Article(id=1317125401672004357, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.03.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956766764, onlineDateStr=2026-10-14, pubDate=1773072000000, pubDateStr=2026-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956766764, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956766764, creator=13701087609, updateTime=1791956766764, updator=13701087609, issue=Issue{id=1317125400581485316, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='3', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1773072000000', pubDateStr='2026-03-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956766504, creator='13701087609', updateTime=1791958763799, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133777898418844, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133777898418845, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125400581485316, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=6, ext={EN=ArticleExt(id=1317125402062074630, articleId=1317125401672004357, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=A Multicenter Randomized Controlled Clinical Study of Xiaoer Dingchuan Granules（小儿定喘颗粒）Treating Respiratory Syncytial Virus Pneumonia（Phlegm-Heat Blocking Lung Syndrome）, columnId=1256183423710970242, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=New Opinion of Ph.D. Supervisor, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the clinical effect of Xiaoer Dingchuan s（小儿定喘颗粒）in children with respiratory syncytial virus pneumonia（phlegm-heat blocking lung syndrome）.
Method A stratified block randomized, single-blind, parallel controlled and multi-center clinical study was conducted. A total of 240 children hospitalized in 10 pediatric centers from October 2022 to June 2024 were randomly divided into control group and experimental group. The control group received the basic treatment, and the experimental group received Xiaoer Dingchuan Granules on the basis of the control group. The medical record observation table was recorded, and the total effective rate, clinical cure time, curative effect of TCM syndromes, curative effect of main symptoms and signs, wheezing score, adverse reactions and wheezing recurrence after discharge were observed and compared between the two groups after the trial.
Results A total of 240 children were included（120 cases in the experimental group and 120 cases in the control group）. After treatment, the total effective rate, clinical healing time and TCM syndrome efficacy of the experimental group were better than those of the control group, and the total effective rate and TCM syndrome efficacy of the experimental group were higher than those of the control group, with statistical significance（P < 0.05）. The effective rate and onset time of main symptoms and signs in the experimental group were better than those in the control group, and the differences were statistically significant（P < 0.05）, especially in the symptom of wheezing and phlegm in the throat. After treatment, the wheezing score of the experimental group was lower than that of the control group, and the difference was statistically significant（P < 0.05）. There was no significant difference in the incidence of adverse reactions between the groups（P > 0.05）. The number of recurrent wheezing after discharge in the experimental group was significantly lower than that in the control group, with statistical significance（P < 0.01）.
Conclusion The application of Xiaoer Dingchuan Granules in the treatment of children with respiratory syncytial virus pneumonia（phlegm-heat blocking lung syndrome）has a good clinical effect, and has a significant effect in improving the symptoms of wheezing and phlegm in the throat, shortening the acute period and reducing the wheezing recurrence, with high clinical application safety. It is worthy of clinical promotion.
, authors=Xuefeng WANG
1, Yuyan CHEN
2, Baoqing ZHANG
3, Mengqing WANG
4, Yu PENG
5, Lingling ZHUANG
6, Ping HE
7, Dan XIE
8, Weiwei LI
9, Na GAN
10, Xiuying ZHANG
1, Ruixue LI
11, Hui WANG
11, authorsList=Xuefeng WANG, Yuyan CHEN, Baoqing ZHANG, Mengqing WANG, Yu PENG, Lingling ZHUANG, Ping HE, Dan XIE, Weiwei LI, Na GAN, Xiuying ZHANG, Ruixue LI, Hui WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125402498282248, articleId=1317125401672004357, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=小儿定喘颗粒治疗呼吸道合胞病毒肺炎（痰热闭肺证）多中心随机对照临床研究, columnId=1256183426563096985, journalTitle=中华中医药学刊, columnName=博士导师新论, runingTitle=null, highlight=null, articleAbstract=
目的 评价小儿定喘颗粒干预儿童呼吸道合胞病毒肺炎（痰热闭肺证）临床疗效。
方法 采用分层区组随机化、单盲、平行对照、多中心临床研究方法，将2022年10月—2024年6月于10家分中心儿科住院纳入试验的受试患儿240例，随机分为对照组和试验组，对照组采取基础治疗，试验组在对照组的基础上加服小儿定喘颗粒，记录病历观察表，试验结束后观察比较两组疾病的总有效率、临床痊愈时间、中医证候疗效、主要症状与体征的疗效、患儿喘息评分、不良反应以及随访出院后是否再发喘息等情况。
结果 共纳入240例患儿（试验组120例，对照组120例），治疗后，疾病总有效率、临床痊愈时间及中医证候疗效试验组优于对照组，差异具有统计学意义（P < 0.05）；主要症状与体征的有效率及起效时间试验组优于对照组，差异均具有统计学意义（P < 0.05），尤其以喉间痰鸣症状效果显著；治疗后试验组患儿喘息评分小于对照组，差异具有统计学意义（P < 0.05）；不良反应发生率组间比较差异均无统计学意义（P > 0.05），随访患儿出院后再发喘息次数试验组明显少于对照组，差异有统计学意义（P < 0.01）。
结论 应用小儿定喘颗粒治疗小儿呼吸道合胞病毒肺炎（痰热闭肺证）具有较好的临床疗效，在改善喘息与喉间痰鸣症状方面疗效显著，缩短病程急性期，临床应用安全性较高，减少日后喘息再发，值得临床推广。
, authors=王雪峰
1, 陈玉燕
2, 张葆青
3, 王孟清
4, 彭玉
5, 庄玲伶
6, 何平
7, 谢丹
8, 李伟伟
9, 甘娜
10, 张秀英
1, 李瑞雪
11, 王辉
