Article(id=1317125402582176227, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956766981, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956766981, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956766981, creator=13701087609, updateTime=1791956766981, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7, endPage=12, ext={EN=ArticleExt(id=1317125403005800932, articleId=1317125402582176227, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Exploring Effect of Jiawei Wendan Decoction（加味温胆汤）in Improving IR in Obesity T2DM Rats Based on PI3K/AKT-GLUT4 Pathway, columnId=1256183423710970242, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=New Opinion of Ph.D. Supervisor, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the intervention effect and mechanism of Jiawei Wendan Decoction（加味温胆汤）on insulin resistance（IR）in obesity type 2 diabetes mellitus（T2DM）rats based on PI3K/AKT-GLUT4 signaling pathway.
Methods Using high-fat feeding induced spontaneous diabetic obese rats（Zucker diabetic fatty, ZDF）, 5 SPF-grade 5 weeks old lean control（fa/+）males were the blank controls, and 10 ZDF（fa/fa）male rats were randomly divided into model control group and Jiawei Wendan Decoction group. The concentration of Jiawei Wendan Decoction was 9.04 g/（kg·d）, while the blank control group and the model control group were given the same volume ultrapure water daily by gavage for 6 weeks. Body weights, food intakes and the levels of fasting blood glucose（FBG）were measured regularly every week, and oral glucose tolerance test（OGTT）was performed at the end of the experiment. The mRNA and protein expression levels of insulin receptor-β（INSR-β）, phosphoinositol 3-kinase（PI3K）, protein kinase B（AKT）, phosphorylated-protein kinase B（p-AKT）and glucose transporter 4（GLUT4）were detected in skeletal muscle tissue by real-time fluorescence quantitative PCR experiment（RT-qPCR）and Western blotting experiment（WB）.
Results Compared with those of the blank control group, the rats of the model control group showed a significant increase in body weight in the early stage, and showed a significant decrease in body weight during the hyperglycemia stage. However, the food intake and FBG increased significantly, and the glucose tolerance decreased significantly. Compared with the model control group, the Jiawei Wendan Decoction group was able to significantly control weekly weight gain and food intake, significantly reducedthe FBG levels, and significantly increased the glucose tolerance. Compared with those in the blank control group, the mRNA and protein expression levels of INSR（β）, PI3K-p85, AKT, p-AKT and GLUT4 were significantly reduced in the model control group. Compared with those in the model control group, the mRNA and protein expression levels of INSR（β）, PI3K-p85, AKT, p-AKT and GLUT4 were significantly increased in the Jiawei Wendan Decoction group.
Conclusion Jiawei Wendan Decoction can effectively reduce the blood glucose and improve the glucose tolerance. The mechanism may be related to the regulation of IR by the PI3K/AKT-GLUT4 pathway.
, authors=Fengyun YAO
1, Yaoyao HAN
1, Kaiyin ZHANG
1, Jielin JIANG
2, Lin WANG
2, Hongfang YANG
3, Wen LI
3, Huanyuan ZHANG
1, Yankun CUI
1, 2, authorsList=Fengyun YAO, Yaoyao HAN, Kaiyin ZHANG, Jielin JIANG, Lin WANG, Hongfang YANG, Wen LI, Huanyuan ZHANG, Yankun CUI, authorCompany=null, correspAuthors=Yankun CUI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125403848856037, articleId=1317125402582176227, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=基于PI3K/AKT-GLUT4通路探讨加味温胆汤改善肥胖型2型糖尿病大鼠胰岛素抵抗的作用, columnId=1256183426563096985, journalTitle=中华中医药学刊, columnName=博士导师新论, runingTitle=null, highlight=null, articleAbstract=
目的 基于PI3K/AKT-GLUT4信号通路探讨加味温胆汤对肥胖型2型糖尿病（Type 2 diabetes mellitus，T2DM）大鼠胰岛素抵抗（insulin resistance，IR）的干预效果和作用机制。
方法 采用高脂饲养诱导自发型2型糖尿病肥胖大鼠（Zucker diabetic fatty，ZDF）动物模型，SPF级5周龄的瘦型对照（fa/+）雄性大鼠（Lean Zucker，LZ）5只为空白对照组，ZDF（fa/fa）雄性大鼠10只，随机分为模型对照组和加味温胆汤组。加味温胆汤组给予生药浓度为9.04 g/（kg·d），空白对照组和模型对照组每日予同体积超纯水，连续灌胃给药6周。每周定期检测大鼠的体质量、摄食量、空腹血糖（Fasting Blood Glucose，FBG），实验末期进行口服葡萄糖耐量试验（Oral glucose tolerance test，OGTT）。采用实时定量聚合酶链反应（Real-time quantitative polymerase chain reaction，RT-qPCR）法和蛋白免疫印迹（Western Blotting，WB）法检测骨骼肌组织中胰岛素β受体［insulin receptor-β，INSR（β）］、磷脂酰肌醇3-激酶（phosphoinositol 3-kinase，PI3K）、蛋白激酶B（protein kinase B，AKT）、磷酸化蛋白激酶B（phosphorylated-protein kinase B，p-AKT）和葡萄糖转运蛋白-4（glucose transporter 4，GLUT4）的mRNA和蛋白表达水平。
结果 与空白对照组相比，模型对照组大鼠体质量初期显著增长，在其高血糖阶段模型对照组大鼠体质量出现明显下降趋势，但其摄食量和FBG显著升高，葡萄糖耐量显著降低；与模型对照组相比，加味温胆汤组能够明显控制每周体质量增长量和摄食量，显著降低FBG水平，显著升高葡萄糖耐量。与空白对照组相比，模型对照组INSR（β）、PI3K-p85、AKT、p-AKT、GLUT4 mRNA和蛋白表达水平显著降低；与模型对照组相比，加味温胆汤组INSR（β）、PI3K-p85、AKT、p-AKT、GLUT4 mRNA和蛋白表达水平显著升高。
结论 加味温胆汤能有效降低肥胖型T2DM大鼠的血糖，改善葡萄糖耐量，其机制可能与调控PI3K/AKT-GLUT4通路改善IR相关。
, authors=姚凤云
1, 韩瑶瑶
1, 张凯茵
1, 姜劼琳
2, 王琳
2, 杨红芳
3, 李雯
3, 张桓源
1, 崔言坤
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姚凤云（1975 -），女，黑龙江绥化人，教授，博士研究生导师，博士，研究方向：方剂配伍规律与现代研究。
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北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
