Article(id=1317125559914713821, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.02.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791956804492, onlineDateStr=2026-10-14, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791956804492, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791956804492, creator=13701087609, updateTime=1791956804492, updator=13701087609, issue=Issue{id=1317125500041015883, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791956790217, creator='13701087609', updateTime=1791958795145, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317133909368877755, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317133909373072060, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317125500041015883, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=130, endPage=136, ext={EN=ArticleExt(id=1317125560103457502, articleId=1317125559914713821, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Analysis of Clinical Anastomosis of Traditional Chinese and Western Medicine of Animal Model of Liver Fibrosis, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective Liver fibrosis is a common chronic liver disease，which is easy to develop into cirrhosis and even liver cancer. Its morbidity and mortality are high. The pathogenesis has not been fully defined，and there are no specific drugs against liver fibrosis. Animal model experiments are commonly used in liver fibrosis research. Based on the clinical characteristics of liver fibrosis，this paper summarized and evaluated the existing animal models of liver fibrosis，providing references for improving the establishment of animal models of liver fibrosis combining disease and syndrome.
Methods According to the clinical diagnostic criteria of traditional Chinese medicine（TCM）and Western medicine for liver fibrosis，the clinical characteristics of TCM and Western medicine were summarized，assigned and evaluated.
Results It was concluded that subcutaneous/intraperitoneal injection of CCl4 suspension modeling，intraperitoneal injection/free drinking of thionoacetamide modeling，caudal vein injection of hepatitis B virus modeling，subcutaneous injection of CCl4 solution + high-fat feed + ethanol solution drinking modeling were highly consistent with Western medicine，but were not well consistent with TCM. The coincidence between TCM and western medicine is good，and the coincidence between TCM and Western medicine is the highest.
Conclusion The existing animal model of the combination of disease and syndrome has a high coincidence between TCM. and Western medicine. According to the syndrome type of traditional Chinese medicine，it is feasible to simulate the development and change of human liver fibrosis in animals and establish the corresponding animal model of liver fibrosis（healthy Qi deficiency，toxin accumulation and blood stasis type）. However，at present，the animal model of combining disease and syndrome still does not cover all syndrome types，and lacks the unified and standardized syndrome differentiation standards. Therefore，it is necessary to use the idea of combining TCM and Western medicine and modern biotechnology to establish a more suitable animal model of combining disease and syndrome with liver fibrosis on the basis of ensuring the accuracy and stability of the model，so as to provide a research basis for the treatment of liver fibrosis by combining TCM and Western medicine.
, authors=Yuanqian MIN
1, Xinxin ZHOU
2, Xianghua LIU
2, Shan LI
3, Yi YANG
3, Baoping LU
4, authorsList=Yuanqian MIN, Xinxin ZHOU, Xianghua LIU, Shan LI, Yi YANG, Baoping LU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317125560380281568, articleId=1317125559914713821, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=肝纤维化动物模型的中西医临床吻合度分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 肝纤维化是一种临床较常见的慢性肝脏疾病，进一步发展易成肝硬化甚至肝癌，其发病率和病死率较高，发病机制尚未完全明确，且目前尚无抗肝纤维化的特效药物。而动物模型实验是肝纤维化研究中常用的手段，基于肝纤维化的临床病证特点，对现有肝纤维化动物模型进行总结评估，为完善肝纤维化病证结合动物模型的建立提供参考。
方法 通过查阅文献，依据肝纤维化的中西医临床诊断标准，对肝纤维化动物模型的中西医临床病证特点进行归纳、总结并进行赋值和评价。
结果 总结发现皮下/腹腔注射四氯化碳（carbon tetrachloride，CCl4）混悬液造模法、腹腔注射/自由饮用硫代乙酰胺造模法、尾静脉注入乙型肝炎病毒造模和皮下注射CCl4溶液+高脂饲料+乙醇溶液饮用造模法与西医吻合度较高，但与中医吻合度不佳；中医证型造模的中西医吻合度均较好，其中正虚毒蕴血瘀型与中西医吻合度最高。
结论 现有的病证结合类动物模型中西医吻合度较高，但应用并不广泛。根据中医证型，在动物中模拟人体肝纤维化的发生发展变化，建立对应的肝纤维化病证结合动物模型具有可行性（正虚毒蕴血瘀型）。但目前已建立的病证结合类动物模型仍未涵盖所有证型，且缺乏统一、规范的辨证标准，因此需要运用中西医结合思路，结合现代生物技术手段，在保证模型准确、稳定的基础上，建立更贴合临床实际的病证结合肝纤维化动物模型，为中西医结合治疗肝纤维化提供研究基础。
, authors=闵远骞
1, 周欣欣
2, 刘湘花
2, 李姗
3, 杨艺
3, 禄保平
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