11, authorsList=王雪峰, 陈玉燕, 张葆青, 王孟清, 彭玉, 庄玲伶, 何平, 谢丹, 李伟伟, 甘娜, 张秀英, 李瑞雪, 王辉, authorCompany=null, correspAuthors=null, authorNote=
王雪峰（1957 -），女，辽宁沈阳人，教授、主任医师，博士研究生导师，博士，研究方向：中医药防治儿科疾病。
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1.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724491819823775, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724491656245916, language=CN, stringName=王雪峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.辽宁中医药大学附属医院，辽宁 沈阳 110032, bio={"content":"
王雪峰（1957 -），女，辽宁沈阳人，教授、主任医师，博士研究生导师，博士，研究方向：中医药防治儿科疾病。
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王雪峰（1957 -），女，辽宁沈阳人，教授、主任医师，博士研究生导师，博士，研究方向：中医药防治儿科疾病。
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1.辽宁中医药大学附属医院，辽宁 沈阳 110032)])]), Author(id=1319724491937264289, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724492021150371, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724491937264289, language=EN, stringName=Yuyan CHEN, firstName=Yuyan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2.Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724492105036453, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724491937264289, language=CN, stringName=陈玉燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2.浙江省中医院，浙江 杭州 310006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724489051583101, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, xref=2., ext=[AuthorCompanyExt(id=1319724489059971710, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724489051583101, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang, China), AuthorCompanyExt(id=1319724489072554623, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724489051583101, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.浙江省中医院，浙江 杭州 310006)])]), Author(id=1319724492172145319, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724492251837097, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492172145319, language=EN, stringName=Baoqing ZHANG, firstName=Baoqing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724492348306090, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492172145319, language=CN, stringName=张葆青, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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3.山东中医药大学附属医院，山东 济南 250014, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724490746081920, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, xref=3., ext=[AuthorCompanyExt(id=1319724490754470529, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724490746081920, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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4, address=
4.The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410036, Hunan, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724492553826991, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492411220652, language=CN, stringName=王孟清, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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4.湖南中医药大学附属第一医院，湖南 长沙 410036, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724490855133827, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, xref=4., ext=[AuthorCompanyExt(id=1319724490863522436, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724490855133827, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
4.The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410036, Hunan, China), AuthorCompanyExt(id=1319724490871911045, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724490855133827, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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5, address=
5.The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, Guizhou, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724492780319412, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492616741553, language=CN, stringName=彭玉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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5.贵州中医药大学第二附属医院，贵州 贵阳 550003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724490934825606, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, xref=5., ext=[AuthorCompanyExt(id=1319724490943214215, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724490934825606, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, Guizhou, China), AuthorCompanyExt(id=1319724490955797128, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, companyId=1319724490934825606, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
5.贵州中医药大学第二附属医院，贵州 贵阳 550003)])]), Author(id=1319724492855816886, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724492927120056, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492855816886, language=EN, stringName=Lingling ZHUANG, firstName=Lingling, middleName=null, lastName=ZHUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
6, address=
6.The First Clinical College, Jilin Academy of Traditional Chinese Medicine, Changchun 130021, Jilin, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724492994228921, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125401672004357, authorId=1319724492855816886, language=CN, stringName=庄玲伶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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