Article(id=1317125514469425481, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956793658, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956793658, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956793658, creator=13701087609, updateTime=1791956793658, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=156, endPage=161, ext={EN=ArticleExt(id=1317125514695917898, articleId=1317125514469425481, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Yishen Huoxue Tongqiao Formula（益肾活血通窍方）Modulates Glu-IR，GFAP and ERK1/2 in Vestibular Dysfunction Rats：Implications for Cerebellar Synaptic Remodeling, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of Yishen Huoxue Tongqiao Formula（益肾活血通窍方）on the expressions of glutamate immunoreactivity（Glu-IR），glial fibrillar acidic protein（GFAP）and extracellular signal regulated kinases 1 and 2（ERK1/2）in the affected cerebellar glomerulus area of rats with unilateral vestibular dysfunction as well as its mechanism of action on synaptic remodeling.
Methods In this experiment，88 rats were selected as the research subjects and randomly divided into six groups：blank group，sham operation group，model group，and low（0.92 mg/mL），medium（1.83 g/mL）and high（3.66 g/mL）dose groups of Yishen Huoxue Tongqiao Formula. A rat model of unilateral vestibular dysfunction was established by injecting chloroform into the right ear tympanic cavity. After modeling，the vestibular function and the expressions of related bio-markers of each group were evaluated by behavioral evaluation，glutamate content detection，immunohistochemistry，immunofluorescence and Western blot methods.
Results 12 h after operation，compared with the sham operation group and the blank group，the imbalance behavior score and spatial posture reflex were significantly increased in the model group，and there were abnormal nerve injury behaviors such as head deviation and rotation（P<0.01）. The glutamic acid content and Glu-IR protein expression were decreased，the proliferation and activation degree of GFAP cells were increased，the degree of cell fiber protration was increased and the ERK1/2 immunofluorescence intensity was significantly increased（P<0.05）. Compared with those in the model group，the glutamate contents，Glu-IR protein expressions，proliferation and activation degree of GFAP cells and ERK1/2 immunofluorescence brightness expressions were increased in Yishen Huoxue Tongqiao Formula low，medium and high dose groups，and the expression was most obvious in high dose group（P<0.05）. After 7 days of operation，compared with those in the sham operation group and the blank group，the unbalanced behavior score and spatial posture reflex disappeared in the model group，the normal movement，abnormal head deviation and turning behavior disappeared（P>0.05），the glutamic acid content decreased，the Glu-IR protein expression decreased，the GFAP cell proliferation and activation increased，and the ERK1/2 immunofluorescence intensity was obvious（P<0.05）. Compared with those in the model group，the glutamate contents，Glu-IR protein expressions，proliferation and activation degree of GFAP cells and ERK1/2 immunofluorescence brightness expressions were increased in the Yishen Huoxue Tongqiao Formula low，medium and high dose groups，and the expression was most obvious in the high dose group（P<0.05）. Compared with those in the model group 12 h after operation，the glutamic acid content and Glu-IR protein expression were increased，the proliferation and activation degree of GFAP cells were decreased，and the immunofluorescence brightness expression of ERK1/2 was decreased in the model group（P<0.05）.
Conclusion By regulating the expressions of Glu-IR，GFAP and ERK1/2 through multiple targets，Yishen Huoxue Tongqiao Formula promotes the synaptic remodeling mechanism，accelerates the vestibular compensatory process，and provides a new direction for the treatment of vestibular dysfunction.
, authors=Yu TIAN
1, Hui LENG
2, Lei SHI
2, Aiping WANG
2, Qi ZHANG
2, Rupeng QU
2, Zhongyuan QU
2, Xiande MA
1, authorsList=Yu TIAN, Hui LENG, Lei SHI, Aiping WANG, Qi ZHANG, Rupeng QU, Zhongyuan QU, Xiande MA, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125514934993227, articleId=1317125514469425481, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=益肾活血通窍方对单侧前庭功能障碍大鼠小脑绒球区Glu-IR、GFAP和ERK1/2调控及突触重塑的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨益肾活血通窍方对单侧前庭功能障碍大鼠患侧小脑绒球区的谷氨酸免疫反应物（Glutamate immunoreactivity，Glu-IR）、胶质纤维酸性蛋白（Glial fibrillary acidic protein，GFAP）和细胞外信号调节激酶1/2（Extracellular signal-regulated kinases 1 and 2，ERK1/2）的表达影响，以及对突触重塑发挥的作用机制。
方法 将88只大鼠作为研究对象，通过随机分组筛选出空白组、假手术组、模型组、益肾活血通窍方低剂量组（9.20 g/kg）、益肾活血通窍方中剂量组（18.39 g/kg）、益肾活血通窍方高剂量组（36.78 g/kg）共6组。采用氯仿进行右耳鼓室注射法建立单侧前庭功能障碍大鼠模型，造模后，通过行为学评价、谷氨酸含量检测、免疫组化法、免疫荧光法和Western blot法，评估各组大鼠前庭功能和相关生物标志物的表达。
结果 术后12 h，与假手术组及空白组比，模型组失衡行为评分及空间姿势反射明显升高，出现头偏斜、转圈异常神经损伤行为（P<0.01），谷氨酸含量降低，Glu-IR蛋白表达降低，GFAP细胞增殖活化程度增多，排列紧密，细胞纤维突起程度增加，ERK1/2免疫荧光强度显著增加（P<0.05）。与模型组相比，益肾活血通窍方低剂量组、中剂量组、高剂量组谷氨酸含量增加，Glu-IR蛋白表达升高，GFAP细胞增殖活化程度降低，ERK1/2免疫荧光亮度表达降低，高剂量组表达最明显（P<0.05）。术后7 d，与假手术组及空白组相比，模型组失衡行为评分和空间姿势反射消失，大鼠运动正常，头偏斜、转圈异常行为消失（P>0.05），谷氨酸含量降低，Glu-IR蛋白表达降低，GFAP细胞增殖活化高，ERK1/2免疫荧光强度明显（P<0.05）。与模型组相比，益肾活血通窍方低剂量组、中剂量组、高剂量组谷氨酸含量增加，Glu-IR蛋白表达升高，GFAP细胞增殖活化程度降低，ERK1/2免疫荧光亮度表达降低，高剂量组表达最明显（P<0.05）。与术后12 h模型组相比，术后7 d模型组大鼠的谷氨酸含量升高，Glu-IR蛋白表达升高，GFAP细胞增殖活化程度降低，ERK1/2免疫荧光亮度表达降低（P<0.05）。
结论 益肾活血通窍方通过多靶点调控Glu-IR、GFAP和ERK1/2的表达，促进突触重塑机制，加快了前庭代偿过程，为前庭功能障碍治疗提供了新方向。
, authors=田雨
1, 冷辉
2, 石磊
2, 王爱平
2, 张琦
2, 曲汝鹏
2, 曲中源
2, 马贤德
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