. The ox-LDL induction（100 μg/mL）was the ox-LDL group. The atorvastatin group were the serum containing ox-LDL and atorvastatin（0.4 μM）. JPHTF low, middle and high dose groups were the serum containing ox-LDL and JPHTF（5%, 10%, 15%）. The identification of the first generation vascular smooth muscle cells？（VSMCs）was carried out by using immunofluorescence staining with α-smooth muscle actin（α-SMA）antibody. The cell counting kit-8（CCK-8）method was used to detect the cell viability. Transwell assay was used to observe the cell migration. Western Blot was used to detect the expressions of α-SMA, Calponin, SM22α, proliferating cell nuclear antigen（PCNA）, osteopontin（OPN）, ASC, NOD-like receptor family pyrin domain containing 3（NLRP3）and cleaved caspase-1 in cells, and enzyme-linked immunosorbent assay（ELISA）was used to detect the levels of interleukin-1β（IL-1β）, interleukin -18（IL-18）, tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）in cell supernatant.

Results

JPHTF inhibited ox-LDL induced VSMCs proliferation and phenotype transition. JPHTF reduced the protein expression levels of NLRP3, ASC and cleaved caspase-1. ELISA results showed that JPHTF significantly reduced the levels of IL-1β and IL-18, as well as the levels of TNF-α and IL-6.

Conclusion

The effect of JPHTF in vitro can inhibit the conversion of VSMCs induced by ox-LDL from contractile phenotype to synthetic phenotype, reduce the ability of cell proliferation and migration, lower the levels of NL-RP3, ASC and cleaved caspase-1, and inhibit the activation of inflammasome, thereby inhibiting the development of atherosclerosis.

Jianpi Huatan Formula（健脾化痰方）  /  atherosclerosis  /  vascular smooth muscle cell  /  phenotype transformation  /  NLRP3
田苗, 贾连群, 宋囡, 闵冬雨, 王洋, 关乐, 鞠业涛, 王凤荣. 健脾化痰方抑制炎症小体改善小鼠主动脉粥样硬化的体外作用机制. 中华中医药学刊, 2026 , 44 (3) : 81 -84 . DOI: 10.13193/j.issn.1673-7717.2026.03.015
Miao TIAN, Lianqun JIA, Nan SONG, Dongyu MIN, Yang WANG, Le GUAN, Yetao JU, Fengrong WANG. Jianpi Huatan Formula（健脾化痰方）Alleviates Atherosclerosis via Inhibiting Inflammasome in vitro[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 81 -84 . DOI: 10.13193/j.issn.1673-7717.2026.03.015
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  • 国家自然科学基金青年科学基金项目(81904079)
  • 辽宁省科技计划联合计划技术攻关项目(2024JH2/102600194)
  • 沈阳市科技局常见多发病医疗技术提升项目(21-173-9-53)
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2026年第44卷第3期
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doi: 10.13193/j.issn.1673-7717.2026.03.015
  • 首发时间：2026-10-14
  • 出版时间：2026-03-10
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基金
国家自然科学基金青年科学基金项目(81904079)
辽宁省科技计划联合计划技术攻关项目(2024JH2/102600194)
沈阳市科技局常见多发病医疗技术提升项目(21-173-9-53)
作者信息
    1.辽宁中医药大学附属医院，辽宁 沈阳 110032
    2.辽宁中医药大学，辽宁 沈阳 110847

通讯作者:

王凤荣（1962 -），女，辽宁沈阳人，主任医师，博士研究生导师，博士，研究方向：中西医结合心血管疾病。E-mail：。
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https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.03.015
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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